Investigators at Cedars-Sinai have proposed a theory for how SARS-CoV-2, the virus that causes COVID-19, infects the body. Their hypothesis, published in Frontiers in Immunology, could explain why some people still have symptoms long after the initial infection.
A new study of 57 people with mild COVID-19 estimates how long people are infectious for and when they can safely leave isolation.
For the past two-plus years, the COVID-19 pandemic has disrupted children’s education and frustrated parents. Today, with the back-to-school season in full swing, Suzanne Silverstein, MA, ART, founding director of Cedars-Sinai Share & Care, and Rose Bisellach, RN, nurse manager in the Providence Cedars-Sinai Tarzana Medical Center Emergency Room, give their best advice for starting a successful school year.
Published in the New England Journal of Medicine, researchers — led by the University of Minnesota Medical School and School of Public Health — have found that metformin, a commonly prescribed diabetes medication, lowers the odds of emergency department visits, hospitalizations, or death due to COVID-19 by over 40 percent; and over 50 percent if prescribed early in onset of symptoms.
Severe breathlessness in COVID patients with co-morbidities should be used as a signal for quicker referral for palliative care to help manage their symptoms sooner, new research has found.
Researchers at the University of British Columbia have discovered a key vulnerability across all major variants of the SARS-CoV-2 virus, including the recently emerged BA.1 and BA.2 Omicron subvariants.
Physicians, nurses, scientists have published 260+ peer-reviewed papers - and list keeps growing
Patients with prior COVID may be twice as likely to have unhealthy endothelial cells that line the inside of the heart and blood vessels, according to newly published research from Houston Methodist. This finding offers a new clue in understanding COVID-19’s impact on cardiovascular health.
The majority of people who were likely infected with the Omicron variant of SARS-CoV-2, the virus that causes COVID-19, didn’t know they had the virus, according to a new study from Cedars-Sinai investigators. The findings are published in JAMA Network Open.
UPTON, NY--Scientists studying a COVID-19 coronavirus enzyme at temperatures ranging from frosty to human-body warm discovered subtle structural shifts that offer clues about how the enzyme works. The findings, published in IUCrJ, the journal of the International Union of Crystallography, may inspire the design of new drugs to counteract COVID-19 -- and possibly help head off future coronavirus pandemics.
Like a case of long COVID-19 itself, the effects of the coronavirus continue to linger in pockets of the state and its economy. They affect Oregonians to a wide range of degrees, ranging from the toll of missed work and lost wages due to long COVID to disruptions with child care and an uneven recovery in the workforce, among others. Those are among the findings in the latest report by University of Oregon researchers.
A new study released in the European Journal of Ageing found that having a partner had a greater impact than having children in helping to stave off loneliness among older adults during the pandemic’s first wave. Researchers at the University of Rhode Island, University of Florence, University of Maryland Baltimore County and the SGH Warsaw School of Economics analyzed data on more than 35,000 adults aged 50 and older from the Survey of Health, Ageing and Retirement in Europe to examine if unpartnered and childless older adults reported more loneliness and how that changed over the course of the pandemic.
Researchers at Massachusetts General Hospital (MGH), published a new paper in Cell Reports Medicine demonstrating the protective potential of multiple doses of the Bacillus Calmette-Guerin (BCG) vaccine against COVID-19 and other infectious diseases.
Researchers at McMaster University have found a class of well-known antiviral drugs could be part of a one-two punch to treat seasonal influenza and prevent a flu pandemic when used in combination with antibody therapies.
Orchestral ensembles have faced many challenges when starting to perform again during the COVID pandemic, and contamination is a chief concern: specifically, whether wind instruments are vectors of contamination through aerosol dispersion. In Physics of Fluids, researchers worked with musicians to deepen our understanding of how much aerosol is produced and dispersed by wind instruments. They used visualization to characterize the flow, tracked fog particles in the air, and measured aerosol concentration from wind instruments with a particle counter. Then they combined these to develop an equation to describe aerosol dispersion.
Researchers are calling for urgent changes to the GCSE science curriculum to help equip learners with sufficient scientific literacy to be able to identify reliable sources and inform their future vaccination decision-making process.
Solid organ transplants — heart, lung, liver, and kidney — are resource-intensive operations that require patients to take immunosuppressive drugs after the procedure to keep the body from rejecting the new organ.
• Among US adults with kidney failure receiving dialysis, risk for SARS-CoV-2 infection during the Omicron-dominant period was higher among patients without vaccination and with 1–2 doses compared with 3 doses of mRNA vaccines. • Irrespective of vaccine doses, risk for infection was higher among patients with low circulating levels of anti–SARS-CoV-2 antibodies.
The Association for the Advancement of Blood and Biotherapies (AABB) has released clinical practice guidelines for the appropriate use of COVID-19 convalescent plasma (CCP) in hospital and outpatient settings. Based on two living systematic reviews of randomized controlled trials (RCTs), the guidelines provide five specific recommendations for treating patients with COVID-19 and suggest that CCP is most effective when transfused with high neutralizing titers to infected patients early after symptom onset. The guidelines are published in Annals of Internal Medicine.
A study led by Kaiser Permanente in Southern California of patients from 8 health care organizations across the United States showed that COVID-19 was associated with a 4% increase in use of health care services over the 6 months after initial infection.
Mayo Clinic researchers say the monoclonal antibody bebtelovimab, already authorized by the Food and Drug Administration for emergency use on the omicron variant of COVID-19, is a reliable option to treat BA.2 and other COVID-19 subvariants. The findings of their multisite, retrospective study involving 3,607 high-risk patients appear in the Journal of Infectious Diseases.
