Released: 19-Sep-1998 12:00 AM EDT
Triple Drug Treatment Keeps Heart Failure From Worsening
University of North Carolina Health Care System

Peoplw withheart failure are less likely to experience a worsening of their condition if they are treated with three drugs, suggests a study co-authored by researchers from the University of North Carolina at Chapel Hill.

Released: 6-Oct-1997 12:00 AM EDT
Medical reporting symposium to bring leading journalists to UNC-CH
University of North Carolina Health Care System

Some of the nation's leading medical reporters will speak at the University of North Carolina at Chapel Hill Nov. 14-15 in a symposium for working medical journalists and medical communications specialists.

25-Sep-1998 12:00 AM EDT
Paradoxical Gene Suppresses Tumors Yet Makes Them Grow
University of North Carolina Health Care System

Scientists at the University of North Carolina at Chapel Hill have found that a gene discovered earlier in the decade has paradoxical properties -- it helps bring about tumor cell death yet is also necessary for their growth.

12-Sep-1998 12:00 AM EDT
Allergy Linked to Common Ear Infection
University of North Carolina Health Care System

In a scientific first, researchers at the University of North Carolina at Chapel Hill have demonstrated that allergy increases susceptibility to otitis media, the most common, recurrent ear infection in young children.

15-Oct-1998 12:00 AM EDT
Drug-Resistant HIV found in Semen.
University of North Carolina Health Care System

A study by the University of North Carolina at Chapel Hill confirms the presence of mutated, drug-resistant human immunodeficiency virus in the semen of men taking antiviral medications for HIV infection.

9-Nov-1998 12:00 AM EST
Arthritis Reduced by Turning off Molecular Switch
University of North Carolina Health Care System

In a scientific first, researchers at the University of North Carolina at Chapel Hill have reduced the severity of arthritis by turning off a molecular switch, a gene called NF-kappa B.

Released: 13-Nov-1998 12:00 AM EST
Severe PMS linked with physical, sexual abuse in childhood
University of North Carolina Health Care System

More than half of women with a very severe form of premenstrual syndrome are likely to have histories of physical or sexual abuse during childhood or adolescence, according to research by scientists at the University of North Carolina at Chapel Hill.

Released: 11-Nov-1998 12:00 AM EST
New Way to Measure Body Fluid Acidity Invented
University of North Carolina Health Care System

Scientists at the University of North Carolina at Chapel Hill have invented a solid-state metal sensor -- roughly the thickness of three human hairs -- that can measure the acidity (pH) of chemical solutions,including body fluids. A report describing the invention is published in the December issue of Analytical Chemistry.

Released: 1-Dec-1998 12:00 AM EST
Externally Regulating Gene Implanted in Brain
University of North Carolina Health Care System

University of North Carolina researchers have used an antibiotic like an on-off switch to externally regulate a gene carried by a defective virus and implanted in the brain. The report in the Dec. 2 journal Gene Therapy, suggests that gene-transfer technology using a recombinant defective virus in laboratory rats may prove feasible for gene therapy in human brain disorders such as Parkinson's disease and epilepsy.

Released: 10-Dec-1998 12:00 AM EST
Study Confirms Safety of Common Heart Drug
University of North Carolina Health Care System

Researchers at the University of North Carolina at Chapel Hill confirmed the safety of digoxin, one of the oldest and most frequently prescribed medicines and the most common digitalis drug for heart failure, in the December 7-21 issue of the Archives of Internal Medicine.

Released: 10-Dec-1998 12:00 AM EST
Seismic Math Finds Early Signs of Heart Tremors
University of North Carolina Health Care System

Researchers at the University of North Carolina at Chapel Hill are applying the same mathematics used for measuring the earth's seismic activity to finding early signs of heart trouble.

4-Jan-1999 12:00 AM EST
Molecular Doorway Holds Key to Gene Therapy
University of North Carolina Health Care System

Molecular doorways on the surface of cells may be important factors in the success or failure of human gene therapy using altered viruses, according to researchers at the University of North Carolina at Chapel Hill, who reported their study Jan. 4 in the journal Nature Medicine.

