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Special Chromosomal Structures Control Key Genes

Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression. Now, Whitehead Institute researchers present the first...
7-Oct-2014 10:25 AM EDT

New Protein Players Found in Key Disease-Related Metabolic Pathway

Cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway—which senses the availability of nutrients—to coordinate their growth with existing environmental conditions. The lab of Whitehead Member David Sabatini has identified...
23-Sep-2014 2:00 PM EDT

Scientists Discover RNA Modifications in Some Unexpected Places

Deploying sophisticated high-throughput sequencing technology, dubbed ψ-seq, a team of Whitehead Institute and Broad Institute researchers collaborated on a comprehensive, high-resolution mapping of ψ sites that confirms pseudouridylation, the...
15-Sep-2014 4:00 PM EDT

New Reprogramming Factor Cocktail Produces Therapy-Grade Induced Pluripotent Stem Cells

Induced pluripotent stem cells (iPSCs) can acquire serious genetic and epigenetic abnormalities that lower the cells’ quality and limit their therapeutic usefulness. Now Whitehead Institute researchers have identified a cocktail of reprogramming...
28-Aug-2014 3:20 PM EDT

Master Heat-Shock Factor Supports Reprogramming of Normal Cells to Enable Tumor Growth and Metastasis

Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat-Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant...
30-Jul-2014 4:00 PM EDT

Innovative Scientists Update Old-School Pipetting with New-Age Technology


A team of Whitehead Institute researchers is bringing new levels of efficiency and accuracy to one of the most essential albeit tedious tasks of bench science: pipetting. Dubbed “iPipet,” the system converts an iPad or any tablet computer into a...
28-Jul-2014 2:00 PM EDT

Whitehead Institute Researchers Create “Naïve” Pluripotent Human Embryonic Stem Cells

Embryonic stem cell (ESC) research has been hampered by the inability to transfer research and tools from mouse ESC studies to their human counterparts, in part because human ESCs are “primed” and slightly less plastic than the mouse cells. Now...
25-Jul-2014 1:00 PM EDT

Faithful Cell Division Requires Tightly Controlled Protein Placement at the Centromeres

The protein CENP-A, which is integrated into human DNA at the centromere on each chromosome, has a vital role in cell division. Work from Whitehead Institute Member Iain Cheeseman’s lab describes how the vital and tightly controlled replenishment...
14-Jul-2014 5:00 PM EDT

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