Feature Channels: Diabetes

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A Mayo Clinic study shows heart conditions such as coronary artery disease and cardiovascular risk factors such as diabetes and high cholesterol have stronger association with decline in memory and thinking skills during midlife for women than men. That's despite a higher prevalence of those conditions in men. The research is published in Neurology, the medical journal of the American Academy of Neurology.

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Minnesota has the lowest age-adjusted heart disease mortality in the U.S.; yet, African American adults 35 to 63 have nearly double the rate of death from cardiovascular disease, compared to their white counterparts.

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Diabetic neuropathy refers to nerve damage due to diabetes and it may lead to pain and numbness, most often in the hands and feet. To help neurologists and other doctors determine the best treatment for people with diabetic neuropathy, the American Academy of Neurology (AAN) has issued a guideline on oral and topical treatments for painful diabetic neuropathy. The guideline is published in the December 27, 2021, online issue of Neurology®, the medical journal of the AAN, and is endorsed by the American Association of Neuromuscular & Electrodiagnostic Medicine. This guideline updates the 2011 AAN guideline on the treatment of painful diabetic neuropathy.

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Joslin discovery about exosomes (cell fragments that regulate other cells) may help to advance RNA gene therapies for many diseases.

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People with diabetes may need to monitor their blood sugar more closely when doing high-altitude activities such as hiking or skiing, according to a small study published in the Society’s Journal of Clinical Endocrinology & Metabolism.

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GLP-1 RA treats diabetes and is linked to positive outcomes for heart disease patients, yet inequities were found in its use along racial, ethnic, and economic lines

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Results of a 12-month multicenter randomized clinical trial led by Erika Petersen, M.D., a professor of neurosurgery at the University of Arkansas for Medical Sciences (UAMS), were published online Nov. 29 in Diabetes Care, highlighting the benefits of a breakthrough treatment for patients with painful diabetic neuropathy (PDN).

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A custom computer program at Children’s Hospital Los Angeles is translating into enhanced patient safety, streamlined workflow—and fewer finger sticks for children with diabetes. The program is a new insulin calculator that is seamlessly integrated into the hospital’s electronic health record (EHR) system.

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The gap in the use of insulin pumps and continuous glucose monitors (CGMs) among Black and white Medicare beneficiaries widened from 2017-2019, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

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A new study in mice shows transplanted brown fat can reduce type 2 diabetes risk factors after a heart attack, an encouraging finding for scientists who hope to apply the so-called “good” fat’s beneficial properties to drugs that can help prevent health problems.

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A new review explores the physiology behind and proposed management strategies for body-wide symptoms of the post-acute sequelae of SARS-CoV-2 (PASC), otherwise known as “long COVID.” The review is published ahead of print in the American Journal of Physiology-Cell Physiology.

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The Endocrine Society urges the Senate to protect the insulin affordability provisions included in the Build Back Better Act and move quickly to pass this crucial legislation.

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Findings from a new study led by Yale Cancer Center show the small molecule inhibitor drug, PF05175157, originally developed to treat diabetes by Pfizer, may help in the treatment of breast cancer. The findings were reported today at the 2021 San Antonio Breast Cancer Symposium in San Antonio, Texas.

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Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye disease. Researchers from the National Eye Institute (NEI), part of the National Institutes of Health generated a “disease-in-a-dish” model to study the disease. The findings are published in Communications Biology.

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Beyond Delta and Omicron: Plant-Based Nutrition for Whole-Body Health in the Age of COVID

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Using artificial intelligence, a team of University at Buffalo researchers has developed a novel system that models the progression of chronic diseases as patients age.

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Researchers at Penn State College of Medicine are seeking volunteers from across the U.S. to participate in a clinical trial examining whether online mindfulness-based stress reduction can reduce stress and average blood sugar levels in those with Type 1 or Type 2 diabetes.

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Transgender women may be at higher risk for type 2 diabetes compared to cisgender women, but not to cisgender men, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

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The Endocrine Society hailed the House of Representatives for including provisions to improve insulin affordability in its version of the Build Back Better Act.

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Researchers at the University of New Hampshire have found that variants of the cone snail venom could offer possibilities for developing new fast-acting drugs to help treat diabetes.

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People with type 2 diabetes who contract COVID-19 are nearly 50% more likely to wind up in intensive care if they have poorly managed their blood sugar levels over the long-term than those with better long-term glycemic control, according to a study using anonymized health care data.

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Studies suggest that exposure to the COVID-19 pandemic has been associated with a variety of different mental health consequences including reports of depression, loneliness, and insomnia. People who are more than 65 years of age and those with underlying medical conditions such as type 2 diabetes and obesity are particularly vulnerable to negative outcomes from COVID-19. Until now, few investigations have identified and separated the mental health consequences of exposure to the COVID-19 pandemic from preexisting factors in this age group. A new prospective study of a large cohort of older adults with type 2 diabetes and overweight/obesity from across the U.S. has explored this subject with surprising results.

