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Newswise Special Wire
Tuesday, July 14, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 14-Jul-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Skin Cancer Marker Plays Critical Role in Tumor Growth

New research from the Johns Hopkins Bloomberg School of Public Health suggests that the protein keratin 17 – the presence of which is used in the lab to detect and stage various types of cancers – is not just a biomarker for the disease, but may play a critical role in tumor growth.

(Embargo expired on 13-Jul-2015 at 11:00 ET)

Nature Genetics

– Johns Hopkins Bloomberg School of Public Health

New Cell Division Mechanism Discovered

Canadian and British researchers have discovered that chromosomes play an active role in animal cell division. This occurs at a precise stage – cytokinesis – when the cell splits into two new daughter cells.

(Embargo expired on 13-Jul-2015 at 11:00 ET)

Nature, July 13, 2015

– Universite de Montreal

Online Registry Improves Clinical Research Study Participation

Research for Her™, Cedars-Sinai’s groundbreaking online registry that matches women with research studies and clinical trials, enrolled study participants more quickly when compared with traditional paper-based registries, according to new research published in the journal Gynecologic Oncology.

Gynecologic Oncology

– Cedars-Sinai Medical Center

Lung Cancer Patients Who Stop Smoking Live Longer

Tobacco cessation provided significant survival benefit for lung cancer patients who quit smoking shortly before or after diagnosis, despite the severity of the disease. Results of the Roswell Park Cancer Institute study were published in the Journal of Thoracic Oncology.

Journal of Thoracic Oncology

– Roswell Park Cancer Institute

Bacteria Lurking in Your Colon Can Influence Cancer Growth

Understanding how these organisms trigger the transformation of normal cells to cancerous ones is the focus of a new National Cancer Institute grant awarded to Shahid Umar, Ph.D., of The University of Kansas Cancer Center.

 • Image(s) embedded • 

NCI 1R01CA185322-01A1

– University of Kansas Cancer Center

Latina Dispels Myth That Women of Color Can’t Get Skin Cancer

As a teen and young adult, Elena Schmidt, 49, visited tanning beds several times a week to maintain her dark skin tone. Mrs. Schmidt, who is of Mexican decent, never wore sunscreen or feared skin cancer.

– Loyola University Health System

Gene Therapy Advance Thwarts Brain Cancer in Rats

Researchers funded by the National Institute of Biomedical Imaging and Bioengineering have designed a nanoparticle gene delivery system that destroys brain gliomas in a rat model, significantly extending the lives of the treated animals. The nanoparticles are filled with genes for an enzyme that converts a prodrug called ganciclovir into a potent destroyer of the glioma cells

 • Image(s) embedded • 

ACS Nano, Feb 2015

– National Institute of Biomedical Imaging and Bioengineering

Cancer Patients Treated in World-First Clinical Trial of Canadian Viral Therapy

Canadian researchers have launched the world’s first clinical trial of a novel investigational therapy that uses a combination of two viruses to attack and kill cancer cells, and stimulate an anti-cancer immune response.

– McMaster University

Aggressive Cancer Treatment Near End of Life Persists Despite Rise in Advance Planning Efforts

In a review of nearly 2,000 surveys with people whose loved ones died of cancer, researchers led by Johns Hopkins experts say they found a 40 percent increase over a 12-year period in the number of patients with cancer who participated in one form of advance care planning — designating durable power of attorney privileges to a loved one — but no corresponding impact on their rates of aggressive medical care received in the last weeks of life.

(Embargo expired on 09-Jul-2015 at 11:00 ET)

K01AG041763; K07CA166210

– Johns Hopkins Medicine

Women Inventors, Treating Anorexia, 3D Models of the Intestine, and More Top Stories 9 July 2015

Other topics include the importance of nursing in medicine, more efficient drug development, studying the arts improves medical care, and more...

– Newswise Trends

Multiple Myeloma Hides in Bones Like a Wolf in Sheep’s Clothing

Multiple myeloma uses a trick akin to a wolf in sheep’s clothing to grow in and spread to new bone sites. By overexpressing Runx2, a gene that normally is a master regulator of bone formation, the cells of this largely incurable cancer produce proteins that mimic the normal bone-resident cells.

Blood

– University of Alabama at Birmingham

Study Advances Potential of Tumor Genome Sequencing and DNA-Based Blood Tests in Precision Treatment and Detection of Pancreatic Cancer

In a genome-sequencing study of pancreatic cancers and blood in 101 patients, Johns Hopkins Kimmel Cancer Center scientists say they found at least one-third of the patients’ tumors have genetic mutations that may someday help guide precision therapy of their disease. Results of blood tests to detect DNA shed from tumors, they say, also predicted cancer recurrence more than half a year earlier than standard imaging methods.

