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Monday, December 11, 2017

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Medical
(39 New)
Science
(11 New)
Life
(6 New)
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Medical News


Researchers Identify Epigenetic Orchestrator of Pancreatic Cancer Cells

Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published December 11 in the Journal of Cell B...

– The Rockefeller University Press

Journal of Cell Biology, February, 2018

Embargo expired on 11-Dec-2017 at 09:00 ET


E-Cig Use Increases Risk of Beginning Tobacco Cigarette Use in Young Adults

Young adults who use electronic cigarettes are more than four times as likely to begin smoking tobacco cigarettes within 18 months as their peers who do not vape, according to new University of Pittsburgh research. The findings demonstrate that e-cig...

– Health Sciences at the University of Pittsburgh

American Journal of Medicine; R01-CA140150, R21-CA185767, R01-CA077026, R21-CA197912

Embargo expired on 11-Dec-2017 at 00:05 ET


Soy, Cruciferous Vegetables Associated with Fewer Common Side Effects of Breast Cancer Treatment

Consuming soy foods (such as soy milk, tofu and edamame) and cruciferous vegetables (such as cabbages, kale, collard greens, bok choy, Brussels sprouts, and broccoli) may be associated with a reduction in common side effects of breast cancer treatmen...

– Georgetown Lombardi Comprehensive Cancer Center

Breast Cancer Research and Treatment

Embargo expired on 11-Dec-2017 at 00:05 ET


Phase 2 CAR-T Study Reports Significant Remission Rates at 15-Month Follow Up

A study involving the recently approved CD19-targeting chimeric antigen receptor (CAR) T cell therapy shows that 42 percent of patients with aggressive large B-cell lymphoma remained in remission at 15 months following treatment with axi-cel (markete...

– University of Texas M. D. Anderson Cancer Center

The New England Journal of Medicine; American Society of Hematology

Embargo expired on 10-Dec-2017 at 10:30 ET


Landmark CAR-T Cancer Study Published in the New England Journal of Medicine

Loyola University Medical Center is the only Chicago center that participated in the pivotal clinical trial of a groundbreaking cancer treatment that genetically engineers a patient's immune system to attack cancer cells.

– Loyola University Health System

New England Journal of Medicine

Embargo expired on 10-Dec-2017 at 00:00 ET


Sequencing Offers Clues to Progression Toward Multiple Myeloma

Researchers at Dana-Farber Cancer Institute have carried out the largest genomic analysis of patients with smoldering multiple myeloma (SMM), a precursor to full-blown blood cancer that doesn’t show outward symptoms.

– Dana-Farber Cancer Institute

ASH #392

Embargo expired on 10-Dec-2017 at 09:45 ET


Tracking How Multiple Myeloma Evolves by Sequencing DNA in the Blood

Although people with multiple myeloma usually respond well to treatment, the blood cancer generally keeps coming back. Following genetic changes in how the disease evolves over time will help to understand the disease and, eventually, deliver more ef...

– Dana-Farber Cancer Institute

ASH #329

Embargo expired on 10-Dec-2017 at 08:30 ET


Rapid Responses, Few Adverse Effects Seen with Targeted Agent in Phase 1 Trial in Rare Blood Disorder

• Clinical Activity in a Phase 1 Study of BLU-285, a Potent, Highly-Selective Inhibitor of KIT D816V in Advanced Systemic Mastocytosis • Study shows one of multiple ways in which novel targeted cancer therapies are now being deployed to improv...

– Dana-Farber Cancer Institute

ASH #2

Embargo expired on 10-Dec-2017 at 08:00 ET


Study Shows Combining Chemotherapy with Targeted Drug Boosts Response in Chronic Lymphocytic Leukemia

Among younger patients newly diagnosed with chronic lymphocytic leukemia (CLL), treatment with a combination of chemotherapy and a molecularly targeted drug significantly improves response over what is typically seen with chemotherapy alone, accordin...

