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Newswise Special Wire
Tuesday, May 12, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 12-May-2015
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U-M Researchers Take Step Toward Bringing Precision Medicine to All Cancer Patients

Researchers have developed and tested a new tool that searches for the most common genetic anomalies seen in cancer. The assay demonstrates the ability to make gene sequencing easier over a large volume of samples.

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Neoplasia; CA183857; CA181605; CA 159945; CA154365; HG006508

– University of Michigan Health System

Trending Stories Report for 12 May 2015

Trending news releases with the most views in a single day. Topics include: tick-borne disease, 3D printing, childhood cancer and obesity, nursing, low-back pain, brain cells, and fluid dynamics.

– Newswise Trends

Failure to Expand ACA Medicaid Coverage Would Widen Disparities in Screening Uninsured and Low-Income Women for Breast and Cervical Cancer

Virginia Commonwealth University Massey Cancer Center researchers recently conducted a study that found low-income and uninsured women in states that are not expanding their Affordable Care Act (ACA) Medicaid coverage are less likely to receive breast and cervical cancer screenings compared to states that are implementing expansions.

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American Journal of Preventive Medicine, Oct-2014; R01CA178980; P30 CA016059

– VCU Massey Cancer Center

Survival From Rare Bone Cancer Remains Low

Ten-year survival of a rare malignancy called mesenchymal chondrosarcoma has been reported to be as low as 20 percent. But a Loyola study has found survival is not as dismal as prior reports. More than half (51 percent) of patients survived at least five years, and 43 percent survived at least 10 years.

Mid-America Orthopaedic Association annual meeting

– Loyola University Health System

Dartmouth Team Devises Use of Food Dye, Near Infrared Light to Aid in Breast Resection

Dartmouth team focuses on coming up with a practical solution that both preserves the surgical practice of inking the margins of breast cancer tumors, and allows quality imaging post-inking.

Journal of Biomedical Optics ; RO1 CA192803

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Disrupting Cancer Pathway Could Enhance New Immunotherapies

Understanding how to overrule a signaling pathway that can cause treatments to fail in metastatic melanoma patients should help physicians extend the benefits of recently approved immunity-boosting drugs known as checkpoint inhibitors to more patients.

(Embargo expired on 11-May-2015 at 11:00 ET)

Nature

– University of Chicago Medical Center

Breast Cancer Patients Over 60 with Luminal a Subtype May Not Need Radiation if Already on Hormone Therapy

Women with luminal A subtype breast cancer – and particularly those older than 60 – may not need radiation treatment if they are already taking hormone therapy, shows clinical research led by radiation oncologists at the Princess Margaret Cancer Centre published online today in the Journal of Clinical Oncology.

(Embargo expired on 11-May-2015 at 16:00 ET)

Journal of Clinical Oncology

– University Health Network (UHN)

Trending Stories Report for 11 May 2015

Trending news releases with the most views in a single day. Topics include: vision research, DOE research, aging, mental health, children's health, cancer, tick-borne disease, and drone technology.

– Newswise Trends

Childhood Cancer Treatment and Age Influence Obesity Risk for Childhood Cancer Survivors

Childhood cancer survivors – especially those whose treatment included brain irradiation or chemotherapy with glucocorticoids – are 14 percent more likely to be obese than their healthy peers. The St. Jude Children’s Research Hospital study appears today in the journal Cancer.

Cancer; CA021765

– St. Jude Children's Research Hospital

First Cancer-Promoting Oncogenes Discovered in Rare Brain Tumor of Children and Adults

Researchers have identified three genes that play a pivotal role in the brain tumor choroid plexus carcinoma (CPC), a discovery that lays the groundwork for more effective treatment of this rare, often fatal cancer. St. Jude Children’s Research Hospital scientists led the study, which appears today in the journal Cancer Cell. The genes – TAF12, NFYC and RAD54L – are involved in DNA repair and regulation. Researchers showed that CPC often has at least one extra copy of each gene and demonstrated that the genes work cooperatively to launch and sustain the tumor.

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Cancer Cell; CA129541; CA96832; CA021765; W81XWH1010674

– St. Jude Children's Research Hospital

80 Percent of Cervical Cancers Found To Be Preventable With Latest 9-Valent HPV Vaccine

The new 9-valent human papillomavirus vaccine, can potentially prevent 80 percent of cervical cancers in the United States, if given to all 11- or 12-year-old children before they are exposed to the virus.

Journal of the National Cancer Institute

– Cedars-Sinai Medical Center

Researchers Work to Determine Why Some Prostate Cancer Patients Experience More Hot Flashes during Therapy

Androgen deprivation therapy (ADT) is a common treatment option for patients with advanced stage prostate cancer. But nearly 80 percent of patients who receive ADT report experiencing hot flashes during and after treatment. Moffitt Cancer Center researchers are working to determine what genetic factors and other characteristics might make prostate cancer patients more likely to experience hot flashes during and after therapy.