Released: 22-Jan-1999 12:00 AM EST
Gene Therapy Trial Approved for Rare Anemia
University of North Carolina Health Care System

A gene therapy clinical trial for Fanconi anemia, a fatal inherited blood disease, is set to begin at the University of North Carolina at Chapel Hill.

Released: 27-Jan-1999 12:00 AM EST
$1 million McDonnell Fellowship
University of North Carolina Health Care System

An associate professor of social medicine and history at the University of North Carolina at Chapel Hill, has been named one of 10 international recipients of a $1 million James S. McDonnell Centennial Fellowship.

Released: 28-Jan-1999 12:00 AM EST
Testing First in New Class of AIDS Drugs
University of North Carolina Health Care System

AIDS investigators at the University of North Carolina at Chapel Hill are testing the first of a new class of drugs that attacks HIV before it enters the cell and may prove effective for patients with drug-resistant HIV.

Released: 29-Jan-1999 12:00 AM EST
Protein Clues to Early Embryo Development
University of North Carolina Health Care System

In a study of life's beginnings, scientists at the University of North Carolina at Chapel Hill have moved a step closer to unraveling the biochemical mystery of embryogenesis, the process by which an egg cell transforms into an embryo.

Released: 13-Feb-1999 12:00 AM EST
UNC surgeons correct "Funnel Chest" using new operation
University of North Carolina Health Care System

In a medical first for North Carolina, pediatric surgeons at the University of North Carolina at Chapel Hill have corrected a common chest-wall deformity called "funnel chest" by using a new, simpler operation.

1-Mar-1999 12:00 AM EST
Abnormal Pain Syndrome Linked to Nerve Cell Changes
University of North Carolina Health Care System

A study by researchers at the University of North Carolina at Chapel Hill has identified molecular changes in nerve cells that may play an important role in an abnormal pain syndrome -- causalgia -- which often eludes effective treatment.

17-Mar-1999 12:00 AM EST
Estrogen Replacement Lowers Blood Pressure of Older Women with Hypertension
University of North Carolina Health Care System

New research at the University of North Carolina at Chapel Hill ties estrogen replacement to reducing blood pressure in older women with hypertension.

17-Mar-1999 12:00 AM EST
Breast-Feeding Hormone Lowers Nursing Moms' Blood Pressure
University of North Carolina Health Care System

A new study at the University of North Carolina at Chapel Hill links increased levels of the hormone oxytocin to lower blood pressure among mothers who nurse their babies. The findings help explain why many breast-feeding mothers report feeling mellow and relaxed after nursing.

Released: 19-Mar-1999 12:00 AM EST
Poor Health in Pregnancy and After Childbirth, History of Abuse
University of North Carolina Health Care System

Women with a history of sexual and physical abuse are more likely to have poor health during pregnancy and after childbirth, according to a study at the University of North Carolina at Chapel Hill.

Released: 23-Mar-1999 12:00 AM EST
New Drug for Recurrent Brain Tumors in Tests at UNC
University of North Carolina Health Care System

Clinical trials are now underway at the University of North Carolina at Chapel Hill on a promising new drug in the fight against malignant and recurrent brain tumors that have so far proved very difficult to treat.

Released: 27-Apr-1999 12:00 AM EDT
Genes Found that Label Cell Proteins for Disposal
University of North Carolina Health Care System

Scientists at the University of North Carolina at Chapel Hill have discovered three genes crucial to the survival of cells, they reported in the April 23 issue of the journal Molecular Cell. The genes select cellular proteins for the disposal and eventual recycling of their components.

Released: 28-Apr-1999 12:00 AM EDT
New Breast Cancer Biopsy and Misdiagnosis
University of North Carolina Health Care System

The demand for the new sentinel lymph node biopsy has prompted a surge in requests from community-based surgeons for lessons in the technique.

