De acuerdo con la investigación dirigida por la Alianza para Ensayos Clínicos en Oncología y el Centro Oncológico Integral de Mayo Clinic, las pacientes que tengan varios tumores en una sola mama podrían evitar una mastectomía si los tumores se pueden extraer dejando bastante tejido mamario.
Yale Cancer Center (YCC) and Smilow Cancer Hospital (SCH) physicians and scientists are presenting research studies at the 2023 American Association for Cancer Research (AACR) Annual Meeting at the Orange County Convention Center in Orlando, Florida, April 14 to 19th.
A trio of premier Southwest biomedical research centers — HonorHealth Research Institute, City of Hope and the Translational Genomics Research Institute (TGen), part of City of Hope — have developed a more precise method that may help determine when it is best to surgically remove of pancreatic cancer tumors.
In this randomized clinical trial, anakinra did not prevent the need for mechanical ventilation or reduce mortality risk compared with standard of care alone among hospitalized patients with severe COVID-19 pneumonia. Future research should assess anakinra in patients with less severe pneumonia.
After helping to develop and test new mRNA technologies for COVID-19 vaccines, University of Maryland School of Medicine (UMSOM) researchers and scientists are turning their attention to utilizing this innovative technology to ward off other infectious diseases like malaria and influenza.
Read about cutting-edge cancer research centered around elephant genes, a new clinical trial, and grants to study vaccination hesitance in the Mountain West as well as chronic lymphocytic leukemia.
In an analysis of published clinical trials, investigators found that phototherapy—or exposure to sessions of bright light—may be a promising non-pharmacological intervention for lessening symptoms of dementia.
Hackensack University Medical Center is the only site in New Jersey that is participating in the ROADSTER 3 clinical trial to assess real-world outcomes for patients with carotid artery disease who have an average surgical risk and undergo a minimally invasive surgical procedure called transcarotid artery revascularization (TCAR).
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Spinal cord stimulation (SCS) has demonstrated effectiveness for neuropathic pain. Unfortunately, some patients report inadequate long-term pain relief. Patient selection is emphasized for this therapy; however, the prognostic capabilities and deployment strategies of existing selection techniques, including an SCS trial, have been questioned.
The NANT pediatric cancer consortium at Children’s Hospital Los Angeles has published results of a phase 1 trial for high-risk neuroblastoma.
A significant clinical trial under the direction of Michael Kappelman, MD, MPH, professor of pediatrics at UNC School of Medicine, found that patients receiving the tumor necrosis factor inhibitor adalimumab combined with a low dose of methotrexate, a second immunosuppressant, did better than those treated with infliximab alone. Patients who received infliximab, another tumor necrosis factor inhibitor, had similar outcomes with or without methotrexate.
In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children’s Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma.
A groundbreaking human clinical trial published in the Journal of Biochemistry and Biotechnology reveals AstraGin®'s significant impact on various factors related to gut health in patients with Ulcerative Colitis (UC).
More than 75% of patients facing amputation from the most severe form of peripheral artery disease were able to keep their limb after an innovative treatment as part of a multicenter study published in the . The alternative to amputation, known as “limb salvage,” for patients with chronic limb-threatening ischemia (CLTI) came from the PROMISE II clinical trial.
A novel approach to administer intrathecal (IT) immunotherapy (directly into the spinal fluid) and intravenous (IV) immunotherapy was safe and improved survival in a subset of patients with leptomeningeal disease (LMD) from metastatic melanoma, according to interim analyses of a Phase I/Ib trial led by researchers at The University of Texas MD Anderson Cancer Center.
A newly published study paves the way for some patients with testicular cancer to avoid chemotherapy and radiation.
A new drug combination for men with advanced prostate cancer has shown sustained increase in survival rates.
A study, co-led by University Hospitals Harrington Heart & Vascular Institute, could lead to the first FDA approval of a therapy giving thousands of patients hope for an alternative to amputation.
