An international consortium published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).
In the first year after the sudden removal of a requirement that prescribers get special permission to prescribe medication for opioid addiction, a study finds more prescribers started providing it, but the number of patients receiving it didn't rise very much.
Learn more about five research centers at Argonne National Laboratory that help researchers bring climate science from the lab to the world.
Immigrants to Canada who have spent a greater proportion of their lives in Canada have a greater risk of developing multiple sclerosis (MS) than people who have spent a smaller proportion of their lives there, according to a study published in the April 24, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that an increased proportion of life in Canada causes MS; it only shows an association.
People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a study published in the April 24, 2024, online issue of Neurology® Clinical Practice, an official journal of the American Academy of Neurology. The acid-reducing drugs include proton pump inhibitors such as omeprazole and esomeprazole, histamine H2-receptor antagonists, or H2 blockers, such as cimetidine and famotidine, and antacid supplements.
Sweet potato quality assessment is crucial for producers and processors because features influence texture and taste, consumer preferences, and viability for different purposes. A new study from the University of Illinois Urbana-Champaign explores the use of hyperspectral imaging and explainable artificial intelligence (AI) to assess sweet potato attributes.
Supervised exercise therapy allows a Wyomissing woman with peripheral artery disease to dance again. She and a Penn State Health expert talk about why exercise is a game changer.
Colonoscopy is often recommended following an episode of diverticulitis to exclude missed colorectal cancer (CRC). Now one study, published in the Clinical Gastroenterology and Hepatology journal, shows that the prevalence of CRC is low in most patients with diverticulitis. However, patients with complicated diverticulitis are the exception.
A university professor has found a way to help students – and himself – power through long lecture classes: exercise breaks. A new study showed that five-minute exercise sessions during lectures were feasible and that students reported positive impacts on their attention and motivation, engagement with their peers and course enjoyment.
A new way of quickly distinguishing between illegal elephant ivory and legal mammoth tusk ivory could prove critical to fighting the illegal ivory trade. A laser-based approach developed by scientists at the Universities of Bristol and Lancaster, could be used by customs worldwide to aid in the enforcement of illegal ivory from being traded under the guise of legal ivory.
A thin film that combines an electrode grid and LEDs can both track and produce a visual representation of the brain’s activity in real-time during surgery–a huge improvement over the current state of the art.
As patients with congenital heart diseases live longer, researchers are attempting to understand some of the other complications they may face as they age. In a new study, a team from Children’s Hospital of Philadelphia (CHOP) used state-of-the-art technologies to understand the underlying biology of Fontan-associated liver disease (FALD).
The Association for Diagnostics & Laboratory Medicine (ADLM, formerly AACC) is proud to announce the recipients of the 2024 ADLM and Academy of Diagnostics & Laboratory Medicine Awards. Through this annual awards program, ADLM and its Academy recognize individuals around the world for outstanding research and service in the field of laboratory medicine and highlight the vital contributions made by all lab professionals to patient care.
The American Society for Pharmacology and Experimental Therapeutics (ASPET) and Elsevier, a global leader in information and analytics, are partnering to publish the Society’s four journals.
Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges. But how do cells swiftly adapt to these environmental fluctuations? A new Moffitt Cancer Center study, published in iScience, is answering that question by challenging our understanding of how cells function. A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes.
A new study led by Indiana University School of Medicine researchers found a brain network condition called “explosive synchronization” could be the cause of extreme pain crises in people with sickle cell disease.
Alzheimer’s treatment studies offer hope as UNLV expert predicts new potential drugs, biomarkers will yield critical insight for future development.
Acclaimed psychologist Roxane Cohen Silver of the University of California, Irvine – whose groundbreaking studies on stress and coping have advanced understanding of how traumatic incidents like terror attacks, infectious disease outbreaks and natural disasters affect people – has been elected a member by the American Academy of Arts & Sciences.
Conditions such as diabetes, heart attack and vascular diseases commonly diagnosed in people with spinal cord injuries can be traced to abnormal post-injury neuronal activity that causes abdominal fat tissue compounds to leak and pool in the liver and other organs, a new animal study has found.
AI is a valuable asset, so long as it’s used properly, though customer service organizations shouldn’t rely on it exclusively to guide their strategies, according to new research from Binghamton Univesity, State University of New York.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Investigators in the Smidt Heart Institute at Cedars-Sinai and colleagues report that women with Type 2 diabetes diagnosed with hypertension before age 50 may benefit from intensive blood pressure treatment.
The genus Musa, encompassing approximately 70 herbaceous species, is predominantly found in the tropical and subtropical regions of Asia and Oceania.
