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From Liability to Viability: Genes on the Y Chromosome Prove Essential for Male Survival

The human Y chromosome has over the course of millions of years of evolution has preserved a small set of genes that has ensured not only its own survival but also the survival of men. Moreover, the vast majority of these tenacious genes appear to...
4/17/2014 10:00 AM EDT

Scientists Find Potential Target for Treating Mitochondrial Disorders

Mitochondria, long known as “cellular power plants” for their generation of the key energy source adenosine triphosphate (ATP), are essential for proper cellular functions. Mitochondrial defects are often observed in a variety of diseases,...
3/25/2014 11:00 AM EDT

Whitehead Institute and Biogen Idec Initiate Discovery Research Collaboration

Whitehead Institute today announced it has entered into a scientific research collaboration with Biogen Idec (NASDAQ:BIIB) aimed at driving early stage research that may lead to the development of novel therapies across a broad range of disease...
3/25/2014 10:00 AM EDT

How Diabetes Drugs May Work Against Cancer

Scientists at Whitehead Institute have pinpointed a major mitochondrial pathway that imbues cancer cells with the ability to survive in low-glucose environments. By identifying cancer cells with defects in this pathway or with impaired glucose...
3/16/2014 2:00 PM EDT

Yeast Model Reveals Alzheimer’s Drug Candidate and Its Mechanism of Action

Whitehead Institute scientists have used a yeast cell-based drug screen to identify a class of molecules that target the amyloid-β (Aβ) peptide involved in Alzheimer’s disease (AD).
3/3/2014 2:00 PM EST

A Protein-Production Tale of the Tape

Whitehead Institute researchers have determined that poly(A) tails on messenger RNAs (mRNAs) shift their role in the regulation of protein production during early embryogenesis. This finding about the regulation of mRNA translation also provides...
1/30/2014 8:00 AM EST

Rapid Evolution of Novel Forms: Environmental Change Triggers Inborn Capacity for Adaptation

In this week’s edition of the journal Science, a team of researchers from Harvard Medical School and Whitehead Institute report that, at least in the case of one variety of cavefish, one agent of evolutionary change is the heat shock protein known...
12/10/2013 4:00 PM EST

Gene Responsible for Hereditary Cancer Syndrome Found to Disrupt Critical Growth-Regulating Pathway

Whitehead Institute scientists report that the gene mutated in the rare hereditary disorder known as Birt-Hogg-Dubé cancer syndrome prevents activation of mTORC1, a critical nutrient-sensing and growth-regulating cellular pathway.
11/4/2013 11:00 AM EST

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