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Newswise Special Wire
Wednesday, August 12, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 12-Aug-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Blood Vessel “Doorway” Lets Breast Cancer Cells Spread Through Blood Stream

Using real-time, high-resolution imaging, scientists have identified how a “doorway” in the blood vessel wall allows cancer cells to spread from breast tumors to other parts of the body. The findings support emerging tests that better predict if breast cancer will spread, which could spare women from unnecessary treatments and lead to new anti-cancer therapies. The research from Albert Einstein Cancer Center and Montefiore Einstein Center for Cancer Care published today in Cancer Discovery.

(Embargo expired on 12-Aug-2015 at 00:05 ET)

Cancer Discovery; Department of Defense Breast Cancer Research Program; National Institutes of Health; Einstein’s Integrated Imaging Program

– Albert Einstein College of Medicine of Yeshiva University

Tell-Tale Biomarker Detects Early Breast Cancer in NIH-Funded Study

Researchers have shown that MRI can detect the earliest signs of breast cancer recurrence and fast-growing tumors. Their approach detects micrometastases, breakaway tumor cells with the potential to develop into dangerous secondary breast cancer tumors elsewhere in the body. The approach may offer an improved way to detect early recurrence of breast cancer in women and men. The work was completed at Case Western Reserve University and was funded by the National Institute of Biomedical Imaging and Bioengineering, part of NIH.

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Nature Communications, Aug 12, 2015; EB00489

– National Institute of Biomedical Imaging and Bioengineering

Pancreas Cancer Spread From Multiple Types of Wayward Cells

Tumor cells associated with pancreatic cancer often behave like communities by working with each other to increase tumor spread and growth to different organs. Groups of these cancer cells are better than single cancer cells in driving tumor spread.

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Cancer Discovery; CA169123, CA076931

– Perelman School of Medicine at the University of Pennsylvania

New Simple Proteins Play Active Role in Cellular Function

Yale scientists have developed simple new proteins almost devoid of chemical diversity that still play a surprisingly active and specific role in cellular function, causing cells to act like cancer cells, they report Aug. 10 in the Proceedings of the National Academy of Sciences.

Proceedings of the National Academy of Sciences

– Yale Cancer Center

Radiation Costs Vary Among Medicare Patients with Cancer

Cost of radiation therapy among Medicare patients varied most widely because of factors unrelated to a patient or that person’s cancer, report University of California, San Diego School of Medicine researchers in the Journal of Oncology Practice.

Journal of Oncology Practice

– University of California, San Diego Health Sciences

Finding a Fingerprint for an Invasive Cancer Still in Hiding

A new study of a biomarker that can identify DCIS patients who are not at risk for subsequent invasion could save many lives and keep women from having to go through medical and surgical therapy.

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NIH R21 CA185460; American Association for Cancer Research - Breast Cancer Research Foundation

– University of Kansas Cancer Center

Novel Therapeutic Agent for Pediatric Cancer Developed at UC San Diego in Clinical Trials

Donald L. Durden, MD, PhD, pediatric researcher at University of California, San Diego School of Medicine and Moores Cancer Center has identified and developed a novel therapeutic target for neuroblastoma, the second most common solid-tumor childhood cancer. The agent, named SF1126, acts by inhibiting the part of the cancer cell engine that promotes tumor angiogenesis and growth.

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– University of California, San Diego Health Sciences

Cedars-Sinai Medical Tip Sheet for Aug. 2015

The August tip sheet includes story ideas related to prostate and breast cancer research, an enhanced Cedars-Sinai footprint, and the establishment of the Dr. Jerry H. Buss Surgical Oncology Fellowship.

– Cedars-Sinai

miR-7 Suppresses Stomach Cancer

Researchers reveal that the microRNA miR-7 suppresses stomach cancer by inhibiting a key signaling pathway, and that this protective mechanism is compromised by the cancer-causing bacterium <em>H. pylori</em>. Finding drugs capable of inducing miR-7 could therefore prove to be an effective treatment against the progression of gastric cancer.

