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Newswise Special Wire
Tuesday, June 16, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 16-Jun-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Prenatal DDT Exposure Tied to Nearly Four-fold Increase in Breast Cancer Risk

Women who were exposed to higher levels of the pesticide DDT in utero were nearly four times more likely to be diagnosed with breast cancer as adults than women who were exposed to lower levels before birth, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).

(Embargo expired on 16-Jun-2015 at 13:00 ET)

Journal of Clinical Endocrinology & Metabolism

– Endocrine Society

Researchers Sequence and Assemble First Full Genome of a Living Organism Using Technology the Size of Smartphone

Researchers in Canada and the U.K. have for the first time sequenced and assembled de novo the full genome of a living organism, the bacteria Escherichia Coli, using Oxford Nanopore’s MinIONTM device, a genome sequencer that can fit in the palm of your hand.

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Nature Methods

– Ontario Institute for Cancer Research

What’s in a Name? “Death-Associated Protein” Promotes Cancer Growth in Most Aggressive Breast Cancers

Although traditionally understood to induce death in cancer cells, researchers at The University of Texas MD Anderson Cancer Center have discovered that the DAPK1 protein is actually essential for growth in breast and other cancers with mutations in the TP53 gene. This discovery indicates DAPK1 may be a promising new therapeutic target for many of the most aggressive cancers.

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Journal of Clinical Investigation

– University of Texas M. D. Anderson Cancer Center

New Discovery Could Explain How Prostate Cancer Becomes Lethal

New research published in the Proceedings of the National Academy of Sciences has provided a major boost for the prostate cancer field by uncovering an unprecedented mechanism for developing cancer.

PNAS; CA90270 ; CA95616

– University of New Mexico Cancer Center

New Procedure Tested to Relieve Pain from Cancer that has Spread to Spine

Loyola University Medical Center is the first center in the country to enroll patients in a clinical trial of a minimally invasive treatment for patients living with cancer that has spread to the spine.

– Loyola University Health System

Focused Ultrasound Could Play a Role in Cancer Immunotherapy

Cancer immunotherapies are agents that harness the power of the immune system to fight cancer. Unlike traditional cancer treatments that directly kill tumor cells (such as chemotherapy and radiation), immunotherapy operates through the intermediary of the immune system. Immunotherapies empower the immune system to specifically seek out and destroy cancer cells.

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Science Magazine

– Focused Ultrasound Foundation

Study Finds Gene Mutations Sensitize Tumors to Specific Cancer Drugs

Mutations in ARID1a, which are common in many cancer types, disrupt DNA damage repair in cancer cells, allowing the cancer to progress.

 • Image(s) embedded •  (Embargo expired on 11-Jun-2015 at 00:05 ET)

Cancer Discovery

– University of Texas M. D. Anderson Cancer Center

Scientists Find Way to Disrupt Brain Tumor Stem Cells

Brain tumor stem cells can resist treatment and regrow tumors, but scientists have identified a vulnerability in these cells that could lead to a new approach in battling deadly brain tumors.

 • Audio / Image(s) embedded •  (Embargo expired on 11-Jun-2015 at 12:00 ET)

Cell Reports

– Washington University in St. Louis

ADAMTS Family of Genes May Be the Next ‘Thing’ in Ovarian Cancer Treatment

There is the Addams Family. And then there is the ADAMTS family. While one is mindless entertainment, the latter may prove to be a new genetic avenue for designing ovarian cancer treatment.

 • Image(s) embedded •  (Embargo expired on 11-Jun-2015 at 11:00 ET)

Journal of the American Medical Association (JAMA) Oncology

– University of Texas M. D. Anderson Cancer Center

Comorbid Conditions Associated with Worse Lung Cancer Survival

Lung cancer patients with comorbid conditions such as chronic obstructive pulmonary disease, diabetes, or congestive heart failure have a higher risk of death than lung cancer patients without comorbid conditions. The prevalence of these comorbidities is higher in older lung cancer patients than patients who are younger. As the population of the United States ages, there will be a higher number of lung cancer patients with comorbidities at diagnosis. An estimated 74 percent of patients have one or more comorbidities. More than 50 percent of those with comorbidities had pulmonary disease, while 16 percent had diabetes, and 13 percent had congestive heart failure.

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Cancer Epidemiology, Biomarkers & Prevention

– University of Nebraska Medical Center (UNMC)

Penn Study Shows Nearly 10 Percent of Women Live Too Far from Access to Gynecologic Cancer Care

More than one-third of counties in the Unites States are located more than 50 miles from the nearest gynecologic oncologist, making access to specialty care for ovarian and other gynecologic cancers difficult for nearly 15 million women.

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Gynecologic Oncology

– Perelman School of Medicine at the University of Pennsylvania

Multi-Center Study Redefines Brain Tumor Diagnosis and Treatment

Not all brain cancers are the same but together they represent a deadly disease that has been difficult to identify and treat.

 • Image(s) embedded •  (Embargo expired on 10-Jun-2015 at 17:00 ET)

New England Journal of Medicine

– University of Texas M. D. Anderson Cancer Center

New Low-Grade Brain Tumor Classification Uses Molecular and Genetic Analysis

Scientists and physicians from federally designated cancer centers used molecular and genetic analysis to develop a new method of classifying low-grade brain tumors. The approach reduces the role of individual observers’ assessments of the tumors’ appearance.

