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Newswise Special Wire
Tuesday, April 7, 2015

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Newswise Cancer Research Wire for 07-Apr-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Risk of Breast and Ovarian Cancer May Differ By Type of BRCA1, BRCA2 Mutation

In a study that involved more than 31,000 women who are carriers of disease-associated mutations in the BRCA1 or BRCA2 genes, researchers identified mutations that were associated with significantly different risks of breast and ovarian cancers, findings that may have implications for risk assessment and cancer prevention decision making among carriers of these mutations, according to a study in the April 7 issue of JAMA.

(Embargo expired on 07-Apr-2015 at 11:00 ET)

JAMA

– JAMA - Journal of the American Medical Association

Penn Study Shows Risk of Breast and Ovarian Cancer May Differ By Type of BRCA1, BRCA2 Mutation

In a study involving more than 31,000 women with cancer-causing mutations in the BRCA1 or BRCA2 genes, researchers at The Basser Center for BRCA, the Abramson Cancer Center, and the Perelman School of Medicine at the University of Pennsylvania identified mutations that are associated with significantly different risks of breast and ovarian cancers.

(Embargo expired on 07-Apr-2015 at 11:00 ET)

JAMA

– Perelman School of Medicine at the University of Pennsylvania

Tiny Hair Follicle Holds Big Clues About the Life and Death of Stem Cells

Inside the microscopic world of the mouse hair follicle, Yale Cancer Center researchers have discovered big clues about how stem cells regenerate and die. These findings, reported in the journal Nature, could lead to a better understanding of how the stem cell pool is maintained or altered in tissues throughout the body.

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Nature

– Yale Cancer Center

Too Much of a Bad Thing Can Be Good in Brain Tumors

DNA mutations can cause cancer but in some cases, more mutations may mean a better prognosis for patients. A Yale-led comprehensive genomic analysis of more than 700 brain tumors has revealed one such subtype of the most malignant brain tumor, called glioblastoma, or GBM. This subtype possesses thousands of tumor-specific DNA errors or mutations instead of dozens observed in most glioblastoma cases. It is also associated with longer survival.

Neuro-Oncology

– Yale Cancer Center

Physicians Pioneer the Use of Stereotactic Body Radiation for Deadly Kidney Cancer Complication

UT Southwestern Medical Center Kidney Cancer Program investigators have published what is believed to be the first reported successful use of stereotactic body radiation therapy for an often deadly complication of kidney cancer.

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– UT Southwestern Medical Center

Researchers Discover Novel Mechanism Controlling Lung Cancer Stem Cell Growth

Lung cancer is the second most common type of cancer and the number one cause of cancer-related mortality. It is estimated that more than 158,000 people will die from lung cancer in the United States this year. Many scientists believe that targeting a type of cell called a cancer stem cell may be necessary to completely cure lung cancer. Moffitt Cancer Center researchers discovered a novel mechanism that plays an important role in the maintenance of lung cancer stem cells. This finding may lead to new potential therapeutic targets.

Stem Cells, March-2015

– Moffitt Cancer Center

Cerebral Curiosity

Steven Keating's curiosity led to the detection of a baseball-sized brain tumor and sparked an interest into the potential of open health data to help himself and others.

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– Koch Institute for Integrative Cancer Research at MIT

The Medical Minute: HPV’s Link to Head and Neck Cancer

Tobacco and alcohol use may be the most common cause of head and neck cancers, but a new culprit has come on the scene in recent years. The human papillomavirus (HPV) is now responsible for more than 60 percent of cases of oropharyngeal cancer diagnosed at Penn State Milton S. Hershey Medical Center.

– Penn State Milton S. Hershey Medical Center

Study Suggests New Role for Gene in Suppressing Cancer

Scientists at The University of Manchester have discovered that a previously known gene also helps cells divide normally and that its absence can cause tumours.

 • Image(s) embedded •  (Embargo expired on 06-Apr-2015 at 15:00 ET)

PNAS, April 2015

– University of Manchester

A Third of Breast Cancer Patients Concerned About Genetic Risk

A new study from the University of Michigan Comprehensive Cancer Center finds that many women diagnosed with breast cancer are concerned about the genetic risk of developing other cancers themselves or of a loved one developing cancer.