 • Image(s) embedded •  (Embargo expired on 10-Aug-2015 at 09:00 ET)

The Journal of Cell Biology

– The Rockefeller University Press

Researchers Identify Nerve-Guiding Protein that Aids Pancreatic Cancer Spread

Scientists at the Johns Hopkins Kimmel Cancer Center have identified a molecular partnership in pancreatic cancer cells that might help to explain how the disease spreads — metastasizes — in some cases. Their findings reveal urgently needed new targets to treat pancreatic cancer, which strikes nearly 50,000 people in the U.S. each year and has only a 5 percent survival rate five years after diagnosis.

Science Signaling; R01 CA169702; K23 CA148964-01; HL42093; MOD FY15-226; P50 CA062924; P30 CA006973

– Johns Hopkins Medicine

Scripps Florida Scientists Determine How Antibiotic Gains Cancer-Killing Sulfur Atoms

With implications for future drug design, scientists The Scripps Research Institute’s Florida camps have shown an unprecedented mechanism for how a natural antibiotic with antitumor properties incorporates sulfur into its molecular structure, an essential ingredient of its antitumor activity.

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Proceedings of the National Academy of Sciences

– Scripps Research Institute

New Combination Treatment Effective Against Melanoma Skin Metastases

In findings never before seen in melanoma, a novel combination therapy was found to be highly effective at treating patients with skin metastases, new research from UC Davis has shown.

Journal of the American Academy of Dermatology

– UC Davis Comprehensive Cancer Center

Common Class of ‘Channel Blocking’ Drugs May Find a Role in Cancer Therapy

Drugs called ion channel blockers, which are commonly used to treat cardiac, neurological, and psychiatric disorders, might prove useful in cancer therapy, according to research findings in fruit flies and mice by UC San Francisco scientists that led to unconventional treatment of a case of metastatic brain cancer.

Nature Neuroscience

– University of California, San Francisco (UCSF)

Poor Survival Among Colorectal Cancer Patients Tied to Biomarker CSN6

A protein called CSN6 has been found to be correlated with poor survival among patients with colorectal cancer, according to a study at The University of Texas MD Anderson Cancer Center.

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Expert(s) available

– University of Texas M. D. Anderson Cancer Center

Pediatric Brain Tumors Can be Classified Noninvasively at Diagnosis

Medulloblastoma, the most commonly occurring malignant brain tumor in children, can be classified into four subgroups—each with a different risk profile requiring subgroup-specific therapy. Currently, subgroup determination is done after surgical removal of the tumor.

Neuro-Oncology; CA009659-18

– Childrens Hospital Los Angeles

Shorter Course of Radiation Therapy Associated with Less Toxicity, Improved Quality of Life in Women with Early Stage Breast Cancer

Women who receive a shorter course of whole breast radiation therapy for early stage disease experience less toxicity and improved quality of life compared to those who undergo a longer course of treatment, researchers report from The University of Texas MD Anderson Cancer Center.

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JAMA Oncology

– University of Texas M. D. Anderson Cancer Center

A Powerful Molecular Promoter of Colon Cancers

Cancer researchers already know of some oncogenes and other factors that promote the development of colon cancers, but they don’t yet have the full picture of how these cancers originate and spread. Now researchers have illuminated another powerful factor in this process, by unraveling an additional pathway for the origin of colon cancer.

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PLoS Genetics; R01 DK 056645

– Perelman School of Medicine at the University of Pennsylvania

Topical Gel Proves Safe, Effective Treatment for Patients with Skin T Cell Lymphoma

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL) – a rare type of non-Hodgkin lymphoma that affects the skin. Currently, there is no cure for CTCL aside from a bone marrow transplant. However, the new study shows that the topical gel can eliminate malignant T cells, leading to diminished lesions.

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Blood

– Perelman School of Medicine at the University of Pennsylvania

New Biomarker Identified in Breast and Prostate Cancers Holds Promise for Treating Disease

Cedars-Sinai researchers have identified a novel genetic biomarker responsible for the progression of many breast and prostate cancers. The finding could bolster efforts to better identify patients who respond to certain types of chemotherapy drugs.

