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Newswise Special Wire
Tuesday, July 28, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 28-Jul-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

University of Colorado Cancer Center and Loxo Oncology Announce Publication That Provides Clinical Validation For LOXO-101 Against TRK Fusion Cancer

Published today in Cancer Discovery, results of LOXO-101 against TRK fusion cancer confirm that stage IV patient's tumors had substantially regressed. With four months of treatment, additional CT scans demonstrated almost complete disappearance of the largest tumors.

 • Image(s) embedded •  (Embargo expired on 27-Jul-2015 at 16:00 ET)

Cancer Discovery; NIH/NCI P50CA058187; NIH/NCI CCSG P30CA046934 ; V Foundation Scholar Award ; State of Colorado and University of Colorado Technology Transfer Office Bioscience Discovery Evaluation Grant Program...

– University of Colorado Cancer Center

New Drug for Blood Cancers Now in Five Phase II Clinical Trials

Researchers at University of California, San Diego School of Medicine have established the safety and dosing of a new drug for treating blood cancers.

The Lancet Haematology

– University of California, San Diego Health Sciences

Small Grants Supply the Research “Lifeblood” of Early Career Scientists

Researchers are familiar with the old scientific mantra “publish or perish,” but it leaves out a critical early step. Securing grant funding for research is imperative for early-career scientists to perform their own independent research, publish in prestigious journals and ultimately earn university tenure.

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– Georgetown Lombardi Comprehensive Cancer Center

For Prostate Cancer Patients, Risk-Specific Therapies Now More the Norm

After decades of overtreatment for low-risk prostate cancer and inadequate management of its more aggressive forms, patients are now more likely to receive medical care matched to level of risk, according to a study by researchers at UC San Francisco.

– University of California, San Francisco (UCSF)

Medicare Payment Cuts, Schizophrenia Gene, Leukemia Treatment, and More Top Stories 24 July 2015

Other topics include ethnic disparities in pain treatment, colon cancer and IBD, halting Liver cancer, and more...

– Newswise Trends

Understanding Why Some Latina Women Discontinue Participation in Cancer Prevention Outreach

It has long been known that rates of breast and cervical cancer screening among Latinas are low compared to rates for U.S. women overall. A study led by researchers at Roswell Park Cancer Institute (RPCI) found that age and fear of cancer diagnosis are among the reasons why Latina women do not continue participation following breast and cervical cancer education programs. The research was published in the Journal of Health Communication: International Perspectives.

Journal of Health Communication: International Perspectives

– Roswell Park Cancer Institute

Leading Experts Prescribe How to Make Cancer Drugs More Affordable

A group of 118 of the nation's leading cancer experts have drafted a prescription for reducing the high cost of cancer drugs and voiced support for a patient-based grassroots movement demanding action on the issue. Their recommendations and support are outlined in a commentary, co-authored by the group, in the journal Mayo Clinic Proceedings.

(Embargo expired on 23-Jul-2015 at 00:05 ET)

Mayo Clinic Proceedings

– Mayo Clinic

Moffitt Cancer Center Researchers Develop First Genetic Test to Predict Tumor Sensitivity to Radiation Therapy

Moffitt Cancer Center researchers have contributed to these advances by developing the first test that analyzes the sensitivity of tumors to radiation therapy. They discovered that colon cancer metastases have varying sensitivity to radiation therapy based on their anatomic location.

International Journal of Radiation Oncology, Biology and Physics, July-2015

– Moffitt Cancer Center

Novel Algorithm Identifies DNA Copy-Number Landscapes in African American Colon Cancers

The algorithm ENVE could be the Google for genetic aberrations — and it comes from Case Western Reserve. The findings about the algorithm that distinguishes “noise” from real evidence, as well as some genetic characteristics of colon cancer in African Americans, appears this week in Genome Medicine.

Genome Medicine; K08 CA148980,P50 CA150964, P50 CA150964, R21 CA149349, P30 CA043703, U54 CA163060

– Case Western Reserve University

Mayo Clinic Researchers Decode Molecular Action of Combination Therapy for a Deadly Thyroid Cancer

In their bid to find the best combination of therapies to treat anaplastic thyroid cancer (ATC), researchers on Mayo Clinic’s Florida campus demonstrated that all histone deacetylase (HDAC) inhibitors are not created equal.

