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Thursday, February 22, 2018

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Medical News


Phase I Clinical Trial Shows Some Promise for Investigational Drug for Melanoma

In JCI Insight, researchers reported the results of a phase I, multi-institution clinical trial for an investigational treatment for melanoma and other cancers with mutations in the BRAF or RAS genes.

– University of North Carolina Health Care System

JCI Insight, Feb-2018

Embargo expired on 22-Feb-2018 at 09:00 ET


Simple Walking Test May Help Make Difficult Diagnosis

There’s a cause of dementia that can sometimes be reversed, but it’s often not diagnosed because the symptoms are so similar to those of other disorders. Now researchers say a simple walking test may be able to accurately diagnose the disease, ac...

– American Academy of Neurology (AAN)

Neurology®

Embargo expired on 21-Feb-2018 at 16:00 ET


New Therapeutic Gel Shows Promise Against Cancerous Tumors

UNC and NC State scientists created an injectable gel-like scaffold that can hold combination chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results in animal models suggest this approach could one day ra...

– University of North Carolina Health Care System

Science Translational Medicine

Embargo expired on 21-Feb-2018 at 14:00 ET


Precision Cancer Therapy Effective in Both Children and Adults

Three quarters of patients with a variety of advanced cancers occurring in different sites of the body responded to larotrectinib, a novel therapy that targets a specific genetic mutation. The oral treatment is based on the genetic traits of the tumo...

– Childrens Hospital Los Angeles

New England Journal of Medicine, Feb 21, 2018

Embargo expired on 21-Feb-2018 at 17:00 ET


Kinase Inhibitor Larotrectinib Shows Durable Anti-Tumor Abilities in Patients of All Ages with 17 Unique Cancer Diagnoses

Three simultaneous safety and efficacy studies of the drug larotrectinib reported an overall response rate of 75 percent for patients ages four months to 76 years with 17 different cancer diagnoses.

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 21-Feb-2018 at 17:00 ET


Cardiac Magnetic Resonance Without Intravenous Contrast May Help Better Assess Need for Mitral Valve Surgery

Atlantic health system cardiologist authors new review on value of non-invasive imaging techniques in valvular heart disease patients

– Atlantic Health System

Journal of the American College of Cardiology


Women Who Suffer with Newly Understood Heart Attack Called Scad May Fare Better with Conservative Care

Patients who suffer from a type of heart attack that affects mainly younger women, called spontaneous coronary artery dissection or SCAD, may benefit most from conservative treatment, letting the body heal on its own. This is according to a new scien...

– Mayo Clinic

includes video


Repairing the Heart One "Z" at a Time

Much like other muscles, when the heart works during the normal daytime hours, it needs a period of rest to repair itself.

– University of Alabama at Birmingham

Life Sciences


Diabetic Nerve Damage May Increase Energy Needed for Walking

A new study suggests that diabetes-related nerve damage (peripheral neuropathy) may reduce the amount of energy stored by the Achilles tendon during walking. The tendon connects the back of the heel to the calf muscles. This reduction increases the e...

– American Physiological Society (APS)

Journal of Applied Physiology


Five Novel Genetic Changes Linked to Pancreatic Cancer Risk

In what is believed to be the largest pancreatic cancer genome-wide association study to date, researchers at the Johns Hopkins Kimmel Cancer Center and the National Cancer Institute, and collaborators from over 80 other institutions worldwide discov...

– Johns Hopkins Medicine

Nature Communications; R01CA154823, HHSN26120080000IE, P50CA062924, R01CA97075


Animal Study Shows How to Retrain the Immune System to Ease Food Allergies

Treating food allergies might be a simple matter of teaching the immune system a new trick, researchers at Duke Health have found. In a study using mice bred to have peanut allergies, the Duke researchers were able to reprogram the animals' immune sy...

– Duke Health

Journal of Allergy and Clinical Immunology; R01 AI96305; R01 AI35678; R01 DK077159; R01 AI50021; R37 DK50814 ; R21 AI056101


Deep Neural Networks Identifies Tumours with Unmatched Performance

A team of artificial intelligence researchers developed a new deep-learning method to identify tumours in medical images.