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Scientific Reports

– Cedars-Sinai

Long-Term Ovarian Cancer Survival Higher Than Thought

Combing data collected on thousands of California ovarian cancer patients, UC Davis researchers have determined that almost one-third survived at least 10 years after diagnosis.

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Journal of Obstetrics and Gynecology

– UC Davis Comprehensive Cancer Center

New Approach to Decades Old Treatment Yields Increased Survival for Some Prostate Cancer Patients

Research coordinated by the ECOG-ACRIN Cancer Research Group and just published in the The New England Journal of Medicine, examines the outcomes of giving the chemotherapy drug docetaxel at the start of androgen deprivation therapy for patients with metastatic hormone-sensitive prostate cancer. Results showed an increased survival of 13.6 months for patients treated with ADT plus docetaxel than with ADT alone.

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New England Journal of Medicine, Aug-2015

– Rutgers Cancer Institute of New Jersey

Scientists Solve Structure of Important Protein for Tumor Growth

In a collaborative study between Sanford Burnham Prebys Medical Discovery Institute (SBP) and the Argonne National Laboratory, scientists have used a highly specialized X-ray crystallography technique to solve the protein structure of hypoxia-inducible factors (HIFs), important regulators of a tumor’s response to low oxygen (hyopoxia).

Nature; NIH R01DK09147

– Sanford Burnham Prebys Medical Discovery Institute

Penn Scientists Identify Key Genetic Factor That Keeps Moles From Turning Into Melanoma

Moles are benign tumors found on the skin of almost every adult. Scientists have known for years that a mutation in the BRAF gene makes them start growing, but until now haven’t understood why they stop. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania have identified a major genetic factor that keeps moles in their usual non-cancerous, no-growth state.

Cancer Discovery

– Perelman School of Medicine at the University of Pennsylvania

Two-Drug Combination Boosts Survival in Metastatic Prostate Cancer

Men with metastatic, hormone-sensitive prostate cancer gained more than a year of survival when they received both hormone-blocking medications and chemotherapy right after diagnosis, rather than delaying the chemo until the cancer worsened, according to a study led by Dana-Farber’s Christopher Sweeney published in the New England Journal of Medicine.

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New England Journal of Medicine

– Dana-Farber Cancer Institute

Real-Time Data for Cancer Therapy

Researchers at MIT’s Koch Institute for Integrative Cancer Research are developing a tiny biochemical sensor that can be implanted in cancerous tissue during initial biopsy. The sensor wirelessly sends data about telltale biomarkers to an external “reader” device, allowing doctors to better monitor a patient’s progress and adjust dosages or switch therapies accordingly.

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Lab on a Chip, Aug-2015

– Koch Institute for Integrative Cancer Research at MIT

Announcements

Markey's D'Orazio Receives Funding to Further Skin Cancer Research

It's well-known that excessive UV exposure can lead to skin cancer — but Dr. John D'Orazio at the University of Kentucky Markey Cancer Center focuses his research on exactly why this happens, with the hopes of eventually developing longer-lasting forms of UV protection other than topical sunscreen.

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Melanoma Research Alliance, Markey Cancer Foundation, DanceBlue

– University of Kentucky

UNM Cancer Center Awarded National Cancer Institute’s Highest Comprehensive Designation

The University of New Mexico Cancer Center (UNMCC) has been awarded the highest designation and rating in the United States for cancer treatment and research programs. It has received the National Cancer Institute’s “NCI Comprehensive Cancer Center” designation, identifying it as one of the leading cancer centers in the nation and the only such cancer center in New Mexico.

P30CA118100

– University of New Mexico Cancer Center

Physician-Scientist Named Head of Neuro-Oncology at NYU Langone’s Laura and Isaac Perlmutter Cancer Center

Renewing its commitment to enhance its stature in the field of Neuro-Oncology, NYU Langone Medical Center has announced the appointment of physician-scientist and brain tumor specialist Andrew S. Chi, MD, PhD, as the new chief of Neuro-Oncology for its Laura and Isaac Perlmutter Cancer Center and co-director of the NYU Langone Brain Tumor Center.

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– NYU Langone Medical Center

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