Journal of Urology, March-2015

– Moffitt Cancer Center

Fragments of tRNA Suggest a Novel Mechanism for Cancer Progression

Researchers at Rockefeller University have discovered that particular genetic fragments, a type of RNA known as transfer RNA, appear to be capable of reducing the growth and spread of breast cancer cells.

Cell

– Rockefeller University

Tracking Defects Caused by Brain Tumor Mutation Yields Insight to Advance Targeted Therapy

St. Jude Children’s Research Hospital scientists have gained ground toward developing more targeted therapies for the most common childhood brain tumor. The findings appear today in the Journal of Molecular Biology. The findings involve the DDX3X gene. In 2012, the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project highlighted DDX3X as a promising focus for efforts to develop targeted therapies against medulloblastoma. Such treatments target the genetic mistakes that give rise to the brain tumor’s four subtypes.

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Journal of Molecular Biology; CA21765

– St. Jude Children's Research Hospital

New Combination Treatment Strategy to “Checkmate” Glioblastoma

Therapies that specifically target mutations in a person’s cancer have been much-heralded in recent years, yet cancer cells often find a way around them. To address this, researchers at University of California, San Diego School of Medicine and Moores Cancer Center identified a promising combinatorial approach to treating glioblastomas, the most common form of primary brain cancer. The study published May 5 by Oncotarget.

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Oncotarget

– University of California, San Diego Health Sciences

May Is Skin Cancer Awareness Month: Take Practical Steps Now to Help Stave Off Skin Cancer

Mississippi State University Extension Service agent Shelaine Pennington and MSU Extension health specialist Dr. David Buys discuss Pennington's skin cancer scare and tips for lifestyle changes for Skin Cancer Awareness Month.

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– Mississippi State University, Office of Agricultural Communications

Study Finds Metabolic Link Between Bacterial ‘Biofilms’ and Colon Cancer

team led by scientists at The Scripps Research Institute and Johns Hopkins University School of Medicine has uncovered a big clue to how bacteria may promote some colon cancers.

 • Image(s) embedded •  (Embargo expired on 07-May-2015 at 12:00 ET)

Cell Metabolism, May 20`15

– Scripps Research Institute

New Anti-Cancer Stem Cell Compound in Development

Cardiff University scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumour forming cells common to breast, pancreas, colon and prostate cancers.

(Embargo expired on 07-May-2015 at 02:00 ET)

– Cardiff University

TSRI Researchers Connect Haywire Protein to Breast Cancer, Leukemia

A new study led by scientists at The Scripps Research Institute sheds light on the cause of some cancers, including breast cancer and leukemia.

 • Image(s) embedded •  (Embargo expired on 07-May-2015 at 12:00 ET)

Current Biology, May 7, 2015

– Scripps Research Institute

Statin Drugs Can Delay Prostate Cancer Progression in Patients Receiving Androgen Deprivation Therapy, Study Shows

Men who went on cholesterol-lowering statin drugs when they began androgen deprivation therapy for prostate cancer had a longer time in which their disease was under control than did men who didn’t take statins, a clinical trial led by Dana-Farber Cancer Institute investigators shows.

 • Image(s) embedded •  (Embargo expired on 07-May-2015 at 11:00 ET)

JAMA Oncology

– Dana-Farber Cancer Institute

Psychologists to help Dr Google

Psychologists are to improve online health information on lung cancer after research showed that family members are more likely to search online to encourage loved ones to seek help.

Annual Conference of the British Psychology Society

– University of Manchester

Potential for a More Personalised Approach to Womb Cancer

Manchester doctors have helped show that high-risk womb cancer patients can be genetically profiled to allow them to receive more appropriate treatment.

Modern Pathology

– University of Manchester

Trending Stories Report for 7 May 2015

Trending news releases with the most views in a single day. Topics include: WWII and PTSD, stem cells, cancer, racial segregation, supplements and glaucoma, medical research, cybersecurity, vision research, and physics.

– Newswise Trends

Protein "Cement" that Stabilizes the Crossroad of Chromosomes

A new study describes how the centromere is stabilized during replication.

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Science; GM082989, CA186430, DMR-0944772

– Perelman School of Medicine at the University of Pennsylvania

Genetic Testing, Angelina Jolie, and the Nature of Beauty

Dr. Gail Vance shares insights into genetic testing for breast and ovarian cancer in lieu of Angelina Jolie's recent announcement to have her ovaries removed. Dr. Vance is the Sutphin professor of Cancer Genetics and interim chairperson of the Department of Medical and Molecular Genetics at the Indiana University School of Medicine. As well, she is director of the Division of Diagnostic Genomics and the Indiana Familial Cancer Program, which provides genetic counseling, risk assessment, and genetic testing to individuals with an elevated risk for developing cancer.

