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Monday, December 3, 2018

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Medical News


Clinicians Tackle Difficult Topics in Interdisciplinary Sessions

An educational initiative at Boston Children’s Hospital offers specialized content on timely topics and sensitive subjects to help clinicians face communication challenges confidently and effectively.

– American Association of Critical-Care Nurses (AACN)

Critical Care Nurse, December 2018

Embargo expired on 03-Dec-2018 at 06:00 ET


More than half of patients alive two years after receiving CAR-T therapy for diffuse large B-cell lymphoma in ZUMA-1 trial

A follow-up analysis of patients enrolled in a Phase I/II multi-center trial for diffuse large B-cell lymphoma (DLBCL) reported 51 percent of patients receiving an anti-CD19 chimeric antigen receptor (CAR T) called axi-cel were still alive two years ...

– University of Texas M. D. Anderson Cancer Center

The Lancet Oncology; 60th American Society of Hematology Annual Meeting & Exposition

Embargo expired on 02-Dec-2018 at 12:00 ET


Dana-Farber Researchers Report Clinical Trial Results in Treatment of Leukemia and Lymphoma

New results from clinical trials of immunotherapy and experimental targeted agents for patients with leukemia and lymphoma are being presented by Dana-Farber Cancer Institute researchers at the ASH Annual Meeting.

– Dana-Farber Cancer Institute

American Society of Hematology (ASH) Annual Meeting

Embargo expired on 02-Dec-2018 at 12:30 ET


Studies Suggest that Immunotherapy Adds Punch to Earlier Attempts to Treat Recurrent Non-Hodgkin and Hodgkin Lymphoma

New drugs that harness the body’s immune system to destroy cancer cells appear to increase the effectiveness of later drug therapies for non-Hodgkin and Hodgkin lymphoma patients, new research suggests. This happens, scientists say, even for repeat...

– NYU Langone Health

ASH Annual Meeting, December 2018; R01 CA180820; R01 CA180794; R01 CA180790; R01 CA180795; U10 CA180799; R01 CA180802; R01 CA180816; R01 CA180833...

Embargo expired on 01-Dec-2018 at 21:15 ET


Calcium Signaling May Play Role in Addressing Drug Resistance to Non-Hodgkin Lymphoma Treatment

Systems biology analyses by Rutgers Cancer Institute of New Jersey researchers examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma suggest calcium signaling may have an influence in addressing this treatment obstacle.

– Rutgers Cancer Institute of New Jersey

American Society of Hematology Annual Meeting, Dec-2018

Embargo expired on 01-Dec-2018 at 12:00 ET


Sickle Cell Anemia Treatment Safely Lowers Disease Burden in African Children

A daily hydroxyurea pill may bring relief for children living with the painful and deadly blood disease sickle cell anemia (SCA) in resource-challenged sub-Saharan Africa, where the disease is prevalent and health care is suboptimal. This is what a m...

– Cincinnati Children's Hospital Medical Center

New England Journal of Medicine Dec. 1, 2018

Embargo expired on 01-Dec-2018 at 10:30 ET


Exploring Clinical Activity of an Immunotherapy Drug that Targets Lymphomas

An investigational immunotherapy drug has demonstrated efficacy and an acceptable safety profile in the treatment of follicular lymphoma, diffuse large B-cell lymphoma and other B cell non-Hodgkin lymphoma subtypes. The lead investigator from Rutgers...

– Rutgers Cancer Institute of New Jersey

American Society of Hematology Annual Meeting, Dec-2018

Embargo expired on 01-Dec-2018 at 12:00 ET


Global Trial Shows CAR T Therapy Can Lead to Durable Remissions in Non-Hodgkin’s Lymphoma

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah® (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refract...

– Perelman School of Medicine at the University of Pennsylvania

New England Journal of Medicine

Embargo expired on 01-Dec-2018 at 12:00 ET


CAR-T cell update: therapy improves outcomes for patients with B-cell lymphoma

An international phase-2 trial of a CAR-T cell therapy—to be published on-line Dec. 1 in the New England Journal of Medicine (and presented at the ASH annual meeting in San Diego)—found that 52% of patients responded favorably to the therapy; 40%...

– University of Chicago Medical Center

ASH annual meeting, New England Journal of Medicine

Embargo expired on 01-Dec-2018 at 12:00 ET


Why Patients Lie to Their Doctors

Up to 80 percent of those surveyed have lied to their doctor about information that could impact their health, including accurately describing their diet and how often they exercised. When survey participants explained their reasoning for doing so, t...

