The Power to Tell Your Story

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Study shows for the first time that HIV can mutate to attack human protective cells, leading to the rapid progression of AIDS. (Nature Medicine, 1-01)

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A study at Columbus Children's Hospital demonstrates that physicians are on board with the recent trend in the increased use of Palm PilotsË™ and other handheld computer devices.

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In the first nationally representative study of its kind, researchers have found that mothers of low birth weight (LBW) children are at increased risk of depressive symptoms compared with mothers of normal birth weight (NBW) children.

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A new study on the use of CAM in HIV-infected children and adults reveals that CAM use is more prevalent among HIV-infected individuals than the general population.

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Researchers are working on ways to replace defective cystic fibrosis genes with normal genes. A new study reveals the strategies that have been developed to physically modify adeno-associated virus (AAV) vectors to permit efficient targeted gene delivery to airway epithelium.

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A Researcher at Columbus Children's Hospital, conducted a study that examined whether or not the diagnosis of ADHD predisposes children to increased risk of serious trauma and if the types of trauma encountered differ from non-ADHD children.

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A clinical study, presented at the 2001 American Thoracic Society Meeting revealed that infants with cystic fibrosis have mild obstruction. The study concluded that the baseline levels of obstruction appear to increase over the first three years of life.

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A study at Columbus Children's Hospital suggests that by decreasing entree sizes in the National School Lunch Program, in accordance with USDA regulations, children may be more likely to consume fruits and vegetables.

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Researchers at Children's Research Institute, located on the campus of Columbus Children's Hospital, designed the first-ever transgenic model (genetically modified) to show how the CREB protein (cyclic AMP response element binding protein) leads to the abnormal function of osteoclasts (cells that break down the bone), resulting in osteopetrosis.

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The trend of club drug use, especially Ecstasy, is rising sharply among children and teenagers because of the mind-altering effects it produces, according to Peter Rogers, M.D., M.P.H., of Columbus Children's Hospital, a presenter at the AAP National Conference and Exhibition in San Francisco.

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Ecstasy and other club drugs are quickly becoming the drug of choice for children and teenagers. The appeal of being able to "party all night" at raves, coupled with the drug's mind-altering effects leaves teens feeling "God-like" and craving the euphoric feeling.

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Principles of Ambulatory Pediatrics, a Web-based course created by physicians at Columbus Children's Hospital, will be awarded the 2002 Ray E. Hefler Award for Innovations in Pediatric Education by the Ambulatory Pediatrics Association on Monday, May 6, 2002 during the Pediatric Academic Societies meeting in Baltimore.

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In a recent study on the effects of second-hand smoke exposure among children ages two weeks to four years, researchers at Columbus Children's Hospital confirmed that even a child whose parents smoke outside the home in places like the garage is exposed to higher levels, as measured by the child's hair cotinine level.

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With new technology emerging to transport people, a leading consumer product safety expert at Columbus Children's Hospital urges caution and encourages lawmakers to consider the safety of pedestrians as they begin to pass legislation in some states allowing personal assistive mobility devices like the SegwayË™ Human Transporter on sidewalks.

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As the number of overweight children increases at an alarming rate, so does the need for more detailed studies regarding childhood obesity. Researchers at the Columbus Children's Research Institute recently released important study findings on the relationship between body mass index and hypertension among children.

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Breakthroughs in protease inhibitors (PIs), drug therapies designed to combat HIV, have enhanced the life expectancies of those infected with the virus. However, there is increasing evidence that PI therapies have significant adverse effects, including the promotion of coronary artery disease, possibly causing premature births in pregnant women.

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With the growing popularity of contact sports such as soccer among children and adolescents, mild head injuries or concussions are becoming more common. In fact, these injuries account for more than 80 percent of all childhood head injuries. However, doctors remain unsure of the long-term symptoms and outcomes.

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In a two-year study on the reduction of plate waste among third graders, researchers at Columbus Children's Hospital found children who dined in the classroom and interacted with the teacher ate 21 percent more of their school lunches as compared to children who dined in a cafeteria setting.

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With one in four children at risk for becoming overweight and one in 10 children already overweight, simple interventions that will have more kids standing in line at their school cafeterias and more pediatricians weighing in on the subject could be the answer, according to a childhood obesity expert from Columbus Children's Hospital.

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Researchers at Columbus Children's Research Institute, located on the campus of Columbus Children's Hospital in Ohio, recently completed a study that examined the relationship between genetic history and primary and secondary hypertension among children.

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Researchers at Columbus Children's Hospital and Samaritan Behavioral Health Inc. Young Children's Assessment and Treatment Services collaborated on a retrospective study involving a Disaster Child Care Center on Pier 94 in New York City, following the attacks on the World Trade Center.

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Researchers at Columbus Children's Research Institute on the campus of Columbus Children's Hospital, conducted a retrospective study of babywalker-related injuries from 1990-2001, revealing that automatic injury prevention strategies including product redesign and the introduction of new alternatives to walkers such as stationary activity centers, were associated with the eventual decline in injuries.

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Researchers at Columbus Children"šs Research Institute on the campus of Columbus Children's Hospital conducted a study examining the effect of non-alcoholic grape product in vascular endothelial dysfunction--an initiating event in coronary artery disease.

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Researchers at Columbus Children's Research Institute on the campus of Columbus Children's Hospital have discovered a large novel gene that, when mutated, causes named congenital hydrocephalus in mice.

