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CRISPR-Cas Genome Editing of Candida albicans Holds Promise for Overcoming Deadly Fungal Infections

Candida albicans causes potentially lethal infections in immunocompromised individuals. Now, using a modified CRISPR-Cas system, Whitehead researchers can edit the fungus’s genome systematically—an approach that could help identify potential...
3-Apr-2015 9:05 AM EDT

Age-Discrimination During Cell Division Maintains the ‘Stem’ in Stem Cells

A team of Whitehead Institute scientists has discovered that during division, stem cells distinguish between old and young mitochondria and allocate them disproportionately between daughter cells.
31-Mar-2015 9:05 AM EDT

Scientists Identify First Nutrient Sensor in Key Growth-Regulating Metabolic Pathway

Whitehead Institute scientists have for the first time identified a protein that appears to be a nutrient sensor for the key growth-regulating mTORC1 metabolic pathway.
6-Jan-2015 3:00 PM EST

Heat-Shock Protein Enables Tumor Evolution and Drug Resistance in Breast Cancer

Long known for its ability to help organisms successfully adapt to environmentally stressful conditions, the highly conserved molecular chaperone heat-shock protein 90 (HSP90) also enables estrogen receptor-positive (ER+) breast cancers to develop...
5-Dec-2014 3:30 PM EST

Direct Generation of Neural Stem Cells Could Enable Transplantation Therapy

Induced neural stem cells (iNSCs) hold promise for therapeutic transplantation, but their potential in this capacity has been limited by failed efforts to maintain such cells in their multi-potent NSC state. Now, Whitehead Institute scientists have...
5-Nov-2014 3:30 PM EST

What’s Mighty About the Mouse? For Starters, Its Massive Y Chromosome

An exhaustive effort to sequence the mouse Y chromosome reveals a surprisingly large and complex biological beast, at the same time providing remarkable insight into a heated battle for supremacy between mammalian sex chromosomes.
27-Oct-2014 4:30 PM EDT

Blocking a Fork in the Road to DNA Replication

A team of Whitehead Institute scientists has discovered the surprising manner in which an enigmatic protein known as SUUR acts to control gene copy number during DNA replication. It’s a finding that could shed new light on the formation of fragile...
29-Oct-2014 12:00 PM EDT

Special Chromosomal Structures Control Key Genes

Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression. Now, Whitehead Institute researchers present the first...
7-Oct-2014 10:25 AM EDT

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