Released: 7-Nov-1997 12:00 AM EST
Abnormal Gene Transcription and Acute Leukemia
St. Jude Children's Research Hospital

Research over the past 10 years has shown that acute leukemia is in fact a genetic disorder. It arises when genes essential to correct blood cell function are not expressed at the appropriate times. In many cases, the failure of gene expression can be traced to an altered protein known as a transcription factor.

Released: 7-Nov-1997 12:00 AM EST
New Cancer Treatments May Improve Survival Rates, Reduce Radiation Side Effects
St. Jude Children's Research Hospital

Doctors at St. Jude Children's Research Hospital today announced new brain tumor research protocols they hope will improve survival rates and reduce side effects of radiation therapy among pediatric cancer patients.

Released: 27-Nov-1997 12:00 AM EST
Cell Article: Single Genetic Locus Linked to Top Cancer-Targeted Biochemical Pathways
St. Jude Children's Research Hospital

While identifying a new cancer-fighting tumor suppressor gene called ARF, scientists at St. Jude Children's Research Hospital have made another, potentially more far-reaching discovery, that a single genetic locus called INK4a encodes protein products that regulate the most frequently targeted biochemical pathways in human cancers.

Released: 4-Dec-1997 12:00 AM EST
90% Leukemia Cure Rate Said Possible As International Meeting of Research Leaders Convenes
St. Jude Children's Research Hospital

A pediatric cure rate of 90 percent should be possible early next century according to the world's top treatment and research specialists associated with acute lymphoblastic leukemia (ALL) meeting at St. Jude Children's Research Hospital.

Released: 13-Dec-1997 12:00 AM EST
Lethal New Hong Kong Flu: Expert Comment Available from St. Jude
St. Jude Children's Research Hospital

Robert G. Webster, Ph.D., who played a key role in helping to identify the new Hong Kong influenza virus (H5N1), will be available to the media Monday morning, December 15, via telephone conference call following recent news of additional infections and a second death. Call 800-289-0730 and give the confirmation number 410960, or ask for the St. Jude conference.

Released: 27-Aug-1998 12:00 AM EDT
Milestone in Treatment of Most Common Pediatric Cancer
St. Jude Children's Research Hospital

Researchers at St. Jude Children's Research Hospital have reached a milestone in the treatment of the most common form of pediatric cancer, acute lymphoblastic leukemia (ALL), and efforts are already underway to test a new treatment protocol that researchers hope will lead to even higher cure rates for this once-deadly disease, they reported in the Aug. 27 New England Journal of Medicine.

Released: 17-Apr-1999 12:00 AM EDT
Ethical Boundaries in Cancer Genetics
St. Jude Children's Research Hospital

12 sessions exploring the ethics of cancer "Ethical Boundaries in Cancer Genetics," organized by St. Jude Children's Research Hospital May 26-29.

Released: 20-May-1999 12:00 AM EDT
Ethical Boundaries in Cancer Genetics
St. Jude Children's Research Hospital

The country's leading legal and theological experts and cancer researchers will discuss and argue the ethical and practical issues of genetic screening, susceptibility and new therapies as they relate to cancer research at symposium at the Memphis Marriott-Downtown Hotel in Memphis, Tenn.

Released: 25-May-1999 12:00 AM EDT
Symposium Tackles Difficult Medical-Ethical Questions
St. Jude Children's Research Hospital

This week, the country's leading legal and theological experts together with top cancer researchers will convene to discuss other moral, ethical, religious and scientific questions at the "Ethical Boundaries in Cancer Genetics" symposium hosted by St. Jude Children's Research Hospital in Memphis, Tennessee on May 26-29.

Released: 27-May-1999 12:00 AM EDT
Symposium on Medical-Ethical Questions
St. Jude Children's Research Hospital

This week leading legal experts will convene with top cancer researchers at St. Jude Children's Research Hospital's symposium, "Ethical Boundaries in Cancer Genetics," to discuss "Gene Therapy in Cancer Treatment and Prevention," the third plenary session of the symposium.

Released: 28-May-1999 12:00 AM EDT
Religion in Medical-Ethical Debate
St. Jude Children's Research Hospital

This week, the country's leading theological experts will convene with top cancer researchers to lend their perspective to moral, ethical, religious and scientific questions about new genetic and medical technology.

31-Aug-1999 12:00 AM EDT
Genetic Reason for HIV Therapy Resistance Disscovered
St. Jude Children's Research Hospital

The gene MRP4 appears to help T cells, key components of the human immune system, "pump out" certain anti-HIV drugs and may allow the development of drug-resistant strains of HIV, report a team of St. Jude Children's Research Hospital scientists in the September issue of Nature Medicine.