24-May-1999 12:00 AM EDT
Stress Speeds Progression to AIDS
University of North Carolina Health Care System

Researchers at the University of North Carolina at Chapel Hill have shown that men infected with HIV will more rapidly develop AIDS as stressful events accumulate in their lives or if their social supports are weak.

Released: 13-May-1999 12:00 AM EDT
Irritable Bowel Syndrome at Digestive Diseases Conference
University of North Carolina Health Care System

The co-directors of the UNC Center for Functional Gastrointestinal and Motility Disorders are senior authors of three scientific reports on Irritable Bowel Syndrome (IBS), slated for presentation at this year's American Gastroenterology Society Digestive Diseases Week meetings, May 16-19 in Orlando, Fla

Released: 21-May-1999 12:00 AM EDT
Cancer Role of Mutated Gene Revealed
University of North Carolina Health Care System

The molecular role in cancer development of a mutated tumor suppressor gene known as ARF has been discovered by University of North Carolina at Chapel Hill scientists. The new findings help clarify why ARF is the second most frequently mutated gene in human cancers.

Released: 25-May-1999 12:00 AM EDT
Family Support Factor in Cardiovascular Responses to Stress
University of North Carolina Health Care System

Married people who receive a high level of social support from their family -- especially from their spouse -- show better heart and blood pressure responses to stress than couples whose family support level is low.

9-Jun-1999 12:00 AM EDT
Possible Gene Therapy for Hemophilia
University of North Carolina Health Care System

New results from gene therapy studies at the University of North Carolina at Chapel Hill may lead to an effective long-term treatment, if not a cure, for hemophilia A, the most common form of this inherited blood disease.

Released: 12-Jun-1999 12:00 AM EDT
Anxiety Best Predicts Persistent Depression
University of North Carolina Health Care System

Symptoms of major depression are most likely to persist in people who also have an anxiety disorder, according to a study headed by a psychiatrist at the University of North Carolina at Chapel Hill.

17-Jun-1999 12:00 AM EDT
Key Predictors of Hypertension
University of North Carolina Health Care System

Researchers at the University of North Carolina at Chapel Hill have found that responses to stress during early adulthood could help predict one's risk for high blood pressure 10 years later.

Released: 7-Jul-1999 12:00 AM EDT
Schizophrenia Linked to Brain Development
University of North Carolina Health Care System

Scientific evidence points to a possible link between schizophrenia and altered brain development in the first three months of pregnancy, according to a new report from the University of North Carolina at Chapel Hill.

Released: 9-Jul-1999 12:00 AM EDT
Less Invasive Repair of Major Artery Defect
University of North Carolina Health Care System

Physicians at the University of North Carolina at Chapel Hill are testing a new, less invasive method for repairing abdominal aortic aneurysms, potentially dangerous defects of the body's major artery found often in the elderly.

Released: 22-Jul-1999 12:00 AM EDT
Gene Mutations Not Always Expressed as Complete Disease
University of North Carolina Health Care System

Gene mutations tied to inherited diseases may cause only a portion of the expected disorder, according to scientists at the University of North Carolina at Chapel Hill. Implications are important for genetic screening and molecular diagnostics.

1-Aug-1999 12:00 AM EDT
Experimental Peptides Prevent and Halt Diabetes Progression
University of North Carolina Health Care System

Scientists at the University of North Carolina at Chapel Hill have used injections of protein fragments to prevent the development of type-I diabetes in a strain of mice that develop the disease.

Released: 30-Jul-1999 12:00 AM EDT
HIV Variant in U.S. and Europe Rare in Africa AIDS Cases
University of North Carolina Health Care System

A genetic variant of HIV that is tied to more rapid disease progression in the United States and Europe is rare in Africa, according to a new study headed by researchers at the University of North Carolina at Chapel Hill.

2-Sep-1999 12:00 AM EDT
Key Molecular Mechanism In Cancer and Rheumatoid Arthritis
University of North Carolina Health Care System

A study at the University of North Carolina at Chapel Hill has identified a novel molecular mechanism in cell proliferation. The study shows that a molecular switch has a pivotal role in the regulation of cell growth and death.

