The Aurora A kinase may contribute to polycystic kidney disease (PKD) by inactivating a key calcium channel in kidney cells, according to a study in the June 13 issue of The Journal of Cell Biology.
A paper published online on June 13 in the Journal of Experimental Medicine identifies new gene mutations in patients with chronic lymphocytic leukemia (CLL)—a disease often associated with lack of response to chemotherapy and poor overall survival.
A small protein called SUMO might prevent the protein aggregations that typify Parkinson’s disease (PD), according to a new study in the July 11, 2011, issue of The Journal of Cell Biology.
A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington’s disease (HD). The article appears online on July 18, 2011, in The Journal of Cell Biology.
Blocking a growth factor receptor cripples cancer growth in a form of T cell leukemia, according to a study published online on August 1 in the Journal of Experimental Medicine (www.jem.org).
Tumors have an arsenal of tricks to help them sidestep the immune system. A study published on September 19 in the Journal of Experimental Medicine reveals a new trick—the ability to keep tumor-fighting T cells out by disabling a T cell–attracting protein within the tumor core.
Cells making slippery mucus provide a sticking point for disease-causing bacteria in the gut, according to a study published on October 3 in the Journal of Experimental Medicine.
Differences in the levels of two key metabolic enzymes may explain why some people are more susceptible to liver damage, according to a study in the October 17 issue of The Journal of Cell Biology (www.jcb.org).
The neurodegeneration associated with Alzheimer's disease is thought to be caused by small, soluble A-beta complexes, partly through their ability to induce excess calcium influx into cells, which stimulates cell death. A new study reveals that A-beta oligomers elevate calcium by forming calcium-permeable pores in the plasma membrane.
Two proteins conspire to promote Lou Gehrig’s disease, according to a study published in the Journal of Experimental Medicine.
Sluggish recycling of a protein-slicing enzyme could promote Alzheimer’s disease, according to a new study in The Journal of Cell Biology.
Prostate tumor cells can be lulled to sleep by a factor released by bone cells, according to a study published online this week in the Journal of Experimental Medicine.
One kind of leukemia sometimes masquerades as another, according to a study in the Journal of Experimental Medicine.
Scientists have pinpointed a protein that allows brains tumors to invade healthy brain tissue, according to work published in the Journal of Experimental Medicine.
The Rockefeller University Press (RUP) has unveiled new iPhone and iPad apps for its three journals: The Journal of Cell Biology (JCB), The Journal of Experimental Medicine (JEM), and The Journal of General Physiology (JGP). iPhone, iPad, and iPod touch users can read full-text articles anywhere at any time, even without an Internet connection.
Stabilizing the cell’s power-generating center protects against Parkinson’s disease (PD) in a rat model, according to a report published online this week in the Journal of Experimental Medicine.
Targeting a single protein can help fight both breast cancers and leukemias, according to two reports published online on January 23 in the Journal of Experimental Medicine.
The Journal of General Physiology has introduced an exciting new feature to expand the online presentation of scientific articles. The Video Summary is an optional tool that authors can use to highlight the main results of their research in a compelling format for JGP audiences.
Injection of a small amount of clumped protein triggers a cascade of events leading to a Parkinson’s-like disease in mice, according to an article in the Journal of Experimental Medicine.
Just as users of Google Earth can zoom in from space to a view of their own backyard, researchers can now navigate biological tissues from a whole embryo down to its subcellular structures thanks to recent advances in electron microscopy and image processing, as described in The Journal of Cell Biology (JCB).
A sugar-loving protein drives the growth of Kaposi sarcoma tumors. Interfering with these sugary interactions inhibited growth of Kaposi sarcomas in mice, hinting at the potential for new treatment strategies in humans.
A new study in JEM may provide a powerful new way to reduce relapses in people who have quit smoking or chewing tobacco.
A study in The Journal of Cell Biology identifies a motor protein that ferries HIV to the plasma membrane, helping the virus escape from macrophages
A JCB study shows how a transcription factor called STAT3 remains in the axon of nerve cells to help prevent neurodegeneration. The findings could pave the way for future drug therapies to slow nerve damage in patients with neurodegenerative diseases.
The orientation of antibody binding to bacteria can mean life or death to the bug, according to a study published in The Journal of Experimental Medicine. These findings may help explain why these bacteria cause millions of localized infections, but more serious, systemic blood infections are rare.
Failure to launch an adequate immune response may be at the root of septic shock, according to a study published in The Journal of Experimental Medicine on December 17th.
