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Newswise Special Wire
Tuesday, March 24, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 24-Mar-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Could a Tampon One Day Help Predict Endometrial Cancer? Mayo Clinic Researchers Says Yes

Researchers at Mayo Clinic have shown that it is possible to detect endometrial cancer using tumor DNA picked up by ordinary tampons. The new approach specifically examines DNA samples from vaginal secretions for the presence of chemical “off” switches — known as methylation — that can disable genes that normally keep cancer in check.

(Embargo expired on 24-Mar-2015 at 00:05 ET)

Gynecologic Oncology

– Mayo Clinic

Is Marijuana Medicine?

White Paper that investigates marijuana as a medicine and the push to legalize medical marijuana.

(Embargo expired on 24-Mar-2015 at 10:00 ET)

– Pennsylvania Medical Society

Brain Tumor Cells Decimated by Mitochondrial "Smart Bomb"

An experimental drug that attacks brain tumor tissue by crippling the cells' energy source called the mitochondria has passed early tests in animal models and human tissue cultures, say Houston Methodist scientists.

 • Image(s) embedded • 

ChemMedChem, April 2015

– Houston Methodist

Expert Alert – Preventive Surgery for Gynecologic Cancers

Jamie Bakkum-Gamez, M.D., an oncologist and gynecologic surgeon, is available to provide context for reporters wishing to better understand preventive surgery for gynecologic cancers in light of Angelina Jolie’s announcement that she had her ovaries and fallopian tubes removed as a cancer prevention strategy.

Expert(s) available

– Mayo Clinic

Stress Granules Ease the Way for Cancer Metastasis

Tumors that produce more stress granules are more likely to metastasize, according to researchers in Canada. The results suggest that drugs to inhibit the formation of these structures might rein in cancer metastasis.

 • Video / Image(s) embedded •  (Embargo expired on 23-Mar-2015 at 09:00 ET)

The Journal of Cell Biology; 1021; T2013-1; DFG GR3728/2-1

– The Rockefeller University Press

How to Get Smarter on Pills for Seniors

Cancer patients over the age of 65 often take multiple drugs, which can interfere with cancer treatment. A new study shows that currently used tools to prevent over-medicating senior cancer patients need improvement

(Embargo expired on 23-Mar-2015 at 16:00 ET)

Journal of Clinical Oncology

– Thomas Jefferson University

Sweeping Prostate Cancer Review Upends Widely Held View on Radiation

Two new studies from the University of Virginia School of Medicine have upended the widely held view that it’s best to delay radiation treatment as long as possible after the removal of the prostate in order to prevent unwanted side effects.

 • Video / Image(s) embedded • 

– University of Virginia Health System

Favorable 15-Year Survival Outcomes for Older Prostate Cancer Patients with Low-Risk Disease

Results from a population-based study from investigators at Rutgers Cancer Institute of New Jersey show favorable survival outcomes among patients with low-risk prostate cancer treated with conservative management initially. The study, which examined men 65 and older, extends previous data examination by the team an additional five years.

 • Image(s) embedded • 

European Urology, Mar-2015

– Rutgers Cancer Institute of New Jersey

Researchers Discover Mechanism to Control Multiple Processes of Cell Growth, Division

Investigators from Dartmouth's Norris Cotton Cancer Center find that the protein Pom1 possesses the ability to modify different sets of proteins to coordinate the processes of cell growth and division.

 • Image(s) embedded • 

Journal of Molecular and Cellular Proteomics; Pew Charitable Trusts; RO1-GM099774; RO1-CA-155260

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Experiments Reveal Key Components of the Body’s Machinery for Battling Deadly Tularemia

Research led by scientists at St. Jude Children’s Research Hospital has identified key molecules that trigger the immune system to launch an attack on the bacterium that causes tularemia. The research was published online March 16 in Nature Immunology.

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AR056296; CA163507; AI101935

– St. Jude Children's Research Hospital

Anti-Diabetic Drug Metformin and Vitamin D3 Show Impressive Promise in Preventing Colorectal Cancer

The concept was simple: If two compounds individually show promise in preventing colon cancer, it’s worth trying the two together. Metformin and Vitamin D3 proved dramatically better than either option alone. Their findings served as the cover feature for the February Cancer Prevention Research.

RO1CA136726, U01CA181770, P50CA50964

– Case Western Reserve University

Measuring Treatment Response Proves to Be a Powerful Tool for Guiding Leukemia Treatment

Measuring the concentration of leukemia cells in patient bone marrow during the first 46 days of chemotherapy should help boost survival of young leukemia patients by better matching patients with the right intensity of chemotherapy. St. Jude Children’s Research Hospital investigators led the research, which appears in the March 20 edition of the journal Lancet Oncology.

Lancet Oncology

– St. Jude Children's Research Hospital

Dartmouth Investigators Make Photodynamic Therapy for Pancreatic Cancer Simpler, Cheaper

Research finds the values measured with dynamic contrast enhanced computer tomography strongly correlated with fluorescence intensity measured directly from the pancreatic tissue.

