Relapse, Poor Survival in Leukemia Linked to Genetic Mutations That Persist in Remission
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival. Using genetic profiling to study bone marrow samples from patients with acute myeloid leukemia (AML), researchers found that those whose cells still carried mutations 30 days after the initiation of chemotherapy were about three times more likely to relapse and die than patients whose bone marrow was cleared of these mutations. The study, by a team at Washington University School of Medicine in St. Louis, is published Aug. 25 in JAMA. • Image(s) embedded • (Embargo expired on 25-Aug-2015 at 11:00 ET)
JAMA, Aug. 25, 2015
– Washington University in St. Louis
Keeping the Cellular Production Line on Track
When our cells copy their DNA to grow and replicate, it’s vital the process runs smoothly. To get this right, cells use a complex “machine”, made from many hundreds of components. • Image(s) embedded • (Embargo expired on 25-Aug-2015 at 08:00 ET)
– MRC Clinical Sciences Centre/Institute of Clinical Sciences (ICS) Faculty of Medicine, Imperial College London
Focused Electrical Blasts Significantly Increase Survival for Patients with Pancreatic Cancer
Use of irreversible electroporation (IRE) doubles the survival time for patients with locally advanced pancreatic cancer say researchers at the University of Louisville in a paper in the September edition of the Annals of Surgery. • Image(s) embedded •
Annals of Surgery, September 2015
– University of Louisville
Study Finds Young Black Women Have a Higher Frequency of BRCA Mutations Than Previously Reported
Moffitt Cancer Center researchers recently conducted the largest U.S. based study of BRCA mutation frequency in young black women diagnosed with breast cancer at or below age 50 and discovered they have a much higher BRCA mutation frequency than that previously reported among young white women with breast cancer.
– Moffitt Cancer Center
Atlantic Health Partners with Rutgers Cancer Institute of New Jersey to Expand Personalized Treatment Offerings to Patients
Rutgers Cancer Institute of New Jersey is joining forces with Atlantic Health System in offering patients with rare forms of cancer access to a precision medicine clinical trial. The research will utilize genomic analysis to identify abnormal changes in the genetic make-up of the cancer in order to better personalize treatments. • Image(s) embedded •
– Rutgers Cancer Institute of New Jersey
Fertility Concerns Impact Breast Cancer Treatment Decisions
Concerns about fertility kept a third of young women with breast cancer from taking tamoxifen, despite its known benefit in reducing the risk of breast cancer coming back. (Embargo expired on 24-Aug-2015 at 16:00 ET)
Journal of the National Cancer Institute; HD076188
– University of Michigan Health System
Mayo Clinic Researchers Find New Code That Makes Reprogramming of Cancer Cells Possible
JACKSONVILLE, Fla. — Cancer researchers dream of the day they can force tumor cells to morph back to the normal cells they once were. Now, researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy. • Video embedded • (Embargo expired on 24-Aug-2015 at 11:00 ET)
Nature Cell Biology; R01 CA100467, R01 NS069753, P50 CA116201, R01 GM086435, R01CA104505, R01CA136665
– Mayo Clinic
Generic Heart Medication Shown to Prolong Ovarian Cancer Patients’ Survival
In a first-of-its-kind study, researchers demonstrate a benefit in overall survival among epithelial ovarian cancer (EOC) patients receiving generic heart medications known as beta-blockers. Survival was shown to be greatest among those prescribed first-generation nonselective beta-blockers. According to The University of Texas MD Anderson Cancer Center investigators, the drugs block the effects of stress pathways involved in tumor growth and spread. • Image(s) embedded • (Embargo expired on 24-Aug-2015 at 00:05 ET)
– University of Texas M. D. Anderson Cancer Center
Promising Class of New Cancer Drugs Might Cause Memory Loss in Mice
New research shows that a family of experimental cancer drugs can induce neurological changes in mice. The findings underscore the need for more research to determine whether these compounds can enter the brain, where they potentially might cause side effects such as memory loss. • Image(s) embedded •
– Rockefeller University
FSU Researcher Identifies Protein with Promise for Cancer Therapy
In the second part of his lab’s recent one-two punch, Florida State University researcher Daniel Kaplan said he has solved a cell division mystery in a way that will intrigue the makers of cancer-fighting drugs.
Journal of Biological Chemistry
– Florida State University
Chasing the Invisible Trail of Targeting Triple-Negative Breast Cancer
Priyanka Sharma, M.D., is looking at what she’s calling “BRCAness” or deficiency in DNA damage repair machinery in triple-negative breast cancer as a potential prognostic and predictive marker. • Image(s) embedded •
Department of Defense: Breakthrough Grant (pending) ; SWOG Developmental Grant; Breast Cancer Research Foundation Grant
– University of Kansas Cancer Center
Memorial Sloan Kettering Cancer Center Researchers Publish Landmark “Basket Study”
Researchers from Memorial Sloan Kettering Cancer Center (MSK) have announced results from the first published basket study, a new form of clinical trial design that explores responses to drugs based on the specific mutations in patients’ tumors rather than where their cancer originated.
New England Journal Medicine - August 20, 2015
– Memorial Sloan Kettering Cancer Center
Cancer Patients Helping UT Southwestern Scientists and NASA Study Pressure Inside the Brain During Zero Gravity
UT Southwestern Medical Center researchers, in conjunction with NASA, will take four volunteer cancer patients on a zero-gravity ride into the upper atmosphere to study why zero-gravity conditions on the International Space Station sometimes affect the vision of astronauts staying there for extended periods. • Video / Image(s) embedded •
– UT Southwestern Medical Center
Complete Resection of High-Grade Brain Cancer Yields Better Survival in Children —Especially Girls
For children with aggressive brain cancers called high-grade gliomas (HGG), the chances of survival are improved when surgery is successful in eliminating all visible cancer, reports a study in the September issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Wolters Kluwer.
– Wolters Kluwer Health: Lippincott Williams and Wilkins
'Jumping Genes' Unusually Active in Many Gastrointestinal Cancers, Studies Find
Results of a trio of studies done on human cancer tissue biopsies have added to growing evidence that a so-called jumping gene called LINE-1 is active during the development of many gastrointestinal cancers.
Nature Medicine; Genome Research; Proceedings of the National Academy of Sciences; R01CA163705; F31CA180682; R01CA163705; P50CA62924 ...
– Johns Hopkins Medicine
Tool Boosts Accuracy in Assessing Breast Cancer Risk
A national risk model that gauges a woman’s chance of developing breast cancer has been refined to give a more accurate assessment.
Journal of Clinical Oncology
– University of California, San Francisco (UCSF)