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Newswise Special Wire
Tuesday, December 18, 2018

Public edition |

Newswise Cancer Research Wire for 18-Dec-2018

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Your Postal Code May Influence Your Health

Researchers at McMaster University have identified trends linking health and lifestyle factors like access to public transit, the variety of fresh fruits and vegetables in grocery stores, the prices of popular foods, the availability and prices of ci...

– McMaster University

Cities and Health

Embargo expired on 18-Dec-2018 at 00:05 ET

Two Ways Cancer Resists Treatment Are Actually Connected, with One Activating the Other

Researcher shows the two most common means of resistance to BRAF and MEK inhibitors are actually connected processes and can be targeted by other therapies.

– Perelman School of Medicine at the University of Pennsylvania

Cancer Discovery; R01CA169134; P01 CA114046; P01 CA165997; P30 CA016520; SPORE P50 CA174523; R01CA198015

Embargo expired on 18-Dec-2018 at 11:00 ET

Prostate cancer scoring method may underestimate mortality risk in black men

Black men diagnosed with prostate cancer classified as low risk may actually have a more aggressive form of the disease that is more likely to be fatal than in nonblack men placed in the same prognostic category, a new study suggests.

– Dana-Farber Cancer Institute

JAMA, Dec-2018

Embargo expired on 18-Dec-2018 at 11:00 ET

Vaccine, Checkpoint Drugs Combination Shows Promise for Pancreatic Cancers

Researchers at the Johns Hopkins Kimmel Cancer Center discovered a combination of a cancer vaccine with two checkpoint drugs reduced pancreatic cancer tumors in mice, demonstrating a possible pathway for treatment of people with pancreatic cancers wh...

– Johns Hopkins Medicine

JCI Insight

FSU Researchers Identify Ways Breast Cancer Avoids Immune System Detection

Researchers analyzed data from more than 1,000 breast cancer patients and found that breast cancer behaves differently than other cancers that are currently treated with immunotherapy. They identified seven clusters of breast cancer patients based o...

– Florida State University


Cancer Caregivers: How to Manage ‘Happy’ During the Holidays

Families and caregivers of people with cancer may view the holidays as a particularly challenging time, often feeling as though they have to live up to the ideal of merry and bright, when they—and those they’re tending—typically don’t feel th...

– Cedars-Sinai

New approach to bowel cancer analysis could lead to better prognosis for patients

Researchers at Queen’s University Belfast have discovered a new way to analyse bowel cancer tumours, which could lead to more personalised treatments and better prognosis for patients.

– Queen's University Belfast

Journal of Pathology,December 2018

An Online Intervention to Reduce Skin Cancer in Young Adults

Rutgers Cancer Institute of New Jersey is leading a research study aimed at improving skin cancer protection behaviors in young adults through an online intervention.

– Rutgers Cancer Institute of New Jersey

American Journal of Preventive Medicine

NIH scientists find that breast cancer protection from pregnancy starts decades later

In general, women who have had children have a lower risk of breast cancer compared to women who have never given birth. However, new research has found that moms don’t experience this breast cancer protection until many years later and may face el...

– National Institute of Environmental Health Sciences (NIEHS)

Annals of Internal Medicine, Dec-2018; Z01ES044005; UM1CA176726; UM1CA186107; UM1CA164974; R01CA058420; R01CA092447; P50CA168504; KL2TR001109...

A Holiday Gift to Primary Care Doctors: Proof That There’s Not Enough Time For Everything They’re Expected to Do

The average primary care doctor needs to work six more hours a day than they already do, in order to make sure their patients get all the preventive and early-detection care they deserve, a new study finds. Fortunately, the new study was written as a...

– Michigan Medicine - University of Michigan

BMJ 2018; 363 doi:

Study identifies location of DNA that gives clues to hidden cancer mutations

A new study by UCLA scientists shows that enhancers, snippets of DNA that contribute to gene regulation, fall into the same “insulated neighborhoods” or chromatin loops as the target gene and other gene-specific regulatory elements.

