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Newswise Special Wire
Tuesday, July 21, 2015

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Newswise Cancer Research Wire for 21-Jul-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Examination of Use of Diabetes Drug Pioglitazone and Risk of Bladder Cancer

Although some previous studies have suggested an increased risk of bladder cancer with use of the diabetes drug pioglitazone, analyses that included nearly 200,000 patients found no statistically significant increased risk, however a small increased risk could not be excluded, according to a study in the July 21 issue of JAMA.

(Embargo expired on 21-Jul-2015 at 11:00 ET)

JAMA

– JAMA - Journal of the American Medical Association

Poverty and Child Development, Race and Heart Health, Pot to Treat Pain, and More Top Stories 21 July 2015

Other topics include genetics to predict prostate cancer, Facebook and body image, bioengineered immune cell response, and more...

– Newswise Trends

Sound Waves Gently Cull Circulating Tumor Cells from Blood Samples

The capture and analysis of circulating tumor cells (CTCs) is a valuable tool for cancer treatment decisions and therapy monitoring. Researchers funded by the National Institute of Biomedical Imaging and Bioengineering are using sound waves to isolate CTCs without physical contact or damage to the cells, assuring that their original characteristics are maintained. The contact-free nature of the method offers the potential for more precise cancer treatment and monitoring.

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PNAS, April-2015

– National Institute of Biomedical Imaging and Bioengineering

Rutgers Cancer Institute of New Jersey Examines Two to Three Day Radiation Course for Breast Cancer

Rutgers Cancer Institute of New Jersey is leading a clinical trial examining if a certain dose of radiation given over a short period of time to the part of the breast affected by cancer is beneficial. The trial, known as the TRI-faction Radiotherapy Utilized to Minimize Patient Hospital Trips – or TRIUMPH-T Trial – will explore the effect of treating patients with radiation delivered over a shortened period of two to three days versus longer periods associated with traditional radiation therapy.

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– Rutgers Cancer Institute of New Jersey

Researchers Aiming to Produce Vaccine to Save the Tasmanian Devil

New research, led by University of Southampton biological scientist Dr Hannah Siddle, is aiming to develop an effective vaccine against an infectious cancer that is eradicating the Tasmanian devil, the world’s largest remaining marsupial carnivore.

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– University of Southampton

Patients' Own Genetically Altered Immune Cells Show Promise in Fighting Blood Cancer

In recent years, immunotherapy has emerged as a promising treatment for certain cancers. Now this strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable. The results appeared in a study published online today in Nature Medicine.

(Embargo expired on 20-Jul-2015 at 11:00 ET)

Nature Medicine Advance Online Publication

– University of Maryland Medical Center/School of Medicine

Study Finds One-Third of Colorectal Cancers Diagnosed Before Age 35 Are Hereditary

Hereditary colorectal cancers, caused by inherited gene mutations, are relatively rare for most patients.

 • Image(s) embedded •  (Embargo expired on 20-Jul-2015 at 16:00 ET)

Journal of Clinical Oncology

– University of Texas M. D. Anderson Cancer Center

Genomic Fingerprint May Predict Aggressive Prostate Cancer in African Americans

A set of genes could help stratify African American men in need of more aggressive treatment for prostate cancer.

Journal of Clinical Oncology

– Thomas Jefferson University

Georgia State Study Finds State Regulations Linked to Late Cancer Diagnoses

States’ regulations of health insurance and practitioners significantly influence when patients receive colorectal or breast cancer diagnoses, especially among people younger than the Medicare-eligible age of 65, according to a new study by researchers at Georgia State University’s School of Public Health and the University of North Carolina at Chapel Hill.

Health Economics Review

– Georgia State University

Life-Saving Breast Cancer Drugs Going Untaken in Appalachia

Nearly a third of breast cancer survivors in Appalachia are not taking the critical, potentially life-saving follow-up treatment – despite having insurance that would pay for it, a troubling new study has found.

