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Scientists Discover RNA Modifications in Some Unexpected Places

Deploying sophisticated high-throughput sequencing technology, dubbed ψ-seq, a team of Whitehead Institute and Broad Institute researchers collaborated on a comprehensive, high-resolution mapping of ψ sites that confirms pseudouridylation, the...
15-Sep-2014 4:00 PM EDT

New Reprogramming Factor Cocktail Produces Therapy-Grade Induced Pluripotent Stem Cells

Induced pluripotent stem cells (iPSCs) can acquire serious genetic and epigenetic abnormalities that lower the cells’ quality and limit their therapeutic usefulness. Now Whitehead Institute researchers have identified a cocktail of reprogramming...
28-Aug-2014 3:20 PM EDT

Master Heat-Shock Factor Supports Reprogramming of Normal Cells to Enable Tumor Growth and Metastasis

Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat-Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant...
30-Jul-2014 4:00 PM EDT

Innovative Scientists Update Old-School Pipetting with New-Age Technology

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A team of Whitehead Institute researchers is bringing new levels of efficiency and accuracy to one of the most essential albeit tedious tasks of bench science: pipetting. Dubbed “iPipet,” the system converts an iPad or any tablet computer into a...
28-Jul-2014 2:00 PM EDT

Whitehead Institute Researchers Create “Naïve” Pluripotent Human Embryonic Stem Cells

Embryonic stem cell (ESC) research has been hampered by the inability to transfer research and tools from mouse ESC studies to their human counterparts, in part because human ESCs are “primed” and slightly less plastic than the mouse cells. Now...
25-Jul-2014 1:00 PM EDT

Faithful Cell Division Requires Tightly Controlled Protein Placement at the Centromeres

The protein CENP-A, which is integrated into human DNA at the centromere on each chromosome, has a vital role in cell division. Work from Whitehead Institute Member Iain Cheeseman’s lab describes how the vital and tightly controlled replenishment...
14-Jul-2014 5:00 PM EDT

A Region and Pathway Found Crucial for Facial Development in Vertebrate Embryos

A signaling pathway once thought to have little if any role during embryogenesis is a key player in the formation of the front-most portion of developing vertebrate embryos. Moreover, signals emanating from this region—referred to as the...
17-Jul-2014 10:00 AM EDT

Engineered Red Blood Cells Could Carry Precious Therapeutic Cargo

Whitehead Institute scientists have genetically and enzymatically modified red blood cells to carry a range of valuable payloads—from drugs, to vaccines, to imaging agents—for delivery to specific sites throughout the body.
25-Jun-2014 11:00 AM EDT

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