Released: 21-Oct-1999 12:00 AM EDT
Receptors that Bind to Reelin, Brain Development
St. Jude Children's Research Hospital

Two lipoprotein receptors bind to the protein made by the reelin gene (which controls development of the brain and is associated with neurodegenerative disorders), St. Jude Children's Research Hospital scientists published in today's issue of Neuron.

6-Dec-1999 12:00 AM EST
Doctors Implement Pediatric Cancer Program
St. Jude Children's Research Hospital

A program proven to dramatically increase cure rates for pediatric cancer has been established in El Salvador by St. Jude Children's Research Hospital. The program will serve as a model for international outreach programs around the world.

28-Jan-2000 12:00 AM EST
Newly Discovered "Death Signal"
St. Jude Children's Research Hospital

Scientists at St. Jude Children's Research Hospital have discovered a death signal that brings about the death of Streptococcus pneumoniae (also known as pneumococcus) - a discovery that could lead to revolutionary new treatments for the killer bacteria.

Released: 19-Oct-2005 8:45 AM EDT
Retinoblastoma Researchers Find Success with Drug Combo
St. Jude Children's Research Hospital

Investigators at St. Jude Children's Research Hospital have demonstrated in laboratory studies a new treatment for the pediatric eye cancer retinoblastoma that appears to be more effective than the current standard therapy, and more likely to prevent the recurrence of this cancer.

Released: 19-Oct-2005 10:45 AM EDT
Ependymomas Arise from Cancer Stem Cells in the Nervous System
St. Jude Children's Research Hospital

Brain tumors called ependymomas that occur in different parts of the central nervous system appear to arise from subpopulations of stem cells called radial glia cells (RGCs), according to investigators at St. Jude Children's Research Hospital.

Released: 10-Nov-2005 1:20 PM EST
Ink4c and Ptch1 Genes Collaborate to Suppress Medulloblastoma
St. Jude Children's Research Hospital

The Ink4c and Ptch1 genes collaborate to suppress the development of medulloblastoma, the most common pediatric brain tumor, according to investigators.

Released: 15-Nov-2005 2:45 PM EST
Synaptic Connections Need Lifelong Nurturing
St. Jude Children's Research Hospital

The ability of the brain to transmit and process information requires a lifelong commitment to maintaining the integrity of synapses, according to investigators at St. Jude Children's Research Hospital and colleagues in Hokkaido University School of Medicine (Japan).

Released: 1-Dec-2005 1:40 PM EST
Disruption of Gene Interaction Linked to Schizophrenia
St. Jude Children's Research Hospital

Disruption of the normal interaction between the genes PRODH and COMT contributes directly to major symptoms of schizophrenia by upsetting the balance of the brain chemicals glutamate and dopamine, according to a group of investigators.

Released: 1-Dec-2005 1:45 PM EST
Scientists Unlock Solid Tumor Treatment Genetic Secrets
St. Jude Children's Research Hospital

A biochemical mechanism that cells use to cope with hypoxia (lack of oxygen) actually cooperates with a less well-known mechanism that helps increase the expression of those hypoxia-sensitive genes, according to investigators at St. Jude Children's Research Hospital.

Released: 1-Dec-2005 2:40 PM EST
Collapse of p53 Into Clumps Might Be Linked to Cancer
St. Jude Children's Research Hospital

The disruption of a molecular bridge that holds together the molecule p53 tends to destabilize this protein, allowing it to form potentially disease-causing aggregates, or "clumps," according to a study by investigators at St. Jude Children's Research Hospital.

Released: 12-Dec-2005 8:10 PM EST
Scythe Balances Life and Death During Development
St. Jude Children's Research Hospital

A protein called Scythe determines which cells live and which die during the growth and development of the mammalian embryo, according to investigators at St. Jude Children's Research Hospital.

Released: 12-Dec-2005 8:15 PM EST
Evidence Links Cocaine Abuse and Parkinson’s Disease
St. Jude Children's Research Hospital

Adults who abuse cocaine might increase their risk of developing Parkinson's disease, and pregnant women who abuse cocaine could increase the risk of their children developing PD later in life, according to results of laboratory studies.

Released: 13-Dec-2005 2:40 PM EST
TRAF3 Protein Is a Key Part of the Early Immune Response to Viruses
St. Jude Children's Research Hospital

A protein called TRAF3 with a previously unknown job in immune cells, is a key part of a mechanism that triggers release of anti-virus molecules as part of the body's rapid response against these invaders, according to investigators.

