A new study finds that a simple, self-administered test developed by researchers at The Ohio State University Wexner Medical Center, College of Medicine and College of Public Health can identify the early, subtle signs of dementia sooner than the most commonly used office-based standard cognitive test.
In a discovery that could one day benefit people suffering from traumatic brain injury, Alzheimer’s disease, and schizophrenia, UT Southwestern researchers have identified the characteristics of more than 100 memory-sensitive neurons that play a central role in how memories are recalled in the brain.
In this study of 3,000 adults with cataracts, the risk of developing dementia was lower in participants who underwent cataract removal compared with those who didn’t.
A new Cleveland Clinic-led study has identified sildenafil – an FDA-approved therapy for erectile dysfunction (Viagra) and pulmonary hypertension (Revatio) – as a promising drug candidate to help prevent and treat Alzheimer’s disease.
Having an elevated resting heart rate in old age may be an independent risk factor of dementia, according to a study at Karolinska Institutet in Sweden published in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
Perturbing the gut microbiome with antibiotics during early life leads to a reduction in amyloid plaques in male mice in adulthood — and microglia are a critical component of the effect.
Difficulty in understanding speech, especially in background noise, is a common concern for older adults. Using a word identification task in quiet and noisy conditions, researchers examined the impact of mild dementia on speech perception. They tested individuals with and without mild dementia and found that word identification scores of those without dementia were significantly better in all conditions, meaning people with mild dementia symptoms recalled fewer words in both quiet and noisy situations.
USC study published in the Journal of Experimental Medicine shows that experimental drug protects against injury caused by tiny blood clots in the brain’s white matter, which can accumulate over time and lead to cognitive decline
A clutter-free environment may not help people with dementia carry out daily tasks – according to a new study from the University of East Anglia.
Isaacson will lead an academic clinical research program aimed at reducing the risk of Alzheimer’s disease (AD), Parkinson’s disease, and Lewy body dementia in individuals with a family history of these diseases who do not yet have any cognitive decline or other clinical complaints.
Good news for those of us who can’t face the day without their morning flat white: a long-term study has revealed drinking higher amounts of coffee may make you less likely to develop Alzheimer’s disease.
The Institute for Molecular Medicine will advance the manufacturing of Duvax for the first clinical trials of a dual vaccine for Alzheimer's disease to begin in 2023
Among the many devastating impacts of Alzheimer’s disease and other types of dementia is the risk that patients will wander and become lost. Indeed, according to the Alzheimer’s Association, six in 10 people with the disease will wander at least once over the course of their illness — and many do so repeatedly.
Using a new model of brain activity, Indiana University computational neuroscientists are exploring striking bursts of activity in the human brain that may have potential to serve as biomarkers for brain disease and conditions such as depression, schizophrenia, dementia, and ADHD.
Intake of 4-6 total cups daily was associated with lowest risks.
In recent studies, researchers find 1) Few people get a timely diagnosis of dementia, especially if they are of color with no college degree. 2) No dementia risk in members of military over 65. 3) Link to hearing and dementia.
Over the last decade, the publications of Jerold Chun and Randal J. Kaufman are among the top 1% in the world for number of citations
New research from Sanford Burnham Prebys has revealed features of the aging Down syndrome brain that could help explain why people with Down syndrome almost inevitably get Alzheimer's later in life.
Researchers at the University of Kentucky’s Sanders-Brown Center on Aging recently received a five-year grant renewal of their MarkVCID program from the National Institutes of Health (NIH). The award total is more than $6 million.
As people age, inflammation within their immune system increases, damaging cells. A new study shows that people who consumed an anti-inflammatory diet that includes more fruits, vegetables, beans, and tea or coffee, had a lower risk of developing dementia later in life. The research is published in the November 10, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.
New research provides a better understanding of the mechanisms behind the development of amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, and points to a potential treatment strategy.
Researchers at the University of Toronto (U of T) and Unity Health Toronto have demonstrated that repeated listening to personally meaningful music induces beneficial brain plasticity in patients with mild cognitive impairment or early Alzheimer’s disease.
Despite the belief that early diagnosis of Alzheimer’s disease and other dementias is crucial, a new Rutgers study found that the diagnosis may unintentionally impact social relationships and activity.
A new study found that people with higher cumulative estrogen exposure over their lifetime had greater brain volumes and fewer indicators of brain disease on their brain scans in midlife . The research is published in the November 3, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A new study suggests that healthy older people who eat two or more servings of fish a week, including salmon, tuna and sardines, may have a lower risk later in life of developing vascular brain disease, a group of conditions that affect blood flow and blood vessels in the brain. The research is published in the November 3, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study found that eating a diet rich in fish had the greatest protective effect on people younger than 75 years old.
Researchers leading the Tau Nex Gen Trial — a worldwide clinical trial aimed at finding treatments for Alzheimer’s disease — are modifying an arm of the trial to target two brain proteins: amyloid and tau. A part of DIAN-TU, the trial originally was announced with a focus on drugs that target tau.
A study by UT Southwestern researchers finds that changing the biochemistry of parts of brain cells abolished the formation of amyloid beta plaques in a mouse model of Alzheimer’s disease. The finding, published in eLife, might eventually lead to treatments that prevent the memory-robbing condition in humans.