 • Image(s) embedded •  (Embargo expired on 10-Jun-2015 at 17:00 ET)

– University Hospitals Case Medical Center

Trending Stories Report for 10 June 2015

Trending news releases with the most views in a single day. Topics include: anxiety and fermented foods, glucose transport, research reproducibility, new MRI approach, enterprise transformation, prostate cancer, oceanography, HPV vaccine, probiotics, clinical research.

– Newswise Trends

Survival Benefit with 'Fully Human' EGFR Antibody Necitumumab in Squamous Non-Small Cell Lung Cancer

Lancet Oncology reports phase III clinical trial results of necitumumab against stage IV non-small cell lung cancer

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Lancet Oncology

– University of Colorado Cancer Center

5 Things to Know About Your PSA Test

Dr. Michael Misialek offers five tips men should know about prostate cancer.

Expert(s) available

– College of American Pathologists (CAP)

Single-Dose HPV Vaccine Could Prevent Most Cervical Cancers

A research paper published in The Lancet Oncology showed that a single dose of the human papillomavirus vaccine Cervarix® may prevent HPV-related cervical cancer.

(Embargo expired on 09-Jun-2015 at 18:35 ET)

The Lancet Oncology, June 8, 2015 online edition

– University of New Mexico Cancer Center

Single Dose of HPV Vaccine May Prevent Cervical Cancer

A single dose of the human papillomavirus (HPV) vaccine Cervarix appears to be as effective in preventing certain HPV infections as three doses, the currently recommended course of vaccination. That is the conclusion of a study published today in The Lancet Oncology and co-authored by Diane Harper, M.D., M.P.H., the Rowntree Endowed Chair and professor in the Department of Family and Geriatric Medicine at the University of Louisville School of Medicine.

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The Lancet Oncology

– University of Louisville

Study Redefines Role of Estrogen in Cervical Cancer

Scientists have prior evidence that the hormone estrogen is a major driver in the growth of cervical cancer, but a new study examining genetic profiles of 128 clinical cases reached a surprising conclusion: Estrogen receptors all but vanish in cervical cancer tumors.

Proceedings of the National Academy of Sciences June 8-2015

– University of Wisconsin-Madison

Brain Lesions in Children Challenging to Diagnose

Brain lesions in children can be especially challenging to diagnose, according to a report in the journal Frontiers in Neurology by a multidisciplinary team of Loyola University Medical Center physicians.

Frontiers in Neurology

– Loyola University Health System

UT Southwestern Scientists Find Cellular Mechanism for How the Body Regulates Glucose Transport

UT Southwestern Medical Center scientists have gleaned a key cellular mechanism of how the body adjusts glucose levels, an important process that when abnormal can promote diabetes, cancer, and rare genetic diseases.

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Molecular Cell

– UT Southwestern Medical Center

Establishing Definitions to Increase Survival After Blood/Marrow Transplant

Blood and Marrow Transplantation (BMT) is a potentially curative treatment for patients with leukemia or other life-threating blood diseases. With a goal of increasing survival rates, a research team led by Roswell Park Cancer Institute (RPCI) investigators verified patient outcome data submitted by more than 150 U.S. transplant centers over an 11-year period to the Center for International Blood and Marrow Transplant Research (CIBMTR). The detailed investigation — published in the journal Biology of Blood and Marrow Transplantation — offers insight into different causes of death. The results of this genome-wide association study led to the development of a first-of-its-kind definition of specific causes of mortality after unrelated-donor, or allogeneic, BMT.

Biology of Blood and Marrow Transplantation

– Roswell Park Cancer Institute

Prostate Cancer Diagnosis: How to Take Control of Your Health

Faced with a diagnosis of prostate cancer, men should “know the right questions to ask, understand their disease and fully engage in a two-way conversation with their doctor. Michael J. Misialek, MD, FCAP, offers tips for men to better understand a diagnosis of prostate cancer.

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– College of American Pathologists (CAP)

Announcements

NCCN Receives $2 Million in Research Funding from Boehringer Ingelheim to Study Targeted Combination Approaches with Afatinib in Lung Cancer

The NCCN Oncology Research Program (ORP) received a $2-million grant from Boehringer Ingelheim Pharmaceuticals, Inc. to facilitate studies of afatinib in non-small cell lung cancer.

– National Comprehensive Cancer Network® (NCCN®)

Conference to Examine Multidisciplinary Approach to Treating Metastatic Brain and Spinal Cancer

Experts from around the country will join faculty experts from the University of Louisville’s James Graham Brown Cancer Center, a part of KentuckyOne Health, to look at the latest evidence-based medicine in treating metastatic cancer of the central nervous system.

– University of Louisville

Marketplace

Roswell Park Cancer Institute Spins Out Transformative New Company – OmniSeq, LLC

OmniSeq, LLC has officially begun its spin-out from Roswell Park Cancer Institute and will immediately begin commercializing its suite of innovative products that match cancer patients to therapies tailored specifically to them.

– Roswell Park Cancer Institute

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