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Cellular Recycling Complexes May Hold Key to Chemotherapy Resistance

Upsetting the balance between protein synthesis, misfolding, and degradation drives cancer and neurodegeneration. Recent cancer treatments take advantage of this knowledge with a class of drugs that block protein degradation, known as proteasome...
1-Sep-2015 11:05 AM EDT Add to Favorites

Tiny Antibodies Point to Vulnerability in Disease-Causing Parasites

By teasing apart the structure of an enzyme vital to the parasites that cause toxoplasmosis and malaria, Whitehead Institute scientists have identified a potentially ‘drugable’ target that could prevent parasites from entering and exiting host...
20-Aug-2015 11:05 AM EDT Add to Favorites

Forks Colliding: How DNA Breaks During Re-Replication

Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of such genomic damage....
27-May-2015 12:00 PM EDT Add to Favorites

Repurposed Anti-Cholesterol Drug Could Improve Treatment-Resistant Anemias

Diamond Blackfan anemia (DBA), a rare inherited bone marrow failure syndrome is typically treated with glucocorticoids that cause a host of often dangerous side effects. Using a mouse model, Whitehead scientists have determined that combining the...
8-May-2015 12:05 PM EDT Add to Favorites

Imaging Immunity

A novel approach that allows real-time imaging of the immune system’s response to the presence of tumors—without the need for blood draws or invasive biopsies—offers a potential breakthrough both in diagnostics and in the ability to monitor...
16-Apr-2015 10:05 AM EDT Add to Favorites

CRISPR-Cas Genome Editing of Candida albicans Holds Promise for Overcoming Deadly Fungal Infections

Candida albicans causes potentially lethal infections in immunocompromised individuals. Now, using a modified CRISPR-Cas system, Whitehead researchers can edit the fungus’s genome systematically—an approach that could help identify potential...
3-Apr-2015 9:05 AM EDT Add to Favorites

Age-Discrimination During Cell Division Maintains the ‘Stem’ in Stem Cells

A team of Whitehead Institute scientists has discovered that during division, stem cells distinguish between old and young mitochondria and allocate them disproportionately between daughter cells.
31-Mar-2015 9:05 AM EDT Add to Favorites

Scientists Identify First Nutrient Sensor in Key Growth-Regulating Metabolic Pathway

Whitehead Institute scientists have for the first time identified a protein that appears to be a nutrient sensor for the key growth-regulating mTORC1 metabolic pathway.
6-Jan-2015 3:00 PM EST Add to Favorites

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