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Newswise Special Wire
Tuesday, June 30, 2015

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Newswise Cancer Research Wire for 30-Jun-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Colon Cancer Genes Step Back to Go Forward

Weizmann Institute studies are revealing a complex picture of colon cancer progression in which certain genes that drive tumor growth in the earlier stages get suppressed in later stages – taking a step back to move forward. This pause could provide an opportunity for researchers to intervene in the metastasis, or provide a means of early detection.

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Oncogene, April 2015

– Weizmann Institute of Science

Similarities Between Embryos and Breast Tumors Identified

It may seem incredulous, but breast tumors may have something in common with embryos … at least in mice, say researchers at The University of Texas MD Anderson Cancer Center.

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Nature Scientific Reports

– University of Texas M. D. Anderson Cancer Center

New Family of Small RNAs Boosts Cell Proliferation in Cancer

Rather than cellular trash, half of a transfer RNA (tRNA) molecule appears to actively spur cell proliferation in breast and prostate cancers, suggesting a new role for tRNA and a possible target for a new class of therapy.

(Embargo expired on 29-Jun-2015 at 15:00 ET)

Proceedings of the National Academy of Sciences (PNAS)

– Thomas Jefferson University

Pinpointing Mutations in a Relapsed Children's Cancer May Lead to Improved Treatments

Researchers studying the pediatric cancer neuroblastoma have detailed how cancer-driving mutations evolve during chemotherapy, and they hope to exploit this knowledge to design better treatments for children.

 • Image(s) embedded •  (Embargo expired on 29-Jun-2015 at 11:00 ET)

Nature Genetics, published online June 29, 2015; CA98543, CA98413

– Children's Hospital of Philadelphia

Treatment With PI3K Inhibitors May Cause Cancers to Become More Aggressive and Metastatic

The enzyme PI3K appears to be exploited in almost every type of human cancer, making it the focus of considerable interest as a therapeutic target. However, PI3K inhibitors have only shown modest clinical activity. Now, new research The Wistar Institute shows that treatment with PI3K inhibitors alone may actually make a patient’s cancer even worse by promoting more aggressive tumor cell behavior and increasing the cancer’s potential of spreading to other organs.

 • Image(s) embedded •  (Embargo expired on 29-Jun-2015 at 15:00 ET)

PNAS, Jun-2013

– Wistar Institute

Mayo Clinic Study Suggests Which Glioblastoma Patients May Benefit From Drug Treatment

Clinicians testing the drug dasatinib, approved for several blood cancers, had hoped it would slow the aggressive growth of the deadly brain cancer glioblastoma; however, clinical trials to date have not found any benefit. Researchers at Mayo Clinic, who conducted one of those clinical trials, believe they know why dasatinib failed — and what to do about it.

Molecular Oncology; R01 NS069753, R21 NS070117

– Mayo Clinic

UNC Lineberger Discovery Could Lead to Personalized Colon Cancer Treatment Approach

In a study published in Nature Medicine, UNC Lineberger Comprehensive Cancer Center researchers report their findings of just how a certain tumor-suppressing protein helps prevent colon cancer. With this discovery, researchers believe they’ve found a possible drug target for colon cancer patients who lack the tumor suppressor.

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Nature Medicine, June-2015

– University of North Carolina School of Medicine

A Step Closer to a Blood Test for Lung Cancer

The Valley Hospital in Ridgewood, NJ, is pleased to announce that two of its oncologists and a research scientist are helping pave the way to an easier, more accurate, less invasive way to screen for the most common form of lung cancer. Lung cancer is the most common cancer in men worldwide and the number one cancer killer in the United States.

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– Valley Health System

Braking Mechanism Identified for Cell Growth Pathway Linked to Several Cancers

Researchers at University of California, San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway, a signaling channel garnering increased attention from cancer researchers due to its role in controlling organ size, cell proliferation and cell death.

(Embargo expired on 26-Jun-2015 at 09:00 ET)

Genes & Development

– University of California, San Diego Health Sciences

SLU Scientists Develop Potential New Class of Cancer Drugs in Lab

For the first time, researchers have found a way to stop cancer cell growth by targeting the Warburg Effect, a trait of cancer cell metabolism that scientists have been eager to exploit.

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Cancer Cell

– Saint Louis University Medical Center

Fatalistic Beliefs May Prevent Appalachian Women from Completing HPV Vaccination Series

Could a fatalistic attitude toward cervical cancer serve as a barrier to prevention of the disease? A recent study conducted by University of Kentucky researchers in the Rural Cancer Prevention Center suggests a link between fatalistic beliefs and completion of the human papillomavirus (HPV) vaccine series among a sample of young Appalachian Kentucky women.

Journal of Rural Health

– University of Kentucky

New Drug Squashes Cancer’s Last-Ditch Efforts to Survive

The Salk Institute and Sanford Burnham Prebys Medical Discovery Institute created a compound that stops a cellular recycling process

 • Video / Image(s) embedded •  (Embargo expired on 25-Jun-2015 at 12:00 ET)

Molecular Cell

– Salk Institute for Biological Studies

E2F4 Signature Can Predicts Progression of Bladder Cancer

Investigators from Dartmouth’s Norris Cotton Cancer Center harnessed genomic data to discover that the previously identified E2F4 signature in breast cancer can be utilized to predict prognosis and response to therapy in bladder cancer.