Academic Radiology; PO1 CA84203/CA/NCI

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Advanced Melanoma Treatments Have Promise for Patients

Within the last five years, targeted therapy and immunotherapy have emerged as viable treatment options for patients with advanced melanoma. Although these therapies have promising implications, early detection still gives patients the best chance of survival.

AAD Annual Meeting, March 2015

– American Academy of Dermatology

Kidney Cancer Detected Early with Urine Test

If kidney cancer is diagnosed early — before it spreads beyond the kidney — 80 percent of patients survive. However, finding it early has been among the disease’s greatest challenges. Now, Washington University School of Medicine have developed a noninvasive method to screen for kidney cancer that involves measuring the presence of proteins in the urine.

 • Audio / Image(s) embedded •  (Embargo expired on 19-Mar-2015 at 11:00 ET)

JAMA Oncology, March 19, 2015

– Washington University in St. Louis

Two Distinct Populations of CD4 T Cells Play Different Roles in Immune System

Utilizing a novel transgenic mouse model, Edward Usherwood, PhD of Dartmouth's Norris Cotton Cancer Center and collaborators found that CD4 T cells divide into two different populations that each has a different job.

Journal of Immunology; RO1CA103642; AI42927; RO1CA082036

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Streamlined 'Military' Work Flow Means More Patient Appointments and Fewer Return Visits

Both patients and physicians may benefit from a “work flow” system developed at military medical facilities and tested at a Johns Hopkins Kimmel Cancer Center clinic, according to results of an efficiency study.

– Johns Hopkins Medicine

Scientists Trace Genomic Evolution of High-Risk Leukemia

By genomic sequencing of leukemia cells from relapsed patients at different stages, scientists have discovered key details of how acute lymphoblastic leukemia (ALL) cells mutate to survive chemotherapy.

Nature Communications

– St. Jude Children's Research Hospital

UCLA Researchers Combine Benefits of Immunotherapy and Cancer-Targeted Treatment in Triple Combo Drug for Melanoma

Results of a new study by UCLA researchers has found that a groundbreaking new triple combination therapy shows promising signs of more effectively controlling advanced melanoma than previous BRAF + MEK inhibitor or BRAF inhibitor + immunotherapy combos alone, and with increased immune response and fewer side effects.

 • Image(s) embedded •  (Embargo expired on 18-Mar-2015 at 14:00 ET)

Science Translational Medicine

– University of California, Los Angeles (UCLA), Health Sciences

mHealth App Ideal for Breast Cancer Risk Assessment, Prevention

Elissa Ozanne, PhD from Dartmouth's Norris Cotton Cancer Center and colleagues concluded that mobile health devices are acceptable to older, diverse, and low income women.

University of California at San Francisco Center for Aging in Diverse Communities ; Resource Centers for Minority Aging Research program of the National Institute on Aging; P30-AG15272 ...

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

KU Cancer Center Physician Develops Strategies to Improve Colorectal Cancer Screening Rates in Low-Income and Minority Populations

Allen Greiner, MD, MPH, and his team are using something called "implementation intentions" questions to determine what will help people get screened for colorectal cancer. The results were published in a recent issue of the American Journal of Preventive Medicine.

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– University of Kansas Cancer Center

Disparities in Defined Value Pose Challenges to Oncology Decision-Makers, Say NCCN Panelists

The second roundtable discussion of the NCCN 20th Annual Conference explored the concept of value in oncology decision-making, challenging the perceived definition of value and true quality for the patient.

– National Comprehensive Cancer Network® (NCCN®)

Announcements

Have a Say in the National Direction of Womb Cancer Research

A national group of researchers, medical bodies and charities, led by The University of Manchester is looking for help in setting the top priorities for fighting womb cancer, with a survey launched today (23 March 2015).

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– University of Manchester

UVA Cancer Center Earns National Radiation Oncology Accreditation

For meeting national quality and patient safety standards, UVA Cancer Center has been awarded a three-year accreditation in radiation oncology by the American College of Radiology (ACR).

– University of Virginia Health System

New Cyclotron Facility at UT Southwestern Expands Research Opportunities and Imaging Capabilities for Detecting, Tracking Cancer

UT Southwestern Medical Center’s Radiology Department has launched a new cyclotron facility that will help create isotopes used in imaging, cancer research, and for tracking cancers in the body.

 • Image(s) embedded • 

– UT Southwestern Medical Center

Call for Applications for ASTRO’s Annual Survivor Circle Grant

The American Society for Radiation Oncology (ASTRO) seeks to recognize two cancer support organizations based in Texas.

– American Society for Radiation Oncology (ASTRO)

Higher Education Events

Highlights from the NCCN 20th Annual Conference Include Expert Roundtables, Presentation of New and Updated Treatment Guidelines

Approximately 1,500 oncology representatives attended the NCCN 20th Annual Conference, which featured presentations of the latest developments in the treatment of more than 15 cancer types, as well as three expert roundtable discussions.

– National Comprehensive Cancer Network® (NCCN®)

Expert Pitch

Physician Expert Available to Discuss JAMA Breast Biopsies Study: What Women Need to Know

 • Video / Image(s) embedded • 

– College of American Pathologists (CAP)

CBC: Insecticide ‘Probably Carcinogenic’ to Humans, Says World Health Organization Agency

– University of Manitoba

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