April Medical Tipsheet From Cedars-Sinai

Released: 10-Apr-2014 6:00 PM EDT
Source Newsroom: Cedars-Sinai Medical Center
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Newswise — Following is a tipsheet of story ideas from Cedars-Sinai Medical Center. To arrange interviews, please contact the individual listed.

Tumors ‘Light Up’ With New, Unique Imaging System Using Scorpion Venom Protein and a Laser
Researchers at the Cedars-Sinai Maxine Dunitz Neurosurgical Institute and Department of Neurosurgery have developed a unique, compact, relatively inexpensive imaging device to “light up” malignant brain tumors and other cancers. The experimental system consists of a special camera designed and developed at Cedars-Sinai and a new, targeted imaging agent based on a synthetic version of a small protein – a peptide – found in the venom of the deathstalker scorpion.
CONTACT: Sandy Van, 808-526-1708; Email sandy@prpacific.com

The Immune System’s Redesigned Role in Fighting Cancerous Tumors
Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents. These two synergistic therapies stimulate an immune response, ultimately allowing solid tumors to act as their own cancer-fighting vaccine. The study’s findings are the first to use these combined agents as an immune stimulator and may have the potential to kill cancerous cells in solid tumors, including some of the most aggressive cancers that form in the lung and pancreas.
CONTACT: Cara Martinez, 310-423-7798; Email cara.martinez@cshs.org

Study: Response to Emotional Stress May Be Linked to Some Women’s Heart Artery Dysfunction
Researchers at the Barbra Streisand Women’s Heart Center at the Cedars-Sinai Heart Institute have found that emotional stressors – such as those provoking anger – may cause changes in the nervous system that controls heart rate and trigger a type of coronary artery dysfunction that occurs more frequently in women than men.
CONTACT: Sally Stewart, 310-248-6566; Email sally.stewart@cshs.org

Detecting, Testing, Treating Rare Diseases: Technology Delivers New Era of Personalization
A team of researchers from the National Institutes of Health, Emory University and Cedars-Sinai – specialists in identifying and treating very rare diseases – used three innovative tools to detect a previously unknown gene mutation, test potential therapies in the lab, and initiate personalized drug treatment for a boy with a lifelong history of uncontrollable seizures that caused significant impact on his cognitive and social development.
CONTACT: Sandy Van, 808-526-1708; Email sandy@prpacific.com

Cedars-Sinai Heart Institute Sets New Standard for Most US Heart Transplants in a Year
The Cedars-Sinai Heart Institute has set a new standard for U.S. heart transplantation by completing 117 adult heart transplants and two adult heart-lung transplants, for a total of 119 adult heart transplants in a single year.
CONTACT: Sally Stewart, 310-248-6566; Email sally.stewart@cshs.org

Variations in Eye Structure and Function May Reveal Features of Early-Stage Alzheimer’s Disease
Investigators at the Cedars-Sinai Regenerative Medicine Institute have discovered eye abnormalities that may help reveal features of early-stage Alzheimer’s disease. Using a novel laboratory rat model of Alzheimer’s disease and high-resolution imaging techniques, researchers correlated variations of the eye structure, to identify initial indicators of the disease.
CONTACT: Cara Martinez, 310-423-7798; Email cara.martinez@cshs.org

Prominent Cardiac Cell Biologist Jennifer Van Eyk, PhD, Joins Cedars-Sinai to Direct New Advanced Clinical Biosystems Research Institute
Prominent proteomic and cardiac scientist Jennifer Van Eyk, PhD, has been named the inaugural director of Cedars-Sinai’s Advanced Clinical Biosystems Research Institute. Van Eyk also will lead basic research at Cedars-Sinai’s Barbra Streisand Women’s Heart Center aimed at unlocking the mysteries of gender differences in heart disease.
CONTACT: Sally Stewart, 310-248-6566; Email sally.stewart@cshs.org

Research Study Takes Deeper Look at the Role of Gut Microbes in the Immune System
New research suggests that gut microorganisms do not merely influence immune cell function, but also support the production of immune cells that form the first line of defense against infection. By understanding the mechanisms responsible for maintaining and replacing immune cells, researchers hope to one day develop targeted therapies to support and boost immune function in humans.
CONTACT: Cara Martinez, 310-423-7798; Email cara.martinez@cshs.org

Cedars-Sinai Designing ‘Operating Room of the Future’ to Streamline, Improve Trauma Care
Cedars-Sinai has partnered with the U.S. military to design the “operating room of the future” that will enable emergency medical teams to respond more quickly and effectively to patients with life-threatening injuries. Under the project, called “OR 360,” research teams have reconfigured the operating room with movable walls and equipment for more flexible use, identified ways to eliminate disruptions during surgery, and developed an iPhone app that provides diagnostic information about blood pressure and other vital signs before patients arrive in the emergency room.
CONTACT: Duke Helfand, 310-336-5914; Email duke.helfand@cshs.org

$2.5 Million Defense Department Grant Funds Gene Therapy Study for Lou Gehrig’s Disease
The Cedars-Sinai Regenerative Medicine Institute has received a $2.5 million grant from the Department of Defense to conduct animal studies that, if successful, could provide the basis for a clinical trial of a gene therapy product for patients with Lou Gehrig’s disease, also called amyotrophic lateral sclerosis, or ALS.
CONTACT: Sandy Van, 808-526-1708; Email sandy@prpacific.com

Research Studies Highlight Advantages and Potential of Computer-Guided Spinal Surgery
In a series of research studies, Cedars-Sinai spinal surgeons show that a new method of computer-guided spine surgery is beneficial for spinal reconstruction and for treating complex tumors and degenerative spine problems, resulting in fewer complications and better outcomes for patients.
CONTACT: Duke Helfand, 310-336-5914; Email duke.helfand@cshs.org


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