Canadian study found 7.3% of pregnant women experienced health events requiring time off work or school or needing medical attention, such as headaches, fatigue and a general feeling of being unwell, within a week after dose two of a COVID-19 mRNA vaccine, compared to 11.3% of vaccinated non-pregnant women.
When it comes to COVID-19 immunity, antibodies do not tell the whole story, according to Cedars-Sinai professor of Medicine Stanley C. Jordan, MD.
In one of the largest follow-up studies to date, involving 25 pediatric hospitals, more than a quarter of children and adolescents hospitalized with coronavirus infection early in the pandemic still had health problems two to four months later, either persisting symptoms or activity impairment.
In a paper published in JAMA Network Open, physician-scientists assessed how pregnancy-related complications and obstetric outcomes changed during the COVID-19 pandemic compared to pre-pandemic.
Individuals with blood-related cancers are more likely to experience a COVID-19 infection even after being vaccinated, a University of Kansas Cancer Center study has found.
As SARS-CoV-2 has evolved and mutated, therapeutic antibodies that worked early in the pandemic have become less effective, and newer variants, especially Omicron, have developed ways to evade the antibodies we make in response to vaccines.
Interpersonal rejection can motivate people who do not normally worry about disease to protect themselves against COVID-19.
Existing health disparities amongst ethnic minorities with diabetes have worsened during the COVID-19 pandemic, a new study published in the journal Diabetes Care has reported.
An analysis of millions of SARS-CoV-2 genomes finds that recombination of the virus is uncommon, but when it occurs, it is most often in the spike protein region, the area which allows the virus to attach to and infect host cells.
Johns Hopkins Medicine researchers say that an experimental dendrimer nanoparticle treatment called OP-101 substantially reduced the risk of death and need for a ventilator in a study of 24 severely ill adults hospitalized with COVID-19.
Physicians at Monroe Carell Jr. Children’s Hospital at Vanderbilt have found another reason to vaccinate children against COVID-19: to help reduce the likelihood of neurologic complications caused by the virus.
RUDN economists analyzed trade risks during the COVID-19 crisis and revealed what corporate social responsibility measures can mitigate them. The results are published in Risks .
A team led by UT Southwestern researchers has identified how SARS-CoV-2, the virus that causes COVID-19, builds a structure called the RNA cap that’s critical for successful viral replication. The finding, published in Nature, could lead to new strategies to attack COVID-19, which has sickened nearly 600 million and killed more than 6 million worldwide thus far.
COVID-19 infection in pregnant women is associated with increased risk of adverse outcomes compared to women who are not pregnant, according to a review published in JACC: Advances from the American College of Cardiology Cardiovascular Disease in Women Committee.
In early 2021, racial and ethnic minorities had higher rates of depression and anxiety than white people, even after controlling for various factors.
Researchers at the University of Illinois Chicago are working with the National Institutes of Health and University of Minnesota to establish a center for antiviral drug development for pandemic-level viruses, including Ebola and SARS-CoV-2.
A University of Minnesota assistant professor is part of a team that has developed a new way to effectively deliver vaccines through the nose that could lead to better protection against diseases like HIV and COVID-19.
JMIR Publications published a study titled “Competition and Integration of US Health Systems in the Post-COVID-19 New Normal: Cross-sectional Survey” in JMIR Formative Research, which reported that the smaller the geographical region in which mergers and acquisitions (M&A) activity is pursued, the higher the likelihood that monopolistic tendencies will result.
Their findings highlight the need for more proactive planning and preparedness for future variants of concern (VOCs), including the development of a universal vaccine that can block SARS-CoV-2 infection as well as prevent severe disease.
Most people in the United States have some degree of immune protection against Covid-19, either from vaccination, infection, or a combination of the two. But, just how much protection does any individual person have?
Following two years of severe restrictions, everyone is eager to be done with the coronavirus pandemic. It’s tempting to think that COVID-19 is history, but the coronavirus and other viruses will regularly resurface.
Over the first year of the COVID-19 pandemic, almost 30% of patients with obesity gained more than 5% of their body weight, and 1 in 7 gained more than 10%. While diet and exercise habits were factors, people with the highest levels of stress, anxiety, and depression reported the most weight gain, UT Southwestern researchers reported in the journal Obesity.
A new poll shows that 61% of people over 50 who have already gotten at least one dose of COVID-19 vaccine are very likely to roll up their sleeves this fall to get an updated booster shot once they become available. That percentage might increase if health care providers specifically recommend the updated vaccine to their patients, the poll suggests.
An increase in the number of non-COVID-19 respiratory infections should be expected this winter, say scientists. The warning comes following the results of a new study, published in The Lancet Regional Health – Europe, which found that over 55% of respiratory disease hospitalisations during the pandemic’s peak were caused by non-SARS-CoV-2 infections. The University Bristol-led study funded and conducted in collaboration with Pfizer Inc., as part of AvonCAP, is the first to compare the number of hospitalisations from respiratory disease infections caused by COVID-19 and non-SARS-CoV-2 infections.
The lockdowns during the COVID-19 pandemic had a significant effect on levels of suicidal ideation, a new study finds. The research, published in De Gruyter’s Open Medicine, was conducted in a Serbian psychiatric clinic shortly after a nationwide lockdown.
Fatigue and headache were the most common symptoms reported by individuals an average of more than four months out from having COVID-19, investigators report.
While research has revealed that children and adults hospitalized with COVID-19 are more susceptible to developing long COVID symptoms, a new study by researchers at UTHealth Houston found that children infected with COVID-19, but not hospitalized, still experienced long COVID symptoms up to three months past infection.
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