Feature Channels: Alzheimer's and Dementia

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3-Apr-2024 9:05 AM EDT
Immunotherapy for Alzheimer’s disease shows promise in mouse study
Washington University in St. Louis

Scientists at Washington University School of Medicine in St. Louis have shown that treating mice with an antibody that blocks the interaction between APOE proteins (white) sprinkled within Alzheimer’s disease plaques and the LILRB4 receptor on microglia cells (purple) activates them to clean up damaging plaques (blue) in the brain.

   
Newswise: High-resolution images reveal similarities in protein structures between Alzheimer’s disease and Down syndrome
Released: 29-Mar-2024 12:05 PM EDT
High-resolution images reveal similarities in protein structures between Alzheimer’s disease and Down syndrome
Indiana University

A new study recently published in Nature Structural and Molecular Biology uses leading-edge cryo-electron microscopy imaging technology to determine whether differences exist between the protein structures in those with Alzheimer’s disease and those with both Alzheimer’s disease and Down syndrome.

Newswise: Gene Therapy Offers Hope for Giant Axonal Neuropathy Patients
Released: 27-Mar-2024 12:05 PM EDT
Gene Therapy Offers Hope for Giant Axonal Neuropathy Patients
UT Southwestern Medical Center

A gene therapy developed by researchers at UT Southwestern Medical Center for a rare disease called giant axonal neuropathy (GAN) was well tolerated in pediatric patients and showed clear benefits, a new study reports. Findings from the phase one clinical trial, published in the New England Journal of Medicine, could offer hope for patients with this rare condition and a host of other neurological diseases.

Newswise: Making Long-Term Memories Requires Nerve-Cell Damage
26-Mar-2024 8:05 AM EDT
Making Long-Term Memories Requires Nerve-Cell Damage
Albert Einstein College of Medicine

Just as you can’t make an omelet without breaking eggs, scientists at Albert Einstein College of Medicine have found that you can’t make long-term memories without DNA damage and brain inflammation. Their surprising findings were published online today in the journal Nature.

18-Mar-2024 9:00 AM EDT
Study links long-term consumption of reused deep-fried oil with increased neurodegeneration
American Society for Biochemistry and Molecular Biology (ASBMB)

A new study found higher levels of neurodegeneration in rats that consumed reused deep fried cooking oils and their offspring compared to rats on a normal diet.

Released: 25-Mar-2024 4:05 PM EDT
Human brains are getting larger. That may be good news for dementia risk
UC Davis Health

A new study published in JAMA Neurology found human brains are getting bigger. The increased size may lead to a brain reserve, potentially reducing the risk of dementia.

18-Mar-2024 9:00 AM EDT
How might diabetes lead to Alzheimer’s? Study suggests the liver is key
American Society for Biochemistry and Molecular Biology (ASBMB)

New research conducted in mice offers insights into what’s going on at the molecular level that could cause people with diabetes to develop Alzheimer’s disease.

Newswise: Immune Cells Identified as Key Players in Brain Health
Released: 21-Mar-2024 9:00 AM EDT
Immune Cells Identified as Key Players in Brain Health
Mount Sinai Health System

Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer’s and other diseases.

Newswise: New research at Case Western Reserve University aims to address racial disparities in cognitive decline
20-Mar-2024 12:05 PM EDT
New research at Case Western Reserve University aims to address racial disparities in cognitive decline
Case Western Reserve University

According to new research at Case Western Reserve University, connecting with friends is key to limiting social isolation—something researchers believe could also reduce Alzheimer’s, dementia

Newswise: Unlocking Alzheimer's Mysteries: A Revolutionary Leap in Brain Network Analysis
Released: 19-Mar-2024 7:05 AM EDT
Unlocking Alzheimer's Mysteries: A Revolutionary Leap in Brain Network Analysis
Chinese Academy of Sciences

Dementia stands as one of the most significant global health challenges of the 21st century, with over 50 million individuals worldwide currently affected, a number projected to triple by 2050, reaching 152 million, due to global population aging.

Released: 19-Mar-2024 3:05 AM EDT
Nanoparticles activated by ultra-low-energy X-rays effectively halt the aggregation and toxicity of amyloid beta in preclinical models
Bar-Ilan University

A collaborative effort between Israeli and Italian researchers has led to the development of a new treatment strategy targeting the early-stage aggregation of A-beta before the formation of toxic oligomers.

Released: 15-Mar-2024 10:05 AM EDT
Study shows that aging adults with mild cognitive impairment may have trouble learning new walking patterns
University of Delaware

University of Delaware researchers are studying how the brain controls movement and how motor skills are learned in health and disease.

Newswise: New study reveals breakthrough in understanding brain stimulation therapies
Released: 15-Mar-2024 7:00 AM EDT
New study reveals breakthrough in understanding brain stimulation therapies
University of Minnesota College of Science and Engineering

For the first time, researchers at the University of Minnesota Twin Cities showed that non-invasive brain stimulation can change a specific brain mechanism that is directly related to human behavior.

Newswise: Blast-related concussions linked to higher Alzheimer’s risk
Released: 13-Mar-2024 6:05 PM EDT
Blast-related concussions linked to higher Alzheimer’s risk
University of Washington School of Medicine and UW Medicine

“While our research does not prove that veterans who experienced these injuries will develop Alzheimer’s disease, it raises the possibility that they may be on a pathway leading to dementia,” said Dr. Ge Li, the paper's first author and an associate professor of psychiatry and behavioral sciences at UW Medicine.

Newswise: “Anti-Choke Mug” – Chula Innovation for Neuro Patients to Drink Water Confidently
Released: 13-Mar-2024 8:55 AM EDT
“Anti-Choke Mug” – Chula Innovation for Neuro Patients to Drink Water Confidently
Chulalongkorn University

Chula Medicine has designed an anti-choke mug with calculated angle, amount, and time of water flow from the mug to the patient’s lips hoping to reduce choking that may lead to lung infection, bring peace of mind to caregivers, and make it safer for patients who will have a better quality of life.

8-Mar-2024 8:05 AM EST
Do Veterans Who Experience Concussions Have an Increased Risk of Alzheimer’s?
American Academy of Neurology (AAN)

Middle-age veterans who experienced concussions due to blasts from explosive devices may have biomarkers in their spinal fluid similar to people who develop Alzheimer’s disease, according to a new study published in the March 13, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Newswise:Video Embedded curved-walking-and-a-depth-camera-new-tool-detects-early-cognitive-decline
VIDEO
8-Mar-2024 1:30 PM EST
‘Curved’ Walking and a Depth Camera: New Tool Detects Early Cognitive Decline
Florida Atlantic University

Gait impairments often are prevalent in the early stages of cognitive decline. Researchers quantitatively compared straight walking and curved walking – a more natural yet complex activity – in healthy older adults and adults with mild cognitive impairment (MCI). A depth camera detected and tracked 25 joints of body movement and signals were processed to extract 50 gait markers. Intriguingly, curved walking illuminated notable disparities between the study groups.

Released: 11-Mar-2024 11:00 AM EDT
Wrist Device That Monitors Activity Could Help Provide Early Warning of Alzheimer’s
Johns Hopkins Bloomberg School of Public Health

Monitoring daily activity patterns using a wrist-worn device may detect early warning signs of Alzheimer’s disease, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health.



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