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Newswise Special Wire
Tuesday, May 19, 2015

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Newswise Cancer Research Wire for 19-May-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Mayo Urologists Present Findings at 2015 American Urological Association 2015 Meeting

Mayo Clinic urologists will present research findings on several topics at the American Urological Association Annual Meeting May 15–19 in New Orleans. Researchers will be available to discuss their research with reporters who are covering the conference.

(Embargo expired on 19-May-2015 at 11:30 ET)

– Mayo Clinic

Study: Most Americans Don’t Use Sunscreen

Exposure to ultraviolet radiation is the most preventable risk factor for all types of skin cancer. But according to new research published in the Journal of the American Academy of Dermatology, the majority of Americans are not regularly using sunscreen to protect themselves from the sun’s harmful UV rays.

Journal of the American Academy of Dermatology

– American Academy of Dermatology

Differences in Tumor Cell Metabolism Affect Tumor Growth, Invasion, Response to Therapy

Cells within a tumor are not the same; they may have different genetic mutations and different characteristics during growth and throughout treatment. These differences make treating tumors extremely difficult and often lead to tumor recurrence dominated by more aggressive tumor cells. Moffitt Cancer Center researchers are using mathematical modeling to characterize these differences within a tumor and hope that the results of their latest study will lead to better therapeutic treatments.

Cancer Research, April-2015

– Moffitt Cancer Center

Trending Stories Report for 19 May 2015

Trending news releases with the most views in a single day. Topics include: nutrition, environment, children's health, education, cancer, Acoustical Society of America (ASA) annual meeting, and agriculture.

– Newswise Trends

Livers Donated after Cardiac Death are Safe to Use in Liver Cancer Patients on a Transplant List

Patients with liver cancer can be cured with a liver transplant. But because of the shortage of donated organs, these patients often die waiting for a liver. That’s because most transplant centers predominantly use livers from donors who die from brain death.

 • Video embedded • 

American Journal of Transplantation

– Mayo Clinic

Microchip Captures Clusters of Circulating Tumor Cells - NIH Study

Researchers have developed a microfluidic chip that can capture rare clusters of circulating tumor cells, which could yield important new insights into how cancer spreads. The work was funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the National Institutes of Health.

 • Image(s) embedded •  (Embargo expired on 18-May-2015 at 11:00 ET)

Nature Methods; EB012493; EB002503

– National Institute of Biomedical Imaging and Bioengineering

Study Finds Non-Invasive Colon Cancer Screening May Be Promising for African-Americans

Stool DNA (sDNA) testing, a new non-invasive technology for colon cancer screening, is a promising alternative to colonoscopy for African Americans, according to a new study presented at Digestive Disease Week.

(Embargo expired on 18-May-2015 at 08:00 ET)

Digestive Disease Week

– University Hospitals Case Medical Center

Researchers Make Progress Engineering Digestive System Tissues

New proof-of-concept research suggests the potential for engineering replacement intestine tissue in the lab, a treatment that could be applied to infants born with a short bowel and adults having large pieces of gut removed due to cancer or inflammatory bowel disease.

(Embargo expired on 18-May-2015 at 11:00 ET)

Digestive Diseases Week

– Wake Forest Baptist Medical Center

Trending Stories Report for 18 May 2015

Trending news releases with the most views in a single day. Topics include: nutrition, fibromyalgia, e-cigarettes, cystic fibrosis, asthma, and gluten

– Newswise Trends

Urine-Based Test Improves on PSA for Detecting Prostate Cancer

A new urine-based test improved prostate cancer detection – including detecting more aggressive forms of prostate cancer – compared to traditional models based on prostate serum antigen, or PSA, levels, a new study finds.

 • Image(s) embedded • 

European Urology; U01 CA111275; U01 CA113913; P50 CA186786 ; R01 CA132874

– University of Michigan Health System

Targeted, High-Dose Stereotactic Body Radiation Therapy Appears to Benefit Some Patients with Pancreatic Cancer

Two studies from Johns Hopkins Kimmel Cancer Center researchers add to preliminary evidence that high-dose radiation treatment, called stereotactic body radiotherapy, appears to be safe and as effective as standard radiation treatment for certain patients with pancreatic cancer whose tumors are advanced but have not spread.

