The Power to Tell Your Story

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This new review in SLAS Discovery analyzes the recent literature and impact of unfolded protein response (UPR) in health and disease.

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Ten new reviews and original research reports that illustrate how the progression of research assays from qualitative outputs toward increasingly sensitive quantitative outputs is transforming life sciences and biomedical research and diagnostics by improving the ability of researchers and clinicians to detect and quantify increasingly complex assays.

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An exploration of the latest understanding of the complex mechanisms behind OA pain offers new possibilities and potential treatment targets for osteoarthritis (OA) pain. New areas of research discussed include the use of combination therapies and the development of biomarkers to target effective pain treatment.

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Discovering new drugs has never been easy and some potential drug targets have historically been viewed as too challenging and thus off limits for prosecution. In a new SLAS Discovery review, authors John S. Lazo et al. of the University of Virginia reflect on the nature of protein tyrosine phosphatases and explores reasons why these enzymes have been eschewed by drug hunters, and how the landscape is beginning to change.

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A new report shows how microsystems can be used to understand processes in heart tissue in detail and to test newly developed compounds applied in the treatment of cardiac diseases.

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SLAS Discovery marks the 30th anniversary of Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI TOF), the soft ionization technique for analyzing non-volatile biomolecules using mass spectrometry, with a special issue showcasing 10 new research reports.

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A review article in the December 2017 issue of SLAS Technology provides important information for life sciences and technology professionals in academia and industry and members of the general public who are interested in antibiotic resistance, general microbial detection principles, in vitro diagnostics, micro- and nanotechnologies, and next generation rapid microbial testing methods.

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A new SLAS Technology review article by researchers at the University of Southern California and the University of California, Los Angeles, sheds light on the growing number and more sophisticated designs of theranostic nanoparticles.

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A new SLAS Discovery article available for free ahead-of-print enables researchers to derive more clinically-relevant information from 3D cell culture models.

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An original research report by Eun Jeong Cho et al. (University of Texas at Austin) in the January 2018 Issue of SLAS Discovery presents a newly designed biochemical assay that is rapid, sensitive, inexpensive, and high-throughput screening (HTS)-friendly to identify antagonist against aldolase A (ALDOA).

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A new article in the February 2018 issue of SLAS Technology describes a new platform that could change the way cancer is diagnosed and treated by automating the isolation of circulating tumor cells (CTCs) directly from cancer patient blood. The article provides unique insight into the development of a commercial system that has the potential to change the standard of care in cancer diagnosis and treatment.

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A new (and freely available) original research article published ahead-of-print at SLAS Discovery Online describes a new methodology that enables the investigation of a large number of structurally conserved enzymes belonging to the Fe(II)/2-oxoglutarate-dependent dioxygenase superfamily.

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This new (and freely available) original research article presents a fast, robust and accurate methodology for correlating compound identity to CYP1A2 potency of inhibitors in metabolic mixtures. The methodology is centered around an at-line nanofractionation platform in which a metabolic mixture is chromatographically separated followed by parallel on-line mass spectrometric (MS) analysis and at-line nanofractionation on high-density microtiter well plates that are then directly exposed to a bioassay.

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A phenotypic high-throughput screen to identify modulators that improve mutant cystic fibrosis transmembrane conductance regulator (CFTR) activity is described in the SLAS Discovery February 2018 front cover feature article by Giuliano and colleagues of Proteostasis Therapeutics, Inc. (Cambridge, MA).

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“The 2018 SLAS Technology Ten represent some of the most innovative scientific achievements that were featured in SLAS Technology in the past 12 months,” says Editor-in-Chief Edward Kai-Hua Chow, PhD (National University of Singapore).

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SLAS Discovery (formerly the Journal of Biomolecular Screening) and SLAS Technology (formerly the Journal of Laboratory Automation), both published by SLAS (Society of Laboratory Automation and Screening) in partnership with SAGE Publishing, hosted a special reception to celebrate the 2018 SLAS Journal Achievement Award honorees on Feb. 6 at SLAS2018, the SLAS International Conference and Exhibition, held Feb. 3-7, 2018, in San Diego, CA.

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A perspective article in the March 2018 issue of SLAS Discovery from the biology group at the European Screening Centre Newhouse details how the European Lead Factory (ELF), a large publicly accessible drug discovery platform, uses microscale thermophoresis (MST) to aid in the prioritization of small molecule hits from high-throughput screening.

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A new original research article in SLAS Discovery presents a fast, sensitive, and robust methodology for screening small molecule inhibitors against CD73/Ecto-5’-Nucleotidase, a promising target for developing anti-cancer drugs.

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A review article by Prof. Stefan Broer, Ph.D., highlights opportunities and challenges in using amino acid transporters as drug targets. Amino Acid Transporters as Disease Modifiers and Drug Targets provides an overview of methods used to identify new inhibitors for amino acid transporters and outlines cell and organ function where these can be used to modulate, prevent or to treat diseases.

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Breitwieser and colleagues of the Karlsruhe Institute of Technology (Germany) describe a fully automated high-throughput sorting system for zebrafish embryo phenotypes that benefits high-throughput screening by saving time and improving accuracy.

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A new original research report available ahead-of-print at SLAS Technology demonstrates the semi-automation of a GlycoWorks RapiFluor-MS (RFMS) Kit using a pipetting robot to improve life sciences research productivity.

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A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled "Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening," the report can be accessed for free.