Researchers used induced pluripotent stem cells (iPSCs) derived from a young patient with Long QT syndrome (LQTS), a congenital heart disorder, to determine a course of treatment that helped manage the patient’s life-threatening arrhythmias.
Synapse development is promoted by a variety of cell adhesion molecules that connect neurons and organize synaptic proteins. Many of these adhesion molecules are linked to neurodevelopmental disorders; mutations in neuroligin and neurexin proteins, for example, are associated with autism and schizophrenia. According to a study in The Journal of Cell Biology, another family of proteins linked to these disorders regulates the function of neuroligins and neurexins in order to suppress the development of inhibitory synapses.
A new book presents the in-depth story about the men and women who created a new science, modern cell biology.
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment of certain cancers.
A mutant protein responsible for Hutchinson-Gilford Progeria syndrome (HGPS) bars large proteins from entering the nucleus, according to a study in The Journal of Cell Biology.
Two gene alterations pair up to promote the growth of leukemia cells and their escape from anti-cancer drugs.
Our ability to hear relies on hair cells, sensory receptors that mechanically amplify low-level sound that enters the inner ear through a transduction channel. A new study in The Journal of General Physiology could help lead to a definitive identification of this mystery channel.
A novel immune-boosting drug combination eradicates an aggressive form of brain cancer in mice, according to a study in The Journal of Experimental Medicine.
Most people have experienced the effects of circadian-rhythm disruption. To have any hope of modulating our biological “clocks,” we need to first understand the physiology at play. A new JGP study helps explain some of the biophysical processes underlying regulation of circadian rhythms.
RNA molecules are generally thought to be “silent” when stowed in cytoplasmic granules. But a protein mutated in some ALS patients forms granules that permit translation of stored RNAs. The finding identifies a new mechanism that could contribute to the pathology of the disease.
Using a new technique to evaluate working muscles in mice, researchers have uncovered physiological mechanisms that could lead to new strategies for combating metabolism-related disorders like muscle wasting and obesity.
The study identifies a common, early marker of senescent cells that could have important implications for tumor suppression and aging-related diseases like Progeria
Study helps explain how nicotine exploits the body’s cellular machinery to promote addiction. The findings could lead to new therapies to help people quit smoking.
Cancer cells have something that every prisoner longs for—a master key that allows them to escape. A new study describes how a protein that promotes tumor growth also enables cancer cells to use this key and metastasize.
Various muscular diseases are associated with changes in the elasticity of the protein titin, but whether these changes are a cause or an effect of disease has been unclear. Researchers help solve this “chicken or the egg” conundrum and identify a key player in determining titin’s size and stiffness.
Kinesins are motor proteins that “walk” along microtubules and transport various cargoes throughout the cell. Researchers uncover an unexpected role for one kinesin in the pathway that regulates cholesterol levels in the blood.
The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen. To develop better methods of protection from the sun, we need to understand how the human skin detects and responds to UVR. Researchers provide new insight into the molecular pathway underlying this process.
The JCB DataViewer archives data for authors and makes those data available for viewing, query, and re-use by other scientists. It has been under continuous development to support new image data formats and to provide new functionality for its users, including the hosting of extremely large images.
Cancer cells have long been known to have higher rates of the energy-generating metabolic pathway known as glycolysis. This enhanced glycolysis is thought to allow cancer cells to survive the oxygen-deficient conditions they experience in the center of solid tumors. Researchers reveal how damaged cells normally switch off glycolysis as they shut down and show that defects in this process may contribute to the early stages of tumor development.
Researchers show that a novel two-pronged strategy targeting DNA synthesis can treat leukemia in mice while sparing damage to normal blood cells.
It is not only genetics that predispose to bowel cancer; microbes living in the gut help drive the development of intestinal tumors, according to new research in mice.
The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells. Sometimes oncogenes manage to initiate tumor development in the presence of p53, which focuses its efforts instead on limiting the tumor’s ability to invade and metastasize. Researchers uncover one way that p53 acts to prevent cancer cell invasion.
The process of producing high-quality, fertile sperm requires many steps. Researchers show the transcription factor p73 promotes this process by regulating the adhesions between developing sperm and their support cells.
In addition to its role as a sodium and potassium ion transporter, the ubiquitous sodium pump displays “hybrid” function by simultaneously importing protons into the cell. Proton inflow might play a role in certain pathologies, including heart attack and stroke.
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