For nearly two decades, how kidney cancer becomes resistant to rapalog drugs has baffled the scientific community. Now a study by researchers at UT Southwestern Medical Center’s Kidney Cancer Program sheds light.
In a large clinical trial, UT Southwestern Medical Center researchers developed a robust model for testing strategies to prevent health problems in patients with multiple chronic conditions.
Strong family relationships have long been associated with a better sense of well-being and connection. Now a team led by UT Southwestern Medical Center researchers has linked the quality of those relationships with how successfully people – particularly aging African Americans – manage pain.
Exercising at a high level doesn’t affect the progression of calcium buildup in the arteries, even among older athletes such as marathoners who tend to have higher coronary artery calcium (CAC) scores, according to new research from UT Southwestern Medical Center. But a longer duration of exercise is associated with higher CAC.
A new initiative funded by The University of Texas System and the state of Texas seeks to improve care for trauma patients, including both service members and civilians.
Two genes working in tandem play a critical role in shaping the identity and behavior of prostate cancer cells and their response to treatment, UT Southwestern Medical Center researchers report.
A novel speech analysis tool that uses artificial intelligence successfully detected mild cognitive impairment and dementia in a Spanish-speaking population, according to research led by UT Southwestern Medical Center. The study, published in Frontiers in Neurology, provides preliminary support for the algorithm as an early screening tool that may help identify patients at risk of developing dementia.
In 2021, researchers at UT Southwestern Medical Center used artificial intelligence and deep machine learning to analyze 1.7 million raw images of patient-derived tumor samples, pinpointing a key distinction between skin cancer cells with high and low potential to metastasize – a discovery that could ultimately mean the difference between life or death for patients.
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In 2023, the U.S. Food and Drug Administration in 2023 approved the world’s first leadless dual-chamber pacemaker, a potential gamechanger for the nearly 80% of patients who require pacing of both the upper and lower chambers of the heart. UT Southwestern is one of just nine heart centers in Texas to offer this advanced technology, which implants two capsule-shaped devices smaller than AAA batteries directly inside the heart in a catheter-based procedure, with no large incisions and no lead wires.
As the warm weather and summer vacations draw more people outdoors, a UT Southwestern Medical Center cancer specialist is reminding everyone to stay vigilant of potential sun damage. Skin cancer is mainly caused by ultraviolet radiation from the sun. And while it is the most common of all cancers in the U.S., it is also one of the most avoidable forms of the disease.
A new study focused on the gene tied to a rare form of autism spectrum disorder (ASD) called FOXP1 syndrome offers hope that gene therapy might be able to help patients with this condition.
The number of mutations in the DNA of cancerous tumors may not be an indicator of how well patients will respond to immune checkpoint inhibitors (ICIs), a commonly prescribed type of immunotherapy, a team led by UT Southwestern Medical Center researchers reported in a retrospective study. The findings, published in Nature Cancer, upend long-held conventional wisdom and could lead to more effective ways of deciding which patients will benefit most from this type of treatment.
Researchers at UT Southwestern Medical Center have developed a novel artificial intelligence (AI) model to improve the detection of breast cancer metastasis, which could reduce the need for needle or surgical biopsies.
Patients with fibromyalgia and irritable bowel syndrome (IBS) who take multiple medications are more likely to develop severe drug intolerance than healthy patients, UT Southwestern Medical Center researchers reported. Their findings, published in The Journal of Allergy and Clinical Immunology: In Practice, could help health professionals prescribe drugs for patients and identify treatment plans for multiple drug intolerance syndrome (MDIS).
A unique collaboration between two UT Southwestern Medical Center labs - one that studies bacteria and another that studies viruses - has identified two immune proteins that appear key to fighting infections.
By completely or even partially depleting a protein called midnolin in B cells, UT Southwestern Medical Center researchers suppressed leukemia and lymphoma in a mouse model genetically prone to these cancers. Their findings, reported in the Journal of Experimental Medicine, could lead to new treatments for these diseases that avoid the serious side effects of current therapies.
A team led by researchers at UT Southwestern Medical Center developed deep learning models to identify a simple set of rules that govern the activity of promoters – regions of DNA that initiate the process by which genes produce proteins. Their findings, published in Science, could lead to a better understanding of how promoters contribute to gene regulation in health and disease.
Blue light improves bladder cancer detection across races; Gamma waves distinguish goal-oriented movements; Giving abnormal bone formation a closer look; Dissecting the HIV-1 transcriptional circuitry
ChatGPT, the artificial intelligence (AI) chatbot designed to assist with language-based tasks, can effectively extract data for research purposes from physicians' clinical notes, UT Southwestern Medical Center researchers report in a new study. Their findings, published in NPJ Digital Medicine, could significantly accelerate clinical research and lead to new innovations in computerized clinical decision-making aids.
Total knee replacements performed with the help of a surgical robot have better outcomes on average than similar surgeries performed manually but can cost significantly more, a new study by UT Southwestern Medical Center researchers shows. T
More people are using online patient portals to view their information while in the emergency room, but access is challenging for members of medically underserved communities and the elderly, UT Southwestern Medical Center researchers and national colleagues found in a new study.