Molecular Cancer Research; IRG-82-003-30; UL1TR001086

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

A microRNA May Provide Therapy Against Pancreatic Cancer

Indiana University cancer researchers found that a particular microRNA may be a potent therapeutic agent against pancreatic cancer. The research was published June 22 in the journal Scientific Reports.

Scientific Reports

– Indiana University

Breast Cancer Treatment with Fewer Potential Side Effects has Equally Good Patient Outcomes

A new study by UCLA scientists has found that women diagnosed with breast cancer and treated with a one-week regimen of partial breast radiation after the surgical removal of the tumor, or lumpectomy, saw no increase in cancer recurrence or difference in cosmetic outcomes compared to women who received radiation of the entire breast for a period of up to six weeks after surgery. The study is one of the largest ever done on partial breast irradiation.

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Annals of Surgical Oncology

– University of California, Los Angeles (UCLA), Health Sciences

The Medical Minute: How Breast Density Can Affect Cancer Screenings

When it comes to breast cancer screening, the density of your breasts affects how well a mammogram can detect cancerous tissues.

– Penn State Milton S. Hershey Medical Center

Tiny Particles in Blood Useful for Early Diagnosis of Pancreatic Cancer

A protein encoded by the gene glypican-1 (GPC1) present on cancer exosomes may be used as part of a potential non-invasive diagnostic and screening tool to detect early pancreatic cancer, potentially at a stage amenable to surgical treatment, according to a study at The University of Texas MD Anderson Cancer Center.

 • Image(s) embedded •  (Embargo expired on 24-Jun-2015 at 13:00 ET)

Nature

– University of Texas M. D. Anderson Cancer Center

Detroit Patients’ Contributions to National Study Help Re-Define Low-Grade Brain Tumor Diagnosis

Sixty-seven patients from the Hermelin Brain Tumor Center at Henry Ford Hospital and their families made important contributions to a national cancer study that proposes a change in how some brain tumors are classified – and ultimately treated. Published in the July 25 issue of the New England Journal of Medicine, the study reveals that a tumor’s DNA is key to determining if a lower-grade malignant brain tumor (glioma) may rapidly progress to glioblastoma.

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New England Journal of Medicine

– Henry Ford Health System

Weight Loss, Combined with Vitamin D, Reduces Inflammation Linked to Cancer, Chronic Disease

For the first time, researchers at Fred Hutchinson Cancer Research Center have found that weight loss, in combination with vitamin D supplementation, has a greater effect on reducing chronic inflammation than weight loss alone. Chronic inflammation is known to contribute to the development and progression of several diseases, including some cancers.

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Cancer Prevention Research; NIH R03 CA162482-01; P50 CA138293

– Fred Hutchinson Cancer Research Center

Study Identifies Multiple Genetic Changes Linked to Increased Pancreatic Cancer Risk

In a genome-wide association study believed to be the largest of its kind, Johns Hopkins researchers have uncovered four regions in the human genome where changes may increase the risk of pancreatic cancer.

Nature Genetics

– Johns Hopkins Medicine

DNA Shed from Head and Neck Tumors Detected in Blood and Saliva

On the hunt for better cancer screening tests, Johns Hopkins scientists led a proof of principle study that successfully identified tumor DNA shed into the blood and saliva of 93 patients with head and neck cancer. A report on the findings is published in the June 24 issue of Science Translational Medicine.

Science Translational Medicine; CA057345; CA43460; CA152753; DE019032)

– Johns Hopkins Medicine

Berkeley Lab Scientists to Develop Better Way to Screen Chemicals for Cancer-Causing Effects

Berkeley Lab scientists are developing a cell culture that could help researchers better identify chemicals that increase breast cancer susceptibility. The scientists will grow the culture using adult stem cells obtained from breast tissue. Their test will show if a chemical causes a breakdown in cell-to-cell communication, which is a fundamental defect of cancer.

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– Lawrence Berkeley National Laboratory

Annual Low-Dose CT Screening Safe and Reliable for Identifying Pre-Cancers

An annual exam using a key imaging technology could spare patients with lung nodules from unnecessary tests and surgery.

Radiology

– Mount Sinai Medical Center

Announcements

Cyrus Ghajar Receives $4.1M Grant to Study Ways to Prevent Metastatic Breast Cancer

Cyrus Ghajar, Ph.D., a metastatic breast cancer researcher at Fred Hutchinson Cancer Research Center, has received a $4.1 million Department of Defense Breast Cancer Research Program (BCRP) “Era of Hope” Scholar Award. He is investigating two different paths for dealing with these dormant disseminated tumor cells: keeping them asleep and inactive, or destroying them altogether.

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w81xwh-15-1-0201

– Fred Hutchinson Cancer Research Center

Edith Sanford Breast Foundation Named Reebok Spartan Race Charity Partner

The Edith Sanford Breast Foundation announced today it will be the official charity partner of the 2015 SoCal Reebok Spartan Race in Vail Lake, California, Sept. 26-27.

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– Sanford Health

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