A fatal genetic disorder that frequently takes years to diagnose may soon be detectable with a simple blood test. For patients with Niemann-Pick type C disease, the test will make it possible to begin treatment earlier, when it is more likely to improve quality of life and to further extend lives.
Researchers at the University of California, San Diego School of Medicine have discovered that a multi-tasking protein called FoxO1 has another important but previously unknown function: It directly interacts with macrophages, promoting an inflammatory response that can lead to insulin resistance and diabetes.
A University at Buffalo endocrinologist has received a three-year $400,000 Junior Faculty Award from the American Diabetes Society to study the effects of low testosterone levels in young men with type 2 diabetes.
New findings by UT Southwestern Medical Center researchers suggest a novel role for the brain in mediating beneficial actions of the hormone leptin in type 1 diabetes.
Phone calls with a peer facing the same self-management challenges helped diabetes patients manage their conditions and improved their blood sugar levels better than those who used traditional nurse care management alone.
Mount Sinai School of Medicine researchers have found that a gene associated with the onset of Type 2 diabetes also is found at lower-than-normal levels in people with Alzheimer’s disease.
University of Michigan scientists have identified events inside pancreatic cells that set the stage for a neonatal form of non-autoimmune Type 1 diabetes, and may play a role in Type 2 diabetes.
A rapid increase in the number of hospitalizations due to diabetes for young adults – particularly young women – echoes the dramatic increase in rates of obesity across the United States in the last 30 years, according to a U-M study published in Journal of Women’s Health.
A clinical trial at UT Southwestern Medical Center aims to determine whether adding the hormone leptin to standard insulin therapy might help rein in the tumultuous blood-sugar levels of people with type 1 (insulin-dependent) diabetes.
Maike Sander, MD, associate professor of pediatrics and cellular & molecular medicine at the University of California, San Diego School of Medicine has been awarded nearly $5 million by the Beta Cell Biology Consortium (BCBC) to lead an interdisciplinary team in cell therapy research for type 1 diabetes.
Researchers at the Johns Hopkins University School of Nursing seek solutions for diabetes and its subsequent effects on patients.
Research findings at Sanford-Burnham point to new ways to treat type 1 and type 2 diabetes.
NYU Langone Medical Center endocrinologists can comment on all aspects of diagnosing and treating diabetes.
A research team led by Mount Sinai School of Medicine has identified the mechanism behind a single gene linked to the causes of both Alzheimer’s disease and Type 2 diabetes. The data show that a gene for a protein called SorCS1, which can cause Type 2 diabetes, impacts the accumulation of amyloid-beta (Abeta) in the brain. Abeta plays a key role in the development of Alzheimer’s disease.
International experts in type 2 diabetes will gather in Rome on September 27-28 to discuss how metabolic surgery may open new treatment opportunities for the disorder, which is on the rise worldwide.
An intensive lifestyle intervention appears to help individuals with type 2 diabetes lose weight and keep it off, along with improving fitness, control of blood glucose levels and risk factors for cardiovascular disease, according to a report in the September 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Physician discusses type 1 diabetes, early recognition and signs.
Taking chromium picolinate may help lessen inflammation associated with diabetic nephropathy (kidney disease), say researchers. In a study comparing diabetic mice treated with chromium picolinate with those that received placebo, the researchers found that mice who received the supplement had lower levels of albuminuria (protein in the urine), an indication of kidney disease.
Researchers from Albert Einstein College of Medicine of Yeshiva University will hold a congressional briefing in Washington, D.C., aimed at focusing attention on the alarming global diabetes epidemic. Incidence of diabetes is increasing worldwide at a rate that eclipses most other diseases. The World Health Organization estimates that by the year 2030, more than 366 million people will be suffering from diabetes, 10 times the number affected by HIV/AIDS. Of that 366 million, more than 298 million will live in developing countries.
South Asians living in the United States are at much higher risk for type 2 diabetes than are whites and immigrants from other Asian countries, a new small study reveals.
Children who have a high risk of developing type 2 diabetes might be identified earlier by way of tell-tale biomarkers being sought in research funded by the U.S. Department of Agriculture (USDA) and the National Institutes of Health.
Between 1997 and 2007, the proportion of Americans treating their diabetes with oral medications increased from 60 percent to 77 percent; the proportion taking insulin decreased from 38 percent to 24 percent.
A diabetes self-management education program delivered by community health workers may be effective in improving the blood sugar levels and behavioral skills among Hispanics/Latinos with type 2 diabetes, according to a recent University of Illinois at Chicago study.
U.S. Rep. Danny Davis will give opening remarks when the Institute of Medicine of the National Academies convenes a regional meeting Sept. 21 at the University of Illinois at Chicago to discuss the rapidly rising rates of diabetes and obesity in the U.S.
Web site features trilingual support, interactive nutrition guides for Asian meals and other culturally relevant information.
Researchers at the Buck Institute for Age Research have discovered a novel way in which insulin affects cell metabolism and cell survival. Surprisingly the insulin signaling pathway, which is involved in aging, diabetes and stress response, is active at a deeper level of cell activity than scientists expected.
