New Theory on Genesis of Osteoarthritis Comes with Successful Therapy in Mice

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Scientists have turned their view of osteoarthritis inside out. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, they now have evidence that the bone underneath the cartilage is also a key player and exacerbates the damage. Blocking the action of a critical bone regulation protein in mice halts progression of the disease.

– Johns Hopkins Medicine|5/19/2013 1:00 PM EDT

Computational Tool Translates Complex Data into Simplified 2-Dimensional Images

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Researchers at Columbia University and Stanford University have developed a computational method that enables scientists to visualize and interpret “high-dimensional” data produced by single-cell measurement technologies such as mass cytometry. The method, published today in the online edition of Nature Biotechnology, has particular relevance to cancer research and therapeutics.

– Columbia University Medical Center|5/19/2013 1:00 PM EDT

In Early Earth, Iron Helped RNA Catalyze Electron Transfer

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A new study shows how complex biochemical transformations may have been possible under conditions that existed when life began on the early Earth. The study shows that RNA is capable of catalyzing electron transfer under conditions similar to those of the early Earth.

– Georgia Institute of Technology, Research Communications|5/19/2013 1:00 PM EDT

Ketamine Shows Significant Therapeutic Benefit in People with Treatment-Resistant Depression

Drug associated with rapid antidepressant effect in largest clinical trial to-date.

– Mount Sinai Medical Center|5/18/2013 12:00 PM EDT

Consuming Coffee Linked to Lower Risk of Detrimental Liver Disease

Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, Mayo Clinic research shows. The findings were being presented at the Digestive Disease Week 2013 conference in Orlando, Fla.

– Mayo Clinic|5/18/2013 11:00 AM EDT

For Combat Veterans Suffering From Post-Traumatic Stress Disorder, “Fear Circuitry” in the Brain Never Rests

Chronic trauma can inflict lasting damage to brain regions associated with fear and anxiety. Previous imaging studies of people with post-traumatic stress disorder, or PTSD, have shown that these brain regions can over-or under-react in response to stressful tasks.

– NYU Langone Medical Center|5/18/2013 1:00 AM EDT

Cracking the Ice Code

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UWM geologist John Isbell reads rock, looking for the natural rules that govern the Earth’s climate in the absence of human activity. His work is challenging many assumptions about the ways drastic climate change unfolds – and what to expect next.

– University of Wisconsin-Milwaukee|5/17/2013 7:00 PM EDT

New Research Suggests Possible Direction for Treatment of Autism

In the first successful experiment with humans using a treatment known as sensory-motor or environmental enrichment, researchers documented marked improvement in young autistic boys when compared to boys treated with traditional behavioral therapies, according to research published by the American Psychological Association.

– American Psychological Association (APA)|5/17/2013 5:30 PM EDT
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