– University of Virginia Health System

New Method to Deliver Glucose to Cancer Cells Could Prove Key to Defeating Deadly Cancers

•UCLA scientists have for the first time demonstrated the importance of sodium-dependent glucose transporters (SGLTs) in delivering glucose to pancreatic and prostate cancer cells •Study results show promising evidence that current SGLT inhibitor drugs (such as those commonly used to treat diabetes) could potentially be used to block glucose uptake and reduce tumor growth in these cancers •Researchers also utilized PET imaging to measure SGLT activity, suggesting the technology could be used to better diagnose pancreatic and prostate cancers •Pancreatic and prostate cancers are among the most deadly forms of cancer in men, and new therapies are urgently needed to combat these diseases

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PNAS

– University of California, Los Angeles (UCLA), Health Sciences

Study: The Angelina Jolie Effect on Breast Cancer Screening

Angelina Jolie received widespread media attention in 2013 when she told the public that she’d tested positive for BRCA1, a gene associated with an increased risk of breast cancer, and subsequently had a double mastectomy. Now research shows this publicity did influence some women’s intentions to seek similar testing.

Journal of Health Communication, DOI: 10.1080/10810730.2015.1064498

– North Carolina State University

New Imaging Contrast Agents Light Up Thyroid and Parathyroid Glands during Surgery

NIBIB-funded researchers have developed two near-infrared contrast agents that are efficiently taken up by the thyroid and parathyroid glands following intravenous injection. The contrast agents could be used to help surgeons operate on the glands with greater precision.

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Nature Medicine

– National Institute of Biomedical Imaging and Bioengineering

Michigan Child Battles, Defeats Rare Shoulder Cancer: Ewing's Sarcoma

Noah Gochanour, 8, of Michigan, recently started complaining about pain that wouldn’t go away. Beaumont Children’s Hospital doctors evaluated Noah and discovered the reason for his pain and discomfort: Ewing’s sarcoma, a rare cancerous tumor in his shoulder.

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– Beaumont Health

Can Protein 14-3-3 Sigma Prevent or Kill Breast Cancer Tumors?

Every parent knows the maxim “feed a cold, starve a fever.” In cancer, however, exactly how to feed or starve a tumor has not been easy to determine.

 • Image(s) embedded •  (Embargo expired on 16-Jul-2015 at 05:00 ET)

Nature Communications

– University of Texas M. D. Anderson Cancer Center

Cell Division Speeds Up as Part of Antibody Selection, Study Shows

In response to an infection, the immune system refines its defensive proteins, called antibodies, to better target an invader. New research has revealed two mechanisms that favor the selection of B cells capable of producing antibodies with the highest affinity for that invader.

 • Image(s) embedded •  (Embargo expired on 16-Jul-2015 at 14:00 ET)

Science, July 16 2015

– Rockefeller University

Increased Radiation Dose Offers No Survival Benefit for Patients with Low-Risk Prostate Cancer

Increased radiation dose is associated with higher survival rates in men with medium- and high-risk prostate cancer, but not men with low-risk prostate cancer, according to a new study from Penn Medicine published this week in JAMA Oncology.

(Embargo expired on 16-Jul-2015 at 11:00 ET)

JAMA Oncology

– Perelman School of Medicine at the University of Pennsylvania

UofL Physicians Conducting Vaccine Trial for Children with Relapsed Tumors at Kosair Children’s Hospital

Children with cancer and their parents are finding hope in a Phase I research study led by Kenneth G. Lucas, M.D., at the University of Louisville, who is making progress in developing a vaccine that one day could possibly prevent recurrence of some childhood cancers.

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– University of Louisville

The Medical Minute: Sunburn Tattoos Both Trendy and Dangerous

They may look neat, but the dangers of sunburn tattoos far outweigh the coolness factor.

– Penn State Milton S. Hershey Medical Center

Cedars-Sinai Medical Tip Sheet for July

Cedars-Sinai's July tip sheet includes story ideas related to Alzheimer's disease research, an upcoming conference on Lou Gehrig's Disease, also known as ALS, identification of critical genes responsible for brain tumor growth, and an online registry that is improving clinical research study participation. To pursue any of these story ideas, please contact the respective individuals listed.

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– Cedars-Sinai Medical Center

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