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Newswise Special Wire
Tuesday, March 3, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 03-Mar-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Flower-like Magnetic Nanoparticles Target Difficult Tumors

Thanks to the work of an interdisciplinary team of researchers at the Dartmouth Center of Nanotechnology Excellence, funded by the National Institutes of Health, the next-generation magnetic nanoparticles (MNPs) may soon be treating deep-seated and difficult-to-reach tumors within the human body.

 • Image(s) embedded •  (Embargo expired on 03-Mar-2015 at 11:00 ET)

Journal of Applied Physics

– American Institute of Physics (AIP)

Computer Simulator Will Improve Radiation Therapy for Cancer Patients

A University of Arkansas researcher helped spearhead a project to develop a computer simulator of dual foil scattering systems used in radiation therapy.

 • Image(s) embedded • 

Journal of Applied Clinical Medical Physics

– University of Arkansas, Fayetteville

Research on Alternative Tobacco Products, Alzheimer’s Disease, Cancer Treatment, and More to Be Presented at Annual Toxicology Meeting

Research related to cardiovascular, respiratory, and neurodegenerative diseases; cancer; food safety; biotechnology; and pharmaceuticals, among others, will be presented and discussed from March 22–26, 2015, at the San Diego Convention Center as part of the 54th Annual Meeting and ToxExpo of the Society of Toxicology (SOT).

– Society of Toxicology

Promising New Strategy to Halt Pancreatic Cancer Metastasis

Researchers have identified a novel treatment that could halt pancreatic cancer and prolong patient survival.

 • Image(s) embedded •  (Embargo expired on 02-Mar-2015 at 09:00 ET)

Journal of Experimental Medicine, Vol. 212, No. 3; MOST-103-2321

– The Rockefeller University Press

U.S. Women’s Awareness of Breast Density Varies by Race and Ethnicity, Education and Income, Mayo Clinic Study Finds

Disparities in the level of awareness and knowledge of breast density exist among U.S. women, according to the results of a Mayo Clinic study published in the Journal of Clinical Oncology.

(Embargo expired on 02-Mar-2015 at 16:00 ET)

Journal of Clinical Oncology

– Mayo Clinic

Sall4 Is Required for DNA Repair in Stem Cells

A protein that helps embryonic stem cells retain their identity also promotes DNA repair. The findings raise the possibility that the protein, Sall4, performs a similar role in cancer cells, helping them survive chemotherapy.

 • Image(s) embedded •  (Embargo expired on 02-Mar-2015 at 09:00 ET)

Journal of Cell Biology, Vol. 208, No. 5; 2012CB966900; RC1-00148

– The Rockefeller University Press

Psychology Has Important Role in Changing Cancer Landscape

Psychology has played, and will continue to play, a critical role in cancer prevention, treatment and control, according to the flagship journal of the American Psychological Association.

(Embargo expired on 02-Mar-2015 at 09:00 ET)

American Psychologist

– American Psychological Association (APA)

U.S. Spends More on Cancer Care, Saves Fewer Lives than Western Europe

Such findings have raised questions about the additional value of U.S. cancer care derived from the additional spending, in comparison to the situation in other high-income countries.

(Embargo expired on 02-Mar-2015 at 16:00 ET)

Health Affairs; RC2CA148529; PO1-AG19783; KL2TR001088

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Basal Cell Carcinoma Drug Encourages Both Cancer Regression and Loss of Taste in Patients

Researchers at the University of Michigan have identified the pathway responsible for taste changes among users of chemotherapy drugs that treat basal cell carcinoma. Manuscript was chosen as an APSselect article for March.

– American Physiological Society (APS)

Lycopene May Ward Off Kidney Cancer in Older Women

A higher intake by postmenopausal women of the natural antioxidant lycopene, found in foods like tomatoes, watermelon and papaya, may lower the risk of renal cell carcinoma, a type of kidney cancer.

Cancer, Feb. 15, 2015

– Wayne State University Division of Research

TSRI Scientists Find Clues to Cancer Drug Failure

Scientists at The Scripps Research Institute have published a pair of studies showing how the primary protein responsible for multidrug chemotherapy resistance changes shape and reacts to therapeutic drugs.

 • Image(s) embedded • 

Structure; Acta Crystallographica Section D

– Scripps Research Institute

MD Anderson Study Shows Why Some Brain Cancers Resist Treatment

Scientists at The University of Texas MD Anderson Cancer Center may have discovered why some brain cancer patients develop resistance to standard treatments including radiation and the chemotherapy agent temozolomide.

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Proceedings of the National Academy of Sciences

– University of Texas M. D. Anderson Cancer Center

Long-Term Care May Not Be Best for Adults with Traumatic Brain Injury; Other Housing Needed

A new, large-scale Canadian study shows that many adults with traumatic brain injury (TBI) live in a long-term health setting – such as a nursing home- which may not be appropriate for their condition and younger age.

Expert(s) available

– University Health Network (UHN)

Mount Sinai Researchers Find Chemotherapy after Bladder Cancer Surgery Improved Survival

Analysis of More Than 5,000 Patients Presented at 2015 Genitourinary Cancer Symposium

(Embargo expired on 27-Feb-2015 at 12:45 ET)

2015 Genitourinary Cancers Symposium

– Mount Sinai Medical Center

Moffitt Cancer Center Researchers Identify Protein Pathway Involved in Brain Tumor Stem Cell Growth

Glioblastomas are a highly aggressive type of brain tumor, with few effective treatment options. Moffitt Cancer Center researchers are one step closer to understanding glioblastoma development following the identification of a key protein signaling pathway involved in brain tumor stem cell growth and survival. Brain tumor stem cells are believed to play an important role in glioblastoma development and may be possible therapeutic targets.