– University of Utah Health

JAMA Network Open

Embargo expired on 30-Nov-2018 at 11:00 ET


Depression, Not Anxiety, Predicts Drinking in Adolescent Girls

Internalizing problems such as depression and anxiety, along with alcohol misuse, increase during adolescence. All three predict poor social, academic, and emotional outcomes – particularly for girls. However, it is unclear what relationships exist...

– Research Society on Alcoholism

Alcoholism: Clinical and Experimental Research

Embargo expired on 30-Nov-2018 at 10:00 ET


App Helps Breast Cancer Survivors Improve Health After Treatment

Breast cancer survivors who used a smartphone app created at Houston Methodist consistently lost weight, largely due to daily, real-time interactions with their health care team via the mobile app.

– Houston Methodist

JCO CCI, Nov. 30, 2018

Embargo expired on 30-Nov-2018 at 16:00 ET


Stopping Sexual Aggression: Alcohol Can Interfere with Good Intentions

The #MeToo movement that began in 2017 has increased attention to bystander training programs that encourage third-party witnesses to intervene (i.e., become involved in stopping aggression) in high-risk sexual situations. With limited information av...

– Research Society on Alcoholism

Alcoholism: Clinical and Experimental Research

Embargo expired on 30-Nov-2018 at 10:00 ET


Immunotherapy Better than Chemotherapy for Subtype of Head and Neck Cancer

A randomized clinical trial involving 97 medical centers in 20 countries, including Moores Cancer Center at UC San Diego Health, found that treating patients with head and neck cancer with the immunotherapy drug pembrolizumab is more effective and le...

– University of California San Diego Health

The Lancet

Embargo expired on 30-Nov-2018 at 18:30 ET


New Two-year Data Show 39 Percent of Non-Hodgkin Lymphoma Patients Treated with CAR T-cell Therapy Remain in Remission

A new article published today in The Lancet Oncology shows 39 percent of large B cell lymphoma patients treated with the chimeric antigen receptor T-cell therapy (CAR T) Yescarta® (axicabtagene ciloleucel) remained in remission more than two years (...

– Moffitt Cancer Center

The Lancet Oncology, Dec-2018


We’ve dropped the ball on physical activity—but not on measuring movement in kids.

While the latest Active Healthy Kids Australia statistics show kids are flatlining in terms of their physical activity participation, researchers from the University of South Australia are ensuring pre-schoolers have the best opportunities to move we...

– University of South Australia

Journal of Sports Sciences


New Study Highlights CAR T-cell Therapy Success for Lymphoma When Used as Standard of Care

Moffitt Cancer Center partnered with 16 academic cancer centers to analyze real world data of 274 patients treated commercially with Yescarta® (axicabtagene ciloleucel), one of two CAR T products that is now standard of care for patients with diffus...

– Moffitt Cancer Center

ASH Annual Meeting, Dec-2018


Rates of chronic kidney disease, deaths outpace other diseases

An abundance of high-sugar, high-salt foods in many American diets and obesity-related health problems such as diabetes are likely driving an increase in kidney disease cases, including in young adults, according to researchers at Washington Universi...

– Washington University in St. Louis

JAMA Network Open, Nov. 30, 2018


Researchers Alleviate Schizophrenia Symptoms in New Mouse Models

In a recent issue of the Proceedings of the National Academy of Sciences, Lin Mei, MD, PhD, asked, does all the tinkering in young mice hamper their brain development, causing schizophrenia-like symptoms? Or, do their brain cells develop normally, bu...

– Case Western Reserve University

PNAS; NIH; NIH; NIH; NIH; NIH; NIH; NIH


Study sheds light on alcohol misuse among never-deployed reservists

In a study of 174 Army Reserve and National Guard soldiers who hadn’t been deployed, researchers found that more negative non-deployment emotions were associated with a range of alcohol use outcomes.

– University at Buffalo

Alcoholism: Clinical and Experimental Research, Oct-2018


Altered microbiome after caesarean section impacts baby's immune system

Together with colleagues from Sweden and Luxembourg, scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have observed that, during a natural vaginal birth, specific bacteria from the mother's gut are ...

– University of Luxembourg

Nature Communications


Many diseases increase the risks of hip fracture surgery

Parkinson's disease, osteoarthritis, rheumatic diseases, alcoholism and mental health disorders increase the risk of surgical complications after a hip fracture surgery, a new Finnish study analysing nationwide registers finds. 4.6% of all hip surger...