– Centre hospitalier de l'Université de Montréal (CHUM)


HIV Patch Being Developed to Reduce Transmission Rates in At-Risk Populations

A novel microarray patch for HIV PrEP is in preparation for future clinical trials. The consortium of Queen’s University Belfast, along with their collaborators, PATH, ViiV Healthcare, the Population Council and LTS Lohmann Therapie-Systeme AG have...

– Newswise


Researchers Uncover Novel Mechanism behind Schizophrenia

An international team of researchers led by a Case Western Reserve University School of Medicine scientist has uncovered a novel mechanism in which a protein—neuregulin 3—controls how key neurotransmitters are released in the brain during schizop...

– Case Western Reserve University

Proceedings of the National Academy of Sciences; NIH; NIH; NIH; NIH; NIH; NIH


Study: Lead and Other Toxic Metals Found in E-Cigarette ‘Vapors’

Significant amounts of toxic metals, including lead, leak from some e-cigarette heating coils and are present in the aerosols inhaled by users, according to a study from scientists at Johns Hopkins Bloomberg School of Public Health.

– Johns Hopkins Bloomberg School of Public Health


Touchstone Center Investigation Provides Insight Into Glucagon's Role in Diabetic Heart Disease

A UT Southwestern study reveals the hormone glucagon's importance to the development of insulin resistance and cardiac dysfunction during Type 2 diabetes, presenting opportunities to develop new therapies for diabetic diseases of the heart muscle.

– UT Southwestern Medical Center


Carbon Monoxide Improves Effectiveness of Antibiotic That Fights Stomach Infection, Study Finds

Carbon monoxide can improve the effectiveness of antibiotics, making bacteria more sensitive to antibiotic medication, according to a study led by Georgia State University.

– Georgia State University

Organic Letters


UCLA Scientists Use Color-Coded Tags to Discover How Heart Cells Develop

UCLA researchers used fluorescent colored proteins to trace how cardiomyocytes — cells in heart muscle that enable it to pump blood — are produced in mouse embryos. The findings could eventually lead to methods for regenerating heart tissue in hu...

– University of California, Los Angeles (UCLA), Health Sciences

Nature Communications Feb-2018

includes video


Cancer Risk Associated With Key Epigenetic Changes Occurring Through Normal Aging Process

Some scientists have hypothesized that tumor-promoting changes in cells during cancer development—particularly an epigenetic change involving DNA methylation—arise from rogue cells escaping a natural cell deterioration process called senescence. ...

– Johns Hopkins Medicine

Cancer Cell; R01CA185357, R21CA212495, R01CA170550


Three Things Every Dentist Should Check Before Performing Root Canal Procedures

To help ensure that patients receive the best possible care from all practitioners at the highest standards, the American Association of Endodontists supports a single standard of endodontic education and care to provide patients with the highest qua...

– American Association of Endodontists (AAE)


Low Vision Research Shifts Into Overdrive

Tim Goetz drives about 200,000 miles each year. Remarkably, Goetz is legally blind. Research funded by the National Eye Institute (NEI) is helping Goetz and others like him get or stay behind the wheel while keeping roads safe for everyone.

– NIH, National Eye Institute (NEI)

EY018966, EY027817, EY025677, EY018680


Researching Smell, From Someone Who Can’t

February 27 is Anosmia Awareness Day. Many people don’t appreciate what it means to be unable to smell. As someone with congenital anosmia, I know first-hand what it feels like to go through each day without the sense of smell.

– Monell Chemical Senses Center


New 3D Technology Giving RIAO Physicians Greater Insight into Foot Ailments

A New Outpatient Rehabilitation Program at the Rubin Institute for Advanced Orthopedics (RIAO) at Sinai Hospital of Baltimore Is Enhancing Orthotic Care with New Pressure-Sensing 3D Technology That Can Help Physicians More Precisely Pinpoint the Caus...

– LifeBridge Health


Annual Dilated Eye Exams Key in Preventing Diabetic Eye Disease

Diabetic eye disease is the leading cause of blindness among people ages 40 to 60. The longer you have diabetes, the greater your likelihood of developing vision problems increases.

