Researchers at RUSH are seeking volunteers to explore how a change in diet may improve brain health after a stroke. The study, called NOURISH — short for Nutrition Effects on Brain Outcomes and Recovery in Stroke After Hospitalization — aims to prevent cognitive and memory decline that is common in stroke survivors.
Cultivated autologous limbal epithelial cells (CALEC) transplant, in which stem cells from the healthy eye and transplanted into the injured eye, for significant cornea injuries was found safe and led to gains in preliminary phase I clinical trial.
Only a small percentage of older adults who are in the early stages of Alzheimer’s disease meet the eligibility criteria to receive new monoclonal antibody treatments, drugs that target amyloid-ß plaques in the brain, an early sign of Alzheimer’s disease. The new research is published in the August 16, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. Clinical trial results for these drugs are only available in people in the early symptomatic stages of the disease, mild cognitive impairment or mild dementia due to Alzheimer’s disease.
For the first time, researchers have found a potential drug candidate that improved outcomes for patients with a type of childhood brain tumor for which there are no effective treatments. The compound, called ONC201, nearly doubled survival for patients with diffuse midline glioma (DMG) or diffuse intrinsic pontine glioma (DIPG), compared to previous patients.
The Food and Drug Administration announced yesterday the approval of HEPZATO Kit to treat ocular melanoma that has spread to the liver. HEPZATO uses a hepatic delivery system to inject the chemotherapy drug melphalan into the liver, a procedure referred to as percutaneous hepatic perfusion (PHP). Moffitt Cancer Center’s Jonathan S. Zager, M.D., was the lead international principal investigator on the multinational FOCUS phase 3 clinical trial to test the procedure, which is manufactured by Delcath Systems, Inc.
A clinical trial evaluating the role of statins in the risk of recurrent intracerebral hemorrhage (ICH) in patients presenting with ICH, has opened for enrollment at UTHealth Houston.
The Project to Accelerate New Treatments for Tuberculosis (PAN-TB) collaboration announced today the start of a phase 2b/c clinical trial, sponsored by the Bill & Melinda Gates Medical Research Institute (Gates MRI).
Following up on positive results from preliminary research, scientists at University of Utah Health are evaluating whether an eight-week program based on positive psychology techniques can improve the mood and well-being of people who have had a stroke and those who care for them.
The New Mexico Cancer Care Alliance (NMCCA) has rebranded as the New Mexico Cancer Research Alliance (NMCRA) to strengthen its focus on delivering cancer clinical trials to New Mexicans. Through the NMCRA’s unique collaboration, every New Mexican has access to cancer clinical trials. Cancer clinical trials test new treatments and new methods of delivering and improving cancer care.
One common side effect of treatment for ovarian cancer is chemotherapy-induced peripheral neuropathy (CIPN), which can damage peripheral nerves, causing severe pain and numbness. The effects can last for months – or even years — after completing chemotherapy. Currently, there is only one treatment with limited efficacy for CIPN.
Sanoj Punnen, M.D., co-chair of the Genitourinary Site Disease Group at Sylvester Comprehensive Cancer Center and associate professor and vice chair of research, Desai Sethi Urology Institute, at the University of Miami Miller School of Medicine, is leading a $2.5 million, five-year National Cancer Institute (NCI) grant to explore a new way to noninvasively detect prostate cancer.
A machine commonly used for pain relief has shown to improve breathing in patients with obstructive sleep apnoea, a clinical trial has found.
Since its inception in 2014, Insilico Medicine has developed multiple AI models for predicting the probability of success of clinical trials focusing on Phase II to Phase III transition probabilities.
Helen is an 8 1/2-year old gentle giant who’s fighting osteosarcoma and, through participation in a clinical trial through the Animal Cancer Care and Research Center, is helping develop a new cancer treatment. The dog's owners have a 1-year-old son enrolled in a clinical trial for a rare liver disease, which gave them the idea to also enroll Helen in a clinical trial.
Cancer research centers conducting clinical trials could enroll more patients from underrepresented racial and ethnic groups by placing greater emphasis on relieving investigators of the costs of translating consent documents into languages other than English, according to a UCLA Jonsson Comprehensive Cancer Center study.
Two clinical trials that will evaluate drugs, biologics, medical devices, and other therapies for long COVID that are sponsored by the National Institutes of Health (NIH) will launch at UTHealth Houston.
Today, the National Institutes of Health launched and is opening enrollment for phase 2 clinical trials that will evaluate at least four potential treatments for long COVID, with additional clinical trials to test at least seven more treatments expected in the coming months. Treatments will include drugs, biologics, medical devices and other therapies.
A report summarizing the results of a series of surveys distributed to AACI cancer center members was published in the Journal of the National Cancer Institute (JNCI) Cancer Spectrum.
UC San Diego Health is among the first in the nation to perform an experimental regenerative brain cell therapy for epilepsy aimed at eliminating seizures.
The Icahn School of Medicine at Mount Sinai will help lead and launch the first clinical trial focusing on women and minority populations to determine which coronary revascularization procedure best improves their survival and quality of life.
A technique that uses imaging technology as a guide can make radiation therapy safer for patients with prostate cancer by helping clinicians accurately aim radiation beams at the prostate while avoiding nearby tissue in the bladder, urethra, and rectum.
A research team led by medical ethicists and physician-researchers has been approved for a $6.2 million award to study strategies to bridge gaps in the healthcare system and help bereaved parents connect with existing community resources after the unexpected or traumatic death of their child.