– University of Eastern Finland

Injury


New chlamydia test delivers results in about 30 minutes

NIBIB-funded researchers recently validated a rapid STD test that delivered accurate results in about 30 minutes for chlamydia, allowing patients to receive treatment immediately, thereby stemming the further spread of disease. Other analyses showed ...

– National Institute of Biomedical Imaging and Bioengineering

Sexually Transmitted Diseases, Nov-2018; EB007958; AI168613; TR001425


NIBIB-funded researchers use non-invasive imaging technique to diagnose, monitor chronic wounds

A team of NIH-funded researchers at the University of Arkansas have demonstrated the novel use of multiphoton microscopy to monitor wound healing in live animals. The scientists measured metabolic changes that occur during healing at the wounds’ su...

– National Institute of Biomedical Imaging and Bioengineering

Communications Biology, 19 Nov 2018; EB017723; AG056560


Experts Present New Recommendations on 'Overlapping' Type of Leukemia

Chronic myelomonocytic leukemia (CMML) is a rare disease with overlapping features of two categories of bone marrow and blood cell disorders that poses challenges in clinical management. Joint recommendations on diagnosis and treatment of CMML from t...

– Wolters Kluwer Health: Lippincott Williams and Wilkins

Hemasphere


A cancer drug may help treat human papillomavirus infections

Preclinical experiments by University of Alabama at Birmingham researchers suggest the cancer drugs vorinostat, belinostat and panobinostat might be repurposed to treat infections caused by human papillomaviruses, or HPVs.

– University of Alabama at Birmingham

Proceedings of the National Academy of Sciences; CA83679


Bigger Brains Are Smarter, but Not by Much

Using a larger dataset than all previous studies on the subject combined, researchers found a small but significant connection between brain size and cognitive performance

– University of Pennsylvania

Psychological Science


Beyond Bone Mineral Density: Assessing Additional Bone Traits Helps ID Those at Risk for Fracture

Large international study confirms measuring bone microarchitecture with new imaging technology accurately predicts risk of fracture in older women and men

– Beth Israel Deaconess Medical Center

The Lancet Diabetes and Endocrinology; R01AR061445


Bloodstream Infection Rates as a Measure of Quality in Hemodialysis Facilities

A new study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) investigated rates of bloodstream infection among patients with or without catheters in outpatient hemodialysis facilities in New England.

– Beth Israel Deaconess Medical Center

Clinical Journal of the American Society of Nephrology (CJASN)


BIDMC Research & Health News Digest: November 2018

A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

– Beth Israel Deaconess Medical Center

The Lancet Diabetes and Endocrinology; American Journal of Sports Medicine; Clinical Journal of the American Society of Nephrology (CJASN)


Targeting tumors with 3D animation

Oregon State University engineers are using 3D animations techniques to increase the precision of radiation therapy for prostate cancer so that neighboring healthy tissues and organs are not affected.

– Oregon State University, College of Engineering


ISPOR CEO Recognized by Stevie® Awards for Women in Business

ISPOR CEO and Executive Director Nancy S. Bergwas recently honored with 3 Stevie Awards®. The Stevie Awards for Women in Business are the world’s top honors for female entrepreneurs, executives, employees, and the organizations they run.

– ISPOR—The Professional Society for Health Economics and Outcomes Research


ISPOR Receives Multiple MarCom Awards Recognizing Its New Branding and Website

ISPOR—the professional society for health economics and outcomes research, has received multiple MarCom Awards for its new organizational rebranding, newly redesigned website, and a number of other communications initiatives.

– ISPOR—The Professional Society for Health Economics and Outcomes Research


Mount Sinai’s Mitral Valve Repair Center Website Honored With Top Marketing Awards

For the 10th year in a row, Mount Sinai Health System’s Mitral Valve Repair Center received honors at the Annual eHealthcare Leadership Awards, announced at the 2018 Healthcare Internet Conference in Scottsdale, Arizona

– Mount Sinai Health System


Baylor Scott & White Health Opens Pflugerville’s First Hospital, Expands Care Delivery in Travis County

Baylor Scott & White Health today opened its newest medical center, Baylor Scott & White Medical Center – Pflugerville, the system’s first hospital constructed in Travis County. The new medical center, at 2600 E. Pflugerville Pkwy, Suite 100, Pfl...

– Baylor Scott and White Health


Three Orlando Health Hospitals Receive ‘A’ Grades for Patient Safety in Fall 2018 Leapfrog Hospital Safety Grade

Orlando Health Dr. P. Phillips Hospital, Orlando Health Orlando Regional Medical Center and Orlando Health South Lake Hospital were awarded ‘A’ grades from The Leapfrog Group’s Fall 2018 hospital safety survey.