Released: 11-Sep-1999 12:00 AM EDT
AIDS Vaccine Researchers Awarded $12 Million Grant
University of North Carolina Health Care System

Scientists at the University of North Carolina at Chapel Hill have won a five-year federal grant totaling more than $12 million to develop a safe and effective vaccine against HIV, the virus that causes AIDS.

21-Sep-1999 12:00 AM EDT
Fruit Flies May Yield New Clues to Colon Cancer
University of North Carolina Health Care System

A study of fruit flies by scientists at the University of North Carolina at Chapel Hill may yield new clues to human colon cancer development.

28-Sep-1999 12:00 AM EDT
Antibody Solution May Prevent Adhesions after Surgery
University of North Carolina Health Care System

New research at the University of North Carolina at Chapel Hill suggests that adhesions following gynecologic and abdominal surgery can be prevented by applying a special antibody solution at the end of the operation.

Released: 22-Sep-1999 12:00 AM EDT
Follow-Up Phone Calls by Nurses Benefit Cancer Patients
University of North Carolina Health Care System

A program of telephone counseling and education by nurses helps cancer patients cope with the effects of their disease, according to studies at the University of North Carolina at Chapel Hill.

Released: 1-Oct-1999 12:00 AM EDT
New Biomarker for Cervical Cancer
University of North Carolina Health Care System

University of North Carolina at Chapel Hill researchers are studying the value of a new biomarker for improving cervical cancer screening. The clinical trial will examine cervical smears for telomerase, a protein released into cells when chromosomes shorten, stick together and become genetically unstable

Released: 13-Oct-1999 12:00 AM EDT
New Molecular Clues to Herpes Control
University of North Carolina Health Care System

A study at the University of North Carolina at Chapel Hill may have identified a new way to halt herpes simplex virus in its molecular tracks.

Released: 15-Oct-1999 12:00 AM EDT
Study of Drugs for Schizophrenia and Alzheimer's
University of North Carolina Health Care System

The University of North Carolina at Chapel Hill has won a $42.1 million federal contract to determine the effectiveness and safety of a new class of anti-psychotic drugs for people with schizophrenia and those with behaviors associated with Alzheimer's disease.

21-Oct-1999 12:00 AM EDT
Gene Mutation Tied to Deafness Found
University of North Carolina Health Care System

A new study at the University of North Carolina at Chapel Hill is the first to establish that a mutation in a gene associated with about 20 percent of all cases of hereditary deafness found in Whites is also found in Blacks.

2-Dec-1999 12:00 AM EST
Study Points to Chromosome Site of Autism Gene
University of North Carolina Health Care System

Evidence for a possible gene on chromosome 13 that causes autism is reported by researchers at the University of North Carolina at Chapel Hill and collaborating institutions.

14-Dec-1999 12:00 AM EST
Fats Prevent Nerve Sheath Abnormality
University of North Carolina Health Care System

A study led by scientists at the University of North Carolina at Chapel Hill points to a group of lipids (fats) that are crucial to proper formation of the myelin sheath surrounding nerve fibers. The findings add important new knowledge to the molecular biology of myelin and diseases of myelin loss.

Released: 4-Jan-2000 12:00 AM EST
Cooperation: Federally Funded Cancer Research
University of North Carolina Health Care System

Cooperation rather than competition may signal a new era of federally funded research for the nation's top scientists who develop and study mouse models of cancer.

Released: 14-Jan-2000 12:00 AM EST
National Prize in Neuroscience Endowed
University of North Carolina Health Care System

A distinguished scientist at the University of North Carolina has endowed a $10,000 national prize to be awarded annually for an outstanding scientific contribution to neuroscience.

Released: 20-Jan-2000 12:00 AM EST
Clarifying How Cells Grow
University of North Carolina Health Care System

A study, led by a University of North Carolina scientist, that focuses on the complex network of biochemical signals between proteins and enzymes sheds new light on the process of cell growth regulation (Nature, 1-20-00).


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