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Johnson & Johnson Endows Professorship Honoring Susan Lindquist, Role Model for Women in Science

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The Susan Lindquist Chair for Women in Science will advance the work of women who are leaders in biomedical research and role models for emerging female scientists. It honors a singular scientist who blazed a path—for women and men alike—into...
16-Nov-2016 10:05 AM EST Add to Favorites

Heat Shock Regulator Controlled by on/Off Switch and Phosphorylation

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Whitehead Institute researchers have determined how the master transcriptional regulator of the heat shock response, known as heat shock factor 1 (HSF1), is controlled in yeast. Understanding how HSF1 works, how it is regulated, and how to fine tune...
13-Nov-2016 4:05 PM EST Add to Favorites

Insight on Rett Syndrome Neurophysiology Finds Mechanisms Underlying its Functional Deficits—and Shows They Are Reversible

Researchers using a mouse model of Rett Syndrome find that cortical pyramidal neurons have faults in excitatory and inhibitory signaling; and demonstrate why recombinant human Insulin Like Growth Factor 1 has had therapeutic effects for RTT patients...
31-Oct-2016 9:30 AM EDT Add to Favorites

Susan Lindquist, Accomplished and Beloved Scientist, Has Died at Age 67

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“Sue has meant so much to Whitehead as an institution of science, and as a community of scientists, and her passing leaves us diminished in so many ways,” reflects David C. Page, M.D., Director of Whitehead Institute
28-Oct-2016 11:05 AM EDT Add to Favorites

Revising the Meaning of “Prion”

Using an unbiased screen in yeast, a team of Whitehead Institute and Stanford University scientists have identified dozens of prion-like proteins that could change the defining characteristics of these unusual proteins.
4-Oct-2016 3:05 PM EDT Add to Favorites

Inherited Parental Methylation Shifts Over Time, May Have Functional Effects in the Brain and Other Tissues

Inherited methylation—a form of epigenetic regulation passed down from parents to offspring—is far more dynamic than previously thought and may contribute to changes in the brain and other tissues over time. This finding by Whitehead Institute...
19-Sep-2016 10:05 AM EDT Add to Favorites

Genome-Wide Toxoplasma Screen Reveals Mechanisms of Parasitic Infections

Whitehead Institute researchers have conducted the first genome-wide screen in Apicomplexa, a phylum of single-celled parasites that cause diseases such as malaria and toxoplasmosis. The screen sheds light into the vast, unstudied reaches of...
30-Aug-2016 3:05 PM EDT Add to Favorites

Novel Method Enables Absolute Quantification of Mitochondrial Metabolites

Whitehead Institute scientists have developed a method to quickly isolate mitochondria from mammalian cells and systematically measure the concentrations of mitochondrial metabolites. Mitochondrial dysfunction is found in several disorders,...
31-Aug-2016 1:05 PM EDT Add to Favorites

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