– LifeBridge Health


PCOS Tricky to Diagnose in Adolescents

A very common cause of infertility in women is a condition called polycystic ovary syndrome (PCOS). Women are usually diagnosed with PCOS in their 20s or 30s after difficulties with getting pregnant, but the condition affects 1 in 10 women of childbe...

– LifeBridge Health


Sinai Hospital’s Brain & Spine Institute Introduces New Procedure for Irritated Nerves in Neck

The Sandra and Malcolm Berman Brain & Spine Institute at Sinai Hospital of Baltimore recently became the first health care facility in Maryland to offer a new, minimally invasive surgical procedure for treating irritated nerves in the neck.

– LifeBridge Health


What You Need to Know about Alzheimer's

Fred A. Kobylarz, MD, associate professor of family medicine and community health at Rutgers Robert Wood Johnson Medical School, is an expert in dementia and Alzheimer’s disease, and offers caregivers and family members information on diagnoses and...

– Rutgers Robert Wood Johnson Medical School

includes video


American Association of Nurse Anesthetists Applauds Purdue Pharma for Eliminating Opioid Promotion

The American Association of Nurse Anesthetists (AANA) applauds Purdue Pharma for its steps to address the opioid epidemic in the United States by ending all promotion of its opioid, OxyContin, to prescribers.

– American Association of Nurse Anesthetists (AANA)


The Medical Minute: Detecting the Subtle Signs of Heart Disease in Women

Many women may write off fatigue, body aches and even nausea as the result of stress, or as an indication that they need to slow down and rest. What they might not realize is that those subtle symptoms could indicate something much more distressing: ...

– Penn State Health Milton S. Hershey Medical Center

Medical Minute


Cotton Swabs Linked to Child Ear Injuries

Tip sheet about potential injuries that could be caused by using cotton swabs to clean ears and safer options.

– University Hospitals Cleveland Medical Center


Minimally Invasive Procedure Increases Options for Mitral Valve Repair

Some heart patients haven’t yet been able to access the growing trend toward minimally invasive procedures. A new clinical trial at the University of Michigan, though, makes a form of mitral valve repair an option without an open-heart surgery.

– Michigan Medicine - University of Michigan


Researcher Jamie Myers Searches for Answers to “Chemo-Brain”

Myers has spent the last decade researching the prevalence, possible causes, management and treatment of chemo-brain.

– University of Kansas Cancer Center


GW Cancer Center Welcomes Inaugural TEAM Training Cohort and Nationally Renowned Speakers to Washington, D.C.

The GW Cancer Center recently welcomed 24 multidisciplinary health care teams from across the country to its inaugural TEAM (Together, Equitable, Accessible, Meaningful) Training program.

– George Washington University


GW Researcher Awarded More Than $1.5 Million to Study PTSD and Cardiovascular Disease

Paul Marvar, PhD, at GW School of Medicine and Health Sciences, received a large grant from the NIH to study a possible link between post-traumatic stress disorder and cardiovascular disease.

– George Washington University

1R01HL137103-01A1


Children’s Hospital Los Angeles Surgeon Kasper Wang Elected to the Pediatric Surgery Board of the American Board of Surgery

Kasper Wang, MD, FACS, FAAP, associate chief of the Division of Pediatric Surgery at Children’s Hospital Los Angeles (CHLA), has been elected to the Pediatric Surgery Board of the American Board of Surgery (PSB-ABS).

– Childrens Hospital Los Angeles

Science News


In a First, Tiny Diamond Anvils Trigger Chemical Reactions by Squeezing

Menlo Park, Calif. —Scientists have turned the smallest possible bits of diamond and other super-hard specks into “molecular anvils” that squeeze and twist molecules until chemical bonds break and atoms exchange electrons. These are the first s...

– SLAC National Accelerator Laboratory

Nature

Embargo expired on 21-Feb-2018 at 13:00 ET


Ancient DNA Tells Tales of Humans’ Migrant History

Fueled by advances in analyzing DNA from the bones of ancient humans, scientists have dramatically expanded the number of samples studied – revealing vast and surprising migrations and genetic mixing of populations in our prehistoric past.

