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Genome-Scale Study ID’s Hundreds of Drug Targets for Huntington’s

Scientists seeking to develop treatments for Huntington’s disease just got a roadmap that could dramatically speed their discovery process. Researchers at the Buck Institute have used RNAi technology to identify hundreds of “druggable”...
11/26/2012 1:30 PM EST

Rapamycin Effective in Mouse Model of Inherited Heart Disease and Rare Muscular Dystrophies

Rapamycin, an FDA-approved immunosuppressant drug under study in aging research labs, improved function and extended survival in mice suffering from a genetic mutation which leads to dilated cardiomyopathy (DCM) and rare muscular dystrophies in...
7/23/2012 8:00 AM EDT

Physical Activity Needed To Reap Benefits Of Dietary Restriction

Dietary restriction alone does not extend lifespan – at least in fruit flies. Flies, which share many genetic similarities with humans, need physical activity in order to live longer on a Spartan diet. If the same axiom holds true in humans,...
6/27/2012 8:00 AM EDT

Scientists Correct Huntington's Mutation in Induced Pluripotent Stem Cells

Researchers at the Buck Institute for Research on Aging have corrected the genetic mutation responsible for Huntington’s Disease (HD) using a human induced pluripotent stem cell (iPSC) that came from a patient suffering from the incurable,...
6/21/2012 8:00 AM EDT

Modifying Scar Tissue Can Potentially Improve Outcome in Chronic Stroke

New research from the Buck Institute, built on spinal cord injury research, shows that modifying the scar tissue that develops following a stroke is a promising avenue for future treatments. The need for therapeutics for chronic stroke is...
5/16/2012 2:00 PM EDT

“Healthspan Campaign” Focuses on Aging as Common Denominator of Chronic Disease

Alliance for Aging Research and the Buck Institute for Research on Aging urge support for research agenda aimed at extending healthy years of life. Nearly 70 prominent scientists endorse the plan and call for more federal funding.
4/13/2012 1:00 PM EDT

Need an Excuse to Book a Massage? Research Shows It Reduces Inflammation and Promotes Growth of New Mitochondria Following Strenuous Exercise

About 18 million individuals undergo massage therapy annually in the U.S. Despite several reports that long-term massage therapy reduces chronic pain and improves range of motion in clinical trials, the biological effects of massage on skeletal...
1/31/2012 12:00 PM EST

Buck Institute and Biotica Investigate Polyketides in Extension of Healthy Lifespan

The partnership, aimed at drug development, builds on observations that rapamycin extends healthy lifespan in several species.
9/14/2011 3:00 AM EDT

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