Newswise — Winner of the Cerebrovascular Section Best Basic Scientific Paper Award, Andrew Gauden, presented his research, Vascular Targeting Causing Thrombosis in an Arteriovenous Malformation Animal Model, during the 2018 American Association of Neurological Surgeons (AANS) Annual Scientific Meeting.
Despite current treatments, one third of brain arteriovenous malformations (AVMs) are untreatable and are a lifelong risk of stroke, neurological disability and death. Previous work has identified the potential target phosphatidylserine (PS) externalized in the plasma membrane of the endothelium in AVMs that have undergone treatment with focused irradiation. Authors hypothesized that treatment of AVMs with gamma knife radiosurgery (GKS) and vascular targeting of PS with a prothrombotic compound would cause localized thrombosis and occlusion of AVM vessels.
This study demonstrates a significant association between use of a PS-targeting Annexin V/Thrombin conjugate and thrombosis and occlusion of AVM vessels both radiologically and histologically. Furthermore, with modification of conjugate dose and delivery, this research has demonstrated increased selective targeting of endothelium that was pretreated with GKS.
This finding is the first of its kind in the treatment of AVMs and may have clinical application in the management of previously untreatable human AVMs.
Author Block: Vivienne Lee; Sinduja Subramanian; Vaughan Moutrie; Zhenjun Zhao, PhD; Lucinda McRobb, PhD; Marcus Stoodley, FRACS, PhD
Disclosure: The author reported no conflicts of interest.
Media Representatives: The 2018 AANS Annual Scientific Meeting website’s press section will include releases on highlighted scientific research, AANS officers and award winners, Neurosurgery Awareness Month and other relevant information about the 2018 program. Releases will be posted on the 2018 AANS Annual Scientific Meeting website. If you have interest in a topic related to neurosurgery or would like to interview a neurosurgeon — either onsite or via telephone — during the event, please contact Alice Kelsey, AANS associate executive director, via email at [email protected].
About the 2018 AANS Annual Scientific Meeting: Attended by neurosurgeons, neurosurgical residents, medical students, neuroscience nurses, clinical specialists, physician assistants, allied health professionals and other medical professionals, the AANS Annual Scientific Meeting is the largest gathering of neurosurgeons in the nation, with an emphasis on the field’s latest research and technological advances. The scientific presentations accepted for the 2018 event will represent cutting-edge examples of the incredible developments taking place within the field of neurosurgery. Find additional information about the 2018 AANS Annual Scientific Meeting and the meeting program here.
Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 11,000 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. Fellows of the AANS are board-certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons of Canada or the Mexican Council of Neurological Surgery, A.C. Neurosurgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the spinal column, spinal cord, brain, nervous system and peripheral nerves.
For more information, visit www.AANS.org.
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