Despite the fact that heart disease is the leading cause of death for both men and women in the U.S., about three-quarters (74 percent) of Americans do not fear dying from it, according to a recent survey from Cleveland Clinic.
Epilepsy Laser Surgery Gives Teen Normal Life
Molecular composition of multiple tumors shows genomic differences.
Cleveland Clinic researchers have published findings in Nature Communications on a new stem cell pathway that allows a highly aggressive form of breast cancer - triple-negative breast cancer - to thrive.
When it comes to heart health emergencies, many Americans don’t have the knowledge to aid others, and often don’t know the proper way to help themselves, according to a new Cleveland Clinic survey. The survey found that slightly more than half of Americans (54 percent) say they know how to perform CPR; however, only one in six know that the recommended technique for bystander CPR consists of just chest compressions – and no breaths – on an adult. Even fewer, 11 percent, know the correct pace for performing these compressions (100 to 120 beats per minute).
ORLANDO: Cleveland Clinic researchers found that implementing a four-step protocol for the most severe type of heart attack not only improved outcomes and reduced mortality in both men and women, but eliminated or reduced the gender disparities in care and outcomes typically seen in this type of event. The research was presented at the American College of Cardiology’s 67th Annual Scientific Session and published in the Journal of the American College of Cardiology.
A team of researchers led by Cleveland Clinic has published first-of-its-kind findings in Science Translational Medicine on a new method of restoring natural movement sensation in patients with prosthetic arms. Led by Paul Marasco, Ph.D., the research team has successfully engineered a sense of complex hand movement in patients with upper limb amputations.
A landmark 2016 Cleveland Clinic study of widely used pain-relieving drugs showed that celecoxib (Celebrex) was associated with comparable cardiovascular safety and better gastrointestinal and kidney safety when compared with either naproxen (Naprosyn) and ibuprofen (Motrin). A new substudy, published today in the Journal of the American College of Cardiology, analyzed outcomes in PRECISION based on the presence or absence of aspirin use with specific NSAIDs (nonsteroidal anti-inflammatory drugs).
New Cleveland Clinic research shows for the first time that ibrutinib, an FDA-approved drug for lymphoma and leukemia, may also help treat the most common – and deadliest – type of brain tumor. The findings, published in Science Translational Medicine, offer hope that the drug may one day be used in patients with glioblastoma and improve poor survival rates.
At the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, researchers from Cleveland Clinic Cancer Center will present data from several new studies, including a prospective clinical trial examining non-small cell lung cancer cells’ response to immunotherapy; research on germline testing for melanoma; and interim results from a study testing a vaccine for glioblastoma.
June 13, 2018, Cleveland: The American Heart Association (AHA) has awarded Cleveland Clinic a $3.7 million grant for atrial fibrillation research. The four-year, competitive award will support three synergistic projects aimed at improving outcomes for patients with atrial fibrillation (AFib), a common heart rhythm abnormality. Cleveland Clinic was selected as one of six research institutions across the country to receive funding from AHA’s new AFib Strategically Focused Research Network (SFRN). Led by Mina Chung, M.D., a multidisciplinary team will focus on questions in AFib care, seek new therapies, and test lifestyle change programs that show promise in preventing worsening AFib.
A genetic anomaly in certain men with prostate cancer may impact their response to common drugs used to treat the disease, according to new research at Cleveland Clinic. The findings may provide important information for identifying which patients potentially fare better when treated with an alternate therapy.
Patients receiving leadless pacemakers experience overall fewer short-term and mid-term complications than those receiving traditional transvenous pacemakers, a Cleveland Clinic-led research study found. The study was published today in the journal Heart Rhythm.
Cleveland Clinic researchers have designed a potential new class of drugs that may reduce cardiovascular risk by targeting a specific microbial pathway in the gut. The research, published in the September issue of Nature Medicine, was led by Stanley Hazen, M.D., Ph.D.
The National Heart, Lung and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $4.7 million grant to Cleveland Clinic to study the prevention of life-threatening, cancer-associated blood clots. The new funding will support a Cleveland Clinic-led research consortium, which will focus on developing strategies to prevent cancer-associated thrombosis (blood clot formation), a potential side effect of cancer treatment.
Cleveland Clinic researchers have discovered a new subtype of multiple sclerosis (MS), providing a better understanding of the individualized nature of the disease. The findings, published in The Lancet Neurology, could potentially lead to more personalized diagnosis and treatments.
A promising drug slowed brain shrinkage in progressive multiple sclerosis (MS) by nearly half, according to new research led by Cleveland Clinic. Very limited therapies are currently available for this disabling form of the disease. The definitive results of the phase 2 trial – published in the New England Journal of Medicine – showed that the drug ibudilast decreased progression of brain atrophy in progressive MS patients by 48 percent versus placebo.
Munich, Germany: Researchers at Cleveland Clinic, University of Oxford and University of Erlangen have identified a novel imaging biomarker, which has been found to be able to predict all-cause and cardiac mortality by measuring inflammation of fatty tissue surrounding the coronary arteries.
