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Newswise Special Wire
Tuesday, April 14, 2015

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Newswise Cancer Research Wire for 14-Apr-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

High Fidelity: SLU Researcher Finds Keys to Genome

Lesions in DNA can occur as often as 100,000 times per cell per day. They can be the result of normal metabolic activities, like free radicals, as well as exposure to environmental factors such as UV radiation, X-rays and chemical compounds. Saint Louis University researchers share a discovery that explains how cells use a process called replication fork reversal in order to deal with these roadblocks and transmit accurate genetic data.

 • Image(s) embedded • 

Journal of Cell Biology

– Saint Louis University Medical Center

Trending Stories Report for 14 April 2015

Trending news releases with the most views in a single day. Topics include: organic chemistry, cybercrime, pancreatic cancer research from Mayo Clinic, diabetes, pediatrics, new cancer treatment in development at Beth Israel Deaconess Medical Center, pain medicine research from the Ohio State University, marijuana in the workplace, and stem cells

– Newswise Trends

U-M Researchers Find Protein That May Signal More Aggressive Prostate Cancers

University of Michigan researchers have discovered a biomarker that may be a potentially important breakthrough in diagnosing and treating prostate cancer.

(Embargo expired on 13-Apr-2015 at 06:30 ET)

– University of Michigan

Researchers Identify Drug Target for ATRA, the First Precision Cancer Therapy

Cancerous tumors have the ability to evade targeted therapies by activating alternative pathways. Tumors also contain cancer stem cells, believed responsible for metastasis and drug resistance. Now scientists in the Cancer Research Institute at Beth Israel Deaconess Medical Center have identified a drug target that addresses both of these challenges.

(Embargo expired on 13-Apr-2015 at 11:00 ET)

– Beth Israel Deaconess Medical Center

Molecular Signature for Outcomes of Triple Negative Breast Cancer

Compared to other types of breast cancer, triple negative breast cancers are often more aggressive and have fewer treatment options. In a new study published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers at Huntsman Cancer Institute and the University of Utah have identified a molecular mechanism that triple negative breast cancer cells use to survive and grow.

 • Image(s) embedded •  (Embargo expired on 13-Apr-2015 at 15:00 ET)

Proceedings of the National Academy of Sciences; GM055668; DK084425; CA42014; CSC-2011659013.

– University of Utah Health Sciences

Promising Developments in Tackling Resistance to Blood Cancer Drugs

A new drug with the potential to reverse resistance to immunotherapy has been developed by scientists at the University of Southampton. It has shown great promise in pre-clinical models and will be available to patients with certain leukaemias and non-Hodgkin lymphomas in clinical trials later this year.

 • Image(s) embedded •  (Embargo expired on 13-Apr-2015 at 12:00 ET)

Cancer Cell

– University of Southampton

Mayo Clinic Creates Profile to Identify Patients Most at Risk of Developing Pancreatic Cancer

When people learn they have a lesion in their pancreas that could become pancreatic cancer, they often request frequent CT scans and biopsies, or surgery. Often the lesion is nothing to worry about. A team of international physicians, led by researchers at Mayo Clinic’s campus in Jacksonville, Florida, has developed a profile of the patient most at risk of developing lesions that are most likely to develop into cancer.

Digestive and Liver Diseases

– Mayo Clinic

Moffitt Cancer Center Researchers Develop New Method to Characterize the Structure of a Protein That Promotes Tumor Growth

Moffitt Cancer Center researchers have developed a new method to identify a previously unknown structure in a protein called MDMX. MDMX is a crucial regulatory protein that controls p53 – one of the most commonly mutated genes in cancer.

Proceedings of the National Academy of Sciences, March-2015

– Moffitt Cancer Center

Nanoparticles at Specific Temperature Stimulate Antitumor Response

Dartmouth researchers identified the precise temperature that results in a distinct body-wide antitumor immune response that resists metastatic disease.

Nanomedicine: Nanotechnology, Biology and Medicine; Dartmouth Center for Nanotechnology Excellence; 1 U54 CA151662; NIGMS P20 RR15639

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Suntanned in Paradise? Baylor Researcher Explores Why Some People Risk Skin Cancer

Tanning as “paradise” — the depiction in ads and magazines of smiling people sporting even tans and often enjoying exotic vacation spots — may influence people to tan in the sun or tanning beds and take risks with UV ray exposure and ultimately, skin cancer, says a Baylor University researcher.