– Dana-Farber Cancer Institute

ASH #496

Embargo expired on 10-Dec-2017 at 17:15 ET


Low-Dose Treatment with Interleukin-2 Across Multiple Studies Shows Benefits in Chronic Graft-Versus-Host Disease

Daily low doses of the immune signaling protein interleukin-2 (IL-2) can safely benefit patients who develop chronic graft-versus-host disease following stem cell transplants, including particular benefit in pediatric patients in one small study, rep...

– Dana-Farber Cancer Institute

ASH #s 74; ASH #511; ASH #515; ASH #3248

Embargo expired on 10-Dec-2017 at 06:00 ET


Global CAR T Therapy Trial Shows High Rates of Durable Remission for Non-Hodgkin’s Lymphoma

In a pair of clinical trials stretching from Philadelphia to Tokyo, the chimeric antigen receptor (CAR) T cell therapy Kymriah™ (formerly known as CTL019) demonstrated long-lasting remissions in non-Hodgkin’s lymphoma (NHL) patients. Results from...

– Perelman School of Medicine at the University of Pennsylvania

ASH Annual Meeting; 1R01CA165206

Embargo expired on 10-Dec-2017 at 10:30 ET


CAR T, Immunotherapy Bring New Hope for Multiple Myeloma Patients

Two investigational immunotherapy approaches, including chimeric antigen receptor (CAR) T cell therapy, have shown encouraging results in the treatment of multiple myeloma patients who had relapsed and were resistant to other therapies. Researchers f...

– Perelman School of Medicine at the University of Pennsylvania

59th American Society of Hematology Annual Meeting

Embargo expired on 10-Dec-2017 at 16:30 ET


Immunotherapy Drug for Rheumatoid Arthritis Nearly Eliminates Severe Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplant

Results from a phase 2 clinical trial, presented by Seattle Children’s Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-...

– Seattle Children's Hospital

American Society of Hematology Annual Meeting, Dec-2017

Embargo expired on 09-Dec-2017 at 14:00 ET


Using Software, Researchers Predict Tumor Markers That Could Be Immune Targets

Researchers report at the 59th Annual American Society for Hematology Annual Meeting in Atlanta on Saturday, Dec. 9, that they were able to validate their approach for predicting markers – called minor histocompatibility antigens – in a group of ...

– University of North Carolina Health Care System

59th American Society of Hematology Annual Meeting

Embargo expired on 09-Dec-2017 at 14:00 ET


Immunotherapy Strategy Could Be Beneficial for Relapsed Acute Myeloid Leukemia, Preliminary Data Show

Researchers present their preliminary results from the ongoing phase II trial of chemotherapy and pembrolizumab in relapsed or refractory acute myeloid leukemia at the 59th American Society of Hematology Annual Meeting in Atlanta on Saturday, Dec. 9....

– University of North Carolina Health Care System

59th American Society of Hematology Annual Meeting

Embargo expired on 09-Dec-2017 at 17:30 ET


St. Jude Gene Therapy Improves Immunity in Babies with ‘Bubble Boy’ Disease

Preliminary findings indicate gene therapy pioneered at St. Jude Children’s Research Hospital is safe and effective for babies with a devastating inherited disorder that leaves them with little or no immune protection

– St. Jude Children's Research Hospital

Embargo expired on 09-Dec-2017 at 10:00 ET


For Women with Genetic Risk, Bi-Annual MRI Beats Mammograms

Intensive surveillance including a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) exam every six months was far more effective in detecting breast cancer in younger women with a high-risk genetic profile than an annual mammogram. DCE-...

– University of Chicago Medical Center

San Antonio Breast Cancer Symposium, 2017

Embargo expired on 08-Dec-2017 at 18:00 ET


Mayo Clinic Study Finds Emojis Promising Tool for Tracking Cancer Patients’ Quality of Life

In findings presented to the American Society of Hematology, Mayo Clinic researchers found that using emojis instead of traditional emotional scales were helpful in assessing patients’ physical, emotional and overall quality of life. Researchers fo...