A drug that targets a protein known as phosphatidylserine boosted the response rate for hepatocellular carcinoma (HCC) patients receiving immunotherapy without compromising their safety, according to results of a phase two clinical trial conducted by UT Southwestern Medical Center.
By examining which genes were turned on and off in a mix of cell types from breast cancer biopsies, a team led by UT Southwestern Medical Center researchers developed a tool that can accurately predict which patients with breast cancer will respond to immunotherapies.
Shutting down a gene called PRMT5 stopped metastatic estrogen receptor-positive (ER+) breast cancer cells from growing after they acquired resistance to a standard therapy known as CDK4/6 inhibitors, UT Southwestern Medical Center researchers showed in a new study.
Patients with a common movement disorder known as essential tremor (ET) developed dementia at three times the rate of similarly aged people in the general population, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in the Annals of Neurology, provide the first concrete data to help doctors counsel those with this condition on their cognitive prognosis, future plans, and potential treatments, the authors said.
In a groundbreaking phase one clinical trial led by UT Southwestern Medical Center, a short interfering RNA (siRNA) drug directed to tumor cells effectively disrupted HIF2α, a key driver of clear cell renal cell carcinoma (ccRCC). Published in Clinical Cancer Research, the findings illustrate the potential of siRNA for cancer therapy.
An intricate simulation performed by UT Southwestern Medical Center researchers using one of the world’s most powerful supercomputers sheds new light on how proteins called SNAREs cause biological membranes to fuse.
Heart failure patients may one day be able to restore cardiac function with medications that revive the body’s ability to regenerate heart muscle, a novel study at UT Southwestern Medical Center suggests.
Women who take oral contraceptives may be significantly less likely to experience certain musculoskeletal injuries than women who do not take the drugs or men, according to a study by UT Southwestern Medical Center.
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Caring for someone with dementia or Alzheimer’s disease is challenging. In addition to the financial and physical demands, many caregivers are unprepared for the stress of trying to effectively communicate with a loved one who may be prone to agitation, verbal aggression, and hallucinations.
Humans aren’t the only living beings who find a singing voice attractive in the opposite sex – songbirds do too. For about a third of the approximately 4,000 songbird species that sing only one song, the features that make these tunes alluring to a potential mate have been a long-standing mystery.
Proteins known as oligomeric chaperones help suppress the formation of misshaped proteins that cause a variety of degenerative and neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s. In a new study, UT Southwestern Medical Center researchers identified a key feature necessary for one of these oligomeric chaperones, known as DNAJB8, to assemble from disparate parts and showed that the parts alone can reshape misfolded proteins. The findings, published in Structure, could lead to better ways to diagnose and treat these conditions.
Labor induction with vaginal misoprostol during childbirth achieves vaginal delivery rates similar to the oral alternative while significantly reducing the need for oxytocin, the most commonly used labor-inducing drug, UT Southwestern Medical Center researchers report.
A lump under the arm. Coughing that won’t go away. These can be the first signs of cancer – and a wake-up call that early detection and screening could save your life.
By focusing on a poxvirus protein, a team led by UT Southwestern Medical Center scientists has discovered an antiviral immune pathway that broadly fights a wide variety of viruses. Their findings, reported in Nature Microbiology, could eventually lead to new ways to prevent or treat viral infections or thwart autoimmune diseases.
Roundup of recent research involving UT Southwestern faculty members: Antibody treatment lowers risk for food allergies; Weight-loss surgery support offered for teens; Racial disparities found among pregnant patients with multiple sclerosis; Gestational age increased at start of COVID-19 pandemic
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A gene therapy developed by researchers at UT Southwestern Medical Center for a rare disease called giant axonal neuropathy (GAN) was well tolerated in pediatric patients and showed clear benefits, a new study reports. Findings from the phase one clinical trial, published in the New England Journal of Medicine, could offer hope for patients with this rare condition and a host of other neurological diseases.
The composition of the gut microbiomes in a group of rectal cancer patients reveals distinct signatures by race, ethnicity, and age of onset, with white Hispanics showing significant presence of one specific type of bacteria, UT Southwestern Medical Center researchers report.
UT Southwestern Medical Center has joined more than a dozen leading medical centers and Microsoft to form the Trustworthy & Responsible AI Network (TRAIN), a national group designed to set standards and safely explore applications of artificial intelligence (AI) in health care.
Surgical nerve decompression, used to treat conditions such as carpal tunnel syndrome and sciatica, could play a role in relieving the pain of diabetic neuropathy patients, researchers at UT Southwestern Medical Center found.
Moncrief Cancer Institute debuted its new Mobile Screening Clinic prior to the Tarrant County Commissioners Court meeting today. The $1 million, 36-foot cancer screening clinic was funded by Tarrant County through a three-year, $9 million grant awarded to Moncrief Cancer Institute in 2022. Part of the federal funding Tarrant County received through the American Rescue Plan Act (ARPA), the grant enabled Moncrief to expand its comprehensive cancer screening program to more underserved residents in Tarrant County.