Cancer; Annals of Surgical Oncology

– Johns Hopkins Medicine

Yale Cancer Center at 2015 ASCO Annual Meeting

Highlights include: new immunotherapy response/survival data for immunotherapy for bladder and lung cancers; advances in small cell lung cancer; exercise and quality of life for cancer survivors; expanding indications for checkpoint blockade

– Yale Cancer Center

Atrial Fibrillation After Surgery Increases Risk of Heart Attacks and Strokes

An irregular heartbeat following surgery known as post-operative atrial fibrillation (POAF) often is dismissed as a transient phenomenon. But a study has found that POAF can significantly increase the risk of heart attack or stroke during the first 12 months after surgery.

Journal of Urology

– Loyola University Health System

Flatiron Health to Incorporate NCCN Chemotherapy Order Templates into OncoEMR®

The integration of the NCCN Chemotherapy Order Templates (NCCN Templates®) into the Flatiron Health OncoEMR® electronic health record will allow for access to evidence-based treatment protocols based on the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®).

– National Comprehensive Cancer Network® (NCCN®)

SMU College Graduate Conquers Ovarian Cancer to Graduate on Time After Receiving Care at UT Southwestern Simmons Cancer Center

Katie Ballard graduated Saturday from SMU having conquered not only her course of studies, but a rare ovarian cancer diagnosis that required removing a four-pound tumor.

– UT Southwestern Medical Center

Experimental Immunotherapy Shows High Response Rate in Advanced Lung Cancer

An early phase study testing an anti-PDL1 agent in combination with standard chemotherapy in the treatment of advanced non-small cell lung cancer has provided promising early results, prompting multiple phase III studies in lung cancer. The findings are being presented at the annual meeting of the American Society of Clinical Oncology (ASCO) May 29-June 2 in Chicago.

annual meeting of the American Society of Clinical Oncology

– Lombardi Comprehensive Cancer Center Georgetown University

Trending Stories Report for 15 May 2015

Trending news releases with the most views in a single day. Topics include: social media trends, lyme disease, cancer, diabetes, HIV, lasers, Hubble, neurology, and the seafood industry.

– Newswise Trends

Minimal Residual Disease Alone Not Predictive in T-Cell Leukemia

Researchers found that the presence of a few remaining leukemia cells, called minimal residual disease (MRD), at the end of induction chemotherapy was not predictive of risk or outcome in children with T-cell acute lymphoblastic leukemia (ALL). This opens the possibility for patients with T-cell ALL who have MRD to achieve complete remission without undergoing intensified cancer treatments and their associated toxicities.

 • Image(s) embedded •  (Embargo expired on 14-May-2015 at 11:00 ET)

Pediatric Blood & Cancer; K12HD052954

– Children's Hospital Los Angeles Saban Research Institute

Revealing Kidney Cancer’s Secret

An international team of scientists, led by UC Davis nephrologist Robert Weiss, have used a sophisticated combination of proteomics and metabolomics to show how renal cell carcinoma (RCC) reprograms its metabolism and evades the immune system. In addition, the study found that cancer grade has a major impact on this reprogramming. These results, published online in the journal Cancer Research, point to new therapeutic options for this particularly deadly cancer.

 • Image(s) embedded • 

Cancer Research, May, 7, 2015

– UC Davis Comprehensive Cancer Center

Georgia State Research Paves Way for Early Detection of Liver Cancer

Led by Georgia State University, researchers have developed the first robust and noninvasive detection of early stage liver cancer and liver metastases, in addition to other liver diseases, such as cirrhosis and liver fibrosis.

Proceedings of the National Academy of Sciences

– Georgia State University

Duke-Led Study Clarifies Best Treatments for Uncommon Kidney Cancers

A head-to-head comparison of two biologic therapies used to treat a subset of patients with advanced kidney cancers provides much-needed clarity on the preferred treatment for the first line of attack.

 • Image(s) embedded • 

ASCO Annual Meeting 2015

– Duke Medicine

Dartmouth Researchers Engineer Micro-Factory to Attack Tumors

A team of Dartmouth investigators have engineered therapeutic cells encapsulated in nanoporous capsules to secrete antitumor molecules from within the tumor.

