Embargo expired: 10/6/2009 7:00 PM EDT
Source Newsroom: Health Behavior News Service
Newswise — When kidney stones become stuck in the urinary tract, the pain can be excruciating and debilitating.
A relatively new ultrasound probe procedure has the highest success rate for breaking down kidney stones in the lower “funnel” area of the kidney, rather than the shock wave treatment used for many years, according to a review of studies.
However, the reviewers caution that the studies were small, comprising only 214 patients, and the study methodology was of low quality.
The review appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews like this one draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.
The authors looked at the effectiveness of three minimally invasive procedures: the older treatment, called extracorporeal shock wave lithotripsy (ESWL); the ultrasound procedure, or percutaneous nephrolithotomy (PCNL); and retrograde intrarenal surgery (RIRS), which uses a fiber-optic endoscope.
ESWL, which has been in use since 1980, sends shock waves directly to the kidney stone to break it up so it can pass through the urinary tract.
In the PCNL approach, the surgeon makes a small incision at the person’s back to put the scope into the kidney and then passes a tube into the kidney through which the surgeon can pass a laser ultrasound probe to remove or break the stone into tiny pieces.
The RIRS procedure involves a fiber-optic endoscope placed through the urethra and into the bladder. The scope locates stones, which the clinician can then disintegrate with an ultrasound probe.
“We found that the ultrasound probe had a much higher success rate in terms of stone-free kidneys than using shock waves,” said lead author Attasit Srisubat, M.D., at the Institute of Medical Research and technology assessment in Thailand. “The success rate of using a fiber-optic endoscope did not differ significantly from shock wave treatment. However, the use of shock wave treatment did result in less time in the hospital and a shorter duration of treatment.”
The overall success rates of each treatment reviewed did not relate to patients’ age, race or sex.
Kidney stones are rock-hard masses that develop when crystals separate from urine. For most people, kidney stones do not pose a major medical problem because they usually pass through the body’s urine stream without any difficulty, but when stones grow too large, intense pain can result, as well as infection, blood in the urine and even kidney failure.
There are three main funnels in the kidney — upper, middle and lower. The review studies focus on kidney stones in the lower funnel (or lower pole), which drains the bottom third of the kidney’s urine collecting system.
Risk factors for developing kidney stones include “family history, anatomical abnormalities of kidney diseases, (and) medications, such as whether a person is taking calcium supplements or vitamin D supplements,” Srisubat said.
Medicine helps some people, but other patients need an alternative approach. With the expanded use of minimally invasive treatments, the need for open surgery to remove stones has decreased.
Glenn Preminger, M.D., of the division of urologic surgery with Duke University Medical Center, routinely performs all three noninvasive forms of stone removal. “All of these treatments work relatively well depending on the size, location and composition of the stone,” he said. “For certain stones that are large or are of a hard composition, they may not fragment well with shock wave treatment. For these we prefer to use an endoscopic means of stone removal.”
Anthony Smith, M.D., chief of the division of urology at the University of New Mexico School of Medicine, said they also use all three methods compared in the review for kidney stone removal. “My overall impression is that we are using less and less shock wave treatment and more ureteroscopic intervention with the laser. With the new bi-directional ureteroscopes, we are able to treat larger stones in the upper urinary tract with great success,” he said.
Smith said that his facility does use shock wave treatment for smaller stones that clearly are visible on film. “But we think we have better success with lower pole stones using either ureteroscopic or percutaneous approaches.”
The Cochrane Library (http://www.thecochranelibrary.com) contains high quality health care information, including Systematic Reviews from The Cochrane Collaboration. These reviews bring together research on the effects of health care and are considered the gold standard for determining the relative effectiveness of different interventions. The Cochrane Collaboration (http://www.cochrane.org) is an international nonprofit, independent organization that produces and disseminates systematic reviews of health care interventions and promotes the search for evidence in the form of clinical trials and other studies of interventions.
Srisubat A. Extracorporeal shock wave lithotripsy (ESWL) versus percutaneous nephrolithotomy (PCNL) or retrograde intrarenal surgery (RIRS) for kidney stones (Review)The Cochrane Database of Systematic Reviews 2009, Issue 4.