Cleveland Clinic researchers have found that better cardiorespiratory fitness leads to longer life, with no limit to the benefit of aerobic fitness. Researchers retrospectively studied 122,007 patients who underwent exercise treadmill testing at Cleveland Clinic between Jan. 1, 1991, and Dec. 31, 2014, to measure all-cause mortality relating to the benefits of exercise and fitness. The paper was published today in the Journal of the American Medical Association Network Open.
A Cleveland Clinic genetic analysis has found that obesity itself, not just the adverse health effects associated with it, significantly increases the risk of Type 2 diabetes and coronary artery disease. The paper was published today in the Journal of the American Medical Association Network Open.
Cleveland Clinic medical oncologist and researcher, Alok Khorana, M.D., is the primary investigator on a study that concluded rivaroxaban for venous thromboembolism (VTE), a blood clot in the venous system, significantly reduced VTE and VTE-related death for outpatient, at-risk cancer patients while they were taking the oral blood thinner. During the on-treatment period, blood clots occurred less frequently (2.62 percent) in patients taking rivaroxaban, compared to and 6.41 percent of the placebo groups. However, during the full study period – which included 180-day observation after the medication was stopped ¬– the gap narrowed with blood clots occurring in 5.95 percent of patients in the rivaroxaban group, compared to 8.79 percent of the placebo groups.
CLEVELAND: In concurrent studies, Cleveland Clinic researchers have uncovered new mechanisms that demonstrate why and how regularly eating red meat can increase the risk of heart disease, and the role gut bacteria play in that process. The research, led by Stanley Hazen, M.D., Ph.D., builds upon previous work showing TMAO (trimethylamine N-oxide) – a gut bacteria byproduct formed during digestion – can lead to the development of cardiovascular disease, including heart attacks and strokes
A Cleveland Clinic survey finds that while most Americans (88 percent) understand that there is a connection between a healthy heart and a healthy weight, most aren’t doing enough – or anything – to combat their own weight issues. The survey found 74 percent are concerned about their weight and 65 percent are worried about getting heart disease due to extra pounds, yet less than half (43 percent) of Americans have tried to make dietary changes to lose weight and 40 percent of those who describe themselves as overweight or obese say they aren’t careful about which foods they eat.
A Cleveland Clinic-led research team has found that using an absorbable, antibiotic-eluting envelope when implanting cardiac devices like pacemakers and defibrillators can cut the rate of major infections by 40 percent. The research was presented today at the American College of Cardiology’s 68th Annual Scientific Session and simultaneously published in the New England Journal of Medicine. It will also be presented tomorrow at the European Heart Rhythm Association 2019 Congress.
New Cleveland Clinic-led research shows that artificial intelligence (AI) can use medical scans and health records to personalize the dose of radiation therapy used to treat cancer patients. Published today in The Lancet Digital Health, the research team developed an AI framework based on patient computerized tomography (CT) scans and electronic health records.
The National Institute on Aging of the National Institutes of Health (NIH) awarded a $4.23 million grant to establish the Cleveland Alzheimer’s Disease Research Center.
A large Cleveland Clinic study shows that weight-loss surgery performed in patients with type 2 diabetes and obesity is associated with a lower risk of death and major adverse cardiovascular events than usual medical care. These patients also lost more weight, had better diabetes control, and used fewer medications for treatment of their diabetes and cardiovascular disease than those undergoing usual medical care. The observational study looked at nearly 2,300 patients who underwent metabolic surgery and 11,500 matched patients with similar characteristics who received usual medical care.
Who are Americans more likely to take health advice from…their doctors or an Instagram influencer? Would U.S. adults rather talk or text? Socialize in real life or scroll through social media? Parade magazine and Cleveland Clinic joined forces for the second year in a row to poll Americans on their adoption of health, lifestyle, fitness and diet trends and takes a look at how social media has helped move health practices that once seemed extreme into the mainstream.
An international team of researchers led by Cleveland Clinic has developed new genetic-based epilepsy risk scores which may lay the foundation for a more personalized method of epilepsy diagnosis and treatment.
A dual-acting osteoporosis drug. Minimally invasive mitral valve surgery. New treatment for peanut allergies. These are some of the innovations that will enhance healing and change healthcare in the coming year, according to a distinguished panel of doctors and researchers.
In the first retrospective cohort study of the functional medicine model, Cleveland Clinic researchers found that functional medicine was associated with improvements in health-related quality of life. The study was published today in the Journal of the American Medical Association Network Open.
Cleveland Clinic has successfully performed the Midwest’s first purely laparoscopic living donor surgery for liver transplantation in an adult recipient. The advanced procedure is available at only a few hospitals worldwide, and Cleveland Clinic is the second U.S. academic medical center to offer this approach for living donor liver transplantation.
