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Inherited Parental Methylation Shifts Over Time, May Have Functional Effects in the Brain and Other Tissues

Inherited methylation—a form of epigenetic regulation passed down from parents to offspring—is far more dynamic than previously thought and may contribute to changes in the brain and other tissues over time. This finding by Whitehead Institute...
19-Sep-2016 10:05 AM EDT Add to Favorites

Genome-Wide Toxoplasma Screen Reveals Mechanisms of Parasitic Infections

Whitehead Institute researchers have conducted the first genome-wide screen in Apicomplexa, a phylum of single-celled parasites that cause diseases such as malaria and toxoplasmosis. The screen sheds light into the vast, unstudied reaches of...
30-Aug-2016 3:05 PM EDT Add to Favorites

Novel Method Enables Absolute Quantification of Mitochondrial Metabolites

Whitehead Institute scientists have developed a method to quickly isolate mitochondria from mammalian cells and systematically measure the concentrations of mitochondrial metabolites. Mitochondrial dysfunction is found in several disorders,...
31-Aug-2016 1:05 PM EDT Add to Favorites

Disrupting Mitochondrial Function Could Improve Treatment of Fungal Infections

Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today’s most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a...
9-Aug-2016 12:00 PM EDT Add to Favorites

Defining What It Means to Be a Naive Stem Cell

Whitehead Institute scientists have created a checklist that defines the “naive” state of cultured human embryonic stem cells (ESCs). Such cells provide a better model of early human embryogenesis than conventional ESCs in later stages of...
13-Jul-2016 12:00 PM EDT Add to Favorites

Tiny Alpaca-Derived Antibodies Point to Targets Preventing Viral Infection

Using tiny, alpaca-derived, single-domain antibody fragments, Whitehead Institute scientists have developed a method to perturb cellular processes in mammalian cells, allowing them to tease apart the roles that individual proteins play in these...
16-Jun-2016 11:00 AM EDT Add to Favorites

Identifying a Genetic Mutation Behind Sporadic Parkinson’s Disease

Using a novel method, Whitehead Institute researchers have determined how mutations that are not located within genes are identified through genome-wide association studies (GWAS) and can contribute to sporadic Parkinson’s disease, the most common...
18-Apr-2016 1:00 PM EDT Add to Favorites

There Goes the Neighborhood: Changes in Chromosome Structure Activate Cancer-Causing Genes

In a finding with enormous implications for cancer diagnostics and therapeutics, Whitehead Institute scientists have discovered that breaches in looping chromosomal structures known as “insulated neighborhoods” can activate oncogenes capable of...
29-Feb-2016 10:05 AM EST Add to Favorites

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