Researchers at the University of California, San Diego School of Medicine have identified the molecular mechanism that makes omega-3 fatty acids so effective in reducing chronic inflammation and insulin resistance.
Older adults with diabetes who have high blood pressure, walk slowly or lose their balance, or believe they’re in bad health, are significantly more likely to have weaker memory and slower, more rigid cognitive processing than those without these problems, according to a new study published by the American Psychological Association.
Many middle-aged and older adults with diabetes are sexually active, according to a new survey. Seventy percent of partnered men with diabetes and 62 percent of partnered women with diabetes engaged in sexual activity two or three times a month, comparable to those without diabetes. The disease takes a toll, however, on the desire for and rewards of sexual activity.
People with insulin resistance and type 2 diabetes appear to be at an increased risk of developing plaques in the brain that are associated with Alzheimer’s disease, according to new research published in the August 25, 2010, issue of Neurology®, the medical journal of the American Academy of Neurology.
Examination of a gene involved in cell signaling finds that four common variants of this gene are associated with the development of end-stage renal disease in Chinese patients with type 2 diabetes, according to a study in the August 25 issue of JAMA.
People with diabetic foot problems can lower their risk of leg amputation by relying on coordinated care that includes a podiatrist, according to a recent study.
U.S. hospitals spent $83 billion in 2008 caring for people with diabetes, nearly one of every five hospitalizations that year.
Joslin scientists nail down proof that some people with type 1 diabetes of extreme duration retain active insulin-producing cells.
Nearly 30 percent of U.S. adults with diabetes over the age of 40 are estimated to have diabetic retinopathy, with about 4 percent of this population having vision-threatening retinopathy, according to a study in the August 11 issue of JAMA.
Researchers looking for differences in eating habits of African Americans based on whether or not they had Type 2 diabetes uncovered an unexpected result: No matter what the blood sugar level was, the dietary intakes were pretty much the same.
A study by researchers at NYU Langone Medical Center have found that obese adolescents with type 2 diabetes have diminished cognitive performance and subtle abnormalities in the brain as detected by Magnetic Resonance Imaging (MRI). Identification of cognitive impairments as a complication of type 2 diabetes emphasizes the importance of addressing issues of inactivity and obesity, two important risk factors for the development of the disease among the young. The study appeared online in the journal Diabetologia, July 30, 2010.
Resveratrol, a popular anti-inflammatory and antioxidant plant extract, appears also to suppress inflammation in humans, based on results from the first prospective human trial of the extract conducted by University at Buffalo endocrinologists.
Jennifer Dyer, MD, MPH, an endocrinologist at Nationwide Children’s Hospital, has developed and completed a pilot study that uses weekly, customized text messages to remind adolescent diabetes patients about their personal treatment activities. At the conclusion of the study, Dr. Dyer found an increase in overall treatment adherence and improved blood glucose levels.
Aggressive blood sugar control does not improve survival in diabetic patients with kidney failure, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that physicians should individualize blood sugar targets for these patients and not rely on recommendations based on studies in the general population.
Postmenopausal women with diabetes taking thiazolidinediones (TZDS), including rosiglitazone and pioglitazone, may be at increased risk for fractures according to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM). Men with diabetes taking both loop diuretics and TZDs may also be at increased risk of fractures.
In high-risk adults with type 2 diabetes, researchers have found that two therapies may slow the progression of diabetic retinopathy, an eye disease that is the leading cause of vision loss in working-age Americans.
Researchers led by Columbia University Medical Center have discovered that the skeleton plays an important role in regulating blood sugar and have further illuminated how bone controls this process. The finding, published in Cell, is important because it may lead to more targeted drugs for type 2 diabetes.
A new study by Johns Hopkins researchers has found that insulin, the sugar-regulating hormone, is required for normal bone development and that it may provide a link between bone health and metabolic disease, such as diabetes.
Discovery raises possibility of safer, more selective diabetes drugs.
Studying a protein already known to play an important role in type 2 diabetes and cancer, genomics researchers have discovered that it may have an even broader role in human disease.
The VA Maryland Health Care System participated in a landmark national study of more than 10,251 high-risk diabetic adults across the nation, testing if three complementary treatment strategies can reduce the high rate of heart disease and stroke associated with type 2 diabetes and if these treatment strategies can also slow the progression of eye disease associated with diabetes, the leading cause of blindness in working-age Americans.
UNC researchers reveal how a protein called Tet1 helps stem cells keep their “stemness” in a paper published in Nature.
Biologists have been studying how the protein AMPK works for several decades and know that once it is activated, AMPK turns on a large number of genes by passing the "make more energy" message through numerous signaling cascades in the cell. What was not known, until now, was that AMPK also works via an epigenetic mechanism to slow down or stop cell growth. Researchers found that AMPK binds directly to sites on chromosomes called promoters that regulate gene expression related to cell metabolism.
A morning urine test is superior to all other tests for detecting declining kidney performance in patients with diabetic kidney disease, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results suggest that clinicians should monitor kidney function by measuring the albumin:creatinine ratio from a first morning urine sample.
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