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Faithful Cell Division Requires Tightly Controlled Protein Placement at the Centromeres

The protein CENP-A, which is integrated into human DNA at the centromere on each chromosome, has a vital role in cell division. Work from Whitehead Institute Member Iain Cheeseman’s lab describes how the vital and tightly controlled replenishment...
14-Jul-2014 5:00 PM EDT

A Region and Pathway Found Crucial for Facial Development in Vertebrate Embryos

A signaling pathway once thought to have little if any role during embryogenesis is a key player in the formation of the front-most portion of developing vertebrate embryos. Moreover, signals emanating from this region—referred to as the...
17-Jul-2014 10:00 AM EDT

Engineered Red Blood Cells Could Carry Precious Therapeutic Cargo

Whitehead Institute scientists have genetically and enzymatically modified red blood cells to carry a range of valuable payloads—from drugs, to vaccines, to imaging agents—for delivery to specific sites throughout the body.
25-Jun-2014 11:00 AM EDT

Seemingly Invincible Cancers Stem Cells Reveal a Weakness

Metastatic cancer cells, which can migrate from primary tumors to seed new malignancies, have thus far been resistant to the current arsenal of anticancer drugs. Now, however, researchers at Whitehead Institute have identified a critical weakness...
5-Jun-2014 4:00 PM EDT

Lost in Translation?

In any animal’s lifecycle, the shift from egg cell to embryo is a critical juncture that requires a remarkably dynamic process that ultimately transforms a differentiated, committed oocyte to a totipotent cell capable of giving rise to any cell...
22-May-2014 10:00 AM EDT

Combination Therapy a Potential Strategy for Treating Niemann Pick Disease

Whitehead Institute researchers have identified a potential dual-pronged approach to treating Niemann-Pick type C (NPC) disease, a rare but devastating genetic disorder. By studying nerve and liver cells grown from NPC patient-derived induced...
14-May-2014 2:00 PM EDT

Scientists Find Gene Behind a Highly Prevalent Facial Anomaly

Whitehead Institute scientists have identified a genetic cause of a facial disorder known as hemifacial microsomia (HFM). The researchers find that duplication of the gene OTX2 induces HFM, the second-most common facial anomaly after cleft lip and...
7-May-2014 9:30 AM EDT

Three-Banded Panther Worm Debuts as a New Model in the Study of Regeneration

Hofstenia_adult.jpg

The lab of Whitehead Institute Member Peter Reddien is introducing the scientific community to the three-banded panther worm (Hofstenia miamia), a small organism with the ability to regenerate any missing body part. As a model, Hofstenia could help...
23-Apr-2014 10:00 PM EDT

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