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Newswise Special Wire
Tuesday, March 31, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 31-Mar-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Scripps Florida Scientists Reveal Unique Mechanism of Natural Product with Powerful Antimicrobial Action

Scientists from The Scripps Research Institute have uncovered the unique mechanism of a powerful natural product with wide-ranging antifungal, antibacterial, anti-malaria and anti-cancer effects. The new study sheds light on the natural small molecule known as borrelidin.

 • Image(s) embedded •  (Embargo expired on 31-Mar-2015 at 05:00 ET)

Nature Communications

– Scripps Research Institute

Researchers Develop New Potential Drug for Rare Leukemia

Researchers at the University of Michigan Comprehensive Cancer Center have developed a new drug that shows potential in laboratory studies against a rare type of acute leukemia. And additional studies suggest the same compound could play a role in prostate cancer treatment as well.

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Cancer Cell; Nature Medicine; R01 CA160467; T32 HD007505 ; T32 GM007315; P50 CA186786; U01 CA111275 ; R01 CA160467

– University of Michigan Health System

Panel Predicts Whether Rare Leukemia Will Respond to Treatment

Patients with chronic myelomonocytic leukemia have limited treatment options, and those that exist are effective only in fewer than half of patients. Now, a new study identifies a panel of genetic markers that predicted which tumor samples would likely respond to treatment.

 • Image(s) embedded •  (Embargo expired on 30-Mar-2015 at 16:00 ET)

Journal of Clinical Investigation; T32 CA967622 ; K08 CA16064701; W81XWH-12-1-0041

– University of Michigan Health System

High-Tech Method Allows Rapid Imaging of Functions in Living Brain

Using a new high-speed, high-resolution imaging method, Lihong Wang, PhD, and his team at Washington University in St. Louis were able to see blood flow and other functions inside a living mouse brain at faster rates than ever before.

 • Image(s) embedded •  (Embargo expired on 30-Mar-2015 at 11:00 ET)

Nature Methods; DP1 EB016986; R01 CA186567; R01 CA159959; CMMI-1131758

– Washington University in St. Louis

Princess Margaret Scientists Convert Microbubbles to Nanoparticles

Biomedical researchers led by Dr. Gang Zheng at Princess Margaret Cancer Centre have successfully converted microbubble technology already used in diagnostic imaging into nanoparticles that stay trapped in tumours to potentially deliver targeted, therapeutic payloads.

(Embargo expired on 30-Mar-2015 at 11:00 ET)

Nature Nanotechnology

– University Health Network (UHN)

Ready, Aim, Fire! Cancer-Targeting Mechanism Underlies Promising UW-Madison Spinoff

A spinoff called Cellectar Biosciences is developing molecules that bind to more than 60 types of cancer. Several are being tested in early-stage clinical trials, including one for brain cancer. These custom-made molecules can carry either a "flag" that shines brightly in standard medical scanners or a bit of radiation to kill the targeted cancer cells.

– University of Wisconsin-Madison

Drug Strategy Improves Survival for Aggressive Breast Cancer Type in the Brain, Study Finds

A UNC Lineberger-led pre-clinical study evaluated the impact of a drug treatment strategy on survival for BRCA1-mutated triple negative breast cancer models with brain metastases, and compared those findings to the outcomes for models lacking the mutation. The findings were published online Monday in Molecular Cancer Therapeutics.

Molecular Cancer Therapeutics, Mar-2015

– University of North Carolina School of Medicine

Natural Extract Shows Promise for Preventing Breast Cancer

In a new study, the extract from rosehips — the fruit of the rose plant — significantly reduced the growth and migration of cells from a type of breast cancer known as triple negative. This particularly aggressive form of cancer does not respond to most available treatments and tends to affect young women as well as those who are African-American or Hispanic.

(Embargo expired on 29-Mar-2015 at 12:30 ET)

Experimental Biology, Mar-2015

– Federation of American Societies for Experimental Biology (FASEB)

New Therapeutic Target May Improve Treatment for Brain Cancer

These data indicate that TG2 is a possible chemotherapeutic target for Glioblastoma Multiforme (GBM) treatment.

(Embargo expired on 29-Mar-2015 at 12:30 ET)

Experimental Biology, Mar-2015

– Federation of American Societies for Experimental Biology (FASEB)

Women with Ovarian Cancer Gain Extra Months with Addition of Drug to Standard Chemotherapy

In a study presented March 28 at the SGO Annual Meeting on Women's Cancer, overall survival for women who received standard chemotherapy treatment plus bevacizumab was a median five months longer than for women who received the standard chemotherapy treatment alone.