Nature Communications; CA121113; CA62924

– Johns Hopkins Medicine

MRI, Near Infrared Spectral Tomography Increases Specificity in Breast Cancer Imaging

Norris Cotton Cancer Center investigators demonstrated that a dual breast exam using MRI and Near Infrared Spectral Tomography (NIRST) is feasible and more accurate than MRI alone.

Clinical Cancer Research; RO1 CA069544 ; RO1 CA132750

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Researchers Identify Critical Genes Responsible for Brain Tumor Growth

After generating new brain tumor models, Cedars-Sinai scientists in the Board of Governors Regenerative Medicine Institute identified the role of a family of genes underlying tumor growth in a wide spectrum of high grade brain tumors.

Cell Reports

– Cedars-Sinai Medical Center

Treating Breast Cancer with Progesterone Could Aid Survival

A special technique where breast cancer cells are “rescued” for research has been developed at the University of Adelaide. Coupled with advanced scientific technologies pioneered by Cambridge University this has provided a unique insight into the hormone regulation of breast cancers, which is expected to lead to new treatments for the disease.

(Embargo expired on 08-Jul-2015 at 13:00 ET)

Nature

– University of Adelaide

UH Seidman Cancer Center Investigators Develop Activated T Cell Therapy for Advanced Melanoma

A new study in the Journal of Immunotherapy finds that T cells from patients with melanoma can trigger a protective immune response against the disease.

Journal of Immunotherapy

– University Hospitals Case Medical Center

UK Study Reveals New Method to Develop More Efficient Drugs

A new study led by University of Kentucky researchers suggests a new approach to develop highly-potent drugs which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.

 • Image(s) embedded • 

Nanomedicine

– University of Kentucky

Ludwig Cancer Research and the Cancer Research Institute Evaluate Immunotherapeutic Strategies for Brain Cancer and Other Types of Solid Tumors

Ludwig Cancer Research (Ludwig) and the Cancer Research Institute (CRI) have launched clinical trials evaluating an immunotherapy for the treatment of the brain cancer glioblastoma multiforme (GBM), and a combination of immunotherapies for a variety of solid tumors.

– Ludwig Cancer Research

Extended-Field Intensity Modulated Radiation Therapy for Cervical and Endometrial Cancers Does Not Increase Risk of Duodenal Toxicity

A study of women with cervical or endometrial cancer who require treatment to the para-aortic (PA) lymph nodes can safely receive extended-field intensity modulated radiation therapy (EF-IMRT) without increased risk of duodenal toxicity, according to a study published in the July-August 2015 issue of Practical Radiation Oncology (PRO), the American Society for Radiation Oncology’s (ASTRO’s) journal focused on the clinical practice of radiation oncology.

Practical Radiation Oncology (PRO)

– American Society for Radiation Oncology (ASTRO)

Policy and Public Affairs

World-Leading Big Data Researchers Call for Support for More Accessible and More Effective Storage of Data in the Cloud to Facilitate Genomics Research

Today in the journal Nature prominent researchers from Canada, Europe and the U.S. have made a powerful call to major funding agencies, asking them to commit to establishing a global genomic data commons in the cloud that could be easily accessed by authorized researchers worldwide.

 • Image(s) embedded • 

Nature

– Ontario Institute for Cancer Research

Announcements

NIH National Cancer Institute Awards Top-Tier Comprehensive Status to UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center

The National Cancer Institute (NCI) has awarded UT Southwestern Medical Center’s Harold C. Simmons Comprehensive Cancer Center its highest designation, making it one of only 45 cancer centers nationally to receive this distinction over the past 44 years.

 • Image(s) embedded • 

– UT Southwestern Medical Center

Ludwig Cancer Research and University of Oxford Launch Cancer Immunotherapy Spinout

Isis Innovation, the University of Oxford’s technology commercialisation company, and Ludwig Cancer Research are proud to announce the launch of a new spinout company, iOx Therapeutics. iOx Therapeutics will develop a novel cancer immunotherapy discovered through a collaboration between Ludwig Cancer Research and Professor Vincenzo Cerundolo, the director of the MRC Human Immunology Unit within the University of Oxford’s Weatherall Institute of Molecular Medicine.

(Embargo expired on 09-Jul-2015 at 06:00 ET)

– Ludwig Cancer Research

National Cancer Institute Awards Huntsman Cancer Institute Elite Comprehensive Cancer Center Designation

The National Cancer Institute (NCI) has awarded Huntsman Cancer Institute (HCI) at the University of Utah its Comprehensive Cancer Center status, the highest designation possible. The announcement was made today in an award letter from NCI to Dr. Mary Beckerle, HCI’s CEO and director. The award was the result of an extensive review process that culminated in a full-day on-site visit by national cancer research experts and thought leaders in the fourth quarter of 2014.

– Huntsman Cancer Institute at the University of Utah

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