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Forks Colliding: How DNA Breaks During Re-Replication

Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of such genomic damage....
27-May-2015 12:00 PM EDT

Repurposed Anti-Cholesterol Drug Could Improve Treatment-Resistant Anemias

Diamond Blackfan anemia (DBA), a rare inherited bone marrow failure syndrome is typically treated with glucocorticoids that cause a host of often dangerous side effects. Using a mouse model, Whitehead scientists have determined that combining the...
8-May-2015 12:05 PM EDT

Imaging Immunity

A novel approach that allows real-time imaging of the immune system’s response to the presence of tumors—without the need for blood draws or invasive biopsies—offers a potential breakthrough both in diagnostics and in the ability to monitor...
16-Apr-2015 10:05 AM EDT

CRISPR-Cas Genome Editing of Candida albicans Holds Promise for Overcoming Deadly Fungal Infections

Candida albicans causes potentially lethal infections in immunocompromised individuals. Now, using a modified CRISPR-Cas system, Whitehead researchers can edit the fungus’s genome systematically—an approach that could help identify potential...
3-Apr-2015 9:05 AM EDT

Age-Discrimination During Cell Division Maintains the ‘Stem’ in Stem Cells

A team of Whitehead Institute scientists has discovered that during division, stem cells distinguish between old and young mitochondria and allocate them disproportionately between daughter cells.
31-Mar-2015 9:05 AM EDT

Scientists Identify First Nutrient Sensor in Key Growth-Regulating Metabolic Pathway

Whitehead Institute scientists have for the first time identified a protein that appears to be a nutrient sensor for the key growth-regulating mTORC1 metabolic pathway.
6-Jan-2015 3:00 PM EST

Heat-Shock Protein Enables Tumor Evolution and Drug Resistance in Breast Cancer

Long known for its ability to help organisms successfully adapt to environmentally stressful conditions, the highly conserved molecular chaperone heat-shock protein 90 (HSP90) also enables estrogen receptor-positive (ER+) breast cancers to develop...
5-Dec-2014 3:30 PM EST

Direct Generation of Neural Stem Cells Could Enable Transplantation Therapy

Induced neural stem cells (iNSCs) hold promise for therapeutic transplantation, but their potential in this capacity has been limited by failed efforts to maintain such cells in their multi-potent NSC state. Now, Whitehead Institute scientists have...
5-Nov-2014 3:30 PM EST

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