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Newswise Special Wire
Tuesday, March 17, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 17-Mar-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Effect of Aspirin, NSAIDs on Colorectal Cancer Risk May Differ From Genetic Variations

Among approximately 19,000 individuals, the use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with an overall lower risk of colorectal cancer, although this association differed according to certain genetic variations, according to a study in the March 17 issue of JAMA.

(Embargo expired on 17-Mar-2015 at 11:00 ET)

JAMA

– JAMA - Journal of the American Medical Association

The Link Between Aspirin, NSAIDs and Colon Cancer Prevention May Hinge on Genetic Variations

The link between taking aspirin, non-steroidal anti-inflammatory drugs, or NSAIDS, and colorectal cancer prevention is well established, but the mechanisms behind the protective effect have not been understood. A new study, co-led by investigators at Fred Hutchinson Cancer Research Center and published March 17 in JAMA, suggests this protection differs according to variations in DNA.

 • Image(s) embedded •  (Embargo expired on 17-Mar-2015 at 11:00 ET)

JAMA; U01 CA137088; R01 CA059045; RFA# CA-95-011; CA 122839; U01 CA097735; U01 CA074783; R01 CA48998; U01 CA074783; R01 CA076366; K05 CA154337...

– Fred Hutchinson Cancer Research Center

Microenvironment Provides Growth Factor for Metastasis

When a person has cancer that spreads to the bone and bone marrow, the tissue becomes increasingly fragile, often leading to increased bone resorption. In a surprising discovery, investigators at Children’s Hospital Los Angeles reported that when neuroblastoma (NB) cells metastasize to the bone, there initially occurs an increase in bone deposition, not resorption. This process is driven by a chemical messenger called VEGFA.

International Journal of Cancer; PO1-CA81403; 2-T32-CA 09659

– Children's Hospital Los Angeles Saban Research Institute

Doctors Don't Always Agree on Breast Biopsies; Say Women with Aytpia or DCIS Should Seek Second Opinions

While doctors almost always agree on a pathological diagnosis of invasive breast cancer, there is room for improvement when diagnosing atypia (or atypical ductal hyperplasia-ADH) and DCIS (ductal carcinoma in-situ).

JAMA; RO1 CA140560; K05-CA104669; UO1CA86082; UO1CA70013; UO1CA69976; HHSN261201100031C

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Macrophages May Play Critical Role in Melanoma Resistance to BRAF Inhibitors

In the last several years, targeted therapies – drugs that directly impact specific genes and proteins involved in the progression of cancer – have been approved for a wide variety of cancers, including melanoma, the deadliest form of skin cancer. Now, researchers at The Wistar Institute have discovered one way in which melanoma becomes resistant to a particular form of targeted therapy, and understanding this phenomenon may lead to a new melanoma target or prompt new designs of these treatments.

 • Image(s) embedded • 

Clinical Cancer Research, Jan-2015

– Wistar Institute

Genetic Markers Play Role in Who Benefits From Aspirin, NSAIDs to Lower Colon Cancer Risk

An Indiana University cancer researcher and her colleagues have identified genetic markers that may help determine who benefits from regular use of aspirin and other nonsteroidal anti-inflammatory drugs for lowering one’s risk of developing colorectal cancer.

JAMA, March 17, 2015

– Indiana University

How NORE1A Acts as a Barrier to Tumor Growth

Researchers reveal how cells protect themselves from a protein that is a key driver of cancer.

 • Image(s) embedded •  (Embargo expired on 16-Mar-2015 at 09:00 ET)

Journal of Cell Biology, Vol. 208, No. 6; RR18733; CA133171-01

– The Rockefeller University Press

Oncologists Reveal Reasons for High Cost of Cancer Drugs in the U.S., Recommend Solutions

ROCHESTER, Minn. – Increasingly high prices for cancer drugs are affecting patient care in the U.S. and the American health care system overall, say the authors of a special article published online in the journal Mayo Clinic Proceedings.

(Embargo expired on 16-Mar-2015 at 00:05 ET)

Mayo Clinic Proceedings

– Mayo Clinic

Exercise Slows Tumor Growth, Improves Chemotherapy in Mouse Cancers

One way many cancers grow resistant to treatment is by generating a web of blood vessels that are so jumbled they fail to provide adequate oxygen to the tumor. With oxygen starvation, the tumor gains a sort of cloaking device that protects it from the toxic effects of chemotherapy drugs and radiation, which are designed to seek out well-oxygenated tissue. Researchers have long tested various approaches to improving blood flow to the tumor in the hopes of restoring potency to treatments. Not much has shown promise. Until researchers investigated exercise.