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In a new SLAS Discovery auto-commentary, two authors of an article recently published in eLife (“LINE-1 Protein Localization and Functional Dynamics During the Cell Cycle”) explain their general views on their novel discoveries and discuss ideas on the relevant new questions generated by their data.

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A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.

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This vision of simplifying disease diagnosis using topically-applied nanotechnology could change the way skin diseases such as abnormal scars are diagnosed and managed.

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This vision of simplifying disease diagnosis using topically-applied nanotechnology could change the way skin diseases such as abnormal scars are diagnosed and managed.

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New research highlights a diversity of approaches that an automated high-throughput flow cytometry has enabled for phenotypic drug discovery.

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Researchers share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.

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To aid in the discovery and understanding of lncRNA biology, newly published work features the technological platforms and methodology presently used to identify the roles of lncRNA in biology. This work highlights the databases and tools used to study lncRNA and techniques used to study their function.

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A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.

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Technologies that are reducing costs and changing the ways in which researchers and clinicians process and use therapeutic cells are showcased in the August 2018 special issue of SLAS Technology.

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A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery.

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The internet of things (IoT) is allowing scientists to optimize laboratory operations and combine instruments to measure and respond to complex experimental conditions. As a result, IoT is enabling more detailed and more complex experimental designs.

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Researchers from the University of Manchester explore recent developments and strategies for targeting the NLRP3 inflammasome as a potential therapeutic target in acute and chronic neurological and neurodegenerative diseases, and offer perspective on how this field may develop in the future.

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A new review explores how improved safety screening strategies and methods are improving the pharmaceutical discovery and development process. The authors outline several fundamental methods of the current drug screening processes and emerging techniques and technologies that promise to improve molecule selection. In addition, the authors discuss integrated screening strategies and provide examples of advanced screening paradigms.

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A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.

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A study demonstrates the feasibility of using a steady-state/lifetime fluorescence plate reader for direct optimization of challenging formulation conditions and highlights the importance of performing formulation optimization under commercially relevant conditions.

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The SLAS Technology Ten annually showcases ten individual articles that stand out as the most innovative scientific achievements published in SLAS Technology in the past 12 months.

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A new collection of reviews and original research illustrate how new technologies and advanced cell culture are accelerating basic research, drug discovery and drug development.

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A new review by researchers from the University of Calabria (Italy) explores OCTNs, a small but intriguing group of transporters that are opening new frontiers in drug design research for improving drug delivery and predicting drug-drug interactions.

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The April edition of SLAS Technology features a special collection of articles prepared by biomedical and chemical engineering students at the University of Southern California (Los Angeles, CA, USA) that illustrate the growing use of nucleic acids for gene augmentation.

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The April cover article of SLAS Discovery features “Addressing Antimicrobial Resistance through New Medicinal and Synthetic Chemistry Strategies,” by Monika I. Konaklieva, Ph.D., an online ahead-of-print article first published in December 2018.

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The June cover of SLAS Discovery features cover article “A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction,” by Timothy M. Willson, Ph.D., a noted University of North Carolina Eshelman School of Pharmacy (Chapel Hill, NC, USA) Research Professor and Chief Scientific Officer for the Structural Genomics Consortium (SGC) (Oxford, UK).

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The June issue of SLAS Technology features the article, “Next Generation Compound Delivery to Support Miniaturized Biology,” which focuses on the challenges of changing the established screening paradigm to support the needs of modern drug discovery.

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The International Union of Pure and Applied Chemistry named SLAS Scientific Director Mike Tarselli, Ph.D., to its 2019 “Periodic Table of Younger Chemists.” The recognition is part of the IUPAC’s 100th anniversary celebration and honors a diverse group of 118 outstanding younger chemists from around the world who embody the mission and core values of IUPAC including fostering worldwide communications in the chemical sciences and in uniting academic, industrial and public sector chemistry in a common language.

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In July’s SLAS Discovery feature article, “3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis,” Tijmen H. Booij, Ph.D., Screening Specialist for NEXUS Personalized Health Technologies (Switzerland), discusses the switch from using 2D to 3D cell cultures in drug discovery to more accurately mimic human physiological conditions and improve the success rates of drugs in the early stages of preclinical drug discovery.

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August’s edition of SLAS Discovery showcases research from James Woods, a fourth-year undergraduate student in biochemistry at Brigham Young University (BYU) (Utah). In “Selection of Functional Intracellular Nanobodies,” Woods describes current nanobody selection methods and focuses on those that ensure intracellular functionality.

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The August edition of SLAS Technology features the cover article, “Technologies for the Directed Evolution of Cell Therapies,” a review featured in the journal’s March 2019 edition. The research, led by Dino Di Carlo, Ph.D., (University of California Los Angeles) highlights how the next generation of therapies are moving beyond the use of small molecules and proteins to using whole cells.

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The Society for Laboratory Automation and Screening (SLAS) and Messe München Shanghai Co., Ltd., a wholly-owned subsidiary of Messe München in China, have announced a formally established a strategic partnership.

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In September’s SLAS Discovery cover article, “Using Physicochemical Measurements to Influence Better Compound Design,” authors Robert J. Young, Ph.D., Shenaz B. Bunally, Ph.D., and Chris N. Luscombe, Ph.D., (GlaxoSmithKline) outline commonly used physiochemical properties and how they are assessed and measured throughout the drug discovery process, while also explaining the implications of each property that have led to flawed results.