– Orlando Health


2018 Value Assessment Challenge Award Recipients to Outline Research Projects at Personalized Medicine Coalition Policy Meeting & Webinar on Dec. 12 in Washington, D.C.

The PhRMA Foundation and the Personalized Medicine Coalition (PMC) partnered earlier this year for the 2018 Value Assessment Challenge Awards — designed to encourage innovative approaches in defining and measuring value in health care.

– PhRMA Foundation


PhRMA Foundation Releases Highlights of its 2018 Funding Efforts

The PhRMA Foundation awarded more than $6 million over the last two years to more than 100 leaders in scientific research in the United States. The Foundation is proud to announce another successful year supporting innovative research efforts in are...

– PhRMA Foundation


New UC San Diego Campaign Promotes Sexual Health — and has a Quick Test to Prove It

New UC San Diego campaign promotes sexual health and has a quick test to prove it. “Good to Go” offers combined testing for HIV and five sexually transmitted diseases, providing some results in as little as 60 seconds and access to free treatment...

– University of California San Diego Health

Science News


Why Didn’t 70% of an Ancient Ural Settlement’s Habitants Live Up to the Age of 18?

Artifacts of the Bronze Age at the territory of the Southern Urals for several decades have been the object of active research by archaeologists from around the world. Scientists of South Ural State University together with international colleagues f...

– South Ural State University

American Journal of Human Biology


Wild yeasts may hold key to better wines from warmer climates

Researchers at the University of Adelaide have found yeasts that naturally occur on wine grapes may improve wines produced in warmer climates. Up until now the use of these ‘natural’ or ‘wild’ yeasts during the production process has mostly b...

– University of Adelaide

Scientific Reports


AIP receives $650,000 Grant to Digitize Rare Books

The American Institute of Physics announced today that it has received a grant from the Alfred P. Sloan Foundation to make a unique collection of rare books in the physical sciences universally accessible. The grant will enable AIP's Niels Bohr Libra...

– American Institute of Physics (AIP)


Government Inaction on Climate Change Threatens Lives: Report

The Australian report is part of a joint global initiative between The Medical Journal of Australia and The Lancet to track progress on health and climate change and inform policy makers of political actions needed.

– University of Sydney

Medical Journal of Australia; Lancet Countdown 2018 Global Report


United States Department of Energy to host multi-laboratory CyberForce Competition™

The U.S. Department of Energy (DOE) will host its fourth collegiate CyberForce Competition™ on December 1.

– Argonne National Laboratory


Probing Quantum Physics on a Macroscopic Scale

Why does quantum mechanics work so well for microscopic objects, yet macroscopic objects are described by ‘classical physics’? This question has bothered physicists since the development of quantum theory more than a 100 years ago. Researchers of...

– Delft University of Technology

Physical Review Letters, 121, 220404 – Published 29 November 2018


How the devil ray got its horns

If you ever find yourself staring down a manta ray, you'll probably notice two things right away: the massive, flapping fins that produce the shark cousin's 20-foot wingspan and the two fleshy growths curling out of its head that give it the nickname...

– San Francisco State University

Frontiers in Ecology and Evolution


St. Jude research into leukemia, sickle cell and other blood disorders presented at ASH

The 60th Annual Meeting of the American Society of Hematology will feature research from St. Jude Children’s Research Hospital on topics ranging from the genomic basis and vulnerabilities of leukemia to an update on gene therapy for hemophilia B to...

– St. Jude Children's Research Hospital

The 60th Annual Meeting of the American Society of Hematology


Scientists reveal substantial water loss in global landlocked regions

A new study involving Kansas State University researchers reveals that water storage declines in global landlocked basins has aggravated local water stress and caused potential sea level rise.

– Kansas State University

Nature Geoscience

includes video


Study Reveals Peace in Colombia Has an Unexpected Result – Deforestation

In a first-of-a-kind study published Nature Ecology & Evolution, scientists provide evidence that implementing the peace accords in Colombia coincided with a spike of fires and deforestation in protected areas.

– Stony Brook University

Nature Ecology & Evolution


What are “boutique” soils?

Did you know soils could be “boutique?” The Soil Science Society of America (SSSA) Dec. 1 Soils Matter blog explains how this group of soils can challenge your assumptions.

– Soil Science Society of America (SSSA)


Materials for Solar Batteries of New Generation Are Being Created at SUSU

Alternative energy sources are a way to rational resource saving. Development of nanotechnology is a serious impulse for development of alternative energy sources. For several years, scientists of South Ural State University have been working on crea...

