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Researchers Uncover a Role for HSP90 in Gene-Environment Interactions in Humans

Researchers at Whitehead Institute have now uncovered a role for the protein-folding chaperone HSP90 in humans, not only as a modifier of the effects of mutations, but as a mediator of the impact of the environment on the function of mutant...
23-Feb-2017 10:00 AM EST Add to Favorites

New Clues on the Base of Parkinson’s Disease and Other “Synucleinopathies”

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Parkinson’s disease (PD) and other “synucleinopathies” are known to be linked to the misfolding of alpha-synuclein protein in neurons. Less clear is how this misfolding relates to the growing number of genes implicated in PD through analysis...
23-Jan-2017 1:30 PM EST Add to Favorites

Scientists Engineer Gene Pathway to Grow Brain Organoids with Surface Folding

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Whitehead Institute researchers provide insight into a specific gene pathway that appears to regulate the growth, structure, and organization of the human cortex. They also demonstrate that 3D human cerebral organoids can be effective in modeling...
29-Dec-2016 2:05 PM EST Add to Favorites

Naturally Occurring Mechanism of Cancer Drug-Resistance May Itself Be a Treatment Target

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The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs. But Whitehead Institute researchers have found a mechanism underlying this resistance—a mechanism that...
26-Dec-2016 3:00 PM EST Add to Favorites

CRISPR Screening Identifies Potential HIV Treatment Targets

Targeting human genes required for HIV infection but not T cell survival may avoid inducing treatment resistance
16-Dec-2016 10:00 AM EST Add to Favorites

Johnson & Johnson Endows Professorship Honoring Susan Lindquist, Role Model for Women in Science

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The Susan Lindquist Chair for Women in Science will advance the work of women who are leaders in biomedical research and role models for emerging female scientists. It honors a singular scientist who blazed a path—for women and men alike—into...
16-Nov-2016 10:05 AM EST Add to Favorites

Heat Shock Regulator Controlled by on/Off Switch and Phosphorylation

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Whitehead Institute researchers have determined how the master transcriptional regulator of the heat shock response, known as heat shock factor 1 (HSF1), is controlled in yeast. Understanding how HSF1 works, how it is regulated, and how to fine tune...
13-Nov-2016 4:05 PM EST Add to Favorites

Insight on Rett Syndrome Neurophysiology Finds Mechanisms Underlying its Functional Deficits—and Shows They Are Reversible

Researchers using a mouse model of Rett Syndrome find that cortical pyramidal neurons have faults in excitatory and inhibitory signaling; and demonstrate why recombinant human Insulin Like Growth Factor 1 has had therapeutic effects for RTT patients...
31-Oct-2016 9:30 AM EDT Add to Favorites

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