Antiphospholipid syndrome is a understudied autoimmune disease that is nevertheless a leading causes of deadly blood clots and late-term pregnancy loss. An international study led by the University of Michigan researchers Ray Zuo, M.D., and Jason Knight, M.D., Ph.D., has discovered a new class of functional autoantibodies in APS patients that contributes to the disease's development and the systemic inflammation it induces.
Patients who have multiple tumors in one breast may be able to avoid a mastectomy if the tumors can be removed while leaving enough breast tissue, according to research led by the Alliance in Clinical Trials in Oncology and Mayo Clinic Comprehensive Cancer Center.
Cedars-Sinai and BlackDoctor.org will host a virtual community conversation about the importance of increasing diverse representation in medical research.
From septic shock to sticker shock. Keep up with this ever-growing, changing sector. Below are some of the latest stories on healthcare on Newswise.
The results of two clinical trials, presented today at the Society of Gynecologic Oncology (SGO) 2023 Annual Meeting on Women’s Cancer, showcased adding immunotherapy to standard chemotherapy resulted in significantly longer progression-free survival (PFS) among patients with advanced or recurrent endometrial cancer (EC).
The Departments of Neurology and Neurosurgery at Cedars-Sinai highlighted progress against Alzheimer’s disease, Parkinson’s disease, ALS, multiple sclerosis, brain cancer and stroke in their 2023 Annual Report, which also details advancements in spine surgery.
After resolving missing data burdens, the ENGOT-OV16/NOVA (NCT01847274) study data shows no difference in overall survival for platinum-sensitive recurrent ovarian cancer (PSROC) patients who received PARP inhibitor niraparib maintenance therapy (MT) and those who did not. Results from the trial were presented today at the Society of Gynecologic Oncology (SGO) 2023 Annual Meeting on Women’s Cancer by Ursula Matulonis, MD, of the Dana-Farber Cancer Institute.
Administering PARP inhibitor (PARPi) olaparib prior to surgical intervention and chemotherapy in ovarian cancer patients – a new approach – is feasible and resulted in favorable surgical options, managed adverse events, and positive health outcomes, according to results from the Neoadjuvant Olaparib Window (NOW) Trial presented today by Shannon Westin, MD et al. at the Society of Gynecologic Oncology (SGO) 2023 Annual Meeting on Women’s Cancer.
Researchers have developed a molecule that is, when administered nasally, extremely effective in preventing the disease caused by all known variants of the SARS-CoV-2 virus.
An investigational molecule has been shown to improve kidney function in people with one form of chronic kidney disease in a small phase 2 clinical trial. Martin Pollak, MD, discusses the journey from research question to potential cure.
Staphylococcus aureus, Clostridioides difficile, Candida auris, Drug-resistant Shigella. These bacteria not only have difficult names to pronounce, but they are also difficult to fight off. These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria. Antimicrobial resistance is an urgent global public health threat.
The combination of two oral medications has shown positive results in people with prostate cancer, whose disease has spread to other parts of the body. Compared with XTANDI plus placebo, the investigatory combination of TALZENNA and XTANDI demonstrated a statistically significant and clinically meaningful improvement in radiographic progression-free survival.
A recent study published in JAMA demonstrates the effectiveness of a procedure done under the skin, similar to placing a stent, to treat uncontrolled hypertension, or blood pressure that cannot be controlled despite the use of blood pressure control drugs and agents.
Keck Medicine of USC has launched a Phase 2 clinical trial investigating the effectiveness of a new outpatient, nonsurgical endoscopic procedure in stabilizing blood glucose levels for patients.
Researchers from The University of Texas MD Anderson Cancer Center showed that inhibiting menin with revumenib, previously known as SNDX-5613, yielded encouraging responses for advanced acute leukemias with KMT2A rearrangements or mutant NPM1. Findings from the Phase I AUGMENT-101 trial were published today in Nature.
In a study published in the New England Journal of Medicine co-authored by Vibhor Krishna, MD, associate professor of neurosurgery at the UNC School of Medicine, researchers show that a new focused ultrasound treatment improved dyskinesia and motor impairment in patients with Parkinson’s disease.