Cucumber (Cucumis sativus L.) holds significant importance among greenhouse vegetables in China, despite its relatively low salt tolerance. Grafting cucumber onto pumpkin rootstocks, which exhibit strong salt tolerance, can improve its resistance to saline conditions. Earlier research conducted by the team revealed that the pumpkin rootstock CmoNAC1 boosts salt tolerance in grafted cucumbers by modulating H2O2/ABA signaling and maintaining K+/Na+ balance through its interaction with the promoters of CmoRBOHD1/CmoNCED6 and CmoAKT1;2/CmoHKT1;1.
The frequency and intensity of plant stresses have increased in recent years due to climate change. Among them, low temperature is an unavoidable environmental factor limiting agricultural productivity.
Mercy BioAnalytics, Inc., a pioneer in extracellular vesicle-based liquid biopsy for the early detection of cancer, will present data at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting showing the performance of its Mercy Halo™ Ovarian Cancer screening test in a large cohort of asymptomatic, postmenopausal women.
A Ludwig Cancer Research study has discovered how a lipid molecule found at high levels within tumors undermines the anti-cancer immune response and compromises a recently approved immunotherapy known as adoptive cell therapy (ACT) using tumor infiltrating lymphocytes, or TIL-ACT.
For the second year in a row, engineering students from The University of Alabama in Huntsville, a part of the University of Alabama System, have captured first place in the NASA Human Exploration Rover Challenge (HERC) competition. With the latest victory, UAH has won first place five times in the 30-year history of the event, taking top honors in 1996, 2012, 2018, 2023 and now 2024.
The secondary salinization of saline-alkali land is increasing globally.
When one study says a treatment works, but another says it doesn’t (or worse), how are clinicians supposed to determine what they should do? A Penn Medicine team recently received funding from PCORI to build a guide system for these situations
A three-year, $1.19 million grant from the Tobacco-Related Disease Research Program will allow University of California, Irvine researchers to explore how specific sections of DNA might influence nicotine addiction. Deeper insights into these neurological processes may lead to more effective prevention and treatment strategies for cigarette smoking and vaping habits.
A research team completes a high-quality chromosome-scale assembly of the 'Chuanhonghua 1' safflower genome.
Study identifies key pathways underlying perianal fistula, a disease complication that is more prevalent and severe in African Ameri can populations
Researchers investigated the influence of ploidy level on mitochondrial DNA (mtDNA) copy number and gene expression in fish. They compared mtDNA copy numbers in liver and muscle of red crucian carp, common carp, and two allotriploid fish across different seasons.
Diosgenin, a secondary metabolite isolated from the Dioscorea spp. plant family, is an irreplaceable and ideal starting material for the synthesis of steroid hormone drugs.
Paul Barnes, the Marguerite Scribante Professor of Piano in the Glenn Korff School of Music, will be performing a special program of composer Philip Glass’s works inside “Greenpoint,” a sculpture by Richard Serra on the University of Nebraska–Lincoln’s City Campus at noon, May 1. The performance is free and open to the public.
As Lyme disease cases rise in the U.S., humans are not the only ones at risk. Veterinarians with the Virginia-Maryland College of Veterinary Medicine say dogs are increasingly vulnerable to this tick-borne illness. “Black-legged ticks, also called deer ticks, are most common carriers of Borrelia burgdorfer and can be found in the northeastern and north-central parts of the U.
A new survey has found that for residents living within three miles of a large-scale solar development, positive attitudes outnumbered negative attitudes by almost a 3-to-1 margin. Researchers at Lawrence Berkeley National Laboratory, Michigan State University and the University of Michigan surveyed almost 1,000 residents living near solar projects — the first time a representative survey of this kind has been deployed nationally.
In perennial woody plants, bud endodormancy is crucial for survival under adverse environmental conditions in winter such as low temperature (LT) and dehydration stress.
Patients with a common movement disorder known as essential tremor (ET) developed dementia at three times the rate of similarly aged people in the general population, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in the Annals of Neurology, provide the first concrete data to help doctors counsel those with this condition on their cognitive prognosis, future plans, and potential treatments, the authors said.
Grafting is a traditional and significant strategy to suppress soil-borne diseases, such as the crown gall disease caused by tumorigenic Agrobacterium and Rhizobium.
Pick's disease, a neurodegenerative disease of unknown genetic origin, is a rare type of frontotemporal dementia that affects people under the age of 65.
.Researchers at the Department of Energy’s Oak Ridge National Laboratory developed a comprehensive modeling method to better predict the drop in electricity generation when hurricane clouds overshadow solar panels. The team explored ways to compensate for these energy losses with super grids, a collection of grids connected so electricity can flow across island chains or between continents.
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