For several years, epilepsy practitioners have questioned the U.S. Food and Drug Administration’s (FDA) definition of bioequivalence as it applies to narrow therapeutic index (NTI) drugs, such as those used for epilepsy. In response to these concerns, the FDA has sponsored 3 studies of antiepileptic drugs and also convened an advisory board to help determine which drugs are NTI. The new NTI definition and new bioequivalence guidelines and their impact will be a major point of discussion during a town hall session held with leaders from the FDA during the American Epilepsy Society's 67th annual meeting in Washington DC.
– American Epilepsy Society (AES)|12/9/2013 8:15 AM EST
Screening to detect medical conditions has become standard practice for many diseases, but insufficient attention has been paid to the potential for harm, according to research conducted at the University of North Carolina.
– University of North Carolina School of Medicine|12/9/2013 8:00 AM EST
The clinical context of the administration and dosage of antipsychotics may influence their efficacy, reported Philippe Vincent and Édouard Kouassi, from the Institut universitaire en santé mentale de Montréal and Université de Montréal.
– Universite de Montreal|12/9/2013 8:00 AM EST
Donated umbilical cord blood contains stem cells that can save the lives of leukemia and lymphoma patients. A multi-center study has found that growing cord blood stem cells in a laboratory before transplantation significantly improves survival.
– Loyola University Health System|12/9/2013 8:00 AM EST
In nearly one-third of patients with Waldenstrom’s Macroglobulinemia, a specific genetic mutation switches on the disease, and a new drug that blocks the defective gene can arrest the disease in animal models, researchers at Dana-Farber Cancer Institute and allied institutions will report at the 2013 annual meeting of the American Society of Hematology (ASH). The finding may open the way to clinical trials of the drug in Waldenstrom’s patients whose tumor cells carry the mutation.
– Dana-Farber Cancer Institute|12/9/2013 8:00 AM EST
Sandia National Laboratories researchers have devised a novel way to realize electrical conductivity in metal-organic framework (MOF) materials, a development that could have profound implications for the future of electronics, sensors, energy conversion and energy storage.
– Sandia National Laboratories|12/9/2013 7:00 AM EST
The most tweeted peer-reviewed articles published between 2010 and 2012, and the trends associated with their social media success, have been identified by Stefanie Haustein at the University of Montreal’s School of Library and Information Science.
– Universite de Montreal|12/9/2013 6:25 AM EST
New Study Finds 24 Children a Day are Treated in U.S. Emergency Departments for High Chair-Related Injuries
High chairs and booster seats are commonly used to help make feeding young children easier. Although most parents assume these products are safe, millions have been recalled in recent years, and injuries associated with their use continue to occur.
– Nationwide Children's Hospital|12/9/2013 12:00 AM EST
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