– Mayo Clinic

Embargo expired on 09-Dec-2017 at 19:30 ET


International Research Team Identifies Genetic-Based Model for Predicting Outcomes in Primary Myelofibrosis

A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transpla...

– Mayo Clinic

Embargo expired on 09-Dec-2017 at 15:30 ET


New Mediola and OlympiAD Trial Results Offer Another Boon for PARP Inhibitors in Treatment of Advanced BRCA-Related Breast Cancer

Patients with certain advanced hereditary breast cancers may have new treatments options on the horizon, according to two studies presented this week at the annual San Antonio Breast Cancer Symposium. Susan Domchek, MD, executive director of the Bass...

– Perelman School of Medicine at the University of Pennsylvania

San Antonio Breast Cancer Symposium

Embargo expired on 08-Dec-2017 at 18:00 ET


Sports RDs Fueled by Bama Mentorship

In an unprecedented occurrence, each of the four football programs participating in the College Football Playoff will feature a sports dietitian (Sports RD) who spent time professionally or scholastically at the University of Alabama. Amy Bragg, Al...


Expert Available

– Collegiate and Professional Sports Dietitians Association (CPSDA)

Embargo expired on 08-Dec-2017 at 17:00 ET


NewYork-Presbyterian and Walgreens Collaborate To Bring World-Class Care Through Telemedicine

NewYork-Presbyterian and Walgreens are collaborating to bring convenient access to NewYork-Presbyterian’s world-class care through new telemedicine services, now available through Walgreens digital properties and at self-service kiosks at select Du...

– New York-Presbyterian Hospital

Embargo expired on 11-Dec-2017 at 09:00 ET


Bioethicists Call for Caution in Use of Rare Experimental Fetal Therapy

Citing uncertainties about the risks and benefits of an experimental therapy for fetuses whose kidneys do not develop, bioethicists at Johns Hopkins and a team of medical experts are calling for rigorous clinical trials in the use of a potential trea...

– Johns Hopkins Medicine

Obstetrics & Gynecology


Kidney Disease Increases Risk of Diabetes, Study Shows

Diabetes is known to increase a person’s risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of diabetes. Further, the re...

– Washington University in St. Louis

Kidney International


‘Black Box’ Recorder Puts Surgeons’ Robotic Surgery Skills Under the Microscope

A new study from Keck Medicine of USC finds that data from a novel recorder can be used to objectively measure surgeons’ proficiency in robotic-assisted prostate cancer surgery.

– Keck Medicine of USC

The Journal of Urology


Stress Hormone May Identify Family Members Likely to Suffer from Anxiety After Loved One’s ICU Hospitalization

When a loved one has been hospitalized in intensive care for a critical illness, many family members experience anxiety, depression, post-traumatic stress or other negative effects lasting months, according to new research led by Intermountain Medica...

– Intermountain Medical Center

Journal of Critical Care Medicine


Better Late Than Never - Making a Billion-Year-Old Geologic Feature Great Again

Geologists have corrected a mix-up that made an ancient geological structure in the central U.S. seem hundreds of miles shorter than it really is. The biggest failed rift known to geologists is even bigger than originally thought, according to resear...

– Northwestern University

American Geophysical Union fall meeting


In Lab Research, Scientists Slow Progression of a Fatal Form of Muscular Dystrophy

Saint Louis University researchers report that a new drug reduces fibrosis (scarring) and prevents loss of muscle function in an animal model of Duchenne muscular dystrophy (DMD).

– Saint Louis University Medical Center

Scientific Reports


Deck the Claws

Majoid crabs — known as decorator crabs — adorn themselves with items secured from their surroundings such as sponges, algae and other marine debris. Scientists and students at the University of Delaware are exploring what factors drive this beha...

– University of Delaware


Clinical Trials on Alzheimer’s Disease: Shifting the Focus to Prevention

This past decade, Alzheimer’s science has undergone a paradigm shift toward the disease’s early, silent phase. For trials, this means change at every level: new participants, new screening tools, new outcome measurements. What’s the progress?

