A Science-Based Discussion of the Role of Magtein™, a Novel Compound of Magnesium –L-threonate, For Cognitive Health, including Dementia and Alzheimer’s Disease

Released: 3-Mar-2014 9:00 AM EST
Source Newsroom: AIDP
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Newswise — City of Industry, CA – March 3, – AIDP, the manufacturer of Magtein™, a proprietary blend of magnesium –L-threonate, today released a “White Paper” demonstrating the extensive peer-reviewed and published science behind the product’s mechanism of action, its safety and efficacy. The product helps consumers maintain cognitive health, including slowing down but also reversing memory decline as well as addressing the serious health concerns of dementia and Alzheimer’s disease.

Dr. Guosong Liu, one of the world’s leading cognitive health researchers said, “There is general scientific agreement that magnesium is an essential cofactor for more than 300 enzymes involved in biosynthesis processes and energy metabolism. In addition, it plays an important role in many of the brain’s functions; but most magnesium compounds have low brain bioavailability and severe gastrointestinal side effects.

“However, a significant number of health care providers are unaware that Magtein, is the only magnesium compound that has been shown to effectively raise the brain’s magnesium levels, which leads to enhanced learning abilities, working memory, and short- and long-term memory in both young and aged animals. Four published preclinical studies found that Magtein improved memory, and help prevent the decline and reverse the symptoms of Alzheimer’s. ”1

The White Paper notes:
• The ability to raise brain magnesium levels were evaluated among the most bioavailable organic and inorganic magnesium forms. Magnesium concentration in the cerebrospinal fluid was evaluated following treatment of different magnesium compounds available including Magtein and the most bioavailable inorganic magnesium, magnesium-chloride, and the most bioavailable organic magnesium, magnesium-gluconate in milk. After 24 days, Magtein was the only magnesium compound to raise the cerebrospinal fluid magnesium concentration with statistical significance.
• Learning and memory are fundamental brain functions affected by dietary and environmental factors. Our research shows that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, Magtein) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats.
• Evaluations of animals taking different magnesium forms for their short-term and long-term memory by a novel object recognition test demonstrated that only Magtein subjects showed a significant increase in both short term and long-term memory.

A PDF of the White Paper is available at: http://magtein.com/thescience.html.

Editor’s Note: A double blind, placebo controlled human trial is completed and the exciting data is expected to be published in a peer-reviewed journal later this year. This study shows that human use of Magtein significantly enhances cognitive functions and decrease symptoms of cognitive impairments. For interviews with Dr. Liu, please contact Pamela Stewart, Essenza Communications, 303-570-1678.

In surveys conducted by the American Association of Retired People and ASA-MetLife Foundation, nearly 9 out of 10 consumers believe it is possible to improve cognitive fitness, and more than 4 out of 5 people older than 50 say “staying mentally sharp” is their No. 1 concern. A deteriorating mental state concerns baby boomers more than death itself.2

According to the National Alzheimer’s Association:
• Alzheimer's is the most common form of dementia, a general term for memory loss and other intellectual abilities serious enough to interfere with daily life. Alzheimer's disease accounts for 50 to 80 percent of dementia cases.
• Alzheimer’s is the sixth leading cause of death in the United States3

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AIDP is a leader in functional ingredients, with a focus on extensively researched products that meet consumer demand for wellness and healthy aging. Our commitment is to source high-quality ingredients and provide proprietary solutions that address formulation challenges. AIDP's success is grounded in its depth of experience and commitment to strong science for functional food and beverage product development.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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1 Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer's Disease Mouse Model”, Li W., Yu J., Liu Y., Huang X., Abumaria N., Zhu Y., Huang X., Xiong W., Ren C., Liu X., Chui D., and Liu G., Journal of Neuroscience, 2013. 33(19): p8423-41.
2 http://newhope360.com/supplements/rethinking-brain-health?cid=nl_npi_daily&&sfvc4enews=42&cl=article_1
3 http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp


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