 • Image(s) embedded •  (Embargo expired on 06-Apr-2015 at 16:00 ET)

Journal of Clinical Oncology; R01 CA109696; R01 CA088370; K05 CA111340

– University of Michigan Health System

Long-Term Results of RTOG 9903 Indicate Erythropoietin Combined with Radiation Therapy Does Not Improve Local-Regional Control in Anemic Patients with Head and Neck Cancer

Long-term analysis of RTOG 9903 demonstrates that the addition of erythropoietin (EPO) did not improve local-regional control for anemic patients with head and neck squamous cell carcinoma who receive radiation therapy or chemoradiation, according to a study published in the April 1, 2015 issue of the International Journal of Radiation Oncology • Biology • Physics.

International Journal of Radiation Oncology, Biology, Physics, April 1, 2015

– American Society for Radiation Oncology (ASTRO)

Dartmouth Investigators Identify Mechanism that Drives Melanoma to Metastasize

The significance of this work is its descriptions of alternative mechanisms by which tumors move and settle in new locations.

PLOS One; USPHS T32 ; CA009658; AI007363; USPHS RO1 CA77267; RO1 CA134799

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Trending Stories Report for 3 April 2015

Trending news releases with the most views in a single day. Topics include: nanotech treating cancer, immunology, autism, patient monitoring, research ethics, lingering effects of dispersant in Gulf of Mexico, wildlife conservation.

– Newswise Trends

UAB School of Nursing Research Shows “Culture Shift” Needed for Palliative Care

Early palliative care offers statistically beneficial effects on patient survival and family caregiver burden, according to articles published in the Journal of Clinical Oncology.

Journal of Clinical Oncology

– University of Alabama at Birmingham

Strong Grasp of Immune Response Dynamics Will Enhance Checkpoint Blockade

Spreading the success of cancer immunotherapy beyond those patients currently enjoying powerful, long-term responses to treatment requires greater understanding of the immune response to tumors, two leaders in the field note in a review in the April 3 Science.

 • Image(s) embedded •  (Embargo expired on 02-Apr-2015 at 14:00 ET)

Science

– University of Texas M. D. Anderson Cancer Center

Nanoparticles May Exploit Tumor Weaknesses to Selectively Attack Cancers

Delving into the world of the extremely small, researchers are exploring how biodegradable nanoparticles can precisely deliver anticancer drugs to attack neuroblastoma, an often-deadly children's cancer.

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Cancer Letters, online Feb. 12, 2015; Biomaterials, online Feb. 16, 2015; CA094194

– Children's Hospital of Philadelphia

Moffitt Cancer Center Scientists Identify Genetic Alterations Associated with Risk of Prostate Cancer

Moffitt Cancer Center researchers, working in collaboration with a team of scientists from around the world, have identified 22 genetic variations that are associated with an increased risk of developing prostate cancer.

Cancer Discovery, Feb-2015

– Moffitt Cancer Center

Dartmouth Investigators Develop Antibacterial Enzymes to Combat Drug-Resistant Bacterial Pathogens

By engineering antibacterial enzymes, Dartmouth investigators led by Karl Griswold, PhD are using novel strategies to target the prevalent drug-resistant bacterium Staphylococcus aureus.

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FEMS Microbiology Letters; Applied Microbiology and Biotechnology; ACS Chemical Biology ; R21AI098122; P30GM106394; R21AI094391; T32DK007301

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Mayo Clinic Researchers Combine Common Genetic Variants and Other Factors to Improve Breast Cancer Risk Prediction

Recent large-scale genomic analyses have uncovered dozens of common genetic variants that are associated with breast cancer. Each variant, however, contributes only a tiny amount to a person’s overall risk of developing the disease.

Journal of the National Cancer Institute

– Mayo Clinic

Study Affirms Lethal Prostate Cancer Can Spread From Other Metastatic Sites

A new genomic analysis of tissue from patients with prostate cancer has added more evidence that cells within metastases from such tumors can migrate to other body parts and form new sites of spread on their own.