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– Baylor University

Improving Nutrition in Cancer Survivors

Stories involving cancer and its devastating consequences are a frequent occurrence in the news. We are constantly being told which foods may cause cancer, and which may prevent it, but how much is fact, and how much is fiction is often in dispute. The same is true for cancer survivors trying to find reliable nutritional information which will help them to improve their quality of life and prevent future relapses. A team of researchers at Bournemouth University (BU), led by Dr Jane Murphy, are working with cancer nurse specialists to change that. By developing an e-learning tool for healthcare professionals, the team has created an innovative way of educating and empowering frontline staff to deliver reliable and helpful information about nutrition.

Nurse Education Today, 35 (1), pp. 271-276.

– Bournemouth University

An Appropriate Clinical Frame Is Required to Enhance the Value of Pre-Clinical Work

Once more, the multifactorial and heterogeneous nature of breast cancer fascinates researchers and is newly confirmed and re-interpreted in light of the results of a study entitled “Metformin and breast cancer: basic Knowledge in clinical context” published in April 2015 in the international journal Cancer Treatment Reviews.

Cancer Treatment Reviews

– Sbarro Health Research Organization (SHRO)

Breakthrough in Cancer Research

Israeli scientists have discovered two cancer-suppressing proteins that could hold a key to controlling cancer cell growth and development. The previously undiscovered proteins were found during ongoing research on the ubiquitin system.

CELL, April 9, 2015

– American Technion Society

Trending Stories Report for 10 April 2015

Trending news releases with the most views in a single day. Topics include: Astronomy, Cardiology, Nephrology, Neurology, Neutrinos, oil spills, Toxicology, Cancer, and Nutrition

– Newswise Trends

NIBIB Video Feature: Making Tumors Glow

A head and neck surgeon at UCSD discusses the development of new molecules that cause tumors and nerves to glow, making it easier for them to be identified during surgery.

 • Video embedded • 

EB014929; EB008122

– National Institute of Biomedical Imaging and Bioengineering

Memorial Sloan Kettering Opens First Pediatric CAR T Cell Clinical Trial

Researchers from Memorial Sloan Kettering Cancer Center (MSK) are pioneering a new groundbreaking clinical trial for children and young adults with relapsed or treatment-resistant acute lymphocytic leukemia (ALL) by using one of the most promising methods of cancer treatment today, chimeric antigen receptor (CAR) T cells.

– Memorial Sloan Kettering Cancer Center

UT Southwestern Researchers Lead Collaborative Charge to Uncover Genetic Diversity of Pancreatic Cancer

A genetic analysis led by UT Southwestern Medical Center researchers suggests that most pancreatic cancers harbor genetic alterations that could be targeted by existing drugs, using their genetic features as a roadmap for treatment. The findings support a precision approach to treating pancreatic cancer, the fourth most deadly cancer for both men and women

 • Image(s) embedded •  (Embargo expired on 09-Apr-2015 at 05:00 ET)

Nature Communications

– UT Southwestern Medical Center

Review Highlights Potential of Cancer Immunotherapy Plus Targeted Therapy

The prospect of combining genomically targeted therapies with drugs that free the immune system to attack cancer suggests “we are finally poised to deliver curative therapies to cancer patients,” researchers at The University of Texas MD Anderson Cancer Center note in a review in the April 9 edition of Cell.

 • Image(s) embedded •  (Embargo expired on 09-Apr-2015 at 12:00 ET)

Cell

– University of Texas M. D. Anderson Cancer Center

York Scientists Lead Study on New Treatment for Prostate Cancer

Scientists at the University of York have discovered a potential new treatment for prostate cancer using low temperature plasmas (LTPs).

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British Journal of Cancer

– University of York

A Downward Trend for New Cases of Pediatric Melanoma

A new study finds that the incidence of pediatric melanoma in the United States decreased from 2004 to 2010.

Journal of Pediatrics

– University Hospitals Case Medical Center

Biologists Identify Brain Tumor Weakness

A study led by MIT researchers found that a subset of glioblastoma tumor cells is dependent on a particular enzyme that breaks down the amino acid glycine. Without this enzyme, toxic metabolic byproducts build up inside the tumor cells, and they die. Blocking this enzyme could offer a new way to combat such tumors.

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Nature, Apr-2015

– Koch Institute for Integrative Cancer Research at MIT

Trending Stories Report for 9 April 2015

Trending news releases with the most views in a single day. Topics include: Cancer treatment, meditation, careers in engineering, astronomy, marine conservation, effective dieting, internet marketing, Ebola treatments, and exercise as preventive health for seniors.

