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Newswise Special Wire
Tuesday, August 4, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 04-Aug-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Exercise During Teen Years Linked to Lowered Risk of Cancer Death Later

Women who exercised during their teen years were less likely to die from cancer and all other causes during middle-age and later in life, according to a new study by investigators at Vanderbilt University Medical Center and the Shanghai Cancer Institute in China.

Cancer Epidemiology, Biomarkers & Prevention

– Vanderbilt University Medical Center

Study Reveals New Insight Into DNA Repair

DNA double-strand breaks (DSBs) are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy.

 • Image(s) embedded •  (Embargo expired on 03-Aug-2015 at 11:00 ET)

Nature Cell Biology

– University of Texas M. D. Anderson Cancer Center

Potential New Therapy Approaches to Reverse Kidney Damage Identified

Study shows that cell plasticity program resulting from kidney damage can be targeted to reverse disease and fibrosis.

 • Image(s) embedded •  (Embargo expired on 03-Aug-2015 at 11:05 ET)

Nature Medicine

– University of Texas M. D. Anderson Cancer Center

Combination Therapy May Be More Effective Against the Most Common Ovarian Cancer

High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but why it so frequently comes back after treatment has been a medical mystery. Now a team of UCLA researchers has discovered that a subset of tumor cells that don’t produce the protein CA125, a biomarker used to test for ovarian cancer, has an enhanced ability to repair their DNA and resist programmed cell death — which allows the cells to evade the drug and live long enough to regrow the original tumor.

 • Image(s) embedded •  (Embargo expired on 03-Aug-2015 at 05:00 ET)

Nature Communications

– University of California, Los Angeles (UCLA), Health Sciences

Radiation Dose Reduction and Practice Quality Improvement Highlight August JACR

The August 2015 issue of the Journal of the American College of Radiology (JACR®) highlights radiation reduction efforts , radiology quality improvement steps and future cancer imaging.

(Embargo expired on 03-Aug-2015 at 00:00 ET)

Journal of the American College of Radiology

– American College of Radiology (ACR)

FAU Student and Surgeon Collaborate on New, Alternative Procedure to Radical Mastectomy

Elizabeth Hopkins has spent more than 640 hours shadowing Hilton Becker, M.D. In 2014, she had a double mastectomy as a preventive measure, using a revolutionary procedure developed by Becker that is an alternative to radical mastectomy, is done minimally invasively, and spares the skin, nipple and areola.

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Plastic and Reconstructive Surgery Journal

– Florida Atlantic University

Failure to Control Early Prostate Cancer Results in a Poor Outcome

Research finds an association between positive post-radiation therapy biopsy results and subsequent clinical outcomes in men with localized prostate cancer.

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International Journal of Radiation Oncology Biology Physics

– Beaumont Health

Veterans Returning from Middle East Face Higher Skin Cancer Risk

Soldiers who served in the glaring desert sunlight of Iraq and Afghanistan returned home with an increased risk of skin cancer, due not only to the desert climate, but also a lack of sun protection, Vanderbilt dermatologist Jennifer Powers, M.D., reports in a study published recently in the Journal of Investigative Dermatology.

Journal of Investigative Dermatology

– Vanderbilt University Medical Center

Newly Identified Mechanism of p53-Induced Cell Death Could Aid Cancer Therapy

Research led by St. Jude Children’s Research Hospital reveals how the tumor suppressor protein p53 works in the cytoplasm to trigger death via apoptosis and identifies a potential cancer treatment strategy.

 • Image(s) embedded •  (Embargo expired on 30-Jul-2015 at 12:00 ET)

Molecular Cell

– St. Jude Children's Research Hospital

Identifying a Key Growth Factor in Cell Proliferation

In two companion papers published in Cell, researchers from MIT's Koch Institute reveal why proliferating cells — including those in tumors — require mitochondrial respiration. While there are other ways to make ATP, cells can’t proliferate without access to electron acceptors provided by respiration.

Cell, Jul-2015

– Koch Institute for Integrative Cancer Research at MIT

Immunotherapy: 5 Ways to Stop Cancer

"Immunotherapy: 5 Ways to Stop Cancer" features five 1-minute animated videos that provide a quick overview of the five most common immunotherapies in use: monoclonal antibodies, checkpoint inhibitors, cancer vaccines, adoptive cell therapy, and oncolytic viruses.