– South Ural State University


Notre Dame unveils largest Mach 6 quiet hypersonic test facility in US

The $5.4 million project is the first step in a partnership between Notre Dame and Purdue University to develop multiple hypersonic tunnels.

– University of Notre Dame


Tending the Soil

The world’s leading soil scientists met at Argonne recently to discuss the importance of what’s under our feet.

– Argonne National Laboratory


Penn State CNEU to Help Broaden Participation of Underrepresented Minorities in STEM Fields

With $1.2 million in funding from the National Science Foundation, the Penn State Center for Nanotechnology Education and Utilization, along with Norfolk State University and Tidewater Community College, will form the Southeastern Coalition for Engag...

– Penn State College of Engineering


DHS S&T to Host Industry Day for Start-Ups

Technology start-ups will learn about a new opportunity to collaborate with DHS on combating counterfeit and forged documentation. DHS S&T SVIP will host a DHS Industry Day on December 11th in Menlo Park, California, to describe its operations and ne...

– Homeland Security's Science And Technology Directorate


S&T is Working to Address GPS Vulnerabilities, Improving Critical Infrastructure Resilience

The Department of Homeland Security (DHS) Science and Technology Directorate (S&T) has dedicated a multi‑year program to address GPS vulnerabilities in critical infrastructure, with a multi‑pronged approach.

– Homeland Security's Science And Technology Directorate

Lifestyle & Social Sciences


People Who Prefer Casual Sex Still Desire Intimacy

Casual sex among emerging adults can be a source of intimacy, and often is, according to a new study conducted by an interdisciplinary team of researchers including Binghamton University faculty and members of Indiana’s Kinsey Institute.      ...

– Binghamton University, State University of New York

Journal of Relationships Research


Promises Broken: Persons with Disabilities 
Still Face Barriers to Participation at the United Nations

A new study finds "tremendous barriers" exist that prevent persons with disabilities from fully participating in international policymaking with the United Nations.

– American University


Wunderkind or Innovator? Researchers Have Come up with a Concept for Developing Children’s Aptitude

The study of creativity has a long history. Creative people include those who have the potential to offer progressive ideas, modernize, and implement innovations. Over 16 years, South Ural State University researchers have kept track of the pupils of...

– South Ural State University

Psychology in Russia: State of the Art


Kennesaw State associate professor of exercise science conducts extensive CrossFit injury study

The popular fitness program CrossFit is a safe training method for most people but could result in injuries for those who are new to it or don’t participate often, according to a four-year analysis conducted by Kennesaw State University associate p...

– Kennesaw State University

Orthopaedic Journal of Sports Medicine


How you respond to drama depends on if you are a holistic or analytical thinker

Magnetic Resonance Imaging (MRI) scans of people watching the same clip from a dramatic film show that holistic thinkers all have similar brain responses to the scene, whereas analytical thinkers respond differently to each other.

– Aalto University

Social Cognitive and Affective Neuroscience


Virtual reality could serve as powerful environmental education tool

Utter the words "ocean acidification" in mixed company, and you'll probably get blank stares. Although climate change has grown steadily in the public consciousness, one of its most insidious impacts - a widespread die-off of marine ecosystems driven...

– Stanford University

Frontiers in Psychology

includes video


Changing the conversation Seniors and technology

We laugh at the meme—even those of us over a certain age—of the toddler, hand pressed over his eyes in utter frustration, telling grandma for the umpteenth time how to open a browser on her computer. Or the photo of the older couple staring at a...

Expert Available

– University of Michigan


Stories Since the Storm

The latest issue of The Common presents writing from and about Puerto Rico, a year after Hurricane María.

– Amherst College


Welcoming California’s Fastest Growing Population

To advance its goal of inclusive excellence, UC San Diego is launching the Latinx/Chicanx Academic Excellence Initiative. The campuswide program, led by the Office for Equity, Diversity, and Inclusion, unifies and expands services dedicated to attrac...

– University of California San Diego

Business News


The Evolution of Corporate Governance: 2018 Study of Inception to IPO

Pre-IPO governance systems are highly diverse in maturity, rigor, and structure. The SEC dictates public standards, but pre-IPO companies make vastly different choices on when and how to implement.

– Stanford Graduate School of Business


ASU research finds that women earn 18 percent less than men in online job market

A team at ASU has analyzed a huge data set from an online labor market and discovered that women earn less than men in technology work — primarily because of the women's choices in seeking jobs.

– Arizona State University (ASU)

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