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Heat-Shock Protein Enables Tumor Evolution and Drug Resistance in Breast Cancer

Long known for its ability to help organisms successfully adapt to environmentally stressful conditions, the highly conserved molecular chaperone heat-shock protein 90 (HSP90) also enables estrogen receptor-positive (ER+) breast cancers to develop...
5-Dec-2014 3:30 PM EST

Direct Generation of Neural Stem Cells Could Enable Transplantation Therapy

Induced neural stem cells (iNSCs) hold promise for therapeutic transplantation, but their potential in this capacity has been limited by failed efforts to maintain such cells in their multi-potent NSC state. Now, Whitehead Institute scientists have...
5-Nov-2014 3:30 PM EST

What’s Mighty About the Mouse? For Starters, Its Massive Y Chromosome

An exhaustive effort to sequence the mouse Y chromosome reveals a surprisingly large and complex biological beast, at the same time providing remarkable insight into a heated battle for supremacy between mammalian sex chromosomes.
27-Oct-2014 4:30 PM EDT

Blocking a Fork in the Road to DNA Replication

A team of Whitehead Institute scientists has discovered the surprising manner in which an enigmatic protein known as SUUR acts to control gene copy number during DNA replication. It’s a finding that could shed new light on the formation of fragile...
29-Oct-2014 12:00 PM EDT

Special Chromosomal Structures Control Key Genes

Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression. Now, Whitehead Institute researchers present the first...
7-Oct-2014 10:25 AM EDT

New Protein Players Found in Key Disease-Related Metabolic Pathway

Cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway—which senses the availability of nutrients—to coordinate their growth with existing environmental conditions. The lab of Whitehead Member David Sabatini has identified...
23-Sep-2014 2:00 PM EDT

Scientists Discover RNA Modifications in Some Unexpected Places

Deploying sophisticated high-throughput sequencing technology, dubbed ψ-seq, a team of Whitehead Institute and Broad Institute researchers collaborated on a comprehensive, high-resolution mapping of ψ sites that confirms pseudouridylation, the...
15-Sep-2014 4:00 PM EDT

New Reprogramming Factor Cocktail Produces Therapy-Grade Induced Pluripotent Stem Cells

Induced pluripotent stem cells (iPSCs) can acquire serious genetic and epigenetic abnormalities that lower the cells’ quality and limit their therapeutic usefulness. Now Whitehead Institute researchers have identified a cocktail of reprogramming...
28-Aug-2014 3:20 PM EDT

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