Stereotactic Radiosurgery for the Management of Acromegaly: Outcomes of a Multicenter Retrospective Cohort Study

Winner of the Leksell Radiosurgery Award, Dale Ding, MD, presented his research, Stereotactic Radiosurgery for the Management of Acromegaly: Outcomes of a Multicenter Retrospective Cohort Study, during the 2018 American Association of Neurological Surgeons (AANS) Annual Scientific Meeting.

Stereotactic radiosurgery (SRS) is a treatment option for persistent or recurrent acromegaly secondary to a growth hormone (GH) secreting pituitary adenoma, but its efficacy is inadequately defined. The aim of this multicenter retrospective cohort study is to assess the outcomes of SRS for acromegaly and determine predictors.

Study authors pooled data from ten participating institutions of the International Gamma Knife Research Foundation (IGKRF) for patients with acromegaly who underwent treatment with SRS and had at least six months of endocrine follow-up. Baseline and outcomes data were analyzed, and predictors of endocrine remission were identified using multivariate Cox proportional hazards regression analysis.

Study results indicate that SRS is a definitive treatment option for patients with persistent or recurrent acromegaly after surgical resection. When deemed appropriate by an endocrinologist, acromegaly patients should be taken temporarily off of antisecretory medications prior to SRS to improve the efficacy of this intervention.

The study cohort was comprised of 371 patients with a mean endocrine follow-up of 79 months. Antisecretory medications were held in 56 percent of patients who were on pre-SRS medical therapy.

Author Block: Gautam Mehta, MD; Mohana Patibandla, MBBS; Cheng-Chia Lee, MD; Roman Liscak, MD; Hideyuki Kano, MD, PhD; Roberto Martinez-Alvarez, MD, PhD; David Mathieu, MD; Inga Grills, MD; Christopher Cifarelli, MD, PhD; L. Dade Lunsford, MD; Jason Sheehan, MD, PhD.

Disclosure: The author reported no conflicts of interest.

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About the 2018 AANS Annual Scientific Meeting: Attended by neurosurgeons, neurosurgical residents, medical students, neuroscience nurses, clinical specialists, physician assistants, allied health professionals and other medical professionals, the AANS Annual Scientific Meeting is the largest gathering of neurosurgeons in the nation, with an emphasis on the field’s latest research and technological advances. The scientific presentations accepted for the 2018 event will represent cutting-edge examples of the incredible developments taking place within the field of neurosurgery. Find additional information about the 2018 AANS Annual Scientific Meeting and the meeting program here.

Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 11,000 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. Fellows of the AANS are board-certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons of Canada or the Mexican Council of Neurological Surgery, A.C. Neurosurgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the spinal column, spinal cord, brain, nervous system and peripheral nerves.

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