Journal of Biotechnology; U54 CA151662 DCCNE

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Rutgers Cancer Institute of New Jersey Helps Make Advances with Pembrolizumab in Small Cell Lung Cancer

Rutgers Cancer Institute of New Jersey investigators along with other colleagues have demonstrated that the immunotherapy drug pembrolizumab is generally well tolerated in those with small cell lung cancer, one of the most difficult to treat forms of lung cancer when it is in advanced stages. The results will be presented at the upcoming American Association of Clinical Oncology Annual Meeting.

 • Image(s) embedded •  (Embargo expired on 13-May-2015 at 17:00 ET)

ASCO Annual Meeting 2015

– Rutgers Cancer Institute of New Jersey

Protein FGL2 May Have Potential as Therapy Target for Brain Cancer

Blocking FGL2, a protein known to promote cancer, may offer a new strategy for treating brain cancer, according to a study at The University of Texas MD Anderson Cancer Center.

 • Image(s) embedded •  (Embargo expired on 13-May-2015 at 16:05 ET)

Journal of the National Cancer Institute, May 13, 2015

– University of Texas M. D. Anderson Cancer Center

New Drug Combination Extends Survival of Patients with Metastatic Colorectal Cancer

Research led by scientists at Dana-Farber Cancer Institute showed a new drug and a potentiating agent lengthened the lives of patients with metastatic colorectal cancer, all of whom had exhausted available standard treatments.

 • Image(s) embedded •  (Embargo expired on 13-May-2015 at 17:00 ET)

New England Journal of Medicine

– Dana-Farber Cancer Institute

Variations in Liver Cancer Attributable to Hepatitis Virus Variations

Significant clinical variations exist among patients with the most common type of liver cancer called hepatocellular carcinoma (HCC), depending on the viral cause of the disease –hepatitis B virus (HBV) or hepatitis C virus (HCV). These differences suggest that hepatitis status should be considered when developing treatment plans for newly diagnosed patients, according to researchers at The University of Texas MD Anderson Cancer Center.

 • Image(s) embedded •  (Embargo expired on 13-May-2015 at 17:00 ET)

American Society of Clinical Oncology (ASCO) meeting

– University of Texas M. D. Anderson Cancer Center

Stereotactic Ablative Radiotherapy Achieves Better Overall Survival Than Surgery for Early Lung Cancer

Patients with operable stage I non-small cell lung cancer (NSCLC) could achieve better overall survival rates if treated with Stereotactic Ablative Radiotherapy (SABR) rather than the current standard of care – invasive surgery – according to research from a phase III randomized international study from The University of Texas MD Anderson Cancer Center.

 • Image(s) embedded •  (Embargo expired on 13-May-2015 at 18:30 ET)

Lancet Oncology

– University of Texas M. D. Anderson Cancer Center

Tumor Sequencing Study Highlights Benefits of Profiling Healthy Tissue as Well

As the practice of genetically profiling patient tumors for clinical treatment decision making becomes more commonplace, a recent study from The University of Texas MD Anderson Cancer Center suggests that profiling normal DNA also provides an important opportunity to identify inherited mutations that could be critical for patients and their families.

 • Image(s) embedded •  (Embargo expired on 13-May-2015 at 17:00 ET)

American Society for Clinical Oncology 2015 Annual Meeting

– University of Texas M. D. Anderson Cancer Center

Androgen Deprivation Therapy May Lead to Cognitive Impairment in Prostate Cancer Patients

Cognitive impairment can occur in cancer patients who are treated with a variety of therapies, including radiation therapy, hormone therapy, and chemotherapy. After chemotherapy treatment it is commonly called “chemo brain.” Signs of cognitive impairment include forgetfulness, inability to concentrate, problems recalling information, trouble multi-tasking and becoming slower at processing information. The number of people who experience cognitive problems following cancer therapy is broad, with an estimate range of 15 to 70 percent.

Journal of Clinical Oncology, May-2015

– Moffitt Cancer Center

Trending Stories Report for 13 May 2015

Trending news releases with the most views in a single day. Topics include: Statin drugs and cancer, concussions, women in business, tracking ebola, precision medicine, nursing, Nepal earthquake, and Oak Ridge National Lab researchers working on LHC experiments.