Nature; CA92234

– Johns Hopkins Medicine

"Firefly" Mechanism Makes Cancer Studies More Efficient, Less Expensive

The mechanism that makes fireflies glow through a process called bioluminescence can be used to study tumor response to therapy as well, researchers have found.

Cancer Letters; NIHR01 CA140674 ; U24 CA126608; 1P30 CA142543; NIH 1S10RR024757

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Expanding on Liquid Biopsies with Exosomes

A new type of liquid biopsy for solid tumors based on analyzing exosomes from the blood is being tested at Thomas Jefferson University.

– Thomas Jefferson University

Facilitated Intervention Can Improve Quality of Life for Breast Cancer Survivors

Taking the focus off pain management and specific post-treatment symptoms, Norris Cotton Cancer Center researchers establish a new paradigm for working with breast cancer survivors

OTJR: Occupation, Participation, and Health; Journal of Psychosocial Oncology; 70804; R21 CA140849-01; MRSG-12-113-01-CPPB

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Protein May Improve Liver Regeneration

Researchers at UC Davis have illuminated an important distinction between mice and humans: how human livers heal. The difference centers on a protein called PPARα, which activates liver regeneration. Normally, mouse PPARα is far more active and efficient than the human form, allowing mice to quickly regenerate damaged livers. However, the research shows that protein fibroblast growth factor 21 (FGF21) can boost the regenerative effects of human PPARα. The findings suggest that the molecule could offer significant therapeutic benefits for patients who have had a liver transplant or suffer from liver disease. The study was published in the journal Oncotarget.

Oncotarget, Feb-2015

– UC Davis Comprehensive Cancer Center

Announcements

NCCN Foundation® Awards Grants to Six Young Investigators

The NCCN Foundation® has awarded its fifth series of Young Investigator Awards to six oncology researchers from NCCN Member Institutions; the awards provide grants of $150,000 over a two-year period for research initiatives focused on assessing and improving outcomes in cancer care.

– National Comprehensive Cancer Network® (NCCN®)

Final Roundtable of the NCCN 20th Annual Conference Explores Essential Characteristics of Clinical Practice Recommendations

The third and final roundtable of the NCCN 20th Annual Conference explored essential elements of clinical practice guidelines, as well as the historical development of the NCCN Guidelines®.

– National Comprehensive Cancer Network® (NCCN®)

Call for Entries to ASTRO’s Annual Survivor Circle Award

The American Society for Radiation Oncology (ASTRO) seeks to recognize an individual cancer survivor in San Antonio and the surrounding area who has committed his or her time and energy to volunteering in their local community.

– American Society for Radiation Oncology (ASTRO)

Mercy Medical Center Receives Grant to Establish New Cancer Patient Support Program

Mercy Medical Center has received a $50,000 grant from Ovarian Cancer Research Fund (OCRF) to establish “Woman to Woman,” a patient support program that pairs new gynecologic cancer patients with trained and supervised survivor volunteers to provide mentoring and support.

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– Mercy Medical Center, Baltimore

Noted UCSF Scientist Joins Research Team at Huntsman Cancer Institute

Martin McMahon, Ph.D., joins Huntsman Cancer Institute (HCI) at the University of Utah in August as Professor in the Department of Dermatology and HCI Senior Director of Pre-Clinical Translation.

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– University of Utah Health Sciences

New President of 117-Year-Old Cancer Center Appoints New Leadership Team

Roswell Park Cancer Institute’s 15th and first female president, Dr. Candace Johnson, has begun her tenure by reorganizing the talent around her. The comprehensive center has announced a slate of strategic new appointments and faculty/staff promotions.

– Roswell Park Cancer Institute

Marketplace

CENTOGENE Revolutionizes the Clinical Interpretation of Rare Disease Genetic Variants

CENTOGENE AG (“CENTOGENE”) announces the launch of the world’s largest genetic mutation database for rare diseases, CentoMD®.

– Centogene AG

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