Um plugue absorvível entregou terapia com células-tronco com poucos efeitos colaterais em pacientes com fístulas perianais de trato único, segundo descoberta de pesquisadores da Mayo Clinic.
Los investigadores de Mayo Clinic descubrieron que un tapón soluble administró terapia con células madre ocasionando pocos efectos secundarios en pacientes con fístulas perianales de un solo trayecto.
توصّل باحثو مايو كلينك إلى إمكانية العلاج بالخلايا الجذعية عبر سدادة قابلة للذوبان لديها آثارٌ جانبية قليلة على المرضى المصابين بالناسور الشرجي أحادي السبيل. النواسير الشرجية هي ممرات مؤلمة بين الأمعاء والجلد، ولا تُشفى عادةً بالرعاية الطبية أو الجراحية القياسية. إن المصابين بداء كْرون أو غيره من حالات التهاب الأمعاء هم الأكثر عرضة لخطر الإصابة بهذه الحالة المرضية.
Hackensack University Medical Center interventional cardiologists are regional leaders in the multicenter national PROTECT IV clinical trial, which is evaluating the effectiveness of a novel treatment for high-risk patients with complex heart disease and reduced heart function who require cardiac catheterization.
The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections. Researchers have now discovered that a new class of oral drugs that acts directly on human cells can inhibit a diverse range of pathogenic SARS-CoV-2 strains. In their newly published study, the team found a novel mechanism through which the gene that expresses angiotensin converting enzyme-2 (ACE-2)—the cellular receptor to which SARS-CoV-2 binds so that it can enter and infect the cell—is turned on.
Treatment with an FDA-approved cannabidiol (CBD) oil product does not lower pain scores after surgical treatment and stent placement for patients with urinary stones, reports a clinical trial in the April issue of The Journal of Urology®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Keck Medicine of USC has launched a clinical trial to study the effect of a novel hormone replacement therapy on postmenopausal cardiovascular disease and cognitive decline.
The Patient-Centered Outcomes Research Institute (PCORI) recently awarded researchers at Wake Forest University School of Medicine $10.2 million to study the effectiveness of an individualized model of hemodialysis, a procedure in which the blood is cleaned by a dialysis machine. The project is a collaboration between the School of Medicine, the Renal Research Institute and other health care systems across the country.
In an effort to improve clinical trial diversity, researchers at The Ohio State University Wexner Medical Center and College of Medicine led a study to create solutions to barriers of access, awareness, discrimination and racism and workforce diversity.
Announcement that the Patient-Centered Outcomes Research Institute (PCORI) tapped University Hospitals (UH) as one of 42 health systems nationwide to carry out a pioneering initiative to accelerate the implementation of practice-changing research results in clinical care to improve patients’ outcomes.
Cedars-Sinai has selected Bruce L. Gewertz, MD, the medical center’s surgeon-in-chief, to be the vice dean of Clinical System Development and Faculty Affairs.
Juvenile dermatomyositis, a rare but often severe and chronic systemic autoimmune disease, includes a large number of patients who are treatment resistant, requiring long term immunosuppressive therapy. A small open-label study published in Arthritis and Rheumatology shows promise using a targeted biologic therapy called abatacept to treat such patients.
A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells. The authors published their results on Jan. 19 in the journal Molecular & Cellular Proteomics.
A novel compound that has the potential to starve the bacteria that causes tuberculosis – the world’s leading infectious killer after SARS-CoV2 – is entering human clinical trials.
Denovo Biopharma LLC ("Denovo"), a pioneer in applying precision medicine to the development of innovative therapies, set up a gene registry web portal and invites people who suffer from treatment-resistant depression (TRD) to visit www.iMatchDepression.com to help identify whether they or someone they know may be eligible to participate in a biomarker-guided global Phase 2b clinical trial (the "ENLIGHTEN" study).
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