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Society of Gynecologic Oncology’s Annual Meeting on Women’s Cancer

– Society of Gynecologic Oncology

Immunotherapy Delays Recurrence for Stage III and IV Ovarian Cancers

Personalized medicine is getting closer to reality for women with late-stage ovarian cancer. An experimental immunotherapy is in the works that can target an individual woman’s tumor and extend the time period between initial treatment and the cancer’s return.

(Embargo expired on 28-Mar-2015 at 08:50 ET)

Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer

– Society of Gynecologic Oncology

MRI Based on a Sugar Molecule Can Tell Cancerous from Noncancerous Cells

Imaging tests like mammograms or CT scans can detect tumors, but figuring out whether a growth is or isn’t cancer usually requires a biopsy to study cells directly. Now results of a Johns Hopkins study suggest that MRI could one day make biopsies more effective or even replace them altogether by noninvasively detecting telltale sugar molecules shed by the outer membranes of cancerous cells.

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Nature Communications; R01 EB015032; R01 EB015031; U54 CA151838; MSCRFII-0042

– Johns Hopkins Medicine

Integrative Approaches Key to Understanding Cancer and Developing Therapies, Say Moffitt Cancer Center Scientists

Moffitt Cancer Center researchers are using integrative approaches to study cancer by combining mathematical and computational modeling with experimental and clinical data. The use of integrative approaches enables scientists to study and model cancer progression in a manner that conventional experimental systems are unable to do.

Nature Genetics, Feb-2015

– Moffitt Cancer Center

Latest Jolie Pitt Announcement Broadens Conversation on Cancer Prevention Options

Dr. Henry Lynch, chair of preventive medicine at Creighton University and the discoverer of a syndrome related to linkages between breast and ovarian cancers, weighs in on the pre-emptive surgery option taken by Angelina Jolie Pitt.

Expert(s) available

– Creighton University

Like Angelina Jolie, Study Pinpoints Genetic Cause of Increased Leukemia Risk

A University of Colorado Cancer Center study published today in the journal Nature Genetics describes a newly-discovered, heritable genetic cause of acute lymphoblastic leukemia (ALL), namely mutation of the gene ETV6.

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Nature Genetics

– University of Colorado Cancer Center

Blood Test Can Help Some Bowel Cancer Patients Avoid Unnecessary Drug Side-Effects

Manchester researchers have provided early evidence to suggest that a blood test could be used to identify bowel cancer patients that may benefit from more intensive chemotherapy.

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Clinical Colorectal Cancer. doi: 10.1016/j.clcc.2014.12.006

– University of Manchester

Promising Drug a ‘New Paradigm’ for Treating Leukemia

Researchers at the University of Virginia School of Medicine have developed a compound that delays leukemia in mice and effectively kills leukemia cells in human tissue samples, raising hopes that the drug could lead to improved treatments in people. The researchers call it an exciting “new paradigm” for treating leukemia.

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Science; R01CA140398; R01 CA096983

– University of Virginia Health System

Chemical Tag Marks Future MicroRNAs for Processing, Study Shows

Just as two DNA strands naturally arrange themselves into a helix, DNA’s molecular cousin RNA can form hairpin-like loops. But unlike DNA, which has a single job, RNA can play many parts — including acting as a precursor for small molecules that block the activity of genes. These small RNA molecules must be trimmed from long hairpin-loop structures, raising a question: How do cells know which RNA loops need to be processed this way and which don’t?

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Nature, Mar-2015

– Rockefeller University

Research Shows Gene Removal May Aid Melanoma Treatment

There are nearly 10,000 melanoma deaths in the U.S. each year, and while treatment advances have been made, a majority of melanoma patients will die from their disease. Building on these advances, Rutgers Cancer Institute of New Jersey investigators have demonstrated that removal of a gene involved in the cellular self-cannibalization process of autophagy could provide therapeutic benefit to patients with melanoma.

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Cancer Discovery, Mar-2015

– Rutgers Cancer Institute of New Jersey

Control Switch That Modulates Cell Stress Response May Be Key to Multiple Diseases

Researchers at the University of California, San Diego School of Medicine have discovered a control switch for the unfolded protein response (UPR), a cellular stress relief mechanism drawing major scientific interest because of its role in cancer, diabetes, inflammatory disorders and several neural degenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).

EMBO Reports

– University of California, San Diego Health Sciences

Mount Sinai Researchers Discover Genetic Origins of Myelodysplastic Syndrome Using Stem Cells

Findings Shed Light on the Development of Blood Cancers

Nature Biotechnology

– Mount Sinai Medical Center

Researchers Use Nanoparticles to Selectively Target Tumor Cells in Two Cancer Models

Dartmouth team uses nanomaterials to pursue a systematic study of variables in xenograft models of both breast and ovarian human cancer.

