Mice given a new drug targeting a key gene involved in lipid and glucose metabolism could tolerate a high-fat diet regimen (composed of 60% fat from lard) without developing significant liver damage, becoming obese, or disrupting their body’s glucose balance.
Patient enrollment in clinical trials as the first course of treatment after cancer diagnosis is low, despite the fact that enrollment may increase life expectancy, according to researchers at Penn State.
Acid reflux drugs that are sometimes recommended to ease stomach problems during cancer treatment may have an unintended side effect: impairment of breast cancer survivors’ memory and concentration.
The Jan. 17 issue of the Journal of the American Medical Association (JAMA) features an important study about sepsis with an accompanying editorial by a University of Nebraska Medical Center expert. The study and editorial sets the record straight on an unproven therapy some physicians use to treat sepsis, a deadly infectious disease.
The editorial, written by Andre Kalil, M.D., M.P.H., professor of infectious diseases in the UNMC Department of Internal Medicine, writes in support of the new and rigorous international study based on a randomized clinical trial in Australia, published in the same issue. The editorial appears in the Jan. 17 online issue and also will appear in the Feb. 4 print edition.
A Mayo Clinic está criando uma biblioteca de dados de sequenciamento genômico de 100.000 participantes consentidos da Mayo Clinic para avançar na pesquisa e no atendimento ao paciente.
Researchers from St. Jude Children’s Research Hospital and the Chinese Children’s Cancer Group led the first randomized, Phase III clinical trial comparing targeted therapies for acute lymphoblastic leukemia (ALL) driven by the Philadelphia chromosome. Results showed that the drug dasatinib provides more benefit than the standard of care, which led to changes in the way this leukemia is treated. The findings were reported today in JAMA Oncology.
A virtual system for in-home physical therapy (PT) provides good outcomes for patients undergoing rehabilitation following total knee arthroplasty (TKA) – with lower costs than traditional in-person PT, reports a study in the January 15, 2020 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
CenExel Clinical Research recently strengthened its psychiatric team with the recruitment of Mark N. Lerman, MD, to serve as a principal investigator for phase I-IV studies at the Atlanta Center for Medical Research (ACMR), a CenExel Center of Excellence.
Many liver cancer tumors contain a highly diverse set of cells, a phenomenon known as intra-tumor heterogeneity that can significantly affect the rate at which the cancer grows, Mount Sinai researchers report. The immune system’s contribution to this heterogeneity can have major clinical implications.
The Society has released a statement regarding the controversy over recently published studies on coronary bypass grafting surgery and percutaneous coronary interventions in patients with left main disease.
Scientists present brain-imaging data for a new stroke treatment that supported full recovery in swine, modeled with the same pattern of neurodegeneration as seen in humans with severe stroke.
University of California San Diego School of Medicine researchers report that patients with prostate cancer assigned to eat seven or more servings of vegetables and fruits daily saw no extra protection from the increased consumption of micronutrients, running contrary to current thought.
Investigators at John Theurer Cancer Center at Hackensack University Medical Center in New Jersey were part of the CANDOR global phase III clinical trial for patients with refractory (persistent) multiple myeloma. The study was selected as the prestigious plenary presentation at the 61st American Society of Hematology (ASH) Annual Meeting, the world's leading conference for hematologic cancers and blood disorders, held in Orlando in December.
Personalised cancer treatment is one step closer to becoming a reality for more patients, thanks to a Cancer Council Beat Cancer Project grant awarded to University of South Australia researcher Dr Stephanie Reuter Lange to explore how computer-based modelling can optimise cancer treatment and remove the need for expensive clinical trials.
Due in part to advanced surgical techniques, more effective medicines, and a multidisciplinary approach to treating the disease, University of Colorado Cancer Center is able to operate on 30+ percent of pancreatic cancer patients, nearly double the national average.
Cancer patients may one day be able to get their entire course of radiation therapy in less than a second rather than coming in for treatment over the course of several weeks, and researchers in the Abramson Cancer Center of the University of Pennsylvania have taken the first steps toward making it a reality
Zinc and folic acid, a pair of dietary supplements long touted as an effective treatment for male infertility, failed to improve pregnancy rates, sperm counts, and sperm potency in a new study conducted at University of Utah Health and other medical centers in conjunction with the National Institutes of Health. According to the researchers, the finding presents the most definitive evidence to date that so-called fertility supplements do not live up expectations.
Dana-Farber Cancer Institute will create the Chen-Huang Center for EGFR (epidermal growth factor receptor) Mutant Lung Cancers to stimulate research, promote clinical trials, and strengthen the Institute’s capabilities for studying and treating lung cancer.
Physicians and scientists at Rush University Medical Center have found that injecting tumors with influenza vaccines, including some FDA-approved seasonal flu shots, turns cold tumors to hot, a discovery that could lead to an immunotherapy to treat cancer. The study results were published December 30th in the Proceedings of the National Academy of Sciences.
In response to continued discussion on the validity of the conclusions of the EXCEL trial, The American Association for Thoracic Surgery (AATS) has released a statement calling for the release of all trial data.
The five-year, $5 million Atlas of Retinal Imaging in Alzheimer’s Study (ARIAS) is sponsored by BayCare Health System’s Morton Plant Hospital and St. Anthony’s Hospital and funded largely by Morton Plant Mease Health Care Foundation and St. Anthony’s Hospital Foundation in Pinellas County, Florida.
In a special brain health collection, AACC’s The Journal of Applied Laboratory Medicine highlights the innovative clinical tests that laboratory medicine experts are developing to improve care for concussions.