– Alzforum


PARP Inhibitor Improves Progression-Free Survival in Patients with Advanced Breast Cancers and BRCA Mutations

In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for ...

– University of Texas M. D. Anderson Cancer Center

San Antonio Breast Cancer Symposium


Two Alabamians Push UAB Hospital Past Milestone of 10,000 Kidney Transplants

The hope given from a deceased donor, and a sibling, give two kidney transplant recipients a chance to live

– University of Alabama at Birmingham


Here Are the Things Patients Should Be Doing for Their Health, but Aren’t

Year-end is a great time to reflect on our health and endeavor to improve it. As we do so, it's important to identify the steps that could have a big impact on our wellness.

Expert Available

– University of California, Los Angeles (UCLA), Health Sciences


WFIRM Wound Healing Technology Licensed to XCell Biologix

A potential new cell-free treatment for severe burns and chronic wounds that was developed by scientists at Wake Forest Institute for Regenerative Medicine (WFIRM) has been exclusively licensed to XCell Biologix™, a private company that aims to mak...

– Wake Forest Baptist Medical Center


New Heart Transplant Program Launched at NYU Langone Health

NYU Langone launches a new heart transplant program.

– NYU Langone Health


Complimentary Press Registration Available for 2018 Winter Rheumatology Symposium

The American College of Rheumatology (ACR) welcomes members of the press to write about rheumatology research presented the Winter Rheumatology Symposium in Snowmass Village, CO on January 20-26, 2017.

– American College of Rheumatology (ACR)

Winter Rheumatology Symposium


$23 Million Funding Will Help Tackle Preterm Birth, Major Diseases

The University of Adelaide has been awarded $23.2 million for new research tackling some of the world's most significant health problems, including one of the biggest killers of children: preterm birth.

– University of Adelaide


Rush University Medical Center Named a Top Teaching Hospital

Rush University Medical Center has been named a Top Teaching Hospital by the Leapfrog Group, a nonprofit hospital watchdog organization. Rush is one of only 36 recipients of the Top Teaching Hospital honor nationwide, and one of two in Illinois.

– Rush University Medical Center


Loyola Medicine Radiologist Kathleen A. Ward, Md, Named an Inaugural Fellow of the American Association for Women Radiologists

Loyola Medicine radiologist Kathleen A. Ward, MD, FACR, FAAWR, has been inducted into the first fellowship class of the American Association for Women Radiologists.

– Loyola University Health System

Science News


Reductions in Individual Plant Growth Sometimes Boost Community Resilience

In sports, sometimes a player has to take one for the team. The same appears to be true in the plant world, where reduced individual growth can benefit the broader community.

– University of Michigan

Nature Communications

Embargo expired on 11-Dec-2017 at 05:00 ET


Study Explores Use of Checkpoint Inhibitors After Relapse From Donor Stem Cell Transplant for Hematologic Cancers

Immunotherapy agents known as checkpoint inhibitors have shown considerable promise in patients with hematologic cancers who relapse after a transplant with donor stem cells. Preliminary results from the first clinical trial in these patients of one ...

– Dana-Farber Cancer Institute

ASH #275

Embargo expired on 09-Dec-2017 at 17:00 ET


Volumetric 3D Printing Promises Nearly Instant Builds

By using laser-generated, hologram-like 3D images flashed into photosensitive resin, researchers at Lawrence Livermore National Lab, along with collaborators at UC Berkeley, the University of Rochester, and the Massachusetts Institute of Technology (...

– Lawrence Livermore National Laboratory

Science Advances, Dec. 8, 2017

Embargo expired on 08-Dec-2017 at 14:00 ET

includes video


Scientists Urge Endangered Listing for Cheetahs

In a study published today in the open-access journal PeerJ, researchers present evidence that low cheetah population estimates in southern Africa support a call to list the cheetah as “Endangered” on the International Union for Conservation of N...