Patients struggling with type 2 diabetes and obesity are faced with the decision of whether to receive usual medical care or undergo weight-loss surgery. Now, a new risk calculator developed by Cleveland Clinic researchers can show these patients their risks of developing major health complications over the next 10 years depending on which course of treatment they choose. The research was presented today as one of the Top 10 studies at the ObesityWeek 2019 international conference in Las Vegas.
Cleveland Clinic researchers have found that using lungs from donors who are considered high risk for certain infectious diseases compared to standard risk donors results in similar one-year survival for recipients. In addition, researchers saw no difference in rejection or graft (donor lung) survival after one year in patients receiving lungs from increased-risk donors. The study was published recently in the Journal of Thoracic and Cardiovascular Surgery.
A new Cleveland Clinic study has uncovered a genetic anomaly associated with poor response to a common asthma treatment. The findings, published in Proceedings of the National Academy of Sciences, showed that asthmatic patients with the gene variant are less likely to respond to glucocorticoids and often develop severe asthma.
The U.S. Food and Drug Administration (FDA) has cleared patient-specific airway stents developed by Cleveland Clinic physician Tom Gildea, M.D.
A Cleveland Clinic survey finds that although heart disease is the leading cause of death in the United States, 68% of Americans do not know it’s the foremost killer of women. According to the survey, many Americans incorrectly thought breast cancer was the leading cause of death in women, with men especially likely to think this (44% vs. 33%). Among Millennials, 80% could not identify heart disease as the leading cause of death in women. Heart disease accounts for one in every four deaths in the U.S.
CLEVELAND: As Valentine’s Day approaches, a Cleveland Clinic survey finds that two-thirds of Americans (66%) in a committed relationship are concerned with their partner’s heart health. Moreover, 60% of Americans say they are more motivated to live a heart healthy lifestyle for their partners than for themselves. This is especially true for men – 67% compared to 52% for women. The survey was conducted as part of Cleveland Clinic Heart, Vascular and Thoracic Institute’s “Love your Heart” consumer education campaign in celebration of American Heart Month. It looked at how relationships affect heart health.
In a new Cleveland Clinic-led study published in JAMA Oncology, researchers show that a testosterone-related genetic variant – HSD3B1(1245C) – is associated with more aggressive disease and shorter survival in men with metastatic prostate cancer.
Cleveland Clinic researchers have identified a gut microbe generated byproduct – phenylacetylglutamine (PAG) – that is linked to development of cardiovascular disease, including heart attack, stroke and death. The study was published in Cell today.
Cleveland Clinic is establishing the Center for Global and Emerging Pathogens Research to broaden understanding of emerging pathogens – ranging from Zika virus to SARS-CoV-2 (which causes COVID-19) – and to expedite critically needed treatments and vaccines. The new center has been in the planning stages for 18 months and will span Cleveland Clinic’s Lerner Research Institute and the soon-to-open Cleveland Clinic Florida Research and Innovation Center (FRIC) in Port St. Lucie, Florida.
Cleveland Clinic researchers have developed the world’s first risk prediction model for healthcare providers to forecast an individual patient’s likelihood of testing positive for COVID-19 as well as their outcomes from the disease. According a new study published in CHEST, the risk prediction model (called a nomogram) shows the relevance of age, race, gender, socioeconomic status, vaccination history and current medications in COVID-19 risk.
At a time when the national conversation is focused on narrowing the gap of racial equity, two of Cleveland’s anchor institutions have been awarded grant funding that will help them turn words into action. Cleveland State University and Cleveland Clinic Lerner Research Institute received a five-year, $1.2 million T32 training award from the National Institutes of Health to recruit underrepresented minority Ph.D. students and students underrepresented in the science and technology workforce.
Cleveland Clinic researchers have found a significant increase in patients experiencing stress cardiomyopathy, also known as broken heart syndrome, during the COVID-19 pandemic.
Cleveland Clinic Florida has opened the Florida Research and Innovation Center in Port St. Lucie, Florida. Established in November 2019, the new center will advance innovative translational research, focused on immuno-oncology and infectious diseases, including COVID-19. The Florida Research and Innovation Center will be closely integrated with Cleveland Clinic’s new Center for Global and Emerging Pathogens Research established in April 2020.
A new Cleveland Clinic study has identified genetic factors that may influence susceptibility to COVID-19. Published today in BMC Medicine, the study findings could guide personalized treatment for COVID-19.
A Cleveland Clinic study shows that 5 to 10 percent of surgically induced weight loss is associated with improved life expectancy and cardiovascular health. In comparison, about 20 percent weight loss is necessary to observe similar benefits with a non-surgical treatment. The findings also show that metabolic surgery may contribute health benefits that are independent of weight loss. The study is published in the October issue of Annals of Surgery.
An up-and-coming gene therapy for blood disorders. A new class of medications for cystic fibrosis. Increased access to telemedicine. These are some of the innovations that will enhance healing and change healthcare in the coming year, according to a distinguished panel of clinicians and researchers from Cleveland Clinic. In conjunction with the 2020 Medical Innovation Summit, Cleveland Clinic announced the Top 10 Medical Innovations for 2021.
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