Newswise — CLEVELAND – Harrington Discovery Institute Center for Brain Health Medicines at University Hospitals and the Alzheimer's Drug Discovery Foundation (ADDF) announce a joint request for proposal for the 2023 ADDF-Harrington Scholar Award. The ADDF-Harrington Scholar Award is designed to accelerate the translation of innovative research that could treat, prevent, slow, or reverse Alzheimer's disease or related dementias.
The Request for Proposals (RFP) is open to academic investigators at accredited medical centers, research institutions, and universities in the United States, Canada, and the United Kingdom. Researchers working on drug development programs that are relevant to, but not presently focused on, the Alzheimer’s field are strongly encouraged to apply. This award provides a combination of financial support and expert drug development guidance to provide optimal support for moving research beyond the bench to the bedside.
The 2023 ADDF-Harrington Scholar RFP places high priority on targets related to emerging therapeutic areas for dementia and is particularly seeking projects related to:
- Glymphatic clearance, including aquaporin 4, clearance of interstitial solutes, sleep dynamics, and perivascular space.
- Neurovascular health, including blood brain barrier function and integrity, cerebral hypoperfusion, nutrient supply to the brain, and endothelial interaction with pericytes and astrocytes.
Other novel targets are encouraged. These include, but are not limited to, the following:
- Epigenetics
- Proteostasis
- Neuroprotection
- Synaptic activity and neurotransmitters
- Inflammation
- Mitochondrial health
- Antioxidant defense
- Metabolic function and brain energy
- Brain insulin resistance)
- ApoE
- Postnatal neurogenesis
- Other aging targets (e.g. senescent cells)
Award recipients will receive financial support up to $600,000 over two years, dedicated drug development and project management support, and an opportunity to qualify for investment funds. Proposals should offer creative science or novel approaches to treat, prevent, or slow Alzheimer's disease or related dementias.
Letters of Intent (LOI) must be submitted online here and will be accepted through May 29, 2023 5:00 pm EDT. We encourage an interactive application process in efforts to solicit the best applications. Scientific inquiries can be directed to either:
Andrew A. Pieper, MD, PhD
Director, Center for Brain Health Medicines
Harrington Discovery Institute
[email protected]
or
Meriel Owen, PhD
Associate Director, Search and Evaluation
Alzheimer’s Drug Discovery Foundation
[email protected]
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About the ADDF-Harrington Scholar Award
The ADDF and Harrington Discovery Institute formed a partnership in 2013 to leverage the organizations’ combined expertise and resources to advance highly-promising Alzheimer’s disease discovery projects conducted in academic and medical institutions. The ADDF-Harrington Scholar Award was established as a result of this partnership and is helping scientists chart a path from the bench to clinical studies to improve the lives of people living with, and at risk of, Alzheimer’s. To learn more, visit: HarringtonDiscovery.org/ADDF.
About the Alzheimer’s Drug Discovery Foundation (ADDF)
Founded in 1998 by Leonard A. and Ronald S. Lauder, the Alzheimer's Drug Discovery Foundation is dedicated to rapidly accelerating the discovery of drugs to prevent, treat and cure Alzheimer's disease. The ADDF is the only public charity solely focused on funding the development of drugs for Alzheimer's, employing a venture philanthropy model to support research in academia and the biotech industry. The ADDF’s leadership and contributions to the field have played a pivotal role in bringing the first Alzheimer’s PET scan (Amyvid™) and blood test (PrecivityAD™) to market, as well as fueling the current robust and diverse drug pipeline. Through the generosity of its donors, the ADDF has awarded more than $250 million to fund over 720 Alzheimer's drug discovery programs, biomarker programs and clinical trials in 19 countries. To learn more, please visit: http://www.alzdiscovery.org/.
About the Harrington Discovery Institute
Harrington Discovery Institute at University Hospitals in Cleveland, OH—part of The Harrington Project for Discovery & Development—aims to advance medicine and society by enabling our nation’s most inventive scientists to turn their discoveries into medicines that improve human health. Harrington Discovery Institute was created in 2012 with a $50 million founding gift from the Harrington family and instantiates the commitment they share with University Hospitals to a Vision for a ‘Better World’. For more information, visit: HarringtonDiscovery.org.
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