Feature Channels: Alzheimer's and Dementia

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Researchers at Boston University, USA report that the flow of cerebrospinal fluid in the brain is linked to waking brain activity.

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Once adults reach age 65, the threshold age for the onset of Alzheimer’s disease, the extent of their genetic risk may outweigh age as a predictor of whether they will develop the fatal brain disorder, a new study suggests.

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A study from the UC Davis School of Medicine has identified a gene-enzyme interaction that appears to play a key role in how the brain forms memories. The findings provide insights into how PDE inhibitor medications may help diseases like Alzheimer’s. The research was published in Science Signaling.

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From septic shock to sticker shock. Keep up with this ever-growing, changing sector. Below are some of the latest stories on healthcare on Newswise.

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Alzheimer's disease affects people of all ethnic groups. Armed with $41 million in new federal funding, Mayo Clinic researchers and colleagues from 13 other institutions around the country are pursuing three multiethnic projects to identify targets for treatment.

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For the first time, researchers have developed a form of the omega-3 fatty acid docosahexaenoic acid (DHA) that is capable of crossing into the eye’s retina to ward off visual declines related to Alzheimer’s disease, diabetes and other disorders.

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A team at UT Southwestern has developed a computational approach to uncover mechanisms of protein misfolding linked to neurodegenerative diseases. The study, published in Nature Communications, offers key insights that could help identify new treatments for patients.

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People who have low bone density may have an increased risk of developing dementia compared to people who have higher bone density, according to a study published in the March 22, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that low bone density causes dementia. It only shows an association.

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Depression in Alzheimer's has different risk factors than depression in older adults without the disease, finds a major new study in the Journal of Alzheimer’s Disease. The University of Bristol-led research looked at over 2,000 people with the disease to explain why current anti-depressants are ineffective for people living with depression in Alzheimer’s.

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Researchers from the Uniformed Services University (USU) have shed light on a fatal neurodegenerative disease that has long afflicted the native Chamorro people living on Guam – a unique and mystifying disorder that has baffled scientists for decades.

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University of Delaware associate professor Matthew Cohen offers 11 signs and symptoms that might suggest a health condition, such as dementia, that affects thinking. Cohen is associate director of the Delaware Center for Cognitive Aging Research.

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UC San Diego researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.

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It started with a hunt for lab space and ended with a collaboration born out of what the researchers call a “cosmic coincidence.”

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The risk of death rises among older adults with Alzheimer's or other dementias in the months following exposure to a hurricane, a new University of Michigan study shows.

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Keck Medicine of USC has launched a clinical trial to study the effect of a novel hormone replacement therapy on postmenopausal cardiovascular disease and cognitive decline.

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People who eat diets rich in green leafy vegetables as well as other vegetables, fruits, whole grains, olive oil, beans, nuts and fish may have fewer amyloid plaques and tau tangles in their brain—signs of Alzheimer’s disease—than people who do not consume such diets, according to a study published in the March 8, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Scientific evidence shows how the cognitive decline in Alzheimer’s disease (AD) is caused by the buildup of amyloid beta proteins, which promote synaptic malfunction.

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In Alzheimer’s and related neurodegenerative diseases, the brain protein tau is closely linked to brain damage and cognitive decline. A new study from researchers at Washington University School of Medicine in St. Louis indicates that T cells play a key role in tau-related neurodegeneration, a finding that suggests new treatment strategies for Alzheimer’s and related diseases.

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Cedars-Sinai investigators have produced the most extensive analysis to date of changes in the retina—a layer of tissue at the back of the eye where visual information originates—and how those retinal changes correspond to brain and cognitive changes in Alzheimer’s disease patients.

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Researchers at Chalmers University of Technology in Sweden have developed a method for predicting fall accidents and cognitive illnesses such as Alzheimer’s disease by reading a person’s walking pattern with the aid of a radar sensor.

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Three faculty from the Perelman School of Medicine at the University of Pennsylvania have been named 2023 Hastings Center Fellows. Emily Largent, PhD, RN, Peter Reese, MD, PhD, and Dominic Sisti, PhD, are among 12 new Fellows joining an elected group of over 200.

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Cleveland: A self-administered screening tool, developed by Cleveland Clinic researchers, can effectively and efficiently assess cognition issues in older adults.

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A new technique that targets and breaks apart certain proteins — rather than just interfering with them — may offer a pathway toward treatment of Alzheimer's disease. Researchers reporting in ACS Central Science have designed a compound that breaks down a protein closely associated with the disease.

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According to new research from Wake Forest University School of Medicine, people who experience discrimination during their lifetimes have an increased risk of dementia. The study appears in the February issue of Alzheimer’s & Dementia, the journal of the Alzheimer’s Association.

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New research that followed female participants for two decades has found that seven healthy habits and lifestyle factors may play a role in lowering the risk of dementia. The preliminary study released today, February 27, 2023, will be presented at the American Academy of Neurology’s 75th Annual Meeting being held in person in Boston and live online from April 22-27, 2023.

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Black people are receiving medications for dementia less often than white people, according to a preliminary study released today, February 26, 2023, that will be presented at the American Academy of Neurology’s 75th Annual Meeting being held in person in Boston and live online from April 22-27, 2023.

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Northwestern Medicine scientists have discovered two ways to preserve diseased upper motor neurons that would normally be destroyed in ALS, based on a study in mice. Upper motor neurons initiate movement, and they degenerate in ALS.

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Less than one year after stepping away from acting due to a diagnosis of aphasia, Bruce Willis has been diagnosed with frontotemporal dementia. Here, a neurologist answers key questions about FTD.

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Patients with higher levels of a key molecule involved in the formation of new blood vessels were more likely to have cognitive impairment or evidence of brain injury, a consortium of academic medical centers reported.

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People who regularly use laxatives, a common treatment for constipation, may have more than a 50% increased risk of developing dementia than people who do not use laxatives, according to a study published in the February 22, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. Researchers also found people who used only osmotic laxatives, a type of laxative that attracts water to the colon to soften stool, had an even greater risk. Other types of laxatives are bulk-forming, stool-softening, and stimulating. The study does not prove that laxatives cause dementia. It only shows an association.

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Living closer to outdoor spaces and water sources may reduce older people’s risk of having serious psychological distress, which can lead to mild cognitive impairment and dementia, according to a preliminary study released today, February 22, 2023, that will be presented at the American Academy of Neurology’s 75th Annual Meeting being held in person in Boston and live online from April 22-27, 2023.

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The New England Journal of Medicine (NEJM) Catalyst recently published an article by Ochsner Health neuropsychologist and a team of researchers discussing the critical need for value-based care models for patients with dementia.

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Of all the known genetic risk factors for late-onset Alzheimer’s disease, the strongest is a gene for the protein called ApoE4.

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Leqembi, Recientemente Aprobado por la FDA, Muestra un Beneficio Potencial para los Pacientes con Enfermedad en Etapa Temprana, pero la Disponibilidad Llevará tiempo, Comenta Experta de Cedars-Sinai

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Um grupo de trabalho de especialistas reformulou o que é considerado clinicamente significativo para desacelerar a progressão da doença de Alzheimer durante ensaios clínicos, incluindo o impacto do tratamento ao longo do tempo e a necessidade de terapias combinadas.

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Un grupo de trabajo de expertos ha replanteado qué es importante a nivel clínico para retrasar el avance de la enfermedad de Alzheimer durante los ensayos clínicos, incluidas la repercusión del tratamiento a lo largo del tiempo y la necesidad de terapias combinadas.