The Journal of Biological Chemistry, Feb-2015

– Moffitt Cancer Center

Growth Signal Can Influence Cancer Cells’ Vulnerability to Drugs, Study Suggests

In theory, a tumor is an army of clones, made up of many copies of the original cancerous cell. But tumor cells don’t always act like duplicates, and their unpredictable behavior can create problems for treatment. For while some cells within a tumor succumb to anti-cancer drugs, others may survive to bring the cancer back to life once therapy has ended.

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– Rockefeller University

NYU Langone Gastroenterologists Remind You of the Importance of Colorectal Cancer Screening and Prevention for Colon Cancer Month

Gastroenterologists at NYU Langone Medical Center provide tips for when, who, and how to get screened for colorectal cancer.

– NYU Langone Medical Center

Anderson Algorithm Increases Surgical Success with Advanced Ovarian Cancer

A surgical algorithm developed and implemented by ovarian cancer specialists at The University of Texas MD Anderson Cancer Center dramatically increases the frequency of complete removal of all visible tumor – a milestone strongly tied to improved survival.

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Nature Reviews Clinical Oncology

– University of Texas M. D. Anderson Cancer Center

Noble Hospital Surgeon's Work on Breakthrough Breast Cancer Device to be Featured at International Conference

Steven Schonholz, MD, FACS, will present a scientific poster on how BioZorb is used in the treatment of breast cancer at the 32nd Annual Miami Breast Cancer Conference, in Miami Beach, Fla., Feb. 26 to March 1.

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Miami Breast Cancer Conference

– Noble Hospital

Pancreatic Cancer Patients with Particular Gene Signature May Benefit From Personalized Treatment

Cancer researchers at Indiana University report that about 15 percent of people with pancreatic cancer may benefit from therapy targeting a newly identified gene signature.

Oncotarget; CA-075059

– Indiana University

New Technology Tracks Cell Lineage To Watch Evolution at Work

Evolution is change, and not always for the better. Evolution, in fact, is at the core of many of the diseases that are hardest to treat. Pathogens such as bacteria and parasites evade their host’s defenses or antimicrobial drugs through evolution. Cancer itself in an evolutionary process, whereby “rogue” cells evolve to grow beyond their normal barriers, migrate to distant locations in the body, and ultimately evade chemotherapy.

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Nature

– Stony Brook University

Cherenkov Effect Improves Radiation Therapy for Patients with Cancer

The complex parts of the blue light known as the Cherenkov Effect can be measured and used in dosimetry to make therapies safer and more effective.

 • Video / Image(s) embedded • 

Physics in Medicine and Biology; Prouty pilot funding; R21 EB017559

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Study Reveals Possible Biological Trigger for Canine Bone Cancer

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine (SVM) have identified the biological mechanism that may give some cancer cells the ability to form tumors in dogs. The recent study uncovered an association between the increased expression of a particular gene in tumor cells and more aggressive behavior in a form of canine bone cancer. It may also have implications for human cancers by detailing a new pathway for tumor formation.

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Veterinary and Comparative Oncology, Feb-2015

– University of Wisconsin-Madison

Quick Antibiotics Reduce PICU Needs and Mortality of Pediatric Cancer Patients

A University of Colorado Cancer Center study published in the journal Pediatric Blood & Cancer shows that pediatric cancer patients who receive antibiotics within 60 minutes of reporting fever and showing neutropenia (low neutrophil count), go on to have decreased intensive care needs and lower mortality compared with patients who receive antibiotics outside the 60-minute window.

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Pediatric Blood and Cancer

– University of Colorado Cancer Center

Researchers Find Link Between Inflammation, Tissue Regeneration and Wound Repair Response

Writing in the February 25 online issue of Nature, an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links between inflammation and regeneration: signaling pathways that are activated by a receptor protein called gp130.

Nature

– University of California, San Diego Health Sciences

Using Diet-Drug Combination to Target Cancer

Tumor cells require high levels of glucose to multiply. This, in turn, creates more lactic acid, a byproduct that negatively affects the body’s immune response thereby reducing the effectiveness of drug therapies. Scientists from Sanford Research and South Dakota State University are using a low-glucose diet and specially designed anti-cancer drugs to improve therapeutic outcomes in cancer patients.

 • Image(s) embedded • 
Expert(s) available

– South Dakota State University

Announcements

Fred Hutch Health Economist Gary Lyman Edits Essential Reference Book for Clinical Oncologists

Oncologist and health economist Gary Lyman, M.D., M.P.H., co-director of the Hutchinson Institute for Cancer Outcomes Research at Fred Hutchinson Cancer Research Center, is editor of the second edition of the Oxford American Handbook of Oncology released this week from Oxford University Press.

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– Fred Hutchinson Cancer Research Center

Fred Hutch Approved for a $7.75M Award by the Patient-Centered Outcomes Research Institute

A research team led by Scott Ramsey, M.D., Ph.D., director of the Hutchinson Institute for Cancer Outcomes Research, or HICOR, has been approved for a $7.75 million, four-year funding award by the Patient-Centered Outcomes Research Institute, or PCORI, an independent, nonprofit organization based in Washington, D.C. The award will be used to conduct a pragmatic clinical trial evaluating the use of colony stimulating factors to reduce the risk of serious infection in patients undergoing chemotherapy for breast, colorectal or lung cancer.

 • Image(s) embedded • 

– Fred Hutchinson Cancer Research Center

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