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Researchers at Columbus Children's Hospital and its collaborators, Targeted Genetics Corporation and the International AIDS Vaccine Initiative, have demonstrated that utilizing a recombinant adeno-associated virus (rAAV)-based HIV vaccine resulted in robust and sustained antibody and T cell immune responses in non-human primates (monkeys).

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Researchers have evidence to suggest a relationship between pediatric migraines and the behavioral disorder, ODD "“ one of the most common of the disruptive behavioral disorders occurring in children.

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Researchers have developed novel methods to test the nerve-muscle function using micromanometric catheters (which record pressures generated by muscles in the bowel wall) to enable them to study the swallowing mechanisms in premature infants.

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In a recent study of children with inflammatory bowel disease, researchers have found that children with IBD have significantly more, and more frequent, eating behavior problems than healthy kids, and gender differences in weight and body image contribute to the behaviors.

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Researchers have identified a key component of protective immunity against the hepatitis C virus. The study found that successful control of hepatitis C infection required close cooperation between two types of white blood cells know as CD4+ "helper" and CD8+ "killer" T lymphocytes.

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Researchers have identified that the protein NSDHL, an enzyme involved in the synthesis of cholesterol, is found on the surface of lipid droplets. These findings suggest there may be another way cells regulate cholesterol production and, consequently, the amount of cholesterol in cells of the body.

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Children are naturally active, making tasks as simple as performing an X-ray problematic for pediatric radiology professionals. A unique device has been invented to replace the Pigg-o-stat®, an apparatus currently used throughout the US to restrain a child for radiological examination.

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Psychogenic non-epileptic seizures are common in children and adults and manifest like seizures with episodes in which the patient stiffens and jerks, but are not due to epilepsy. Most physicians consider them physiological in nature.

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Using new research and technology that shows bone marrow-derived mesenchymal stem cells will engraft at the site of a tumor and contribute to the growth of stromal fibroblasts, researchers have now found a way to efficiently genetically modify MSCs using a modified Adeno-Associated Virus vector system and deliver therapeutic genes to the site of a tumor.

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Children with chronic illnesses such as cancer and juvenile rheumatoid arthritis may endure ongoing symptoms from their diseases and side effects from treatment. As they approach young adulthood there was concern that children with chronic illnesses may be more at risk for long-term emotional difficulties.

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Researchers are studying NF2 to understand the underlying molecular mechanisms of tumor origin in an effort to determine if improved therapies for genetic manipulation or prevention of tumor growth may be possible. The Department of Defense recently awarded the team two research grants.

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With government figures estimating 30 percent of all U.S. children are overweight or at risk for being too heavy, there is a necessity for innovative new strategies to prevent these young people from becoming overweight or obese adults.

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More than 150,000 children in the United States are affected by rheumatic diseases. Because of a shortage of pediatric rheumatologists in the country, a majority of these children are not followed by pediatricians trained in the subspecialty, often leading to improper diagnosis and treatment.

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The American Academy of Pediatrics (AAP) Section on Adolescent Health presented its Adele Dellenbaugh Hofmann Award to Robert T. Brown, M.D., chief of the section of adolescent health at Columbus Children's Hospital and professor of clinical pediatrics.

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Mucopolysaccharidosis type VII is a lysosomal storage disorder characterized by a deficiency of the lysomal enzyme beta-glucuronidase. MPS VII leads to bone and joint abnormalities, enlargement of the visceral organs, cardiovascular disease and neurologic impairment.

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Researchers at the Center for Injury Research and Policy at Columbus Children's Research Institute on the campus of Columbus Children's Hospital recommend four key safety guidelines"”based on the results of several new studies"”to help keep children safer during winter sports.

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Though it has been widely recognized that minority adult populations are at an increased risk for trauma, until recently, little was known about trauma injury rates in minority children. Now, a study has determined that trauma has a far greater impact on African-American children than white children.

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An estimated 96 million people in the United States wear prescription eyeglasses. According to researchers, during a two-year period of time, more than 26,000 people were treated in U.S. emergency departments for eyeglasses-related injuries.

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Of the three most common bathtub-related injuries as outlined by the Consumer Product Safety Commission -- scalding, drowning and slips and falls -- a new study from the Columbus Children's Research Institute on the campus of Columbus Children's Hospital has shown that slips and falls are the most common, accounting for more than 80 percent of childhood bathtub injuries.

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Hoping to prevent ear infections for the more than 15 million children in the United States who suffer from them, a promising new vaccine candidate to prevent middle ear infections (otitis media) is being developed.

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Survivin, a molecule highly expressed in malignant tumor cells and even some chronic autoimmune disorders, is known for promoting tumor cell growth. Researchers have now developed a selective biological target that interferes with the expression of survivin, causing a reduction in tumor growth.

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Prior research has already proven the dangers of recreational full-sized trampoline use, but now a new study has proven that injury patterns associated with mini trampolines are similar to those found with full-sized trampolines.

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Haemophilus influenzae is a common cause of otitis media in children and is the number one reason young children are seen by pediatricians.

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Researchers at the Columbus Children's Research Institute have learned that they will collaborate with researchers at Emory University to investigate immunological strategies for curing chronic hepatitis C virus infections.

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Epilepsy, a brain disorder that occurs when the electrical signals in the brain are disrupted, affects about two million Americans. Most people with Epilepsy respond well to medication, but in approximately 25-30 percent of patients, medication doesn't work.

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Columbus Children's Hospital officials today announced a dramatic, wide ranging seven-year strategic effort including a $740 million master site plan that will change the face of health care for central Ohio children while becoming a model for what is possible in pediatric care and research nationally and internationally.