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New Clues on the Base of Parkinson’s Disease and Other “Synucleinopathies”


Parkinson’s disease (PD) and other “synucleinopathies” are known to be linked to the misfolding of alpha-synuclein protein in neurons. Less clear is how this misfolding relates to the growing number of genes implicated in PD through analysis...
23-Jan-2017 1:30 PM EST Add to Favorites

Scientists Engineer Gene Pathway to Grow Brain Organoids with Surface Folding


Whitehead Institute researchers provide insight into a specific gene pathway that appears to regulate the growth, structure, and organization of the human cortex. They also demonstrate that 3D human cerebral organoids can be effective in modeling...
29-Dec-2016 2:05 PM EST Add to Favorites

Naturally Occurring Mechanism of Cancer Drug-Resistance May Itself Be a Treatment Target


The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs. But Whitehead Institute researchers have found a mechanism underlying this resistance—a mechanism that...
26-Dec-2016 3:00 PM EST Add to Favorites

CRISPR Screening Identifies Potential HIV Treatment Targets

Targeting human genes required for HIV infection but not T cell survival may avoid inducing treatment resistance
16-Dec-2016 10:00 AM EST Add to Favorites

Johnson & Johnson Endows Professorship Honoring Susan Lindquist, Role Model for Women in Science


The Susan Lindquist Chair for Women in Science will advance the work of women who are leaders in biomedical research and role models for emerging female scientists. It honors a singular scientist who blazed a path—for women and men alike—into...
16-Nov-2016 10:05 AM EST Add to Favorites

Heat Shock Regulator Controlled by on/Off Switch and Phosphorylation


Whitehead Institute researchers have determined how the master transcriptional regulator of the heat shock response, known as heat shock factor 1 (HSF1), is controlled in yeast. Understanding how HSF1 works, how it is regulated, and how to fine tune...
13-Nov-2016 4:05 PM EST Add to Favorites

Insight on Rett Syndrome Neurophysiology Finds Mechanisms Underlying its Functional Deficits—and Shows They Are Reversible

Researchers using a mouse model of Rett Syndrome find that cortical pyramidal neurons have faults in excitatory and inhibitory signaling; and demonstrate why recombinant human Insulin Like Growth Factor 1 has had therapeutic effects for RTT patients...
31-Oct-2016 9:30 AM EDT Add to Favorites

Susan Lindquist, Accomplished and Beloved Scientist, Has Died at Age 67


“Sue has meant so much to Whitehead as an institution of science, and as a community of scientists, and her passing leaves us diminished in so many ways,” reflects David C. Page, M.D., Director of Whitehead Institute
28-Oct-2016 11:05 AM EDT Add to Favorites

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