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Dartmouth Cancer Researcher on Genetic-Based Testing and Treatment for Breast Cancer

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Dr. Tsongalis is the director of the Molecular Pathology laboratory and co-director of the translational research program in the Geisel School of Medicine at Dartmouth, the Dartmouth Hitchcock Medical Center, and the Norris Cotton Cancer Center in Lebanon, N.H. In 1994, he completed his post-doctoral training in clinical chemistry at the University of North Carolina, Chapel Hill, where he was first exposed to molecular diagnostics. Throughout his career, Dr. Tsongalis has been striving to apply molecular techniques to diagnostic questions that are not adequately addressed by traditional laboratory methods and has challenged the boundaries between clinical pathology and anatomic pathology. His early work described methods for localized in situ amplification of DNA and RNA targets in tissue sections as well as the identification of mutation carriers in the BRCA1 and BRCA2 breast cancer risk genes. He described some of the first applications of molecular methods in identity testing of clinical specimens when mislabeling or a mix-up was suspected. His laboratory was an early adopter of automation for high-volume molecular infectious disease testing and active in the development of molecular techniques for use with unconventional specimen types. His laboratory is currently applying state-of-the-art molecular techniques to improve patient management through precision medicine. His laboratory continually pushes the application of molecular technologies beyond their traditional uses and is now focusing on nanotechnologies for routine use in the clinical setting. His work has led to 140 publications and eight textbooks in the field of molecular pathology. Dr. Tsongalis has served on many professional society committees, including the AACC board of directors, and the editorial boards of several medical journals, including Clinical Chemistry.

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