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– College of American Pathologists (CAP)

Survival of Patients with Cerebral Metastases After Stereotactic Radiosurgery

Winner of the Leksell Radiosurgery Award, Deborah C. Marshall, recently presented her research, Survival Patterns of Patients with Cerebral Metastases after Multiple Rounds of Stereotactic Radiosurgery (SRS).

(Embargo expired on 06-May-2015 at 16:20 ET)

AANS Annual Meeting, May-2015

– American Association of Neurological Surgeons (AANS)

Targeting Cancer Therapy with Phosphoproteomics

Winner of the Louise Eisenhardt Traveling Scholarship Award, Teresa Purzner, MD, presented her research, Quantitative Phosphoproteomics for Targeted Cancer Therapy.

(Embargo expired on 06-May-2015 at 16:50 ET)

AANS Annual Meeting, May-2015

– American Association of Neurological Surgeons (AANS)

Study Reveals Why Almost Half of At-Risk Patients Opt Out of Comprehensive Multiplex Cancer Screening

Some at-risk patients opted out of comprehensive cancer gene screening when presented with the opportunity to be tested for the presence of genes linked to various cancers, according to a recent study led by researchers at the Perelman School of Medicine at the University of Pennsylvania. Concern for uncertainty and potential distress were cited among the most common reasons to refuse testing.

Genetics in Medicine

– Perelman School of Medicine at the University of Pennsylvania

UNC Analysis Shows Advantage for Picture-Based Cigarette Pack Warnings Over Text Warnings

A University of North Carolina at Chapel Hill analysis published in the journal Tobacco Control synthesized the results of 37 different experiments comparing picture-based and text warnings, finding that picture-based warnings were more effective than text warnings on 20 of 25 different outcome measures.

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Tobacco Control, May-2015

– University of North Carolina School of Medicine

New ASTRO Guideline on Definitive and Adjuvant Radiation Therapy for Locally Advanced Non-Small Cell Lung Cancer Featured in May-June Issue of PRO

The American Society for Radiation Oncology (ASTRO) is issuing a new guideline, “Definitive and adjuvant radiotherapy in locally advanced non-small cell lung cancer: An American Society for Radiation Oncology (ASTRO) evidence-based clinical practice guideline.”

Practical Radiation Oncology, May-June 2015

– American Society for Radiation Oncology (ASTRO)

Scientists Identify Promising New Melanoma Treatment Strategy

In findings reported in Cell Death and Differentiation, the researchers demonstrate that the enzyme GMPS drives melanoma growth, and propose a new strategy for targeting that protein.

Cell Death and Differentiation; R01CA120244; R01CA083081; P30CA016056; F32CA189622

– Roswell Park Cancer Institute

Plant-Derived Compound Targets Cancer Stem Cells

A compound and an enzyme that occur naturally in cruciferous vegetables—cauliflower, cabbage, broccoli and Brussels sprouts—may help prevent recurrence and spread of some cancers, according to associate professor Moul Dey of the South Dakota State University Department of Health and Nutritional Sciences. When Dey and her team treated human cervical cancer stem cells with phenethyl isothiocyanate (PEITC) in a Petri dish, about 75 percent died within 24 hours using a 20-micromolar concentration of the compound.

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Expert(s) available

BMC Cancer: (2014) 14:591

– South Dakota State University

Announcements

Eduardo M. Sotomayor, M.D., Renowned Cancer Researcher and Physician-Scientist, to Lead GW Cancer Center

The George Washington University (GW) School of Medicine and Health Sciences, the GW University Hospital, and the GW Medical Faculty Associates are pleased to announce the appointment of Eduardo M. Sotomayor, M.D., who will serve as the inaugural director of the GW Cancer Center. As director, Sotomayor will establish the GW Cancer Center and position GW as the premier cancer center in the Washington, D.C. region.

– George Washington University

GW Cancer Institute Develops First Free, Online, Comprehensive Training for Patient Navigators

The George Washington University Cancer Institute has developed the first free, online, comprehensive training that covers the fundamentals of oncology patient navigation in the U.S.

– George Washington University

Memorial Sloan Kettering Cancer Center “Specializes in You” with an Innovative and Personalized Digital Landscape

Memorial Sloan Kettering Cancer Center (MSK) introduced a new, consumer-friendly web presence for www.mskcc.org (Memorial Sloan Kettering Cancer Center) and www.sloankettering.edu (Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center), featuring an innovative platform and on-demand navigation for patients, caregivers, researchers, healthcare professionals, and graduate students, among other core audiences.

– Memorial Sloan Kettering Cancer Center

GW Cancer Institute Receives $100,000 Grant to Support Avon Patient Navigator

The Avon Foundation for Women awarded a $100,000 grant to the George Washington University Cancer Institute at AVON 39 The Walk to End Breast Cancer in Washington, D.C.

– George Washington University

Expert Pitch

Play It Safe Under the Sun This Summer

– Creighton University

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