– Howard Hughes Medical Institute (HHMI)

Nature, Feb-2018

Embargo expired on 21-Feb-2018 at 13:00 ET


Ancient-DNA Researchers Surpass the 1,000-Genome Milestone, Sharpening Resolution of European Prehistory

In the last eight years, the field of ancient DNA research has expanded from just one ancient human genome to more than 1,300. The latest 625 of those genomes debut Feb. 21 in two papers published simultaneously in Nature, including the largest study...

– Harvard Medical School

Nature

Embargo expired on 21-Feb-2018 at 13:00 ET


Climate Warming Causes Local Extinction of Rocky Mountain Wildflower Species

New University of Colorado Boulder-led research has established a causal link between climate warming and the localized extinction of a common Rocky Mountain flowering plant, a result that could serve as a herald of future population declines.

– University of Colorado Boulder

Science Advances

Embargo expired on 21-Feb-2018 at 14:00 ET


Remembering Really Fast

Colossal magnetoresistance at terahertz frequencies in thin composites boosts novel memory devices operated at extremely high speed.

– Department of Energy, Office of Science

Nano Letters 17, 2506 (2017). [DOI: 10.1021/acs.nanolett.7b00231]


UF Study Shows Why Termite Bait Works and How Scientists Can Improve It

About 25 years ago, University of Florida scientist Nan-Yao Su set out to develop a bait to kill termites. He came up with Sentricon™ and found it worked better than any other termite-killing method to date. Now, scientists know more about why the ...

– University of Florida Institute of Food and Agricultural Sciences

Scientific Reports


Berkeley Lab “Minimalist Machine Learning” Algorithms Analyze Images From Very Little Data

Berkeley Lab mathematicians have developed a new approach to machine learning aimed at experimental imaging data. Rather than relying on the tens or hundreds of thousands of images used by typical machine learning methods, this new approach “learns...

– Lawrence Berkeley National Laboratory

Proceedings of the National Academy of Sciences


Cross-Bred Flies Reveal New Clues About How Proteins Are Regulated

A team from The Scripps Research Institute (TSRI) has revealed that by crossing two species of flies, they can use what they learn from the proteome of the hybrid offspring to find new clues about how proteins interact with each other

– Scripps Research Institute

Science Advances, Feb. 2018; 5R01HL079442-08; P01AG031097; P41GM103533; HHSN268201000035C


Scientists Use Tiny Diamond Anvils to Put Squeeze on Materials

Scientists have turned tiny bits of diamond and super-hard specks into “molecular anvils” that squeeze and twist molecules until chemical bonds break and atoms exchange electrons. They believe the method­ offers a new way to perform chemistry re...

– University of Chicago


Climate Warming Causes Local Extinction of Rocky Mountain Wildflower Species

New University of Colorado Boulder-led research has established a causal link between climate warming and the localized extinction of a common Rocky Mountain flowering plant, a result that could serve as a herald of future population declines.

– University of Colorado Boulder

Science Advances


Defects and Surface Reactions Boost Batteries

Defect-enhanced transport and complex phase growth are changing design rules for lithium-ion batteries.

– Department of Energy, Office of Science

Nature Communication 8, 114 (2017). [DOI: 10.1038/s41467-017-01315-8]


What Are the General Uses of Pesticides?

Agricultural fields can be attacked by insects, disease, and weeds. How can growers defend crops? The February 22 Sustainable, Secure Food blog explains how the safe use of pesticides can maintain crop yields, feed the world, and keep our food supply...

– American Society of Agronomy (ASA), Crop Science Society of America (CSSA), Soil Science Society of America (SSSA)


Threatened Shorebird Species Faces Increased Peril

Scientists from Rutgers University–New Brunswick and elsewhere documented fewer than 10,000 red knot shorebirds in Chile in January, down from more than 13,000 a year earlier.

– Rutgers University-New Brunswick

Rutgers Today


Innovative Training Improves Aviation Security

ScreenADAPT®, a collaborative research and development technology is an X-ray image analysis training system that tracks the eye movement of trainees as they inspect simulated bags to enhance visual search skills. It has been transitioned to Portlan...