– Newswise Trends

Golgi Trafficking Controlled by G-Proteins

A family of proteins called G proteins are a recognized component of the communication system the human body uses to sense hormones and other chemicals in the bloodstream and to send messages to cells. In work that further illuminates how cells work, researchers at University of California, San Diego School of Medicine have discovered a new role for G proteins that may have relevance to halting solid tumor cancer metastasis.

Developmental Cell

– University of California, San Diego Health Sciences

Lower Survival Rates Connected with High-Risk Melanoma with Mutations, Study Finds

A UNC Lineberger-led study found that people with higher-risk melanoma containing either BRAF or NRAS gene mutations had lower survival rates.

 • Image(s) embedded • 

JAMA Oncology, April -2015

– University of North Carolina School of Medicine

Advocate Uses Her Genetic History to Increase Knowledge of Hereditary Cancer Risk

Rachel Koszegi is on a mission to fight cancer, and she’s not alone. The 33-year-old mother who has tested positive for the BRCA2 cancer gene is one of 12 people in her family over three generations linked to the gene or diagnosed with cancer. Now she is using her family’s genetic history to contribute to cancer research, prevention and treatment – with the aim of improving the quality of life for those facing hereditary risk.

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– Cedars-Sinai Medical Center

Researchers Identify Subtype of Lethal Prostate Cancer

Researchers at Upstate Medical University and Harvard University have linked the loss of key gene, WAVE1, to a lethal form of prostate cancer, according to a study published in the journal Oncotarget.

Oncotarget, March 31, 2015

– SUNY Upstate Medical University

Trending Stories Report for 8 April 2015

Trending news releases with the most views in a single day. Topics include: Neurology, memory, pollution, astronomy, schizophrenia, stem cell research, children's health, and lung cancer

– Newswise Trends

Investigators Discover Mechanism Responsible for Tumor Invasion in Brain Cancer

A neuro-oncology research team at Dartmouth's Norris Cotton Cancer Center recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

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The Hitchcock Foundation; Jordan and Kyra Memorial Foundation; Theodora B. Betz Foundation

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Novel Pancreatic Cancer Drug May Also Serve as an Arsenal Against the Accumulation of Malignant Ascites Fluid – A Condition Affecting Many Cancer Patients

A treatment for advanced pancreatic cancer is in an ongoing pre-clinical study to determine if it can also serve as a weapon against malignant ascites fluid accumulation in the abdomen, a condition that affects hundreds of thousands of patients with multiple types of cancer. This groundbreaking research was designed in part by pancreatic cancer expert Dr. Daniel D. Von Hoff, Chief Development Officer of Translational Drug Development (TD2), in the U.S.

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– PharmaCyte

Research Finds Cells Respond to Stress by Folding and Unfolding Their Genomes

Uncovering cellular response to stress may provide leverage to determine how to trick undesirable cells, such as cancer or damaged cells, into dying instead of recovering from stress.

Molecular Cell; RO1 GM069462

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Mount Sinai Experts and Patients Share Their Tips and Stories for Oral, Head and Neck Cancer Awareness Week®

Tongue Cancer Survivor and Basketball Legend Donnie Walsh Urges Public to Attend Free Local Screenings Scheduled at Mount Sinai Health System

Expert(s) available

– Mount Sinai Medical Center

Policy and Public Affairs

8 Reasons the U.S. Surgeon General Should Announce that UV Tanning Causes Skin Cancer

"Tanning beds cause skin cancer. It is time to now more openly announce this causality," says Robert P. Dellavalle, MD, PhD, MSPH, investigator at the CU Cancer Center, in the American Journal of Preventive Medicine.

 • Image(s) embedded •  (Embargo expired on 08-Apr-2015 at 00:00 ET)

American Journal of Preventive Medicine

– University of Colorado Cancer Center

Announcements

Queen’s Researchers in £5million Programme to Improve Bowel Cancer Survival

Researchers at Queen’s University Belfast have launched a revolutionary personalised treatment programme to help improve bowel cancer survival rates.

 • Audio / Image(s) embedded • 

– Queen's University Belfast

UNM Cancer Center Doctor Named One of AAHPM’s “Inspirational Leaders Under 40”

The American Academy of Hospice and Palliative Medicine celebrated the outstanding work of 44 physicians throughout the country who practice palliative medicine. Esmé Finlay, MD, at the University of New Mexico Cancer Center is one of them.

– University of New Mexico Cancer Center

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