– Newswise Trends

Faster, Smaller, More Informative

A new technique invented at MIT can measure the relative positions of tiny particles as they flow through a fluidic channel, potentially offering an easy way to monitor the assembly of nanoparticles, or to study how mass is distributed within a cell. With further advancements, this technology has the potential to resolve the shape of objects in flow as small as viruses, the researchers say.

 • Image(s) embedded • 

Nature Communications, May-2015

– Koch Institute for Integrative Cancer Research at MIT

Research Shows How Antibodies Produce Vaccine-Like Effect Against Tumors

New research at Rockefeller University shows how antibody therapy destroys tumor cells then prompts a patient’s immune system to form an immunological memory that can suppress the same cancer should it try to return.

 • Image(s) embedded • 

Cell

– Rockefeller University

Study Uncovers New Information on Genomic Instability

Using a novel method they developed to map chromosome breaks in a model organism, Wenyi Feng, Ph.D., and her colleagues have discovered new information as to how and where chromosome fragile sites can occur in human DNA.

Genome Research

– SUNY Upstate Medical University

Men with Asthma Less Likely to Develop Lethal Prostate Cancer

In what they are calling a surprising finding in a large study of men who completed questionnaires and allowed scientists to review their medical records, Johns Hopkins researchers report that men with a history of asthma were less likely than those without it to develop lethal prostate cancer.

International Journal of Cancer; P01 CA55075; R01 CA133891; P30 CA006973; P50 CA58236; R01 HL35464

– Johns Hopkins Medicine

Be Sunscreen-Savvy and Lessen a Main Skin Cancer Risk Factor

Three million cases of skin cancer could be prevented annually by avoiding ultraviolet light. UAB experts share how to pick out the proper UV-protection and use it effectively.

 • Image(s) embedded • 

– University of Alabama at Birmingham

Pathologist Offers Four Tips for Women Diagnosed with Breast Cancer in Light of Sandra Lee’s Diagnosis

Dr. Jean Simpson, chair of the CAP Cancer Committee, offers four tips for women diagnosed with breast cancer following Sandra Lee's announcement to receive a double mastectomy as a result of a diagnosis of DCIS.

 • Video / Image(s) embedded • 

– College of American Pathologists (CAP)

Starving Cancer Instead of Feeding It Poison

An enzyme drug can remove asparagine, an essential nutrient for some cancers, but it also degrades glutamine, necessary for all human cells. But an induced mutation in the drug permits it to reduce asparagine without affecting glutamine. Mouse tests now; human tests next.

Blood

– Sandia National Laboratories

Announcements

HOPA Announces New Fellow of the Hematology/Oncology Pharmacy Association (FHOPA) Designation

The Hematology/Oncology Pharmacy Association is pleased to announce the introduction of the Fellow of the Hematology/Oncology Pharmacy Association (FHOPA) designation, recognizing excellence in oncology pharmacy. Individuals awarded will have demonstrated sustained contributions to HOPA and exceptional performance in oncology pharmacy.

– Hematology Oncology Pharmacy Association

Study of Triple-Negative Breast Cancer Is Most Cited in AACR Journal

The American Association for Cancer Research (AACR) announced that a scientific paper describing potential drug targets following the unprecedented genomic sequencing of 14 metastatic triple-negative breast cancer patients was the most cited study in 2013 of any published that year by AACR’s journal Molecular Cancer Therapeutics.

 • Image(s) embedded • 

– Baylor Scott & White Health

NCCN Receives $2-Million Funding Commitment from ImmunoGen, Inc. to Study Mirvetuximab Soravtansine for Folate Receptor Alpha-Positive Cancers

The NCCN Oncology Research Program (ORP) has received a $2-million grant from ImmunoGen, Inc. to facilitate preclinical and clinical research with mirvetuximab soravtansine for Folate Receptor Alpha-positive cancers at NCCN Member Institutions and their affiliate community hospitals.

– National Comprehensive Cancer Network® (NCCN®)

Expert Pitch

UC Davis #Breastcancer Imaging Expert Diana Miglioretti Available 2 Discuss Import of UCSF #Breastdensity Study

 • Image(s) embedded • 

– UC Davis Comprehensive Cancer Center

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