– University of California, Los Angeles (UCLA), Health Sciences

Molecular Cell

E-Cigarette Users Have Lower Exposure to Toxicants — As Long As They Don’t Smoke Combustible Cigarettes Too

The largest study to date to compare exposure to toxicants among users of electronic cigarettes, smokers and nonsmokers has been completed, suggesting possible benefits for smokers who switch completely to electronic cigarettes

– Roswell Park Comprehensive Cancer Center

Jama Network Open

BIDMC’s Research & Health News Digest: December 2018 Edition

A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

– Beth Israel Deaconess Medical Center

The “Greying” of T Cells

Research in mouse cells identifies defective metabolic pathway in aging immune T cells. The pathway is critical for switching T cells from dormancy into illness-fighting mode. In experiments, researchers restored lagging T-cell function by adding s...

– Harvard Medical School


Cancer patients face higher risk for shingles, new vaccines hold promise for prevention

People newly diagnosed with cancer, particularly blood cancers, and those treated with chemotherapy have a greater risk of developing shingles, according to a new study in the Journal of Infectious Diseases. The findings may help guide efforts to pre...

– Infectious Diseases Society of America (IDSA)

Journal of Infectious Diseases

Exercise Significantly Cuts the Risk of Death from Cancer

New research out of Roswell Park Comprehensive Cancer Center shows that cancer patients who exercise regularly both before and after their diagnosis are significantly more likely to survive than those who are sedentary, adding to the growing body of ...

– Roswell Park Comprehensive Cancer Center

Cancer Causes & Control

Fred Hutch 2018 highlights: immunotherapy, prevention strategies, precision screening, value-based care and more

Summaries of this year’s notable advances at Fred Hutchinson Cancer Research Center and beyond.

– Fred Hutchinson Cancer Research Center

Seeing Small-Molecule Interactions Inside Cells (Video)

Like people in a large company, proteins in cells constantly interact with each other to perform various jobs. To develop new disease therapies, researchers are trying to control these interactions with small-molecule drugs that cause specific protei...

– American Chemical Society (ACS)

Analytical Chemistry

Exercise Following Weight Loss May Reduce Colorectal Cancer Risk, Study Finds

New research suggests that exercise is a key factor in reducing colorectal cancer risk after weight loss. According to the study, physical activity causes beneficial changes in the bone marrow. The study is published ahead of print in the American Jo...

– American Physiological Society (APS)

American Journal of Physiology—Endocrinology and Metabolism

What can a snowflake teach us about how cancer spreads in the body?

Conventional math cannot adequately model the interaction of multiple genes over multiple time frames – a necessary foundation for any cancer-fighting drugs. The study, published in “Frontiers in Physiology” by Mahboobeh Ghorbani, Edmond Jonckh...

– University of Southern California Viterbi School of Engineering

DARPA Young Faculty Award; National Science Foundation Career ; Defense Advanced Research Projects Agency

Loss of Tight Junction Protein Promotes Development of Precancerous Cells

BIDMC researchers demonstrated that the lack of claudin 18 prompts the development of precancerous, abnormal cells and polyps in the engineered mouse model.

– Beth Israel Deaconess Medical Center


Mayo Clinic研究人员发现可能改善CAR-T细胞治疗的新策略

Mayo Clinic的研究人员开发了两种新策略,可以提高嵌合抗原受体疗法(CAR-T细胞疗法)在治疗癌症方面的效果。Mayo Clinic研究人员在圣地亚哥举行的2018年美国血液学学会年会上展示了他们的临...

