Whitehead Institute researchers provide insight into a specific gene pathway that appears to regulate the growth, structure, and organization of the human cortex. They also demonstrate that 3D human cerebral organoids can be effective in modeling...
29-Dec-2016 2:05 PM EST Add to Favorites
The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs. But Whitehead Institute researchers have found a mechanism underlying this resistance—a mechanism that...
26-Dec-2016 3:00 PM EST Add to Favorites
Targeting human genes required for HIV infection but not T cell survival may avoid inducing treatment resistance
16-Dec-2016 10:00 AM EST Add to Favorites
The Susan Lindquist Chair for Women in Science will advance the work of women who are leaders in biomedical research and role models for emerging female scientists. It honors a singular scientist who blazed a path—for women and men alike—into...
16-Nov-2016 10:05 AM EST Add to Favorites
Whitehead Institute researchers have determined how the master transcriptional regulator of the heat shock response, known as heat shock factor 1 (HSF1), is controlled in yeast. Understanding how HSF1 works, how it is regulated, and how to fine tune...
13-Nov-2016 4:05 PM EST Add to Favorites
Insight on Rett Syndrome Neurophysiology Finds Mechanisms Underlying its Functional Deficits—and Shows They Are Reversible
Researchers using a mouse model of Rett Syndrome find that cortical pyramidal neurons have faults in excitatory and inhibitory signaling; and demonstrate why recombinant human Insulin Like Growth Factor 1 has had therapeutic effects for RTT patients...
31-Oct-2016 9:30 AM EDT Add to Favorites
“Sue has meant so much to Whitehead as an institution of science, and as a community of scientists, and her passing leaves us diminished in so many ways,” reflects David C. Page, M.D., Director of Whitehead Institute
28-Oct-2016 11:05 AM EDT Add to Favorites
Using an unbiased screen in yeast, a team of Whitehead Institute and Stanford University scientists have identified dozens of prion-like proteins that could change the defining characteristics of these unusual proteins.
4-Oct-2016 3:05 PM EDT Add to Favorites