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International Journal of Nanomedicine; Dartmouth Center for Cancer Nanotechnology Excellence; 1 U54 CA151662

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Protein Shake-Up

A certain class of proteins has challenged researchers’ conventional notion that proteins have a static and well-defined structure.

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– Oak Ridge National Laboratory

Immunomagnetic Assay On-a-Chip Captures, Analyzes Circulating Tumor Cells

Dartmouth bioengineers demonstrate a novel system that couples nano-engineered particles and microfluidic chips for capturing and manipulating circulating tumor cells.

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Scientific Reports, Nature Publishing Group; 1RO1CA130070

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Announcements

NCCN Holds Fourth Annual State Oncology Society Forum

The fourth annual state oncology society forum, held in conjunction with NCCN’s 20th Annual Conference, examined accountable care, payment reform, and best practices from community oncologists.

– National Comprehensive Cancer Network® (NCCN®)

Meridian Health Partners with Rutgers Cancer Institute of New Jersey to Expand Personalized Treatment Offerings to Patients

Rutgers Cancer Institute of New Jersey is joining forces with Meridian Health in offering patients with rare forms of cancer or with cancer that no longer responds to standard treatment access to a clinical trial. The research will use genomic analysis to identify abnormal changes in the genetic make-up of the cancer. The clinical trial is part of the ‘precision medicine’ initiative at the Cancer Institute of New Jersey, which aims to tailor or ‘personalize’ cancer treatment for patients.

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– Rutgers Cancer Institute of New Jersey

UCSF Benioff Children’s Hospital Oakland Raises over $215,000 for Childhood Cancer Research during 8th Annual St. Baldrick’s Foundation Head-Shaving Event Childhood Cancer Research

UCSF Benioff Children’s Hospital Oakland hosted its 8th annual St. Baldrick’s Foundation signature head-shaving event on March 13 and March 14 and made over $215,000 for life-saving childhood cancer research. Two-hundred and forty-two participants shaved their heads to support the event that seeks conquer childhood cancers. Shave-a-thon participants at UCSF Benioff Children’s Hospital Oakland have cumulatively raised $1.4 million for the St. Baldrick's Foundation, the largest non-government funder of childhood cancer grants worldwide.

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– UCSF Benioff Children's Hospital Oakland

ASCP, CAP, AMP, and ASCO Issue Draft Colorectal Cancer Molecular Marker Testing Guideline and Announce Opening of Public Comment Period

The American Society for Clinical Pathology (ASCP), the College of American Pathologists (CAP), the Association for Molecular Pathology (AMP), and the American Society of Clinical Oncology (ASCO) today released a draft of a clinical practice guideline on the use of molecular marker testing for patients with primary or metastatic colorectal carcinoma. This evidence-based guideline will help establish standard molecular marker testing, guide targeted therapies, and advance personalized care for these patients.

– Association for Molecular Pathology

Kentucky Cancer Program at UofL Launches Online Guide to Cancer Resources

The Kentucky Cancer Program at the University of Louisville has launched a new version of its cancer resource guide, "Pathfinder," and moved it online.

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– University of Louisville

Faculty Recruited to UNC Lineberger to Launch T-Cell Cancer Therapy Trials

Two faculty members have joined the UNC Lineberger Comprehensive Cancer Center to help launch a clinical research program in T-cell immunotherapy. The program will be the first of its kind for UNC Lineberger.

– University of North Carolina School of Medicine

OU Research Team Receives NIH Grant to Facilitate Innovative Technique that Enhances Breast Cancer Detection

An innovative technique that enhances breast cancer detection while reducing radiation dose has been proposed by a University of Oklahoma research team. In response, the National Cancer Institute of the National Institutes of Health has awarded a $3 million grant to the OU team to facilitate the technique, which includes building a patient imaging system and conducting preclinical evaluations and Phase I clinical trials.

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R01CA193378

– University of Oklahoma, College of Engineering

Expert Pitch

Matriarch of Modern Cancer Genetics' Legacy Found in MicNerney. #emperorofallmaladies #pbs

– University of Chicago Medical Center

In Cancer Fight, Angelina Jolie Makes Case for Fluidity in Feminine Ideal

– Texas Tech University

BRCA Gene / Angelina Jolie Story - Cancer Expert

– Queen's University Belfast

Preventive Surgery to Remove Ovaries and Fallopian Tubes: Yale Cancer Experts Provide Insight

– Yale Cancer Center

Fred Hutch Ovarian Symptom Screening Expert Available to Discuss Warning Signs, Risk Factors

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– Fred Hutchinson Cancer Research Center

Should Every Woman Undergo Genetic Testing for Breast and Ovarian Cancer?

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– University of Utah Health Sciences

Family History Can Inform Life-Saving Decisions

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– University of Utah Health Sciences

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