– Homeland Security's Science & Technology Directorate


Hunting for Neutrinos: When the Ordinary Is Unexpected

Neutrinos are the most abundant particles in the universe and could reveal insight into physics beyond the Standard Model. However, they’re incredibly difficult to detect. While most neutrino detectors are very large, two experiments supported by t...

– Department of Energy, Office of Science


Testing Lithium Battery Limitations May Improve Safety and Lifetimes

Researchers are using neutrons to study a battery material that could offer a safer alternative to the flammable liquid component found in most types of lithium-ion batteries.

– Oak Ridge National Laboratory


Olympics Scholar Studies Doping, Co-Directs International Network for Doping Research

John Gleaves, who conducts research on doping in sports, comments on the Russian Federation's ban from the 2018 Winter Games and the involvement of government officials in doping.

Expert Available

– California State University, Fullerton


MD Anderson Receives $22 Million in CPRIT Funding for Research, Prevention and Recruitment

The University of Texas MD Anderson Cancer Center was awarded $22.3 million from the Cancer Prevention and Research Institute of Texas (CPRIT), accounting for 30 percent of the $73.5 million in awards CPRIT announced today. The awards included $16.3 ...

– University of Texas M. D. Anderson Cancer Center

Lifestyle & Social Sciences


Violent Video Games May Serve as an Outlet for Aggression, Not a Precursor, Says Virginia Tech Expert

According to a recent study published in Violence and Gender video games decrease the likelihood of producing hate material online and researcher Jim Hawdon says “this finding suggests that violent video games may serve as an outlet for aggression,...

– Virginia Tech


Infant Skull Binding Shaped Identity, Inequality in Ancient Andes

The idea of binding and reshaping a baby’s head may make today’s parents cringe, but for families in the Andes between 1100-1450, cranial modification was all the rage.

– Cornell University

Current Anthropology, Feb-2018


UCI Professor Finds New Digital Divide Threatening Well-Being of Low-Income Teens

In one sense, the digital divide between teenagers from different socio-economic backgrounds is narrowing: All increasingly have access to technologies such as smartphones and computers. But a new digital divide appears to be emerging over the types ...

– University of California, Irvine

Nature, Feb-2018


How The "I Approve" Tagline Boosts Nasty Political Ads

New research co-authored by Berkeley Haas Assoc. Prof. Clayton Critcher finds that adding the required "I approve this message" tagline to negative campaign ads makes them more credible.

– University of California, Berkeley Haas School of Business

Journal of Marketing Research, Feb-2018


Darden Capital Management Assets Under Management Pass $15 Million

Darden Capital Management, which is entirely student-run and available as both a club and an independent study course, offers Darden students an unparalleled experiential learning opportunity in the field of investment management. Students actively m...

– University of Virginia Darden School of Business


14 Courses on 5 Continents Highlight Spring Global Learning Opportunities at UVA Darden

Global course offerings at the University of Virginia Darden School of Business are known as Darden Worldwide courses, and they will live up to their name this spring as students learn on five continents via 14 global learning opportunities in March ...

– University of Virginia Darden School of Business


Iowa State Honors Seminar Deepens Understanding of Global Problems, Encourages Action

Students in Jean-Pierre Taoutel’s honors seminar, “That’s Me in the Corner,” are thinking critically about global problems and how to help solve them. Students in Iowa State University’s Honors Program enroll in these one- or two-credit spe...

– Iowa State University


Researcher Identifies Ways to Break the Bias of STEM Stereotypes

Women who consider careers in the physical sciences, technology, engineering and math (STEM) fields are deterred by stereotypes that impose barriers on the recruitment, retention and advancement of women in STEM, according to a researcher at Missouri...

– Missouri University of Science and Technology


Billy Graham Leaves Controversial Legacy for the #Metoo Generation

In his long career, the evangelical preacher Billy Graham — who died Feb. 21 at age 99 — offered one piece of advice that may be especially relevant to men in the current age of #MeToo sexual harassment scandals — never dine, drink or spend tim...

Expert Available

– Washington University in St. Louis


Temple Ranks Among Top Producers of Fulbright Students

Joining prestigious research universities such as Brown, Cornell, Harvard and NYU, Temple recently ranked among the institutions that produced the most participants in the Fulbright U.S. Student Program.

– Temple University

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