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Tiny Alpaca-Derived Antibodies Point to Targets Preventing Viral Infection

Using tiny, alpaca-derived, single-domain antibody fragments, Whitehead Institute scientists have developed a method to perturb cellular processes in mammalian cells, allowing them to tease apart the roles that individual proteins play in these...
16-Jun-2016 11:00 AM EDT Add to Favorites

Identifying a Genetic Mutation Behind Sporadic Parkinson’s Disease

Using a novel method, Whitehead Institute researchers have determined how mutations that are not located within genes are identified through genome-wide association studies (GWAS) and can contribute to sporadic Parkinson’s disease, the most common...
18-Apr-2016 1:00 PM EDT Add to Favorites

There Goes the Neighborhood: Changes in Chromosome Structure Activate Cancer-Causing Genes

In a finding with enormous implications for cancer diagnostics and therapeutics, Whitehead Institute scientists have discovered that breaches in looping chromosomal structures known as “insulated neighborhoods” can activate oncogenes capable of...
29-Feb-2016 10:05 AM EST Add to Favorites

High-Fat Diet Linked to Intestinal Stem Cell Changes, Increased Risk for Cancer

Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer. Now, a new study from Whitehead Institute and MIT’s Koch Institute for Integrative Cancer...
1-Mar-2016 2:05 PM EST Add to Favorites

Engineered Hydrogel Scaffolds Enable Growth of Functioning Human Breast Tissue

Whitehead Institute researchers have created a hydrogel scaffold that replicates the environment found within the human breast. The scaffold supports the growth of human mammary tissue from patient-derived cells and can be used to study normal...
29-Feb-2016 11:05 AM EST Add to Favorites

B-Cell Diversity in Immune System’s Germinal Centers May Hold Key to Broad-Spectrum Vaccines

The germinal centers that form in the body’s lymph nodes work as a fitness boot camp in which B cells evolve to produce antibodies of increasingly higher affinity to an invading pathogen. This new finding from Whitehead Institute scientists...
17-Feb-2016 11:00 AM EST Add to Favorites

New Mouse-Human Modeling System Enables Study of Disease Development in vivo

Whitehead Institute researchers have created a new mouse-human modeling system that could be used to study neural crest development as well as the modeling of a variety of neural crest related diseases, including such cancers as melanoma and...
22-Jan-2016 11:05 AM EST Add to Favorites

3D Map of Human Genome Reveals Relationship Between Mutations and Disease Development

Whitehead Institute researchers have created a map of the DNA loops that comprise the three dimensional (3D) structure of the human genome and contribute to gene regulation in human embryonic stem cells. The location of genes and regulatory elements...
10-Dec-2015 10:05 AM EST Add to Favorites

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