Endocrine Related Cancers; R01CA136665; FL09B202

– Mayo Clinic

Stem Cell Transplantation for Children with Rare Form of Leukemia Improves Outcomes

Researchers in the Division of Hematology, Oncology and Blood & Marrow Transplantation at CHLA have shown greatly improved outcomes in using stem cell transplantation to treat patients with a serious but very rare form of chronic blood cancer called juvenile myelomonocytic leukemia (JMML).

Blood

– Childrens Hospital Los Angeles

Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support

A new study by researchers at University of California, San Diego School of Medicine reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer. The study was published July 23 in Cell Stem Cell.

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Cell Stem Cell - July 23, 2015 (online)

– University of California, San Diego Health Sciences

UCLA Scientists Discover Breakthrough Experimental Therapy to Treat Colon Cancer and Chronic Inflammatory Bowel Disease

UCLA scientists have discovered a groundbreaking experimental therapy that has the ability to suppress the development of ulcerative colitis (UC), a disease which causes inflammation in the digestive tract and colon cancer. The treatment utilizes a chemical inhibitor able to block an RNA molecule (microRNA-214) involved in the transmission of genetic information.

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Gastroenterology

– University of California, Los Angeles (UCLA), Health Sciences

Researchers Find New Method to Halt the Advance of Liver Cancer

Study suggests that drugs targeting the lymphotoxin-beta receptor may improve liver cancer treatment.

Gut

– Sanford Burnham Prebys Medical Discovery Institute

Changing the Color of Light

University of Delaware researchers have developed a method that could improve medical imaging and cancer treatments and increase the efficiency of commercial solar cells by 25 to 30 percent.

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– University of Delaware

Modified DNA Building Blocks Are Cancer’s Achilles Heel

In studying how cells recycle the building blocks of DNA, Ludwig Cancer Research scientists have discovered a potential therapeutic strategy for cancer. They found that normal cells have highly selective mechanisms to ensure that nucleosides—the chemical blocks used to make new strands of DNA—don’t carry extra, unwanted chemical changes. But the scientists also found that some types of cancer cells aren’t so selective. These cells incorporate chemically modified nucleosides into their DNA, which is toxic to them. The findings, published today in the journal Nature, indicate that it might be possible to use modified nucleotides for specific killing of cancer cells.

(Embargo expired on 22-Jul-2015 at 13:00 ET)

Nature

– Ludwig Cancer Research

New Target to Treat Depression, Sound Waves to Combat Tumors, and Improving Blood Vessels with Age, Top Stories 22 July 2015

Other topics include nursing research, treating hep C and HIV, and more

– Newswise Trends

Evolution Not Just Mutation Drives Development of Cancer

A paper published today in the Proceedings of the National Academy of Sciences argues against the commonly held "accumulation of mutations" model of oncogenesis in favor of a model that depends on evolutionary pressures acting on populations of cells.

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Proceedings of the National Academy of Sciences; NCI R01CA180175

– University of Colorado Cancer Center

Policy and Public Affairs

Proposed Medicare Physician Payment Cuts for 2016 Threaten Access to Community-Based Radiation Therapy

ASTRO concerned about access to care for patients with cancer, particularly in rural and underserved areas

– American Society for Radiation Oncology (ASTRO)

Announcements

UCLA's Jonsson Comprehensive Cancer Center Once Again Ranks Among Top 10 Cancer Centers Nationwide

UCLA’s Jonsson Comprehensive Cancer Center is ranked among the top 10 cancer centers in the nation, according to a U.S. News & World Report survey of board-certified physicians from across the country. The survey reviewed patient outcomes, the cancer center’s reputation among physicians, mortality rates and other care-related factors.

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– University of California, Los Angeles (UCLA), Health Sciences

Expert Pitch

Will One Bad Sunburn Give You Skin Cancer?

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– University of Colorado Cancer Center

@LombardiCancer doc: #osteoporosis drug should be part of treatment for #postmenopausal women w/ #breastcancer

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– Georgetown Lombardi Comprehensive Cancer Center

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