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Disrupting Mitochondrial Function Could Improve Treatment of Fungal Infections

Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today’s most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a...
9-Aug-2016 12:00 PM EDT Add to Favorites

Defining What It Means to Be a Naive Stem Cell

Whitehead Institute scientists have created a checklist that defines the “naive” state of cultured human embryonic stem cells (ESCs). Such cells provide a better model of early human embryogenesis than conventional ESCs in later stages of...
13-Jul-2016 12:00 PM EDT Add to Favorites

Tiny Alpaca-Derived Antibodies Point to Targets Preventing Viral Infection

Using tiny, alpaca-derived, single-domain antibody fragments, Whitehead Institute scientists have developed a method to perturb cellular processes in mammalian cells, allowing them to tease apart the roles that individual proteins play in these...
16-Jun-2016 11:00 AM EDT Add to Favorites

Identifying a Genetic Mutation Behind Sporadic Parkinson’s Disease

Using a novel method, Whitehead Institute researchers have determined how mutations that are not located within genes are identified through genome-wide association studies (GWAS) and can contribute to sporadic Parkinson’s disease, the most common...
18-Apr-2016 1:00 PM EDT Add to Favorites

There Goes the Neighborhood: Changes in Chromosome Structure Activate Cancer-Causing Genes

In a finding with enormous implications for cancer diagnostics and therapeutics, Whitehead Institute scientists have discovered that breaches in looping chromosomal structures known as “insulated neighborhoods” can activate oncogenes capable of...
29-Feb-2016 10:05 AM EST Add to Favorites

High-Fat Diet Linked to Intestinal Stem Cell Changes, Increased Risk for Cancer

Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer. Now, a new study from Whitehead Institute and MIT’s Koch Institute for Integrative Cancer...
1-Mar-2016 2:05 PM EST Add to Favorites

Engineered Hydrogel Scaffolds Enable Growth of Functioning Human Breast Tissue

Whitehead Institute researchers have created a hydrogel scaffold that replicates the environment found within the human breast. The scaffold supports the growth of human mammary tissue from patient-derived cells and can be used to study normal...
29-Feb-2016 11:05 AM EST Add to Favorites

B-Cell Diversity in Immune System’s Germinal Centers May Hold Key to Broad-Spectrum Vaccines

The germinal centers that form in the body’s lymph nodes work as a fitness boot camp in which B cells evolve to produce antibodies of increasingly higher affinity to an invading pathogen. This new finding from Whitehead Institute scientists...
17-Feb-2016 11:00 AM EST Add to Favorites

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