Released: 13-Dec-2005 4:25 PM EST
National Study Improves Outcome for Pediatric AML
St. Jude Children's Research Hospital

A new strategy for treating childhood acute myeloid leukemia based on the individual patient's risk of failure, and guided by the results of a highly sensitive technique for identifying leukemic cells, yielded one-year survival rates of almost 90 percent, according to investigators.

Released: 21-Dec-2005 2:10 PM EST
Antibody Therapy Promising for Pediatric Neuroblastoma
St. Jude Children's Research Hospital

A new strategy that turns small populations of immune system cells into armies that track down and kill neuroblastoma throughout the body could save the lives of many children each year, according to investigators at St. Jude Children's Research Hospital.

Released: 5-Jan-2006 8:25 PM EST
Loss of Caspase-8 Makes Neuroblastoma More Aggressive
St. Jude Children's Research Hospital

The caspase-8 gene plays a critical role in suppressing metastasis (spread) of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively metastasizing, according to investigators.

Released: 11-Jan-2006 4:40 PM EST
St. Jude Projects 90 Percent Cure Rate for ALL
St. Jude Children's Research Hospital

The cure rate for the once almost universally fatal childhood cancer acute lymphoblastic leukemia could reach 90 percent in the near future, thanks to improvements in diagnosis and treatment over the past four decades, according to investigators.

Released: 16-Jan-2006 9:10 AM EST
Patients Now Surviving Once-fatal Immune Disease
St. Jude Children's Research Hospital

Individuals who have a rare genetic immune system disorder that prevents them from making antibodies nevertheless appear to be moderately healthy and lead productive lives, according to results of a study by investigators at St. Jude Children's Research Hospital.

Released: 26-Jan-2006 2:30 PM EST
St. Jude Conducts First Large-Scale Bird Flu Genome Study
St. Jude Children's Research Hospital

Investigators have completed the first large-scale study of bird flu virus genomes, thereby doubling the amount of genetic information available on the genes and proteins of these viruses. The results of the project could lead to major insights into the bird flu virus known as H5N1, the researchers said.

Released: 7-Mar-2006 8:50 PM EST
St. Jude Scientist Named Distinguished Biotechnologist
St. Jude Children's Research Hospital

Robert G. Webster, Ph.D., who holds the Rose Marie Thomas Chair at St. Jude Children's Research Hospital, has been given the Distinguished Biotechnologist of the Year Award by the New Zealand Biotechnology Association (NZBio) for his work in virology and avian influenza.

27-Mar-2006 2:40 PM EST
Powerful New Tool for Studying Brain Development
St. Jude Children's Research Hospital

Scientists have given investigators around the world free access to a powerful tool for studying brain development. The Internet-based tool, called the mouse Brain Gene Expression Map (BGEM), is one of the largest gene expression maps of an organ ever developed.

Released: 29-Mar-2006 6:00 PM EST
St. Jude Develops More Affordable All Follow-up Test
St. Jude Children's Research Hospital

Investigators have developed a relatively simple and inexpensive test that identifies children with acute lymphoblastic leukemia (ALL) who have responded well enough to their first round of chemotherapy that they might be successfully treated with a much less aggressive follow-up treatment.

Released: 18-Apr-2006 9:00 AM EDT
Technique Could Speed New Medulloblastoma Drugs
St. Jude Children's Research Hospital

Investigators at St. Jude Children's Research Hospital have developed a strategy to speed future development of more effective and less toxic treatments for medulloblastoma, a type of brain cancer.

Released: 19-Apr-2006 5:25 PM EDT
Researchers Unlock Mystery of Very Aggressive Leukemia
St. Jude Children's Research Hospital

Investigators at St. Jude Children's Research Hospital have used mouse models to determine why some forms of acute lymphoblastic leukemia (ALL) are extremely aggressive and resist a drug that is effective in treating a different type of leukemia.

Released: 2-May-2006 9:30 AM EDT
St. Jude Test of Bird Flu Vaccine Proves Successful
St. Jude Children's Research Hospital

A commercially developed vaccine has successfully protected mice and ferrets against a highly lethal avian influenza virus, according to the investigator who led the study at St. Jude Children's Research Hospital. The vaccine was developed by Vical Incorporated in San Diego, California.