The Icahn School of Medicine at Mount Sinai in New York, NY is pleased to announce that CastleVax, Inc. has completed enrollment and a preliminary analysis of a phase 1 trial of its licensed Newcastle disease virus (NDV)-based COVID-19 booster vaccine.
Researchers found that cancer patients who continued to smoke after their diagnosis were significantly more likely to receive treatment for tobacco use when “nudges” to provide tobacco treatment were directed at clinicians through the electronic health record.
Scientists have long used community advisory boards to engage communities and provide feedback on studies, but this model has limitations. Now, Wistar Institute researchers are sharing how a more inclusive model for community engagement can lead to deeper insights and greater community participation in HIV research.
A Penn Medicine research team has been approved for a $27.5 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) for a large study on effectively and equitably scaling and delivering inpatient palliative care.
Brushing twice a day keeps the dentist away – but can we improve on the toothpaste we use to maintain clean teeth, preventing medical issues that spiral from poor dental health? Most toothpastes use fluoride, a powerful tool for oral hygiene.
The randomized controlled study was conducted by 15 liver transplant centers in the United States, including Ochsner Health Liver Transplant Institute, and compared the use of normothermic machine preservation (NMP)—which maintains the organ at normal body temperature-- with static cold storage (SCS) in 383 donor organs.
Penicillin allergy affects more than 25 million people in the United States (up to 1 in 10 Americans) and has been shown to lead to particularly poor health outcomes in pregnant women and surgical patients. It is also a public health threat, leading to antibiotic resistance and infections in hospitalized patients that can be life threatening.
A new study conducted by Luther College finds that a neuroplasticity-based treatment using an online amygdala & insula retraining (AIR) program significantly reduces fatigue and increases energy levels among Long COVID patients when compared to a general wellness program.
A low-cost version of ketamine to treat severe depression has performed strongly in a double-blind trial that compared it with placebo.
When an ill person schedules a doctor visit, blood work or other diagnostic testing is often required before a diagnosis is determined. Missouri University of Science and Technology electrical engineering researcher Dr. Jie Huang is developing technology that would allow patients to “just breathe” and avoid that testing.
Value in Health, the official journal of ISPOR—The Professional Society for Health Economics and Outcomes Research, announced the publication of an ISPOR Good Practices Report providing recommendations on performance outcome (PerfO) assessments.
The American Association for Thoracic Surgery (AATS) and Memorial Sloan Kettering Cancer Center’s (MSK) Thoracic Surgery Oncology Group (TSOG) completed its first clinical trial involving 330 patients who have ground glass lung nodules identified on a CT scan.
Versil Joyles-Stapleton, 76, can’t seem to slow herself down — a drastic change to how she lived her life just 2 years ago.
Rakuten Medical, Inc., a global biotechnology company developing and commercializing precision, cell targeting therapies based on its proprietary Alluminox™ platform, today announced that new interim evaluation data from the ASP-1929-103 study has been presented at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2023 Annual Meeting held from June 24 to 27.
July is Sarcoma Awareness Month. Few people can tell you that sarcoma is a rare cancer of the soft tissue and bone with over 70 subtypes. And even advocacy groups call it “a forgotten cancer.” But for the tens of thousands of Americans living with sarcoma, sarcoma isn’t rare: it’s a daily reality.
UC San Diego researchers find a combination of drugs outperformed other treatments in human and mouse models of pancreatic cancer; now urge clinical trial.
IgniteData, a global leader in the fast, accurate transfer of data between electronic healthcare records (EHR) and study databases, is announcing a new collaboration with Memorial Sloan Kettering Cancer Center (MSK).
A consortium of government, industry, and nonprofit partners will fund gene therapy clinical trials for three different rare diseases at UT Southwestern Medical Center and Children’s Health, where scientists are working on gene therapies to treat neurodevelopmental disorders in children.
Researchers with UC San Diego School of Medicine identified a potential new drug that improved liver fibrosis in patients with NASH by 27%.
Clinical testing is underway for a potentially groundbreaking new treatment for cystic fibrosis.
Overlook Medical Center in NJ, is the 1st site in the nation to dose a patient in the Phase IIb RESTORE Trial for newly-diagnosed glioblastoma tumors. Researchers will see whether using NanO2 TM, a drug by NuvOx Pharma to infuse oxygen into hypoxic tissues, can boost traditional radiation and chemo.
A 2022 outbreak of mpox (formerly monkeypox) sickened more than 30,000 people and caused 38 deaths in the United States. It highlighted the lack of an approved vaccine for those under 18 years old.
UCSF researchers have found that aggressive blood pressure control can lower the risk of left ventricular conduction disease, a common heart condition that often leads to pacemaker implantation.
Neeraj Agarwal, MD, led a global study analyzing the combination of two cancer drugs to treat metastatic prostate cancer. Results showed this reduces the risk of cancer progression by 55%.
MD Anderson and Replay announced that the FDA has issued a 'safe to proceed' for the Investigational New Drug application for NY-ESO-1 TCR/IL-15 NK, an engineered T cell receptor natural killer (TCR NK) cell therapy for sarcoma.
Receiving rapid access to testosterone therapy reduced feelings of gender dysphoria and led to a clinically significant reduction in depression as well as a 50% reduction in suicidality among transgender and gender diverse adults, according to research being presented Sunday at ENDO 2023, the Endocrine Society’s annual meeting in Chicago.
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