 • Image(s) embedded •  (Embargo expired on 16-Mar-2015 at 16:00 ET)

Journal of the National Cancer Instittue; BC093532; CA40355

– Duke Medicine

Study Identifies “Lethal” Subtype of Prostate Cancer

University of Colorado Cancer Center study shows that of prostate cancer patients with combination MAP3K7 and CHD1 deletions, about 50 percent will have recurrent prostate cancer, which ultimately leads to death. About 10 percent of all prostate cancers harbor combined MAP3K7-CHD1 deletions.

 • Image(s) embedded • 

Cancer Research; R01 CA129418; W81XWH-12-1-0188

– University of Colorado Cancer Center

Scripps Florida Scientists Confirm Key Targets of New Anti-Cancer Drug Candidates

Scientists from the Florida campus of The Scripps Research Institute have confirmed the ribosome assembly process as a potentially fertile new target for anti-cancer drugs by detailing the essential function of a key component in the assembly process.

 • Image(s) embedded • 

The Journal of Cell Biology

– Scripps Research Institute

Study Details MicroRNA’s Role as a Double Agent During Hep C Infection

In the battle between a cell and a virus, either side may resort to subterfuge. Molecular messages, which control the cellular machinery both sides need, are vulnerable to interception or forgery. New research at Rockefeller University has revealed the unique twist on just such a strategy deployed by the liver-infecting Hepatitis C virus – one that may help explain the progression of liver disease and that the researchers suspect may be found more widely in the world of disease-causing viruses.

 • Image(s) embedded • 

Cell, Mar-2015

– Rockefeller University

Vanderbilt Team First to Blend High-End Imaging Techniques

Vanderbilt University researchers have achieved the first “image fusion” of mass spectrometry and microscopy — a technical tour de force that could, among other things, dramatically improve the diagnosis and treatment of cancer.

 • Image(s) embedded • 

Nature Methods

– Vanderbilt University Medical Center

Stem Cells Lurking in Tumors Can Resist Treatment

Scientists are eager to make use of stem cells’ extraordinary power to transform into nearly any kind of cell, but that ability also is cause for concern in cancer treatment. A new study shows stem cells are found even in low-grade tumors, where they can resist treatment.

 • Image(s) embedded •  (Embargo expired on 12-Mar-2015 at 12:00 ET)

Cell Reports

– Washington University in St. Louis

Naproxen Plus Acid Blocking Drug Shows Promise in Preventing Bladder Cancer

Researchers combined the NSAID naproxen with the proton pump inhibitor omeprazole and found it reduced the incidence of bladder cancer in rats.

(Embargo expired on 11-Mar-2015 at 00:05 ET)

Cancer Prevention Research; N01-CN43301

– University of Michigan Health System

Depression Symptoms of African-American Cancer Patients May Be Under-Recognized, Study Finds

Case Western Reserve University nurse scientist Amy Zhang, who has long examined quality-of-life issues in cancer patients, wondered whether depression in African-American cancer patients has been under-recognized for treatment.

The Journal of Mental Health

– Case Western Reserve University

Repeated Exposure of Children to Secondhand Smoke Is Child Abuse, Goldstein Argues

Purposefully and repeatedly exposing children to secondhand smoke — a known human carcinogen — is child abuse, according to an opinion piece written by Adam Goldstein, MD, MPH, a professor in the Department of Family Medicine at the University of North Carolina School of Medicine.

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Annals of Family Medicine

– University of North Carolina School of Medicine

New Clues About the Risk of Cancer From Low-Dose Radiation

Berkeley Lab scientists studied mice and found their risk of mammary cancer from low-dose radiation depends a great deal on their genetic makeup. They also learned key details about how genes and the cells immediately surrounding a tumor (also called the tumor microenvironment) affect cancer risk.

Scientific Reports

– Lawrence Berkeley National Laboratory

Announcements

New NCCN Member Institution: Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute has been named the newest NCCN Member Institution; NCCN now has 26 Member Institutions serving patients throughout the United States.

– National Comprehensive Cancer Network® (NCCN®)

Wistar Receives $1.1M Grant from the Jayne Koskinas Ted Giovanis Foundation for Health and Policy to Establish a Consortium for Breast Cancer Research

The Jayne Koskinas Ted Giovanis (JKTG) Foundation awarded The Wistar Institute a $1.1 million grant to create The Jayne Koskinas Ted Giovanis Breast Cancer Research Consortium at The Wistar Institute. The Consortium will support the highly synergistic, multidisciplinary research projects of three Wistar scientists dedicated to advancing breast cancer research.

– Wistar Institute

Expert Pitch

Rutgers Cancer Institute of New Jersey Experts Address Smoking Dangers and Quitting in Advance of March 18 ‘Kick Butts Day’

 • Image(s) embedded • 

– Rutgers Cancer Institute of New Jersey

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