Released: 4-May-2006 6:55 PM EDT
H5N1 Threat Puts Human Flu Back in Spotlight
St. Jude Children's Research Hospital

The emergence of the avian influenza virus H5N1 that is currently devastating chicken flocks in many countries and threatening to unleash a worldwide epidemic among humans has triggered a renewed interest among scientists in studying influenza A viruses, according to investigators at St. Jude Children's Research Hospital.

Released: 8-May-2006 3:30 PM EDT
Genetic Insights May Explain Retinal Growth, Eye Cancer
St. Jude Children's Research Hospital

Investigators at St. Jude Children's Research Hospital have discovered the role of several key genes in the development of the retina, and in the process have taken a significant step toward understanding how to prevent or cure the potentially deadly eye cancer retinoblastoma.

Released: 6-Jun-2006 4:00 PM EDT
Hospital Helps Brazil Improve Outcomes of Children with Leukemia
St. Jude Children's Research Hospital

St. Jude Children's Research Hospital has significantly reduced the rate at which families in Recife, Brazil abandon treatment for their children who have acute lymphoblastic leukemia (ALL), and has significantly increased the rate of event-free survival during a single decade.

Released: 17-Jun-2006 8:20 PM EDT
H5N1 Vaccine Could be Basis for Life-Saving Stockpile
St. Jude Children's Research Hospital

Scientists at St. Jude Children's Research Hospital have announced that a vaccine they developed a few years ago against one antigenic variant of the avian influenza virus H5N1 may protect humans against future variants of the virus.

Released: 19-Jun-2006 2:00 PM EDT
DNA Repair in Mammal Embryos Is a Matter of Timing
St. Jude Children's Research Hospital

Investigators at St. Jude Children's Research Hospital have discovered that the cells of the developing nervous system of the mammalian embryo have an exquisite sense of timing when it comes to fixing broken chromosomes: the cells use one type of repair mechanism during the first half of development and another during the second half.

Released: 19-Jul-2006 4:20 PM EDT
Leukemia Gene Normally Has Mammary Gland Function
St. Jude Children's Research Hospital

A gene critical for normal mammary gland function during nursing helps trigger highly lethal leukemias when it undergoes a mutation that fuses it to another gene, according to investigators at St. Jude Children's Research Hospital.

Released: 27-Jul-2006 5:50 PM EDT
Anemic Children with Cancer Benefit from Erythropoietin
St. Jude Children's Research Hospital

Children with cancer who develop anemia during chemotherapy can benefit from a weekly dose of erythropoietin (EPO), according to researchers at St. Jude Children's Research Hospital. The drug reduces the need for red blood cell transfusions and improves quality of life in children whose anemia is corrected by this treatment, according to results of a Phase III clinical trial at St. Jude.

Released: 1-Aug-2006 6:35 PM EDT
Discovery in "Bubble Boy" Disease Gene Therapy
St. Jude Children's Research Hospital

Scientists at St. Jude Children's Research Hospital have developed a mouse model of a severe disease of the immune system that helps explain why gene therapy used to treat children with this disease at an institution in Europe caused some of them to develop leukemia.

Released: 1-Aug-2006 6:45 PM EDT
Key Event in Cell Death Occurs as Single, Quick Event
St. Jude Children's Research Hospital

Scientists at St. Jude Children's Research Hospital have demonstrated that a key event during apoptosis (cell suicide) occurs as a single, quick event, rather than as a step-by-step process. Apoptosis eliminates extraneous cells from the developing body; and disposes of cells that sustain irreparable harm to their DNA or are infected with microorganisms.

Released: 15-Aug-2006 12:00 PM EDT
Experts Available for Commentary During Sickle Cell Awareness Month
St. Jude Children's Research Hospital

St. Jude Children's Research Hospital took on the fight against sickle cell disease very early in its history. Today, the St. Jude Comprehensive Sickle Cell Center is one of the largest such programs in the United States; and it is one of only 10 Comprehensive Sickle Cell Centers funded by the National Heart, Lung and Blood Institute.

Released: 31-Aug-2006 5:00 PM EDT
Solution to Bacterial Mystery Promises New Drugs
St. Jude Children's Research Hospital

A 25-year quest to identify the first biochemical step that many disease-causing bacteria use to build their membranes has led to a discovery that holds promise for effective, new antibiotics against these bacteria, according to investigators at St. Jude Children's Research Hospital.

Released: 31-Aug-2006 7:30 PM EDT
Hospital First to Describe New Statistical Method
St. Jude Children's Research Hospital

Statisticians at St. Jude Children's Research Hospital have developed a new technique that allows researchers to statistically analyze results of clinical trials.


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