Children who undergo expansive genetic sequencing may not be getting the thorough DNA analysis their parents were expecting, say experts at UT Southwestern Medical Center.
Ein Studie von Mayo Clinic an 5540 Patienten mit metastasiertem kolorektalem Karzinom hat ergeben, dass für Patienten, deren Krankheit unter Kontrolle ist, eine Erhaltungs-Chemotherapie nach der Erstbehandlung nützlicher als eine aggressivere Behandlung ist.
Une étude de Mayo Clinic portant sur 5 540 patients atteints d'un cancer colorectal métastatique révèle que la chimiothérapie d’entretien réalisée après le traitement initial est plus bénéfique pour les patients dont la maladie est sous contrôle, par rapport à un traitement plus agressif.
Um estudo da Mayo Clinic que envolveu 5.540 pacientes com câncer colorretal metastático revelou que a quimioterapia de manutenção após o tratamento inicial é mais benéfica para pacientes cuja doença está sob controle, em contraste com um tratamento mais agressivo.
اكتشفت دراسة أجرتها Mayo Clinic شملت 5540 مريضًا من مرضى سرطان القولون والمستقيم النقيلي أن تلقي علاج المداومة الكيميائي بعد المعالجة الأولية كان أكثر فائدة للمرضى الذين يعانون من مرض يمكن السيطرة عليه، مقارنةً بالمزيد من العلاج المكثف
Un estudio de Mayo Clinic que abarcó a 5540 pacientes con cáncer colorrectal metastásico descubre que la quimioterapia de mantenimiento después del tratamiento inicial es más beneficiosa para los pacientes cuya enfermedad está bajo control que el tratamiento más agresivo.
A worldwide research effort is underway for finding a treatment option for hyperphagia, the most common genetic cause of life-threatening childhood obesity.
Brain imaging of pathological tau-protein "tangles" reliably predicts the location of future brain atrophy in Alzheimer's patients a year or more in advance, according to a new study by scientists at the UC San Francisco Memory and Aging Center.
For sick or prematurely born babies spending their first days of life in a hospital’s neonatal intensive care unit (NICU), the soothing voice and gentle touch of a loving parent can have a tremendous impact toward a positive outcome — that is, unless mom or dad’s visit leaves the infant with something extra: a dangerous bacterial infection.
Yale Cancer Center (YCC) announces the launch of the Center for Community Engagement and Health Equity (CEHE). Building on YCC’s longstanding commitment to high-quality, expert, and patient-centered cancer care, screening, and prevention across the state of Connecticut, the new Center is dedicated to ensuring cancer health equity and improving outcomes with an emphasis on traditionally underserved neighborhoods.
An innovative approach to analyzing the medical scans of patients in clinical trials could help ensure the accuracy of trial results while reducing the workload for busy oncologists, according to a new study by researchers at the University of Michigan Rogel Cancer Center.
Proton therapy leads to significantly lower risk of side effects severe enough to lead to unplanned hospitalizations for cancer patients when compared with traditional radiation, while cure rates between the two groups are almost identical
Pregnant women living with HIV don’t always receive antiretroviral medications recommended for use in pregnancy, according to a recent study published in Jama Network Open this week. Ann & Robert H. Lurie Children's Hospital of Chicago’s researchers collaborated in the multi-site Surveillance Monitoring for ART Toxicities (SMARTT) study of the Pediatric HIV/AIDS Cohort Study (PHACS) network.
Saint Louis University’s Enrico Di Cera, M.D., has been named a Fellow of the American Association for the Advancement of Science (AAAS) for his distinguished contributions to science.
GB Sciences, Inc. (OTCQB: GBLX) announced significant preclinical results for their Parkinson's disease ("PD") formulations from the midterm report for their preclinical study being performed by Dr. Lee Ellis of the National Research Council (NRC) in Halifax, Nova Scotia, CANADA.
A GPS map to guide neural navigation devices developed by a Case Western Reserve University cancer researcher has shown 90% accuracy in pinpointing brain tumors and will soon be tested in real time with patients at Cleveland Clinic under a three-year, $600,000 V Foundation grant.
A Mayo Clinic study involving 5,540 patients with metastatic colorectal cancer finds that maintenance chemotherapy after initial treatment is more beneficial for patients whose disease is under control, compared with more aggressive treatment.
Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way to move precision immunotherapy forward by using genomics to inform immunotherapy for multiple myeloma, a blood cancer, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research, in December.
The U.S. Food & Drug Administration (FDA) granted accelerated approval to the drug enfortumab vedotin (EV) to treat adult patients with advanced urothelial or bladder cancer.
Tired of living with painful arthritic knees, 54-year-old Deborah Brown’s interest was piqued when she saw a recruitment flyer for a clinical trial on an innovative pain treatment at The University of Texas Health Science Center at Houston (UTHealth).
In the search for an Alzheimer’s cure, the scientific community has focused on drugs to lessen the buildup of amyloid protein in the brain. But new research published today in Science Translational Medicine finds that targeting tau pathology shows promise.The discovery came by looking at what could make worms resistant to pathological tau protein. That’s when researchers discovered the role of the MSUT2 gene. The latest study applied to mice as well. And held true in autopsy samples of Alzheimer's patients.
A new study published in Journal of Vascular and Interventional Radiology details the first study of its kind in the U.S. to examine the use of genicular artery embolization (GAE) for extended treatment of knee pain caused by osteoarthritis (OA). Principal investigator of the study, Ari Isaacson, MD, clinical associate professor of vascular and interventional radiology in the UNC School of Medicine, says the results are positive.