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Consuming a low amount of caffeine during pregnancy could help to reduce gestational diabetes risk, according to researchers in the Perelman School of Medicine at the University of Pennsylvania.

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Just in time for National Diabetes Awareness Month in November 2021, Hackensack Meridian Hackensack University Medical Center’s MOLLY Diabetes Education/Management Center for Adults and Children will celebrate its 25th anniversary. Since 1996, the MOLLY Center has provided comprehensive diabetes education for children and adults with all types of diabetes.

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Dasatinib, a drug that often is used to treat certain types of leukemia, may have antidiabetic effects comparable to medications used to treat diabetes, and with more research may become a novel therapy for diabetic patients, according to new research published in Mayo Clinic Proceedings.

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Results from SUGAR, a randomized, controlled, multicenter trial conducted exclusively in patients with diabetes mellitus (DM) and with minimum exclusion criteria, found that amphilimus-eluting stents (AES) were superior to zotarolimus-eluting stents (ZES) with regard to target lesion and target vessel failure composite outcomes at one year.

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• Taking sodium-glucose cotransporter 2 inhibitors was linked with lower risks of developing cardiovascular disease and kidney failure among patients with type 1 diabetes when using prediction models called the Steno Type 1 Risk Engines. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.

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• Results from a recent clinical trial indicate that the diabetes drug dapagliflozin slows kidney function decline in patients with chronic kidney disease, regardless of whether they have diabetes. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.

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• Investigators found that the Kidney Disease Risk Equation can predict a patient’s likelihood of developing chronic kidney disease, based on readily available information. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.

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Beth Israel Lahey Health (BILH) and Joslin Diabetes Center announced that Joslin has officially joined the BILH system.

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New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that statins are associated with reduced rates of cardiovascular disease (CVD) and mortality in people with rheumatoid arthritis, but only modestly increase risk of type-2 diabetes, suggesting that statins’ benefits outweigh the risks in these patients.

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November is American Diabetes Awareness Month, and with one in 10 West Virginians being affected by the disease, it can be an important time for people to learn more.

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Weight loss after gestational diabetes can prevent the onset of type 2 diabetes. Yet finding the most effective way to lose weight and keep it off can be a challenge, especially for mothers with a new baby. Now, new research from the University of South Australia suggests that the popular 5:2 or intermittent fasting diet ¬is just as effective as a conventional energy-restricting diet, enabling women greater choice and flexibility when it comes to weight loss.

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This year marks 100 years since physiologists discovered insulin. The lifesaving drug has given millions of people with diabetes worldwide a second chance at life.

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Diabetic retinopathy affects nearly 8 million Americans, and that number is expected to double by 2050, but knowing the risks and symptoms and seeking an early diagnosis and treatment from a retina specialist can preserve sight and virtually eliminate vision loss from the condition, according to the American Society of Retina Specialists (ASRS).

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A new nationwide study led by researchers from NYU Grossman School of Medicine published online today in JAMA Network Open suggests that living in neighborhoods with higher availability of fast-food outlets across all regions of the United States is associated with higher subsequent risk of developing type 2 diabetes.

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In Australia, one in every five employees are shift workers. But when you work irregular hours, you eat at irregular hours and this can put you at increased risk of weight gain, type 2 diabetes, and cardiovascular disease.

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Weight gain and high blood sugar caused by a damaged internal clock was corrected by researchers, who changed the length of the “day” in mice

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Just as bright light can illuminate the depths of a darkened room, researchers in Japan have found that blue light can be used to probe the depths of the eye and uncover areas affected by diabetic retinopathy (DR), a leading cause of blindness.

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A team of researchers studying genetic data to identify hormone responses in a population of Mexican Americans with prediabetes, Type 2 diabetes, and obesity recently received a $3.5 million grant to fund a five-year study set to begin in late 2021.

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The number of people experiencing numbness, tingling and pain in their feet with no known cause has been increasing over the last two decades, according at a new study published in the October 27, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. Called small fiber neuropathy, the condition has different symptoms than large fiber neuropathy, which can cause weakness and balance issues. But in many cases people have both types of neuropathy.

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University of California San Diego researchers, with international colleagues, describe how energy expenditure and heat production are regulated in obesity through a previously unknown cellular pathway.

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Keeping blood insulin levels within strict, healthy parameters is a daily goal for people with diabetes.

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Technion researchers are working on a novel treatment approach for treating type 2 diabetes using an autograft of muscle cells engineered to take in sugar at increased rates. Mice treated in this manner displayed normal blood sugar levels for months after a single procedure.