– PeerJ

PeerJ


Underappreciated Microbes Now Get Credit for Holding Down Two Jobs in Soil

Soil microbes work as both decomposers and synthesizers of carbon compounds in soil, offering new answers with impacts to crops and eco-health.

– Department of Energy, Office of Science

Nature Microbiology 2, 17105 (2017). [DOI: 10.1038/nmicrobiol.2017.105]


New Online Database Brings the Genome Into Focus Using Molecular Structure

An online database built by Iowa State University scientists provides a new tool with which researchers can study human biology. The database is freely accessible to anyone on the web, where it allows scientists to study the functions and structure o...

– Iowa State University

Scientific Reports


Final Call for Abstracts - Due January 2, 2016

The Science of Consciousness ('TSC') is an interdisciplinary conference emphasizing broad and rigorous approaches to all aspects of the study and understanding of conscious awareness. Topical areas include neuroscience, philosophy, psychology, langua...

– Center for Consciousness Studies, University of Arizona, Department of Anesthesiology


Finding More Calibration Sites to Improve Accuracy of Satellite Images

Identifying more sites worldwide to determine the accuracy of satellite sensors will allow engineers to select sites ideally suited to specific spectral bands of reflected light.

– South Dakota State University


Solar Instruments, Experiments Headed for International Space Station

A solar instrument package designed and built by the University of Colorado Boulder to help monitor the planet’s climate is now set for launch Dec. 12 aboard a SpaceX rocket from NASA’s Kennedy Space Center in Florida.

– University of Colorado Boulder


US Dept. Of Energy Grant to Advance Combined Heat and Power Systems in the Midwest

The University of Illinois at Chicago has received a five-year, $4.2 million grant from the U.S. Department of Energy to help industrial, commercial, institutional and utility entities evaluate and install highly efficient combined heat and power (CH...

– University of Illinois at Chicago


Three Rare Black-Necked Storks Hatch in Kulen Promtep Wildlife Sanctuary

The Wildlife Conservation Society (WCS) and Ministry of Environment (MoE) announced today that after five weeks of active nest protection by community members, three Black-necked stork chicks have hatched in Kulen Promtep Wildlife Sanctuary (KPWS) in...

– Wildlife Conservation Society

Lifestyle & Social Sciences


Major Life Events Shared on Social Media Revive Dormant Connections, Study Shows

New research from the University of Notre Dame examines the impact of major life events, on social network evolution, which, the study shows, has important implications for business practices, such as in marketing.

– University of Notre Dame


Ithaca College Professor Finds Emotion Makes Memory Unreliable

In a new article in the journal Memory, entitled “The Robustness of False Memory for Emotional Pictures,” Ithaca College assistant professor Brandy Bessette-Symons shows that while under certain circumstances emotion can improve memory, it also m...

– Ithaca College

Memory


When a Celebrity Dies, Social Media Gets Toxic, New Study Shows

A study of 7,000 Facebook comments found that even in the wake of a death, people are remarkably mean to each other online. A few technological fixes could improve things, researchers say.

– University of Colorado Boulder

includes video


Peace Corps Volunteer Goes From Senegal to ... Wherever She Chooses

Nurse scholar rewarded for her Peace Corps service and her promise.

– Johns Hopkins School of Nursing


Can Game Design Concepts Increase Journalism Engagement? New Report Says Yes

New research from American University finds interactive games can increase reader engagement with and understanding of news.

– American University


What’s in a Name? How the Perception of Taking a Spouse’s Surname Can Define Power in Marriage

A new study led by a UNLV psychology professor shows that a wife’s choice of surnames may influence perceptions of her husband’s personality and the distribution of power in the marriage.

– University of Nevada, Las Vegas (UNLV)

Business News


Tulane University Launches Its Most Ambitious Fundraising Campaign with $1.3 Billion Goal

Tulane University launched Only the Audacious, The campaign for an ever bolder Tulane today. The campaign is the most ambitious fundraising endeavor in Tulane’s 184 years

– Tulane University

Embargo expired on 08-Dec-2017 at 16:00 ET

includes video

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