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– Cancer Research Institute

What Cancer Patients Should Know: Latest Immunotherapy News From ASCO

Learn the latest news in cancer immunotherapy for melanoma, lung cancer, leukemia, liver cancer, and other cancer types.

 • Video embedded • 

– Cancer Research Institute

"Global Perspectives on Cancer: Incidence, Care, and Experience"

Kenneth Miller, M.D., co-authors a book exploring why and how cancer is treated differently around the world and how those differences affect outcomes.

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– LifeBridge Health

Overcoming Why a New Treatment Is Resisted by Lung Cancer

A promising agent for the treatment of cancer has so far had little effect on the most common lung tumours, but new research from The University of Manchester has suggested how this resistance might be overcome.

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PNAS

– University of Manchester

Scientists Identify Gene Vital for Rebuilding Intestine After Cancer Treatment

Scientists at the UNC School of Medicine and the UNC Lineberger Comprehensive Cancer Center found that a rare type of stem cell is immune to radiation damage thanks to high levels of a gene called Sox9.

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Gastroenterology

– University of North Carolina Health Care System

Real-Time Imaging of Lung Lesions During Surgery Helps Localize Tumors and Improve Precision

New molecular tools are emerging to identify lung adenocarcinomas during pulmonary resection. The results of a proof-of-concept study suggest that lung cancer fluorescent imaging during surgery using targeted molecular agents may soon be a reality. While the methodology still needs refinement, the technique holds the possibility of precise visualization of tumor margins, detection of other tumors or metastases, localization of small malignant ground glass opacities, and accurate identification of lymph nodes containing metastatic cancer cells.

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The Journal of Thoracic and Cardiovascular Surgery

– American Association for Thoracic Surgery (AATS)

Targeted Therapy Shows Effectiveness Against a Subtype of the Brain Tumor Medulloblastoma

A subset of medulloblastoma tumors briefly stopped growing or disappeared entirely during treatment with vismodegib; St. Jude Children’s Hospital led the Pediatric Brain Tumor Consortium trials in children and adults.

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Journal of Clinical Oncology

– St. Jude Children's Research Hospital

New Tool Uses ‘Drug Spillover’ to Match Cancer Patients with Treatments

Article in journal Bioinformatics from University of Colorado Cancer Center describes a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker (KAR) predicts what genetics are truly driving the cancer in any population of cells and chooses the best “kinase inhibitor” to silence these dangerous genetic causes of disease.

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Bioinformatics; P30CA046934; P50CA058187; T32CA17468

– University of Colorado Cancer Center

Announcements

NCCN Seeking Poster Presentations from Nation’s Top Oncology Researchers

NCCN is now accepting original abstracts from investigators for consideration for the NCCN 21st Annual Conference General Poster Session; the deadline for submissions is Friday, November 6, 2015.

– National Comprehensive Cancer Network® (NCCN®)

The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation

The Tisch Cancer Institute (TCI) at the Icahn School of Medicine at Mount Sinai has been named a National Cancer Institute (NCI)-designated cancer center. TCI joins an elite group of 69 cancer institutions nationwide that have earned this designation, which is based on scientific excellence, robust clinical research, and beneficial community impact.

– Mount Sinai Medical Center

GW Cancer Institute Approved for a $250K Engagement Award by the Patient-Centered Outcomes Research Institute

The George Washington University Cancer Institute has been approved for a $250,000 Eugene Washington PCORI Engagement Award by the Patient-centered Outcomes Research Institute to create the first-ever online Community of Practice for patient-centered care.

– George Washington University

NYU’s Bluestone Center Receives a $369,250 High Priority, Short-Term Project Award from NIDCR to Study Oral Cancer Pain

The proposed studies are designed to test whether nonviral gene delivery into the oral cancer could be used to treat cancer pain effectively and safely.

R56DE025393

– New York University

Five New Centers Awarded Signature Centers Initiative Grants

A team of scientists searching for an innovative repair strategy for spinal cord and brain injuries, and another looking for cures for the "wasting away," experienced by AIDS and cancer patients are among five research center teams awarded development funding in IUPUI Signature Centers Program.

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– Indiana University

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