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Newswise Special Wire
Tuesday, July 7, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 07-Jul-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Findings Suggest Improvement in Management of Localized Prostate Cancer

After years of overtreatment for patients with low-risk prostate cancer, rates of active surveillance/ watchful waiting increased sharply in 2010 through 2013, and high-risk disease was more often treated appropriately with potentially curative local treatment rather than androgen deprivation alone, according to a study in the July 7 issue of JAMA.

(Embargo expired on 07-Jul-2015 at 11:00 ET)

JAMA

– JAMA - Journal of the American Medical Association

Association Between Genetic Condition, Hormonal Factors, and Risk of Endometrial Cancer

For women with Lynch syndrome, an association was found between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use, according to a study in the July 7 issue of JAMA. Lynch syndrome is a genetic condition that increases the risk for various cancers.

(Embargo expired on 07-Jul-2015 at 11:00 ET)

JAMA

– JAMA - Journal of the American Medical Association

Cancer Drug 49 Times More Potent Than Cisplatin

Tests have shown that a new cancer drug, FY26, is 49 times more potent than the clinically used treatment Cisplatin.

PNAS, May 13, 2015; (Grant 324594), Council (Grants 247450 and 324594), (Grants 086357 and 102696)

– University of Warwick

Divided They Conquer – tRNAs Are Segmented Into Fragments In a Manner That Depends on Race, Gender and Tissue, A Finding That May Impact Future Studies Of Disease

The study reports on a newly discovered category of tRNA fragments as well as shows that all tRNAs are rich sources of very diverse short molecules whose characteristics depend on a person’s gender, population, and race and differ according to tissue and disease type.

Oncotarget

– Thomas Jefferson University

Protein Implicated in Osteosarcoma’s Spread Acts As Air Traffic Controller

The investigation of a simple protein has uncovered its uniquely complicated role in the spread of the childhood cancer, osteosarcoma. It turns out the protein, called ezrin, acts like an air traffic controller, coordinating multiple functions within a cancer cell and allowing it to endure stress conditions encountered during metastasis.

Molecular and Cellular Biology; DoD award: W81XWH-10-1-0137

– Georgetown Lombardi Comprehensive Cancer Center

Epigenetic Driver of Glioblastoma Provides New Therapeutic Target

Using human tumor samples and mouse models, researchers at University of California, San Diego School of Medicine and Moores Cancer Center discovered that cancer stem cell properties are determined by epigenetic changes — chemical modifications cells use to control which genes are turned on or off.

 • Image(s) embedded • 

Proceedings of the National Academy of Sciences

– University of California, San Diego Health Sciences

New Clinical Trial Harnesses the Power of the Immune System to Fight Brain Cancers

Already pioneers in the use of immunotherapy, City of Hope researchers are now testing the bold approach to cancer treatment against one of medicine’s biggest challenges: brain cancer. This month, they will launch a clinical trial using patients’ own modified T cells to fight advanced brain tumors.

 • Image(s) embedded • 

– City of Hope

Supercharging Stem Cells to Create New Therapies

Researchers at the University of Adelaide have discovered a new method for culturing stem cells which sees the highly therapeutic cells grow faster and stronger.

Stem Cells; This research was supported by the Hospital Research Foundation, The Queen Elizabeth Hospital

– University of Adelaide

New Understanding of Retinoblastoma Proteins' Role in Cell Death and Cancer Progression

A review article published on the journal Oncotarget focusing on RB role in apoptosis provides a comprehensive overview on the role of RB proteins in the coordinated control of cell decisions.

Oncotarget

– Sbarro Health Research Organization (SHRO)

Launch of First European Nanomedicine Characterization Lab

Empa, the Swiss Federal Laboratories for Materials Science and Technology, is part of the «European Nanomedicine Characterization Laboratory», a European project funded by the EU framework program «Horizon 2020». Its goal is to reach a level of international excellence in nanomedicine characterization for diseases like cancer, diabetes, inflammatory diseases or infections. This competence will be made accessible to all organizations developing candidate nanomedicines prior to their submission to regulatory agencies to get approval for clinical trials and, later on, for marketing authorization.

– Empa Swiss Federal Laboratories for Materials Science and Technology

Announcements

Conducting Cancer Clinical Trials Using Immunotherapies: The Seventh Annual AACI CRI Meeting

The Association of American Cancer Institutes (AACI) Clinical Research Initiative (CRI) will convene its seventh annual meeting July 8-9 in Chicago. The meeting will focus on immunotherapies for cancer and their impact on cancer clinical trials.

– Association of American Cancer Institutes (AACI)

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