Researchers tested the effectiveness of affordable, interactive robotic pet cats to improve mood, behavior and cognition in older adults with mild to moderate dementia.
A new study led by researchers at UCLA Health has found that women over the age of 50 who had breastfed their babies performed better on cognitive tests compared to women who had never breastfed. The findings, published in Evolution, Medicine and Public Health, suggest that breastfeeding may have a positive impact on postmenopausal women’s cognitive performance and could have long-term benefits for the mother’s brain.
Older adults who sleep short or long experienced greater cognitive decline than those who sleep a moderate amount, even when the effects of early Alzheimer’s disease were taken into account, according to a study by researchers at Washington University School of Medicine in St. Louis.
Infrared light therapy might have the potential to help people living with dementia, according to researchers.
University of Virginia School of Medicine researchers have revealed a vital but previously unknown role for immune cells that protect the brain from disease and injury: The cells, known as microglia, also help regulate blood flow and maintain the brain’s critical blood vessels.
Research conducted by the Ph.D student Mohamed Raâfet Ben Khedher and the postdoctoral researcher Mohamed Haddad of the Institut national de la recherche scientifique (INRS) has shown that an oxidation-antioxidant imbalance in the blood is an early indicator of Alzheimer's disease, rather than a consequence.
New research from the Florida State University College of Medicine found that changes in the brain associated with Alzheimer’s disease are often visible early on in individuals with personality traits associated with the condition.
An anti-viral gene that impacts the risk of both Alzheimer’s disease and severe Covid-19 has been identified by a UCL-led research team.
A recently released paper from the Department of Physiology and Sanders-Brown Center on Aging at the University of Kentucky College of Medicine suggests that your genetics can influence your response to Alzheimer’s disease pathology.
Researchers with the John P. Hussman Institute for Human Genomics (HIHG) at the University of Miami Miller School of Medicine, will serve as principal investigators for a major five-year initiative with Vanderbilt University Medical Center and the University of Southern California, to pool and standardize research data gathered from individuals in multiple studies of Alzheimer’s disease and related dementias (ADRD).
Cells that normally nourish healthy brain cells called neurons release toxic fatty acids after neurons are damaged, a new study in rodents shows. This phenomenon is likely the driving factor behind most, if not all, diseases that affect brain function, as well as the natural breakdown of brain cells seen in aging, researchers say.
Some devastating diseases, like Alzheimer's and autoimmune conditions, are hard to diagnose correctly because doctors don’t yet know what genes or molecules to look for. But a new technique inspired by the Star Trek tricorder can spot disease without the clues, using infrared light and machine learning.
Poor sleep quality is associated with Alzheimer’s disease (AD). This award will support the development of non-invasive methods to monitor sleep quality, which will provide a key advance to assess if new candidate drugs truly restore sleep quality in the brain. These indicators of sleep brain quality could speed up the development of sleep treatments to improve the quality of life and the progression of AD. Because sleep disruption also occurs in other dementias, the indicators developed could positively impact additional diseases.
Lu Sun, Ph.D., Assistant Professor of Molecular Biology at UT Southwestern, has been awarded $1.5 million from the National Institutes of Health (NIH) to study interactions between neurons and glial cells in the brain, which could provide insight into the causes of neurological disorders.
Lorena Saelices Gomez, Ph.D., Assistant Professor of Biophysics and in the Center for Alzheimer’s and Neurodegenerative Diseases at UT Southwestern, has been awarded $1.5 million from the National Institutes of Health (NIH) to determine the structure of amyloids, key proteins that have been tied to diseases including Alzheimer’s and ATTR amyloidosis.
Individuals who are diagnosed with high blood pressure at ages 35-44 had smaller brain size and were more likely to develop dementia compared to people who had normal blood pressure, according to new research published today in Hypertension, an American Heart Association journal.
The results of three new studies indicate there could be new treatments for Alzheimer’s and stroke.
Vanderbilt University Medical Center has been awarded a five-year, $31.7 million grant by the National Institute on Aging, part of the National Institutes of Health (NIH), to harmonize research data gathered on human subjects in scores of disparate studies of Alzheimer’s disease and related dementias (ADRD).
Worms lose their wiggle when they get Alzheimer’s disease, but UD researchers found that worms fed a diet of E. coli with higher levels of vitamin B12 were given a layer of protection from the dreaded degenerative brain disease
In a study published in the September issue of the journal Communications Biology, UNLV neuroscientists show that chronic hyperglycemia impairs working memory performance and alters fundamental aspects of working memory networks.
An inexpensive anti-seizure medication markedly improves learning and memory and other cognitive functions in Alzheimer’s patients who have epileptic activity in their brains, according to a study published in the Sept. 27th issue of JAMA Neurology.
A common treatment for Alzheimer’s disease may help people with the earliest stages of the disease maintain mitochondrial function in their muscles in addition to slowing cognitive decline. The first-of-its-kind study is published ahead of print in Function.
Empa researcher Peter Nirmalraj wants to image proteins with unprecedented precision – and thus gain insights into the molecular pathogenesis of Alzheimer's. This should pave the way for an earlier diagnosis of the dementia disorder via a simple blood test. Together with neurologists from the Kantonsspital St.Gallen, a successful pilot study has now been completed.
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