– Mayo Clinic

Mayo 研究人员:口服阿哌沙班治疗癌症患者血栓安全有效


– Mayo Clinic

The annual meeting of the American Society of Hematology

الباحثون لدى Mayo: أبيكسابان الفموي آمن وفعال لعلاج جلطات مرضى السرطان

سان دييغو —اكتشف الباحثون لدى Mayo Clinic أن العقار الفموي أبيكسابان الذي يُستخدم لعلاج جلطات الدم لدى المرضى الذين يُعالَجون من مرض السرطان ...

– Mayo Clinic

الباحثون لدى Mayo Clinic يحددون استراتيجيات جديدة قد تحسن العلاج بالخلايا التائية خيمرية المستضد (CAR-T cell)

سان دييغو — طوّر الباحثون لدى Mayo Clinic استراتيجيتين جديدتين قد تعملا على تحسين أداء العلاج بالخلايا التائية خيمرية المستضد (CAR-T cell therapy) لعل...

– Mayo Clinic

New Technology for Profiling Myeloma Cells

Weizmann Institute scientists Profs. Ido Amit and Amos Tanay, working with hemato-oncologists, have created a new way to profile myeloma tumor cells. The machine-learning-based technique will allow earlier and better diagnosis of the cancer, includin...

– Weizmann Institute of Science

Nature Medicine, Dec-2018


SCCA Bone Marrow Transplant Program Survival Rates Recognized Nationally

The Fred Hutch Bone Marrow Transplant (BMT) Program at Seattle Cancer Care Alliance (SCCA) has once again earned national recognition for outperforming expected one-year survival rates, for the sixth consecutive year.

– Seattle Cancer Care Alliance

AACI Joins American Cancer Society & Centers for Disease Control and Prevention to Recognize High HPV Vaccination Rates

The HPV Vaccine is Cancer Prevention Champion Award program is a joint effort to increase the number of American young adults completing the full human papillomavirus (HPV) vaccine series.

– Association of American Cancer Institutes (AACI)

Cancer Researcher Identifying Ways to Overcome Drug-Resistance

Assistant Professor Iram Surtaj will use a new imaging technique to identify drugs that can disrupt overexpression of multidrug resistance protein 1, one of the main mechanisms through which cancer cells gain resistance to chemotherapy drugs.

– South Dakota State University

Moffitt Names New Associate Center Director of Community Outreach & Engagement

Moffitt Cancer Center has named Susan Thomas Vadaparampil, Ph.D., M.P.H, its first Associate Center Director of Community Outreach & Engagement. The newly created leadership role is of great importance to the cancer center, as it focuses on the impac...

– Moffitt Cancer Center

Children's Hospital of Philadelphia Announces Endowed Chair in Pediatric Neuroblastoma Research

Pediatric oncologist and researcher Yael Mossé, MD, Director of the Neuroblastoma Development Therapeutics Program at Children’s Hospital of Philadelphia, has been named the inaugural holder of the Patricia Brophy Endowed Chair in Neuroblastoma Re...

– Children's Hospital of Philadelphia

The Nicola-Musso Charitable Foundation and Carol Musso Foley Commit to a Generous Donation for Cancer Care at Two Hackensack Meridian Health Hospitals

Hackensack Meridian Health and the Meridian Health Foundation are pleased to announce a gift of $750,000 from the Nicola-Musso Charitable Foundation of New York, N.Y. and Carol Musso Foley of New York and Spring Lake, NJ, to be used to enhance cancer...

– Hackensack Meridian Health

Cells ‘dance’ through endocytosis, metastasis

Celldance, a program of the American Society for Cell Biology (ASCB), helps researchers tell the story of their research through video. Two new Celldance videos premiere Tuesday, Dec. 11 at the Society’s annual meeting, held jointing with the Europ...

– American Society for Cell Biology (ASCB)

The Weizmann Institute of Science Establishes the Dr. Barry Sherman Institute for Medicinal Chemistry

The new Sherman Institute will advance basic research on novel therapies for a range of disorders, including autoimmune, neurodegenerative, and infectious diseases, as well as cancer.

– Weizmann Institute of Science





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