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Architecture of Protein Complex Hints at Its Foundational Function in Chromosome Segregation

Whitehead Institute researchers have determined the organization of a protein complex that is critical during chromosome segregation. Without the foundation it supplies, the link between chromosome and kinetochore would fail, as would chromosome...
16-Nov-2015 4:05 PM EST Add to Favorites

Screen of Human Genome Reveals Set of Genes Essential for Cellular Viability

Scientists at Whitehead Institute and Broad Institute of MIT and Harvard have for the first time identified the universe of genes in the human genome essential for the survival and proliferation of human cell lines or cultured human cells.Their...
14-Oct-2015 4:05 PM EDT Add to Favorites

Scientists Discover Essential Amino Acid Sensor in Key Growth-Regulating Metabolic Pathway

Whitehead Institute scientists have at last answered the long-standing question of how the growth-regulating pathway known as mechanistic target of rapamycin complex 1 (mTORC1) detects the presence of the amino acid leucine—itself a key player in...
5-Oct-2015 10:05 AM EDT Add to Favorites

New Methodology Tracks Changes in DNA Methylation in Real Time at Single-Cell Resolution

Whitehead Institute researchers have developed a tool that allows scientists to monitor changes in DNA methylation over time in individual cells. Certain diseases, including cancer, cause changes in DNA methylation patterns, and the ability to...
22-Sep-2015 3:05 PM EDT Add to Favorites

New Role for an Old Protein: Cancer Causer

A protein known to play a role in transporting the molecular contents of normal cells into and out of various intracellular compartments can also turn such cells cancerous by stimulating a key growth-control pathway.
3-Sep-2015 11:05 AM EDT Add to Favorites

Variations in Cell Programs Control Cancer and Normal Stem Cells

In the breast, cancer stem cells and normal stem cells can arise from different cell types and tap into distinct yet related stem cell programs, according to Whitehead Institute researchers. The differences between these stem cell programs may be...
3-Sep-2015 11:05 AM EDT Add to Favorites

Cellular Recycling Complexes May Hold Key to Chemotherapy Resistance

Upsetting the balance between protein synthesis, misfolding, and degradation drives cancer and neurodegeneration. Recent cancer treatments take advantage of this knowledge with a class of drugs that block protein degradation, known as proteasome...
1-Sep-2015 11:05 AM EDT Add to Favorites

Tiny Antibodies Point to Vulnerability in Disease-Causing Parasites

By teasing apart the structure of an enzyme vital to the parasites that cause toxoplasmosis and malaria, Whitehead Institute scientists have identified a potentially ‘drugable’ target that could prevent parasites from entering and exiting host...
20-Aug-2015 11:05 AM EDT Add to Favorites

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