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Tumor Suppressor Promotes Some Acute Myeloid Leukemias, Study Reveals


Researchers in Germany have discovered that a tumor suppressor protein thought to prevent acute myeloid leukemia (AML) can actually promote a particularly deadly form of the disease. The study, “RUNX1 cooperates with FLT3-ITD to induce...
13-Feb-2017 10:05 AM EST Add to Favorites

Researchers Identify “Achilles’ Heel” of Key Anti-Cancer Protein


Researchers at Cold Spring Harbor Laboratory in New York have discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it into the cell nucleus. The study, “The nuclear transport receptor...
7-Feb-2017 1:05 PM EST Add to Favorites

Researchers Identify New Cause of Brain Defects in Tuberous Sclerosis Complex


Boston Children’s Hospital researchers have uncovered a new molecular pathway that inhibits the myelination of neurons in the brains of patients with the rare genetic disorder tuberous sclerosis complex (TSC). The study, “Neuronal CTGF/CCN2...
6-Feb-2017 9:05 AM EST Add to Favorites

Murine Study Finds Potential Boost for Ovarian Cancer Drug Olaparib


Researchers from the Chinese Academy of Sciences have discovered that the metabolic enzyme phosphoglycerate mutase 1 (PGAM1) helps cancer cells repair their DNA and found that inhibiting PGAM1 sensitizes tumors to the cancer drug Olaparib...
25-Jan-2017 10:00 AM EST Add to Favorites

Gut Bacteria May Hold Key to Treating Autoimmune Disease


Defects in the body’s regulatory T cells cause inflammation and autoimmune disease by altering the type of bacteria living in the gut, researchers from the University of Texas Health Science Center at Houston have discovered. The study, which will...
15-Dec-2016 11:05 AM EST Add to Favorites

Huntington’s Disease Affects Muscle as Well as Neurons, Study Reveals


Researchers have discovered that mice with Huntington’s disease (HD) suffer defects in muscle maturation that may explain some symptoms of the disorder. The study, “Progressive Cl− channel defects reveal disrupted skeletal muscle maturation in...
21-Nov-2016 3:05 PM EST Add to Favorites

Study shows low-dose chemotherapy regimens could prevent tumor recurrence in types of breast cancer and pancreatic cancer


Conventional, high-dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors’ recurrence in more aggressive forms, researchers have discovered. Frequent, low-dose chemotherapy...
16-Nov-2016 1:05 PM EST Add to Favorites

Protozoan Parasite Increases Risk of Colitis, Study Reveals


Researchers from the University of Toronto have discovered that mice infected with the common gut parasite Tritrichomonas muris are at an increased risk of developing inflammatory colitis. Their findings, which have been published online in The...
11-Nov-2016 9:05 AM EST Add to Favorites

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